利他能錠 10 毫克 - ktgh.com.t · PDF file主成份:Methylphenidate hydrochloride ......

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    10 Ritalin Tablets 10 mg (methylphenidate) Methylphenidate hydrochloride Methylphenidate hydrochloride 10 Methylphenidate (INNalpha-phenyl-2-piperidine acetic acid methyl ester) /(ADHD, DSM-IV) ADHD

    Ritalin

    DSM-IV ICD-10 EEG ADHD

    EEG

    ()/

    Ritalin ADHD Ritalin 60

    3

    027080

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    / Ritalin

    ADHD ADHD (6 6 ) - 5 () 5-10 - 20-30 2-3 40-60 10-15 6

    60

    methylphenidate

    (MAO) 2

    (Tourettes)

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    Ritalin/

    Ritalin

    Ritalin

    Ritalin

    Ritalin

    RitalinRitalin

    Ritalin

    Ritalin

    Ritalin

    central nervous stystemCNS(

    )/() Ritalin

    ()

    Ritalin /(

    )

    ADHD

    Ritalin

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    ( Ritalin)

    ADHD ADHD

    Ritalin

    ( Ritalin)

    ()

    ( Ritalin)

    ADHD

    ADHD

    ADHD

    Ritalin (Tourettes)

    methylphenidate ADHD

    Ritalin

    methylphenidate(serotonergic drugs)

    (selective serotonin reuptake inhibitors; SSRIs) -

    (serotonin-norepinephrine reuptake inhibitors; SNRIs)

    methylphenidate

    (

    (hallucinations) (delirium))

    /

    methylphenidate

    ()

    (Priapism)

    methylphenidate

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    ()

    Ritalin

    Ritalin

    Ritalin

    Ritalin

    Ritalin

    Ritalin

    6

    Ritalin 6 6

    Ritalin

    /

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    10%1%

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    ()

    *

    ****

    **

    *

    *

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    *

    * ADHD Ritalin LA

    ** ADHD

    (NMS)

    Ritalin

    ()

    Ritalin

    MEDRA

    ()

    methylphenidate

    Ritalin

    methylphenidate

    Raynaud's phenomenon

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    Ritalin

    Ritalin

    Methylphenidate HCl

    Ritalin

    Ritalin(

    )

    Ritalin MAO 2

    (psychoactive)( Ritalin) CNS

    Ritalin

    alpha-2 clonidine

    clonidine

    methylphenidate ()

    Methylphenidate

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    Dopaminergic

    Ritalin (dopamine)(

    DOPA(tricyclic antidepressants))(

    haloperidol)Ritalin

    Ritalin

    Ritalin P450

    P450 Ritalin

    Ritalin methylphenidate D L

    P450 1A22C82C92C192D62E1 3A

    Ritalin CYP2D6 desipramine

    Ritalin coumarin (

    phenobarbitalphenytoinprimidone)phenylbutazone

    4 ethylbiscoumacetate

    (n=12)

    Ritalin

    /

    Methylphenidate

    Methylphenidate

    RitalinMethylphenidate (

    )

    methylphenidate

    2.5()

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    Ritalin

    methylphenidateMethylphenidate

    ()

    barbiturate

    Ritalin

    calcium gluconate

    (PD) Ritalin racemate d-methylphenidated-MPH l-methylphenidatel-MPH Ritalin

    (striatum) Ritalin

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    L 75 40 dexmethylphenidate hydrachlorideRitalin d QT/QTc intervalQTcF interval < 5 ms90% 10 ms (PK) - (methylphenidate hydrochloride) D 228 % L 53 % 1-2 40 nmol/L (11 ng/ml) - (AUC)(Cmax) methylphenidate (57%)(43%)(10-33%) D 2.651.11 L/kg L 1.800.91 L/kg methylphenidate 0.2%(6 11 ) Methylphenidate Carboxylesterase CES1A1 alpha-phenyl-2-piperidine acetic acid (ritalinic acid) 2 30-50 alpha-phenyl-2-piperidine acetic acid Methylphenidate 0.17 L/hr/Kg( hydroxymethylphenidate hydroxyritalinic acid) Methylphenidate 2 D 0.400.12 L/h/kg L 0.730.28 L/h/kg 48-96 78-97%1-3%(

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    Methylphenidate 200 mg/kg/day (Spina bifida with malrotated hind limbs)AUC(MRHD) 60mg 5.1 MRHD 0.7 300 mg/kg 12 (92 ) 300 mg/kg MRHD 7.5 Methylphenidate 75 mg/kg( MRHD (AUC) 20.9 )(fetuses with short supernumerary ribs) 18 methylphenidate methylphenidate 160 mg/kg/day ( mg/kg MRHD 90 ) methylphenidate 45 mg/kg mg/kg MRHD 26 B6C3F1 methylphenidate () 60 methylphenidate (MRHD 35 )()

    B6C3F1

    F344 methylphenidate 45 mg/kg/day ( mg/kg MRHD 26 )

    3 (Ames)

    250 B6C3F1 Big Blue cII

    HPRT Pig A locus 28 DNA 9 methylphenidate 100 mg/kg/day( 7 )( 10)( 13-14 ) 50 mg/kg/day ( mg/kg MRHD 29) 100 mg/kg/day ( mg/kg MRHD 58 )

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    Calcium phosphate, lactose, wheat starch, gelatin, magnesium stearate, and talc. 4-1000 EXP 30C 99 11 Novartis Farmaceutica S.A. Ronda de Santa Maria 158, 08210 Barbera del Valles, Barcelona, Spain. : Novartis Pharma AG Lichtstrasse 35, 4056 Basel,Switzerland Information issued: IPL 07-Jan-2014, TFDA 02-Jul-2015 TWI- 050617

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