i Pingstkyrkan Falköping 2015 ATT VÄLJA HÄLSA¶ping-20… · stig@bengmark.se Falköpings Radio,...

www.bengmark.comstig@bengmark.sewww.foodpharmacy.se

Falköpings Radio, Hälsofrämjandet, Riksförbundet Pensionärsgemenskap

(RPG), Pingstkyrkan Falköping arrangerar i Pingstkyrkan Falköping 2015–10-10

ATT VÄLJA HÄLSA:”Hedra Dina tarmbakterier på det att det må gå

Dig väl och Du må länge leva på jorden” Stig Bengmark MD PhD

UCL, London University, UK

I ödmjuk tacksamhet till:Rolf JohanssonChrister AspPO Dalesjö - videoThomas Henning Agnetha Lagergren Martin Sandström Hasse Sjöstrand Margaretha SödergrenMaria Söhrman

ENVAR SIN EGEN HÄLSAS SMED !

Tillägnas min Mamma med stor kärlek Berta Sofia Bengmark f. 3 April 1897 i Misterhult, Småland

Lars Olov Bygren

HUR BEHANDLAR VI MÄNNISKOSLÄKTET?Dramatisk ökning av kroniska sjukdomar, allt större babies,

allt tidigare pubertet & svåra förlossningsskador!

INDUSTRIAL & AGRICULTURAL REVOLUTION100 % increase in intake of animal fats

5000 % increase in intake of dairy-derived foods 10000 % increase in intake of refined sugar (1 lb => 100 lb)

Baguette (95, pumpernickel 40)), White suger (68), Candy bar (55), Yellow Banana (54),

FORSKNING & FRAMSTEG 2011

Bebac 26, and Mokolo 23, two male Western lowland gorillas at the Cleveland Metropark Zoo are

obese and with heart disease.

The Plain Dealer July 5 2011

MOST FATTENING FOODSJon Brower Minnoch, USA 1941 -1983, 635 kg

• Alcohol

• Bread & Pasta, Pastries

• Butter

• Cheese

• Chips

• Fast food & takeaways

• Fried food

• Jam and marmalade

• Milk & Latte

• Potatoes & other tubers

• Red meat

• Salted nuts

• Tomato ketchup

• Soft drinks

NEGATIVT FÖR MÄNNISKORS HÄLSA?

Bröd 1 - Mycket högt glykemiskt index -GI

2 - För litet fibrer

3 - Starkt upphettat

4 - Innehåller gluten

Mejerivaror1 - För mycket hormoner och tillväxtfaktorer,

2 - Innehåller proinflammatoriskt kasein,

3 - långkedjiga fetter (ofta mättade) dominerar

FRUCTOSE IN FRUITS Dr Mercola 2010

FRUCTOSE & MEMORY LOSSAgrawal R, Gomez-Pinilla F J Physiol 2012;590:2485–2499

MEDITERANIEN DIET & MEMORY Valls-Pedret C et al JAMA Intern Med 2015 E-pub

INCREASED LIFE EXPECTANCY: 47 78 YEARS but an TZUNAMI OF CHRONIC DISEASES

Fontana L Biochimica et Biophysica Acta 2009;1790:1133–1138

• Cardiovascular disease (CVD), cancer, stroke and diabetes account for about 70% of deaths in the US and Europe.

• About 80% of adults > 65 yrs have at least one chronic disease, & 50% have two or more of these chronic diseases.

• > 40% of cancer & > 80% of all heart disease, stroke and type 2 diabetes are preventable with elimination of unhealthy diets, physical inactivity, and tobacco consumption)

DIFFERENT LIFESTYLE – DIFFERENT DISEASE PATTERNClayton P, Rowbotham J Int. J. Environ. Res. Public Health 2009;6:1235-1253

OBESITY - THE GLOBAL TZUNAMI- strongly associated to modern

agriculture & mass-produced cheap processed foods

Leonardo Dicaprio i filmen Cowspirary

1. 51 procent av världens koldioxidutsläpp orsakas av boskap och deras biprodukter - endast 13 procent orsakas av transporter med bilar, båtar, tåg och flyg.2. Det går åt 3000 liter vatten för att tillverka en hamburgare, det är lika

mycket som går åt när man duschar i två månader.3. 4000 - 8000 kvadratmeter regnskog avverkas varje sekund, köttindustrin

ligger bakom 91 procent av avverkningen.4. Kött- och mjölkindustrin använder 1/3 av jordens tillgångar av

dricksvatten.5. En köttgård med 250 kor skapar lika mycket avfall som en stad med

41100 invånare – ca 1.2 ggr Falköping. 6. 110 djur- och insektsarter försvinner varje dag till följd av skövlingen av

regnskog.7. För varje kilo som fiskas upp kastas 5 kilo av andra marina arter som

fångats av misstag.8. Boskap täcker 45 procent av jordens landyta.

9.Du kan halvera ditt koldioxidavtryck genom att byta kött mot frukt och grönsaker i din kost.

Metabolic Syndromedangerous manifestations:

• Abdominal obesity

• High blood pressure

• Elevated blood sugar

• Elevated blood triglycerides

• Low HDL cholesterols

• Fatty liver (& tty skeletal muscles)

• High Uric acid

THE QUARTET OF DEATHwww.bengmark.com

• Excessive body weight

• Hypertension

• Impaired glucose homeostasis/insulin resistance – glucose intolerance

• Atherogenic dyslipidemia: changes in serum

cholesterol, increased triglycerides, decreased high density lipoprotein (HDL) cholesterol, and an increase of “small dense” low-density lipoprotein (LDL) particles

Waist circumference men: < 102 cm women: <88 cm Fasting glucose: 3,9 - 5,9 mmol/LTriglycerides: < 1,7 mmol/LLow-density lipoprotein cholesterol(LDL): < 2,5 – 3,0 mmol/LSystolic blood pressure: (SBP): < 130 mmDiastolic blood pressure: (DBP): < 85 mm

NORMAL VALUES

POSTPRANDIAL HYPERLIPIDEMIA IN METABOLIC SYNDROMEAlcala-Diaz JF et al. Plos One 2014;9:e96297

GLOBAL STROKE STATISTICS

Thrift AG et al Int J Stroke2014;9:6-18

CANCER & GENES Anand P et al Pharm Res 2008;25:2097-2116

“HARMONY

LIFESTYLE

&

HEALTHEXERCISE FOOD

REGULAR EXERCISE & MORTALITYGebel K et al JAMA Intern Med 2015

WHO’s guidelines suggest that “significant health benefits can accrue through accumulation of at least 150 minutes of moderate activity per week”

661 000 persons followed during 14 years:

• No exercise – the highest mortality

• 150 min/w moderate exercise, low speed - 20 %

• 150 min/w moderate exercise, more speed - 31 %

• 450 min/w moderate exercise, more speed - 39 %

• 1500 min/w moderate exercise, high speed - 20 %

“CONTENT

FOOD

&

HEALTH

AMOUNT TIME

“GOOD FOR MICROBIOTA – GOOD FOR HEALTH

Avoid toxic substances:

Alcohol, tobacco, pesticides, drugs, AGE & ALEs, casein, gluten, zein, refined sugars, flour etc

Avoid processed foods Eat fresh greens

GUIDE TO PESTICIDES

THE MICR0BIOTA-OBESITY CONNECTIONMoran CP, Shanahan F Best Pract Res Clin Gastroenterol 2014;28:585–597

METABOLIC SYNDROME – DYSBIOSISTremellen K, Pearce K Med Hypotheses 2012;79:104-112

JOHANNA´S (28 år) ERFARENHET”Jag har sett många av dina föreläsningar och läst dina texter många gånger om.”

Fick våren 2013 Ulcerös proktit & gjorde då helomvändning gällande kosten.

Jag äter numera varken spannmål, mjölkprotein eller socker.

