Doç. Dr. Gazi YILDIRIM Yeditepe Üniversitesi Hastanesi Kadın Hastalıkları ve Doğum AD
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- Slide 1
- Do. Dr. Gazi YILDIRIM Yeditepe niversitesi Hastanesi Kadn
Hastalklar ve Doum AD
- Slide 2
- Reproductive Aging Process begins in embryonic life. 20 weeks
gestation - 6 - 7 million follicles. At birth - 1.5-2 million
follicles At menarche - 300,000- 400,000 follicles Follicular
atresia continues throughout life. Follicular loss accelerates when
the total number of follicles is ~25,000 When follicles are
sufficiently depleted (
- prevention of postmenopausal osteoporosis PRIMARY PREVENTION 1.
HRT 2. SERMS 3. TIBOLONE 4. Biophosphonate SECONDARY PREVENTION 1.
Biophosphonates 2. Calcitonin (>5 yrs menopause) 3. Teriparatide
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- Slide 47
- Bisphosphonates Promotes bone formation and decreases bone
resorption Mechanism of Action First line treatment for
osteoporosis in both men and post- menopausal women 1 Application
Approved in both sexes for the prevention and treatment of
osteoporosis Aledronate 2, Risedronate 3 and Zoledronic Acid 4
- Slide 48
- DrugVertebral Fracture RR Hip Fracture RR Non- vertebral RR
Route/ Frequency Indicated for which gender AlendronatePO/QDay,
QWeek Women Men RisedronatePO/QDay, QWeek, QMonth Women Men
IbandronateNE PO/QMonth IV/Q3Mont h Women Zoledronic Acid
IV/QYearWomen Men RR = Risk ReductionNE = No effect demonstrated
Bisphosphonates