”Denna kostomläggningen är det bästa som har hänt mig då alla mina problem (förstoppning, depression, ångest, PMS (mensbesvär), urinvägsinfektioner, näsblod, migrän etc har försvunnit helt. ”

LIFE STYLE CAUSES OF DEATH – USADanaei G Plos Med 2009,6(4),e

THE BATTLE FIELD

POSTPRANDIAL INFLAMMATIONGENERAL INFLAMMATION

CHRONIC DISEASES

Myles IA Nutrition Journal 2014;13:61

LIFESTYLE, THE DEADLY QUARTET & LIVER DISEASEDyson JK et al Postgrad Med J 2015;91:92-101

MICROBIOTA – FAVORITE FOODS – UNCOOKED! www.bengmark.com

INFLAMMATION REDUCTION – ECOBIOLOGICALS

raw & fresh plants, pro- and synbiotics

isothiocyanates in cruciferous vegetables, anthocyanins and hydroxycinnamic acids in cherries, blueberries, epigallocatechin-3-gallate (EGCG) in green tee, chlorogenic acid and caffeic acid in fresh coffee beans & fresh tobacco leaves,capsaicin in hot chili peppers, chalcones in apples, euginol in cloves, gallicacid in rhubarb, hisperitin in citrus fruits, naringenin in citrus fruits, kaempferol in white cabbage, blueberries myricetin in berries,rutinand quercetin in apples and onions, resveratrol and other procyanidin dimers in red wine. virgin peanuts, blueberries various curcumenoids, the main yellow pigments in turmeric curry foods, and daidzein and genistein from soybean

FOODS RICHEST IN ANTIOXIDANTS

• Cloves, ground 314,446

• Sumac bran 312,400

• Ceylon Cinnamon 267,536

• Sorghum, bran, raw 240,000

• Oregano, dried 200,129

• Turmeric, ground 159,277

• Acai berry, freeze-dried 102,700

• Sorghum bran, black 100,800

• Sumac grains, raw 86,800

• Cocoa powder 80,933

• Cumin seed 76,800

• Maqui berry, powder 75,000

• Parsley, dried 74,349

• Sorghum bran, red 71,000

• Basil, dried 67,553

• Curry powder 48,504

• Sorghum, grain 45,400

• Sage 32,004

1 Cloves, ground 314,446

2 Sumac bran 312,400

3 Cinnamon, ground 267,536

4 Sorghum, bran, raw 240,000

5 Oregano, dried 200,129

6 Turmeric, ground 159,277

7 Acai berry, freeze-dried 102,700

8 Sorghum, bran, black 100,800

9 Sumac, grain, raw 86,800

10Cocoa powder, unsweetened

80,933

11 Cumin seed 76,800

12 Maqui berry, powder 75,000

13 Parsley, dried 74,349

14 Sorghum, bran, red 71,000

15 Basil, dried 67,553

16Baking chocolate, unsweetened

49,926

17 Curry powder 48,504

18 Sorghum, grain 45,400

19 Chocolate,powder 40,200

20 Maqui berry, juice 40,000

21 Sage 32,004

TWO VERY DIFFERENT CINNAMONS

Ceylon (true) cinnamon 267536 μmolTE/100g compare turmeric – 159277 TE

Saigon (cassia) cinnamon 15170 µmolTE/100g

Eat with care – contains a substance, coumarin, which may harm the liver, also in a small dosis - should not exceed

0,1 mg/kg body weight & day

ANTI-INFLAMMATORISK GURKMEJA-COCKTAIL

½ - 1 glas fruktjuice – t.ex. ananas, äpple el dyl

1 toppad matsked gurkmeja

1 rågad tesked Ceylonkanel, ej Saigonkanel (giftigt)

Upp till ¼ tesked chilipeppar (Cayenne)

Knivsudd pulver av kryddnejlika

½ - 1 matsked äppelcidervinäger

1 tesked citronjuice

Blandas och dricks 1-2 gånger dagligen

Alternativ är att köpa färsk gurkmeja, skära i små tärningar

och mixa i sallad dagligen!

2015-06-26 Stig Bengmark

ANTI-INFLAMMATION FOODS• Artichokes

• Avocado

• Berries:blackberries, blueberries, raspberries, strawberries

• Fermented, microb-enriched vegetables

• Garlic

• Green tea

• Kale

• Maitake mushroom

• Nutmeg

• Parsley

• PRE-, PRO- & SYNBIOTICS

• Red grapes

• Tomato,

• Turmeric

GLUTATHION IN FOODS Nmol/g Broccoli (flower) 440

Parsley (leaf) 400

Spinach 400

Yellow squash (fresh) 320

Yellow squash (frozen) 70

Potato (raw) 230

Potato (boiled 15 min) 110

Tomato 170

Green pepper 170

Tangerine 140

Broccoli (stem) 140

Cauliflower 130

CHLOROPHYLL IN FOODS microg/cup

Parsley 380Spinach 240Cress, garden 160Green beans 80Arugula 80Leeks 80Endive 50Sugar peas 50Chinese cabbage 40

OMEGA 3 IN FOODS mg/200 cal. serving

Flax seeds 12060

Chia seeds 7160

Radish seeds 3360

Salmon, wild, raw 2840

Walnuts 2780

Basil fresh 2750

Oregano, dried 2730

Cloves, dried 2650

Mackerel, fresh 2610

Salmon, farmed, raw 2410

Broccoli, cooked 2350

ADVANTAGES OF RAW FOOD VEGAN DIET 1Fontana L et al . Rejuvenation Res. 2007;10:225–234

Consuming a low-calorie low-protein vegan diet, composed of unprocessed and uncooked plant derived foods

Recruited from The St. Louis Vegetarian Society and a Raw Food online magazine (Raw Food News, www.rawfoods.newsmagazine.com).

SBP=Systolic blood pressure, DBP=Diastolic blood pressure, HOMO-IR=homeostatic model assessment - a method used to quantify insulin resistance and beta-cell function, hsCRP=high sensitive c-reactive protein – indicator of inflammation

ADVANTAGES OF RAW FOOD VEGAN DIET 2Consuming a low-calorie low-protein vegan diet, composed

of unprocessed and uncooked plant derived food. Recruited from The St. Louis Vegetarian Society and a Raw Food online

magazine (Raw Food News, ww.rawfoods.newsmagazine.com)

SBP=Systolic blood pressure, DBP=Diastolic blood pressure, HOMO-IR=homeostatic model assessment - a method used to quantify insulin resistance and beta-cell function, hsCRP=high sensitive c-reactive protein – indicator of inflammation ,HDL-C “good cholesterol”, LDL-C “bad cholesterol ”

ADVANTAGES OF RAW FOOD VEGAN DIET 3 Fontana L ET AL. Rejuvenation Res. 2007;10:225–234.

PROSTATIC CANCER – PSA & PLANT DIETNguyen JY Integr Cancer Therapies 2006;5:214-223

6 Months 1600 calorie Green Diet with or without meat consumption – 14 patients

BRISK WALKING & PROGRESS OF PROSTATIC CANCERRichman AL et al. 2011;71:3889-3895

TELOMERE/TELOMERASE ACTIVITY & LIFESTYLE IN LOW-RISK PROSTATIC CANCER

Ornish D et al Lancet Oncol 2013;14:1112-1120

VEGAN DIET & HEALTHKatcher HI et al Ann Nutr Metab 2010;56:245–252

Employees ( insurance company) with overweight and/or diabetes received either a low-fat vegan diet or regular food for 22 weeks. The vegan group reported improvements in: ● general health (p = 0.002)

● physical functioning (p = 0.001)

●mental health (p = 0.03)

● general vitality (p = 0.004)

● overall diet satisfaction (p = 0.001)

● reduced food costs (p = 0.003), but

● increased difficulty finding foods when eating out

FOOD INTAKE & INFLAMMATION www.bengmark.com

• 1. Low intake of fresh plant foods; GREENS, vegetables, fruits, SPICES • 2. High intake of proteotoxins in

certain foods: casein, gluten, zein (corn) etc.• 3. Highintake of heat- and

storage-induced proteotoxins: glycated (AGEs), lipoxidatedmolecules (ALEs),processed

Homo erectus2 milj – 100 000 years BC

”diet consisted in GREEN LEAVES, WILD GRASSES, flowers,berries, nuts, honey,& less tubers, roots, occasional in red meat, shellfish and bird's eggs.”

PALEOLITHIC DIET“Much support that our genes, adapted during million of years to the lifestyle of our prehistoric ancestors badly tolerate the dramatic changes, especially in food habits, which have occurred”.

Eaton BS, Konner M. Paleotlithic nutrition: a consideration of its nature and

current implications. N Engl J Med 1985;312:283-289

Contained more of: (X = times more) Minerals 2 X Fibers 4 to 10 XAntioxidants 10 XOmega-3 FA 50 X Lactic acid bacteria >1010 X

Contained less of:(X = times less)

Protein 2 XSaturated FA 4 XSodium 10 X

80/10/10 DIET80 % raw greens

10 % vegetable fats

10 % vegetable proteins

FUTURE NUTRITION OF CRITICALLY ILL !Hospital-made nutrition solutions !

Fresh fruit and vegetable juices ! Green Smoothies! Gaspacho etc !

DIET & LONGEVITYRobbins J: Healthy at 100: The Scientifically Proven Secrets of the

World's Healthiest and Longest-Lived Peoples

Read: http://thepdi.com/hunza_health_secrets.htm

STORAGE & UTILIZATION OF ENERGY

EASY ACCESS 1 – GLYCOGENSkeletal muscles 500 gr (2500 cal)

Liver 100 gr (500 cal)

EASY ACCESS 2 – TRIGLYCERIDES Visceral fats up to 6 kg = app 55000 cal

DEPOT FAT – TRIGLYCERIDES Subcutaneous, slow release, examples:

App 30 % fat (app 70 kg) = 190 000 cal

App 50 % fat (90-100 kg) = 315 000 cal

App 90 % fat (635 kg) = 540 000 cal

PRESENT POOR EATING – POOR IMMUNITY PALEO

THE FRONT DOOR – SHORTCUT 1app 60 % are Sugar and Suger-like substances

which enters the body in upper jejunum via mainlythe arterial system < 15 %

THE BACK DOOR – THE DANGEROUS ROUTEapp 30 % animal fats & vegetable oil enters via the the body via the lymphatic system and remains in circulation for hours > 10 %

THE MAIN DOOR< 20 % raw greens, vegetables, fruits are Foods for

Microbiota and reaches the large intestineafter 2-3 hours, enhancing immune system &

preventing inflammation app 80 %

PREVENTING DYSBIOSIS IS KEY TO DISEASE & INFECTION CONTROL

1936- Brandtzaeg P et al Gastroenterology 1989;97:1562-84

• A striking local preponderence(70-90 %) of IgA immunocytes(plasma cells, plasma blasts) in the gut

• The gut content is constantlytested by recognition cells such as dentritic cells (DC), which

• Programmes/”Tunes” the immune system

• Each DC commands about1200 T-cells

DENDRITIC CELL & IMMUNE REGULATIONVan Baarlen P et al PNAS 2009;106:2371–2376

THE DENDRITIC CELL IN ACTION Kraehenbuhl JP, Corbett M. Science 2004;303:1624-1625

DISCRETE PERSISTANT INFLAMMATION - A MOTHER OF DISEASE

Bengmark S. J Clin Nutr 2004;23:1256-1266

SYSTEMIC INFLAMMATIONFinch CE, Crimmins EM Science 2004; 305:1736–1739

Individuals with higher levels of inflammatory markers/s: C-reactive protein, fibrinogen, factor VIII activity, interleukin-6 and TNF-α etc.

but yet no obvious signs of disease,

are candidates to develop

CHRONIC DISEASES and

COMPLICATIONS TO DISEASE & TREATMENTS

SIGNS OF CHRONIC INFLAMMATIONUnexplained fatigue, sleep problems, frequent headache, hair loss, gray hair, dandruff, acne, skin rashes, dry eyes, frailnails, dry mouth or increased salivation, reduced sex functions, irregularmenstruations, obstipation or diarrhea, osteoporosis, overweight, frequentinfections, mental depression, easybreathless, sweaty feet, sweaty hand

palms etc. www.bengmark.com

BREAKING THE VICIOUS CIRCLE

INFLAMMATION

INFECTION

Treatment alternatives:Antibiotics Reduces infections but Deranges Microbiota - Creates DysbiosisIntestinal Reconditioning - Pro/Synbiotics - Restores Microbiota

PHARMA & MICROBIOTA – INCOMPATIBLE!Antibiotics destroys about 90 % of microbiota functions: bile acid metabolism, eicosanoid and steroid hormone synthesis etcCaetano L et al. Antimicrob Agents Chemother. 2011;55:1494-1503

Chemotherapeutics reduces microbiota 100-fold;

decrease anaerobic bacteria up to 10,000-fold &

increase in PPMs 100-foldVan Vliet MJ et al. Clin Infect Dis 2009;49:262-270

Pharma as proton pump inhibitors (peptic ulcer) during pregnancy increase the risk of offspring getting asthmaAndersen AB et al. Aliment Pharmacol Ther 2012;35:1190-1198

Anti-hypertensives induce gastrointestinal dysbiosis &reduce mucosa protection, espec mucus production Nonzee V et al J Med Assoc Thai 2012;95:96-104.

HYPNOTICS & RISK OF DEATHKripke DF et al BMJ Open 2012:2

Any Hypnotic

Hazard Ratio

(95% Confidence

Interval)

P Value

< 18 pills/year 3.60 (2.92 - 4.44) <.001

18 - 132

pills/year4.43 (3.67 - 5.36) <.001

> 132 pills/year 5.32 (4.50 - 6.30) <.001

MICROBIOTA, IMMUNITY, DISEASEMaynard CL et al Nature 2012;489, Sept 13:431-441

EUBIOSIS DYSBIOSIS

DYSBIOSISfacilitates

OBESITY& DISEASE

DIFFERENT MICROBIOTA IN OBESE vs LEANAngelakis E et al Future Microbiol. 2012;7: 91–109

GUT MICROBIOTA & DERANGED METABOLISMVrieze A et al Diabetologia 2010;53:606-613

• ↓ FFA oxidation

• ↑ endotoxin/s

• ↑SCFA production

• ↓incretin secretion

• ↓ butyrate production

• ↑FFA oxidation

• ↓ endotoxin/s

• ↓ SCFA production

• ↑Incretin secretion

• ↑butyrate production

CLUSTERING & RISK PROFILEQvarnstrom M et al J Clin Periodontol 2010; 37: 805–811

PROCESSED FOODS INDUCE DYSBIOSIS

• Certain foods induce systemic inflammation: - animal products, espec diary, rich in IGF-1 - refined carbohydrates promotes IGF-1 synthesis (liver)

• Induce dysbiosis

• Increase membrane leakages &

• Destabilize the immune system

Contributory are: Mental & physical stress, lack of physical activity,, vitamin D deficiency, lack of anti-inflammatory minerals; Mg, Zn, Se, lack of omega-3 etc. www.bengmark.com

HIGH FAT DIET & MICROBIAL TRANSLOCATIONAmar J et al EMBO Mol Med 2011;13:559-572

Live intestinal bacteria found present in large numbers in adipose tissue (MAT), mesenteric lymph nodes (MLN) and blood AFTER ONLY ONE WEEK ON HIGH FAT DIET (HFD)

Dubos RJ, Schaedler RW J Exp Med 1962;115:1161-1172

CASEIN & GLUTEN IMPAIRS LACTOBACILLUS GROWTH

Without casein and gluten With casein and gluten

GLUTEN & SURFACE MOLECULE EXPRESSIONSClass II, CD86, CD40, CD54 Nikulina M et al J Immunol 2004;173:1925-1933

100 µg/ml gluten matches the effects of 10 ng/ml LPS (ENDOTOXIN)

GLUTEN SENSITIVITY & CHRONIC DISEASESRuuskanen A et al. Scand J Gastroenterol. 2010;45:1197-1202

Glutenoids affects genetic markers: HLA-B8, HLA DQ2, HLA DQ8,

increase systemic inflammation & are associated with diseases such as: • ADHD

• arthritis

• Addison´s disease allergy

• Autoimmune disorders

• Autism

• Bipolar disease

• Dermatitis herpetiformis

• Diabetes mellitus

• Epilepsia• Graves´disease, infections

• Inflammatory bowel diseases – IBD

• Irritable bowel syndrome – IBS

• Lupus erythematosus

• Mental depression

• Myasthenia gravis

• Obesity • Osteoporosis

• Pernicious anemia

• Polymyalgia rheumatica

• Psoriasis

• Schizophrenia

• Scleroderma

• Sepsis

• Sjögren’s syndrome

• Thyreotoxicosis

• Vitiligo

A NEW ENTITY - GLUTEN SENSITIVITY (GS) Sapone A et al. BMC Medicine 2011, 9:23

Often seen in diffuse often ignored distresses: lack of energy, mental depression, encephalopathy/‘foggy mind’, diffuse abdominal pain, bloating, diarrhea, eczema and/or rash, various headaches, numbness in the legs, arms or fingers, joint pain, fatigue etc.

Gluten-free diet - increases energy, enthusiasm, well-being &

- improve clinical signs.

- Prevent & improve chronic diseases.

Freedom of symptoms reported in several chronic diseases & also a few cases of therapy-resistant EPILEPSY & NON-ALZHEIMER DEMENTIA

GLUTEN-FREE DIET & TYPE 1 DIABETESMatteo-Rocco P et al. J Clin Endocrinol Metab 2003;88: 162–165

Gluten-free diet tried in 15 patients with diabetes but no gluten intolerance

Insulin sensitivity increased significantly in 12/14 subjects after six months on gluten-free diet (P 0.04) & decreased again in 10/13 subjects after 6 months on “normal” diet (P=0.07)

GLUTEN-FREE DIET in IRRITABLE BOWEL SYNDROME Biesiekierski Jr et al. Am J Gastroenterol 2011;106: 508-514

GLUTEN-RESTRICTED DIET IN ADHDPelsser LMJ et al Lancet 2011;377:494-503

Crossover study 100 children, aged 4-8 yrs, 9 weeks + 4weeksA. Total, B. Inattention, C. Hyperactivity D. Abbreviated Connor Scale scores (ACS)

PROLAMINS & TRYPTOPHAN/CORTEXChoi S et al Physiol Behov 2009;98:156-162

An up to 8-fold decrease in cortex tryptophan & similar decrease in serotonin observed after feeding:

• Marked reductions; Zein (corn)

• Significant reductions: Casein (dairy) & Gluten (wheat, rye, barley)

• Small reductions: Lactalbumin (dairy)

• Small increases: Vegetable protein (soy)

ANCIENT GRAINS

• Amaranth – Aztec culture, high protein & mineral content• Quinoa – Inca culture, high protein & mineral content• Sorghum (durra, jowari, milo) -

5th in world, versatile, low energy, most cost-effective• Millet – 6th highest in world, versatile, mild flavor• Teff – staple in Ethiopia, tiny seed, high mineral content •

SORGHUM (durra, jowari, milo) – A SUPER GRAIN!Dykes L, Rooney LW Cereal Foods World 2007;52:105-111

Many thousend top athletesagree, among them the two best

tennis players of the world –Novak Djokovic & Andy Murray, who abstain from gluten, lactose

and processed carbohydrates, insisting that this gives them

much greater energy.

ENDOTOXIN - THE VILLAIN & ASSOCIATED DISEASES:• Alzheimer Jaeger LB et al. Brain

Behav Immun. 2009; 23: 507–17

• Cognitive impairment Lee JW et

al. J Neuroinflammation 2008; 5: 37

• Arterio-/Coronary Diseases Heo SK et al Immunol Lett 2008;120:57-64

• Diabetes type 1 Nymark M et al

Diabetes Care 2009 32(9): 1689–1693

• Diabetes type 2 Andreasen AS

Intensive Care Med. 2010;36:1548-1555

• Cancer Hsu RY et al Cancer Res.

2011;71(5):1989-1998

• Chronic Liver diesases Nolan JP

Hepatology 2010;52:1829-1835.

•ADHD, allergy, ALS, autism, autoimmune diseases, bipolardisease, cataracts, chronicfatigue syndrome, COPD, fibromyalgia, glaucoma, gulf warsyndrome, HIV, iritis, macular degeneration, minimal encephalopathy, multiplesclerosis, nephropathies, obesity, osteoporosis, paradontosis, Parkinson, polycystic ovary syndrome, rheumatoid disease, stress, schizophrenia, stroke, uveitis

DYSBIOSIS-INDUCED METABOLIC DISORDERS Cani PD et al Diabetes 2008;57:1470-1481

LPS concentration 10 to 50 X higher than those obtained during septic shockMitaka C. Clin Chim Acta 2005; 351:17-29

Bifidobacterimspp.

FAMILY DIFFERENCES – AMERICANS, AMERINDIANS, MALAWIANSYatzunenko T et al Nature 2012;486:222-227

MICROBIOTA OF HUNTERER-GATHERERS – HADZAsSchnorr SL et al Nat Commun. 2014,5,3654

Paleolithic lifestyle (Hadza, Tanzania) leads to compared to European (Italians):

• Much greater Microbial Richness

• Much Richer Biodiversity

• Absence of Bifidobacterium (no dairy?)

• Enrichment: in Prevotella, Treponema & unclassified Bacteroidetes

• Peculiar arrangement of Clostridiales taxa most likely reflecting an enhanced ability the Hadzas to digest and extract valuable nutrition from fibrous plant foods.

MICROBIOTA - AFRICAN & EUROPEANDe Filippo C et al Proc Natl Acad Sci USA 2010; 107:14691–14696

MICROBIOTA DIVERSITY – ANCIENT CULTURESClemente JC et al Science Advances 2015 E-pub

HIGH FODMAP CONTENT

• Lactose (also known as milk sugar; in milk, yogurt and ice cream)

• Fructose (also known as fruit sugar; in fruit, high-fructose corn syrup, honey and agave syrup)

• Sorbitol, mannitol, and other “-ol” sweeteners (also known as sugar alcohols); in certain fruits and vegetables & some sugar-free gums and candies)

• FOS (fructo-oligosaccharides, Fructans); in bananas, onion, chicory root, garlic, asparagus, leeks

• GOS (galacto-oligosaccharides); artichoke, lentils, soy

1. Fruktos - Undvik: Äpple, päron, vattenmelon, fruktjuice, torkad frukt, honung. Välj i stället: Apelsin, kiwi, bär, honungsmelon, banan, druvor, ananas, jordgubbar.2. Laktos - Undvik: Mjölk från ko, get, får, glass, mjölkchoklad. Välj i stället: Laktosfria produkter, havre-och risbaserade produkter.3. Oligosackarider - Undvik: Ärtor, bönor, linser, lök, vitlök, vete, råg, korn. Välj i stället: Tomat, palsternacka, morot, squash, paprika, ris, potatis.4. Sockeralkoholer - Undvik: Tuggummi och halstabletter med xylitol och sorbitol, blomkål, sockerärtor, avokado.Välj i stället: Drycker sötade med sackaros, glukos, syntetiska sötningsmedel eller stevia.

Maccaferri S et al Dig Dis 2011;29:525–530

LEAKY BARRIERS

• Gastrointestinal tract

• Airways

• Skin

• Oral cavity

• Vagina

• Nose

• Eye cavity

• Placenta

• Blood brain barriers

INFLAMMATION IN OBESE PREGNANT WOMENBasu S et al Obesity 2011;19:476-482

MCP1 IL-8 IL-6 TNFα Leptin CD14 TLR4 TRAM2

LEAKY PLACENTAA shocking 9/20 (43 %) of umbilical cord blood, cultivated from healthy neonates, born by cesarean section, demonstrate positive growth: Enterococcus faecium, Propionibacterium acnes, Staphylococcus epidermidis & Streptococcus sanguinisJiménez E et al. Curr Microbiol 2005;51:270–274.

ATHEROSCLEROSIS & BACTERIAL DEBRISNicolaou G et al J Atheroscler Thromb 2012;19:137-1498

Bacteria & bacterial debrisin human atheroma, in the past considered harmless,

seems to contribute to disease progression via TLR- dependent lipid body formation in macrophages

THE MARCH from AGRICULTURE AQVA- & HORTICULTURE-based diet

Friday Aug 18.2011

President Bill Clinton – now a vegan

radically changed diet, lost 20 lbs. in weight

& improved his health, Clinton tells CNN.

After experiencing periodic heart problems leading up to the 2004 surgery, the former junk food lover now calls himself a vegan,

shunning meat, eggs, dairy and almost all oil

saying: "I like the vegetables, the fruits, the beans, the stuff I eat now“

"I feel good, and I also have … more energy."

PLANT-BASED DIET & CORONARY ARTERY DISEASEEsselstyn CB Prev Cardiol. 2001;4:171–177

• Safe: grains?, legumes, lentils, vegetables, fruits, nuts and seeds

• Unsafe: oils, dairy foods, meat, poultry, & fish (frequently containing unacceptable levels of PCBs, dioxin, and mercury)

VITAMIN K IN FOODS micrg/100 gr

Thyme, dried 1715

Sage, dried 1700

Parsley raw 1640

Amaranth leaves 1160

Kale raw 817

Mustard greens, raw 497

Spinach, raw 483

Basil, fresh 413

Beat greens, raw 400

Turnip greens, raw 251

Leetuce, raw 174

Broccoli raw 102

Dennis Burkitt 1911 - 1993Suggested that many Western diseases, rare in Africa are primarily the result of diet and lifestyle.

Reported an association between low fibre in diet higher risk of colorectal cancer as well as other diseases such as CHD and diabetes

GI PERISTALSIS – UK vs UGANDAAppr GI transit time: UK: 100 hrs vs Uganda: 20 hours Appr stool weight: UK 60 g/day vs Uganda 600 g/day Burkitt DP et al Lancet 1972;300 (7792):1408-11

British geriatric patients:

GI transit time: >14 days in > half of the patientsBrocklehurst JC, Khan MY. Gerontol Clin 1969;11:293-300

DAVID JP BARKER 1838 –The thrifty epigenotype hypothesis -

Barker, D.J.P. Maternal Nutrition, Fetal Nutrition, and Disease in Later Life". Nutrition, 1992;13: 807-813

Curr Opin Nephrol Hypertens 1997; 6:106-110

We know that “disorders of adult life, including coronary heart disease, stroke and diabetes, arise through interaction between influences in our adult lifestyle and genetically determined susceptibility.”

“Recent research, however, suggest that growth in utero may also play an important role” “Even brief periods of … may permanently change/`reprogramming´ the body…and lead to persistent changes in blood pressure, cholesterol metabolism, insulin response to glucose, and in a range of other metabolic, endocrine and immune parameters.”

Louis Camille Maillard 1878 – 1936Undertook studies of the reaction between amino acids and sugars, and suggested association to development of chronic disease, especially renal disease.

This work was considered a major contribution, and the reaction was named after him – Maillard reaction & he was awarded several prices, including the French Academy of

Medicine award in 1914.

AGES/ALES IN TISSUESDys-functioning, glycated proteins induceabout 50 times more FREE RADICALS thannon-glycated proteins (AGEs and ALEs), • accumulate in tissues (amyloid) &

• make the body auto-fluorescing,

• impair DNA repair mechanisms, induce tissue accumulation of toxins reduce antioxidant defense * induce inflammation & infection * weaken immune system & * accelerate development of various diseases Thorpe SR, Baynes JW Amino Acids 2003;25:275-281

AGEs & INFLAMMATION-INDUCTIONBohlender JM Am J Physiol Renal Physiol 2005;289:F645-659

AGEs IN VARIOUS MILK PRODUCTSBaptista J, Carvalho R Food Res Int 2004;37:739-747

ACRYLAMIDE IN FOODS & HEALTHDas AB, Srivastav BB Toxicol Mech Methods 2012;22:163-169

Acrylamide has been studied

extensively for more than 40 years, but the first detection of acrylamide in carbohydrate-rich foods was made as late as 2002

Acrylamide has a number of adverse effects on the human body -two major effects being NEUROTOXICITY & CARCINOGENICITY

Toasted bread contains several-fold more of acrylamide than untoasted

Wheat: 11–161 vs < 5 mg/kg . Rye: 27–205 vs 7–23 mg/kg

Granby K et al Food Additiv Contamin 2008; 25:921–929

HEAT & ACRYLAMIDE PRODUCTIONTareke C et al J. Agric. Food Chem. 2002;50:4998-5006

AGEs/ALEs IN FOODSHEATED MEAT (espec. bacon, sausages), POULTRY,

FISH: AGE content increases with exposure to temperature:

boiling (1000 kU/serving), frying (9000 kU/serving)Goldberg T et al. J Am Diet Assoc 2004;104:1287-1291

HEATED DAIRY: powdered milk (rich in ice cream, baby & clinical nutrition formulas) & cheese, espec. hard cheeses

HEATED GRAIN PRODUCTS: Toasted bread, breadcrusts & crisp breads

HEATED VEGETABLE OILS: heated olive oil ca 8000 kUOTHERS: Egg yolk powder, lecithin powder, coffee, espec

dark roasted, hard-cured teas, roasted and salted peanuts, dark and sugar-rich alcoholic beverages, broth, Chinese soy, balsamic vinegar, Cola drinks etc

DISEASES WITH ELEVATED AGEs/ALEs• ADHD

• Aging

• Allergy

• Autoimmune diseases

• Alzheimer´s disease

• Amyotrophic lateral sclerosis

• Atherosclerosis

• Cardiovacular diseases

• Cataract• Chronic liver diseases• Chronic pulmonary disorders

• Creutsfeldt-Jakob disease

• Diabetes

• Epilepsia

• Familial amyloidoticpolyneuropathy

• Fibromyalgia• Glaucoma• Hormone deficiencies• Macula degeneration• Nephropathies

• Obesity• Osteoporosis• Paradontosis• Parkinson´s disease • Polycystic Ovary Syndrome• Rheumatoid diseases• Ruptured Achilles tendon• Sepsis• Stroke

AGE PRODUCTION & POSTPRANDIAL INFLAMMATIONAlssema M et al Br J Nutr 2014;11:1-10

AGE & PREMATURE AGINGNagai R et al J Clin Biochem 2014;2014:55:1-6

AGE – ALE & OPHTALMIC DISEASES Smuda M et al Biochemistry 2015;54:2500-2507

INTAKE OF AGES IN JAPAN 1950-2010Perrone L, Grant WB J Alzheimers Dis 2015;45:965-979

SPICES – EFFECTS ON HB-GLYCATIONwild caraway = vild kummin Naderi Gh et al Indian J Pharm Sci. 2014; 76: 553–557.

PROCESSED MEAT & RISK OF CANCER• Oesophageal cancer

Salehi M et al Nutr Rev 2013;71:257-267, Huang W et al Cancer Causes Control 2013;24:193-201

• Stomach cancer Larsson SC J Natl Cancer Inst 2006;98:1078-1087

• Pancreatic cancer Larsson SC, Wolk A Br J Cancer 2012;31;106:603-607

• Colorectal cancer Chan DS et al Plos One 2011;6:e20456

• Bladder cancer Wang C, Jiang H Med Oncol 2012;29:848-855

• Lung cancer Yang WS et al Ann Oncol 2012;23:3163-3170

• Ovarian cancer Kolahdooz F et al Am J Clin Nutr 2010;91:1752-

1763, Wallin A et al Br J Cancer 2011;104:1196-1201

PROCESSED MEAT AND UNHEALTHMicha R et al. Circulation 2010;121(21):2271-2283

Metaanalysis of 20/1598 totally including 1218380 individuals with 23889 cases of CHD, 10797 cases of diabetes mellitus and 2280 cases of stroke.

Conclusion: Processed, but not unprocessed, meat is associated with 42% higher risk of CHD and 19% higher risk of diabetes mellitus (P<0.001).

No association with stroke observed.

Nitrates? AGEs? ALEs?

Nitrates & byproducts promote vascular dysfunction and atherosclerosis, reduce insulin secretion, impair glucose tolerance, & streptozotocin, a nitrosamine-related compound containd diabetogenic compound.

37 698 men and 83 644 women (2.96 million person- years) followed for > 28 years.

- Premature deaths increased with 13 % by eating red meat &

- 20 % by eating processed meat: cured, bacon, sausages, patémeatballs, hamburgers etc Pan A et al Arch Intern Med 2012;172:555-563

448,568 men and women, age 35-69 studied during 13 years:

- A daily piece of steak is associated with a 13 % greater chance of dying during the study (13 years)

- An extra daily serving of processed red meat linked to a 20 % higher risk of death during the study.

- 72 % increased risk of dying in heart disease &

- 11 % increased risk of dying in cancer Rohrmann S et al BMC Medicine 2013;11:63

FISH INTAKE & HEALTH

Vegetarians have a 22 % lower risk to get colorectal cancers; in the colon 19 %, in the rectum 29 % comp to non-vegetariansOrlich MJ et al JAMA Intern Med. 2015 E-pub

A meta-analysis shows that fish consumption is associated with a 63 % reduction in prostate cancer-specific mortality.

Szymanski KM et al Am J Clin Nutr 2010;92:1223-1233.

THE JAPANESE EXPERIENCE

The age-adjusted death rate in ChDs

such as prostatic cancer rose in Japan

during the period 1948 - 98

25-foldParallel to increases in intake of :

egg 7 X

meat 9 X

dairy 20 X Ganmaa D et al Medical Hypotheses 2003;60:724-730

DAIRY-INDUCED INFLAMMATION

Dietary proteins of cow´s milk induce inflammation:• release inflammatory mediators

• increase intestinal permeability

• induce leakage of large molecules; albumin, hyaluronan etcJalonen T J Allerg Clin Immunol 1991;88:737, Isolauri E Gastroenterology 1993;105:1643, Bengtsson U et al. J Clin Exp Allerg 1996;26:197, Allerg Clin Immunol 1997;100:216

DIET AND BREAST CANCERCarroll KK Cancer Res 1975;35:3374-3383

PROSTATIC CANCER&

MILKCONSUMPTION

Ganmaa D et al Int. J. Cancer 2002,98,262–267

BOVINE MILK &

CORONARY HEART DISEASE

Artaud-Wild SM et al. Circulation 1993;88:2771-

2779

PROSTATIC CANCER DEVELOPMENT IN EASTASIA

Zho Y et al Asian J Androl 2015;17:48–57

BREAST CANCER: INCIDENCE & MORTALITY - 2030

Chajès V, Romieu I Maturitas 2014;77:7– 11

EARLY MILK CONSUMPTION & RISK OF PROSTATIC CANCER

Torfadottir JE et al Am J Epidemiol 2012; 175:144-538,894 men born 1907 to1935 followed a mean 24.3 years & 1123 diagnosed with prostatic cancer

2,268 participants reported their milk intake in early, mid-, and current life.

Daily milk intake in adolescence associated with a 3.2-fold risk of advanced prostate cancer (95% CI: 1.25, 8.28)

suggesting that frequent milk intake in adolescence increases risk of advanced prostate cancer later in life.

DAIRY RISK FACTORS IN PROSTATIC CANCERAune D et al Am J Clin Nutr 2015;101:87-117

In a Physicians Health Study, 21,660 men were followed for 28 years. 2806 men developed prostatic cancer & 305 died.

- Larger intake of skim/low-fat milk was associated with greater risk of nonaggressive prostatic cancer &

- Larger intake of whole milk only with fatal prostatic cancer & progression to fatal disease after diagnosis (HR = 2.17)

BOVINE MILK & CHRONIC DISEASES• Allergy Rautava S, Isolauri EJ

Pediatr Gastroenterol Nutr. 2004 Nov;39:529-535

• Breast cancer Outwater JL et al Med Hypotheses1997;48:453-461, Hjartåker A et al Int J Cancer 2001;93:888-893

• Colorectal cancerManousos O et al Int J Cancer 1999;83:15-17, Ma et al J Nat Cancer Inst;2001:93:1330-1336

• Chronic constipationIacono G et al N Engl J Med 1998;339:1100-1104

• Coronary heart diseaseBriggs RD et al. Circulation1960;21:538-542, Marshall T BMJ 2000;320:301-305

• Diabetes type 1 Gimeno SGA, De Souza JMP Diabetes Care 1997;20:1256-1260, Virtanen SM et alDiabet Med 1998;15:730-738

• Malabsorption O´Keefe SJD et al Am J Clin Nutr 1991;54:130-135

• Ovarian cancer Larsson SC et alAm J Clin Nutr. 2004;80:1353-1357, Ganmaa D, Sato A Med Hypotheses.

2005;65:1028-1837

• Parkinson disease Park M et al. Neurology 2005;64:1047-1051

• Testicular and prostatecancer Ganmaa D et al. Med Hypotheses 2003;60:724-730, Qin LQ et al Nutrition and Cancer 2004;48:22-27

CALCIUM I FOOD mg/100 g food

Daily need: 1000-1300 mg

• Baking powder 11300

• Herb salt 3180

• Parmesan cheese 1380

• Sesami seeds 980

• CHEESE 28 % 750

• Agar 600

• Nettles 490

• Persil 340

• Dill 343

• Peas 300

• Beans 300

• Almonds 265

• Sunflower seeds 265

• Flax seeds 198

• Sardines 190

• Brazil nuts 180

• CREAM 135

• MILK 120

• Digestive biscuits 110

• Fish 100

• Spinach 90

• Black current 90

• BREAD, wheat whole 48

• BUTTER 18

• HAMBURGERS 10

• FRENCH FRIES 9

• KETCHUP 7

MAGNESIUM IN FOODS mg/100 gr

• Pumpkin &Squash seeds 540

• Cacao 20-22 % 520

• WHEAT bran 355

• Sesami seeds 350

• WHEAT germs 290

• Almonds 280

• Soya beans 265

• Cashew nuts 260

• Rosehip, dry 240

• Oat bran 235

• Peanuts 190

• Beans 190

• Peanuts 188

• Peas 150

• Lentils 80

• Spinach 79

• Prunes 52

• Avocado 41

• Banana 35

• CHEESE 35

• Broccoli 23

• FRENCH FRIES 35

• BREAD, whole wheat 24

• HAMBURGERS 20

• KETCHUP 18

• MILK 15

• CREAM 14

• BUTTER 3

MAGNESIUM DEFICIENCY - MANIFESTATIONSMg involved in > 300 biochemical processes• Bone demineralization - osteoporosis

• Obesity

• Body aches, muscle twitches

• Leg cramps, headaches and migraines

• Fatigue or low energy

• Restless sleep

• Premenstrual syndrome

• Chronic bowel problems

• Insulin resistance

Left untreated Mg deficiency will lead to more life-threatening conditions: hypertension, heart disease, stroke, type 2 diabetes, osteoporosis ….

HORMONAL ENVIRONMENTAL ”DISRUPTORS”

Up to 80 % of milk come from pregnant cows & contains significant amounts of:- Pituitary hormones: PRL, GH, TSH, FSH, LH, ACTH - Steroid hormones: estrogen, progesterone, testosterone etc- Hypothalamic hormones: TRH, LHRH, GnRH, GRH - Gastrointestinal peptides- Halogenated aromatic hydrocarbones- Advanced glycation & lipoxidation end products(AGEs/ALEs)

ESTROGENS IN MILK Malekinejad H et al J Agric Food Chem 2006;54: 9785-9791

Background: The dramatic increase in testicular, breast, prostate, ovarian, and corpus uteri, and large bowel cancers.

60-80% of the intake of estrogens originates in the Western world from milk and other dairy foods.

The daily intake of total estrogens through milk

is 372 ng/L

“which is dramatically more than currently recognized.”The content is twice as high in 3.5 % fat milk than in non-fat milk & extremely high in butter!

FREE ESTROGENS IN DAIRYpg/g Wolford ST, Argoudelis CJ J Dairy Science 1979;62:1458-1463

E1 E2 - 17β E3

Whole milk 3.7 6.4 9.0 Skimmed milk 20.2 3.4 8.2 Whey 3.6 1.5 3.0 Cottage cheese 34.9 10.8 6.1 Butter 539.4 82.3 86.8

Compare 1266 322 51 Malekinejad H et al J Agric Food Chem 2006;54: 9785-9791

MEJERIFRIA – MJÖLKALTERNATIVwww.bengmark.com

METABOLIC SYNDROME IN COWSHostettler-Allen RL et al J Anim Sci 1994;72:160-173

Modern feeds of dairy cows, less forage-based and rich in starch & carbohydrates (corn, maize grains, barley, molasses and dextrose) are likely to induce, also in cows: Insulin resistance,

observed in calves fed on intensive milk- and lactose diet

ENTERAL NUTRITION INDUCES DYSBIOSISHaskel Y et al. Crit Care Med 1994;22:108-113

Synthetic clinical nutrition solutions induce:

• loss of mucosal protein content

• intestinal microbial overgrowth

• leaky gut- Vivonex (Nestle) 53%

- Criticare (Mead-Johnson) 67%

- Ensure (Ross Lab) 60%

• "Cow's milk in the past has been oversold as the perfect food, but we are now seeing that it isn't the perfect food at all and the government really shouldn't be behind any efforts to promote it as such.“ Benjamin Spock, M.D., Los Angeles Times, November 18, 1992

• “I would call milk perhaps the most unhealthful vehicle for calcium that one could possibly imagine, which is the only thing people really drink it for, but whenever you challenge existing dogma...people are resistant.“ Neal Barnard, M.D., Director of the Physician's Committee for Responsible Medicine www.pcrm.org

IGF-1, INFLAMMATION CHRONIC DISEASECarrera-Bastos P et al. Res Rep Clin Cardiol 2011;2:15-35

• The Neolithic Revolution, provided increasing access food to insulinotropic & IGF-1-raising foods; - dairy products are rich in IGF1 - grains & sugars induce synthesis of IGF-1.

• The human genome has not, and will not, adapt to the high levels of insulin/IGF-1 signaling (I1S)

• Modern man should attempt to develop a more Paleolithic-type diet.

IGF & TOLL-STIMULATORY FOODSExcess in refined, processed foods e.g. - Foods rich in IGF-1, and/or IGF-1 promoting &

- Toll-stimulatory (inflammation-inducing) foods:

• increase expression of inflammatory messengers

• reduce microbiota

• increase membrane leakages

• destabilize the immune system

Contributory are: Lack of physical activity, mentaland physical stress, Vitamin D deficiency, lack of anti-inflammatory minerals; Mg, Zn, Se, lack of omega-3 fatty acids etc. www.bengmark.com

DAIRY CONSUMPTION & IGF-1The Endogenous Hormones and Breast Cancer Collaborative Group

Lancet Oncol 2010; 11: 530–42

• a positive association between intake of dairy products or milk and IGF-I conc. reported in several cross-sectional studies

• increase in IGF-I in response to a higher intake of milk and dairy products observed in both younger and older participants

• IGF-I conc. found significantly lower in vegans compared with lactoovo-vegetarians and omnivores in the EPIC-Oxford cohort

PRO- & PREBIOTICSDruarte C et al Adv Nutr 2014;5:S624-S633

DEVELOPMENT AND TREATMENT OF Clostridium difficile infections (CDI) Rao K, Safdar N J Hosp Med 2015 E-pub.

FLORA IN WESTERNERS• Lb plantarum, a dominating LAB, observed

in only 25 % of omnivorous Americans & in 65 % of vegetarian AmericansFinegold SM et al. Human intestinal microflora in health and disease Academic Press, London, UK, 1983. pp 3-31

• Benefial & common colonic LACROBACILLI present only in about 50 % or less of healthy Scandinavians:Lb plantarum 52 %, Lb rhamnosus 26 %, Lb paracasei ssp paracasei 17 %Ahrné S et al. J Appl Microbiol 1998;85:88-94

MICROBIOTA & OBESITYMillion M et al. Int J Obesity 2012;36:817-825

Obese (n=68) Controls (n=44) P-value

L. plantarum 0 (0%) 8 (18.2%) 0.0004

L. paracasei 10 (14.7%) 17 (38.6%) 0.004

L. reuteri 6 (8.8%) 1 (2.3%) 0.16

L. rhamnosus 3 (4.4%) 4 (9.1%) 0.27

L. ruminis 3 (4.4%) 4 (9.1%) 0.27

L. salivarius 5 (7.4%) 2 (4.5%) 0.43

ENDOTOXIN & OBESITYFei N, Zhao L. ISME J. 2012 E-pub

A person weighing 175 kg lost 51.4 kg after

23 weeks on VEGAN TYPE FOOD recovered from hyperglycemia and hypertension.

The endotoxin-producing Enterobactercloacae B29 - found to constitute 35% of the gut bacteria - decreased to non-detectable.

The Enterobacter cloacae inoculated in germfree mice induced obesity & insulin resistance.

THE GREAT Pwww.bengmark.com

•Plantarum

•Paracasei

•Pediococcus pentosaceus

Lb paracasei – the master?• the strongest inducer of Th1 & repressor of Th2 cytokines when more than 100 strains are compared Fujiwara D et al. Int Arch Allergy Immunol 2004;135:205–215

CONTROL OF PATHOGENS

The ability of 50 different LAB to control 23 different pathogenic Clostridium difficiletested:

27 were totally ineffective18 antagonistic to some

5 effective against all:2 strains - Lb paracasei s. paracasei

3 strains - Lb plantarum

Naaber P et al. Med Microbiol 2004;53:551-554

FERMENTATION ABILITY• The ability of 712 different LAB to ferment

oligofructans (inulin, phleins) studied:

• 16/712 able to ferment the phleins &

• 8/712 able to ferment the inulin type fibre.

• Only four species had the ability:Lactobacillus plantarum (several)Lactobacillus paracasei subsp. paracasei, Pediococcus pentosaceus &

Lactobacillus brevisMüller M, Lier D. J Appl Bact 1994;76:406-411

CHOICE OF LACTIC ACID BACTERIA (LAB) AS

PROBIOTICSWe harvested and studied the abilities of various LAB to controlinflammation and infection of

355 strains from humans

180 strains from plants www.bengmark.com

UNIQUE PROPERTIES OF LAB IN SYNBIOTIC 2000

• All induce several Bioactive Proteins – five cross-react with stress proteins

• All transcribe NF-B – to the largest extent L plantarum and L paracasei

• All produce pro-inflammatory (IL-1, IL-8) and anti-inflammatory (IL-10) cytokines, to a large extent L plantarum, and to less extent Leuconostoc mesenteroidesLjungh Å, Microb Ecol Health Dis 2002;3, Suppl 4:4 Kruszewska D et al Microecol. Ther. 2002;29:37

UNIQUE PROPERTIES OF LAB IN SYNBIOTIC 2000

• All induce several Bioactive Proteins – five cross-react with stress proteins

• All transcribe NF-B – to the largest extent L plantarum and L paracasei

• All produce pro-inflammatory (IL-1, IL-8) and anti-inflammatory (IL-10) cytokines, to a large extent L plantarum, and to less extent Leuconostoc mesenteroidesLjungh Å, Microb Ecol Health Dis 2002;3, Suppl 4:4 Kruszewska D et al Microecol. Ther. 2002;29:37

SYNBIOTIC 2000 & BETA-DEFENSINSWehkamp J et al Infect Immun. 2004;72:5750-5758

SYNBIOTIC 2000Synbiotics AB, Sweden: www.synbiotics.se, synbiotics@gmail.com

400 billion Lactic acid bacteria:

1010 of Pediococcus pentosaceus 5-33:3

1010 of Leuconostoc mesenteroides 32-77:1

1010 of Lactobacillus paracasei sbsp. paracasei

1010 of Lactobacillus plantarum 2362

10 gram bioactive fibers:

2.5 g of betaglucan

2.5 g of inulin

2.5 g of pectin

2.5 g of resistant starch www.bengmark.com

SYNBIOTIC 2000 INHIBITS GROWTH OF MULTIRESISTANT BACTERIAProfessor Val Edwards-Jones, Manchester, UK

Multi-resistant Acinetobacterbaumanii

Multi-resistant Klebsiella

SYNBIOTIC 2000 IN LUNG INJURYIlkgul O et al Br J Int Care. 2005;15:52-57

• Placebo Only fibres Synbiotic 2000

SYNBIOTIC 2000 IN LIVER TRANSPLANTATIONRayes N et al. Am J Transplant 2005;5:125-131

50 to 85 % of transplant patients develop nosocomial infections within 30 days.

Synbiotic 2000 or Only fibres daily from the day before surgery + during 14 postop days

30 day-infection rate:

Synbiotic 2000 1/33 - 3 %

Only fibres 17/33 - 51 %

SYNBIOTIC 2000 IN LIVER TRANSPLANTATION

Isolated bacteria: Synbiotic 2000 Fibres only

Enterococcus faecalis 1 11

Escherichia coli 0 3

Enterobacter cloacae 0 2

Pseudomonas aeruginosa 0 2

Staphylococcus aureus 0 1

Total 1 18

Rayes N et al. Am J Transplant 2005;5:125-131

SYNBIOTIC 2000 IN PANCREATECTOMYINFECTIONS:

Control (Only fibers) 16/40 - 40 % Synbiotics 2000 5/40 - 13 % p< 0.05

Synbiotic 2000 Control Wound infections 4 6Peritonitis 0 5Pneumonia 0 4Urinary 1 1Sepsis 0 2Cholangitis 0 1Empyema 0 1Total 5 20

Rayes N et al. Ann Surg 2007;246:36-41

SYNBIOTIC 2000 IN PANCREATECTOMYISOLATED BACTERIA:

Synbiotic 2000 FibresEnterobacter cloacae 2 8Enterococcus faecalis/faecium 1 7Escherichia coli 0 7Klebsiella pneumoniae 2 2Proteus mirabilis 1 1Staphylococcus aureus 0 2Total 6 27

Rayes N et al. Ann Surg 2007;246:36-41

SYNBIOTICS IN ACUTE PANCREATITISOláh A et al Hepato-gastroenterology 2007;54:36-41

Synbiotic 2000 Fibres OnlyTotal number of infections 9/33 ( 27 %) 15/29 ( 52 %)Pancreatic abscesses 2 2Infected necrosis 2 6Chest infections 2 4Urinary infections 3 3SIRS 3 5MOF 5 9SIRS + MOF 8 14 p<0.05Late (>48h) MOF 1 5Complications 9/33 15/29 p<0.05Surgical drainage 4/33 ( 12 %) 7/29 ( 24 %)Mean hospital stay 14.9 ±6.5 19.7±9.3Dead 2/33 ( 6 %) 6/29 ( 18 %)

SYNBIOTICS IN ACUTE PANCREATITIS

Oláh A et al Hepato-gastroenterology 2007;54:36-41

Isolated Microorganisms: SYNBIOTIC 2000 Fibres Only

Pseudomonas aeruginosa 1 4Enterococcus faecalis 1 2

Enterobacter spp 1 1

Streptococcus spp 2 -

Staphylococcus aureus 1 1

Enterococcus faecium 1 -

Candida spp - 2

Staphylococcus haemolyticus - 1

Serratia spp - 2

Klebsiella spp - 1

Escherichia coli - 1

Stenotrophomonas maltophilia - 1

Citrobacter freundii - 1

Total 7 17

SYNBIOTIC 2000 IN MULTIPLE TRAUMA102 patients supplied 15 days with either Synbiotic2000 Forte or placebo

The treated patients demonstrated reduced:- Mortality- Rate of infection (P = 0.01)- Rate of SIRS & severe sepsis (P = 0.02) - Numbers of days on mechanical ventilation (P= 0.001) - ICU stay (P = 0.01)Kotzampassi K et al. World J Surgery 2006;30:1848-1855

SYNBIOTIC 2000 IN TRAUMA PATIENTS

Spindler-Vesel A et al. JPEN 2007;31:119-126

TOTAL NUMBER OF INFECTIONS:

Alitraq Abbott-Ross (glut+arg) 16/32 50 %

Nova Source Novartis (+guargum) 17/29 58 %

Nutricomp peptide Braun (+peptide) 13/26 50 %

Nutricomp standard (+Synbiotic 2000) 4/26 15 %

NUMBER OF CHEST INFECTIONS: Alitraq Abbott-Ross (glut +arg) 11/32 34 %

Nova Source Novartis (+guargum) 12/29 41 %

Nutricomp Braun (peptide) 11/26 42 %

Nutricomp standard (+Synbiotic 2000) 5/26 19 %

MULTI-STRAIN SYNBIOTICS IN

DISTAL COLITISRectal application, 10 patients, studied before (D0), and after 7 (D7), 14 (D14) and 21 (D21) days of treatment:

D0 D7 D14 D21

Urgency 1.9 1.2 1.0 1.0

Episodes of diarrhoea 2.4 1.3 0.9 0.8

Nightly diarrhoea 0.5 0.1 0 0

Visible blood 2.2 1.2 0.8 0.8

Consistency of stool 1.1 0.9 0.7 0.8

Pathmakanthan S, et al, Gut 2002; 51(Supp lIII) A307

REDUCTIONS IN INFECTIONS/POSITIVE BLOOD CULTURES

Liver transplantation, 66 patients1

Patients with postop. infections 16 => 1 = 94 per cent

Patients with pos. blood cultures 11 => 1 = 91 per cent

Pancreatdoudenectomy for cancer, 80 patients2

Patients with postop. infections 16 => 5 = 69 per cent

Patients with pos. blood cultures 27=> 5 = 82 per cent

Severe pancreatitis – 62 patient3

Patients with infections 15 => 9 = 40 per cent

Patients with pos. blood cultures 17 => 7 = 59 per cent

Severe trauma, treated with Synbiotic 2000 Standard – 52 patients4

Patients with infections 23/30 (77 %) => 17/35 (49 %)

Severe trauma, treated with Synbiotic 2000 Forte – 72 patients5

Patients with post-trauma infections 13 => 5 = 62 per cent Patients with pos. blood cultures 13 => 5 = 62 per cent

REDUCTIONS IN USE OF ANTIBIOTICS, ARTIFICAL RESPIRATION, TIME IN ICUs & IN HOSPITAL

Liver transplantation – 66 patients1

Days on Antibiotics 3.8 => 0.1 = 3.7 (97 %)

Days in ICUs 10.2 => 8.8 = 1.4 (14 %)

Days in Hospital 27.9 => 27.8 = 0.1(3 %)Pancreatdoudenectomy for cancer - 80 patients2

Days on Antibiotics 10 => 2 = 8 (80 %)Days in ICUs 6 => 2 = 4 (67 %)

Days in Hospital 22 => 17 = 5 (23 %)

Severe acute pancreatitis – 62 patients3

Days in Hospital 19.7 => 14.9 = 4.8 (24 %)Severe trama treated with Synbiotic 2000 Forte – 65 patients5

Days on Artificial Respiration 24 => 19 = 5 (21 %)

Days in ICUs 41.3 => 27.7 = 13.6 (33 %)

MULTI-STRAIN SYNBIOTICS IN

DISTAL COLITIS

Rectal application, 10 patients, studied before (D0), and after 7 (D7), 14 (D14) and 21 (D21) days of treatment:

D0 D7 D14 D21

Urgency 1.9 1.2 1.0 1.0

Episodes of diarrhoea 2.4 1.3 0.9 0.8

Nightly diarrhoea 0.5 0.1 0 0

Visible blood 2.2 1.2 0.8 0.8

Consistency of stool 1.1 0.9 0.7 0.8

Pathmakanthan S, et al, Gut 2002; 51(Supp lIII) A307

COMMUNICATION BETWEEN THE GUT, GUT MICROBIOTA &

THE BRAIN –endocrine,

neurocrine and inflammation-related

communications

Mayer et al J Neurosci2014;34:15490-15496

DIET, MICROBIOTA ANXIETY &

DEPRESSION

Luna RA, Foster JA Current Opinion in Biotechnology

2015, 32:35–41

DIET, MICROBIOTA

ANXIETY &

DEPRESSION

Luna RA, Foster JA Current Opinion in Biotechnology

2015, 32:35–41

FMT IN MULTIPLE SCLEROSIS – 3 PATIENTSBorody Th et al Am J Gastroenterol 2011;52, Suppl 2; abstract 952

Patient 1. Male 30 yr, wheel-chaired, constipation.

5 FMT infusions. Regained ability to walk. Remains well & without any relapses, 15 years post-FMT.

Patient 2. Male 29 yr, wheel-chaired, severe constipation. 10 daily FMT infusions. Regained ability to walk. 3 years on maintains normal motor, urinary and GI function.

Patient 3. Female 80 yr, severe chronic constipation. now walking long distances unassisted. Two years post-FMT, the patient is asymptomatic.

VITAMIN D – FUNCTIONSHolick MF Mol Asp Med 2008;29:361–368

VITAMIN D – IMMUNE EFFECTS - decrease T-cell activation &

proliferation,

- inhibit dendritic cell maturation/ differentiation

- induce tolerogenic dendritic cells

Supplementing vitamin D reported to: - prevent acute and chronic diseases

- improve allograft survival

- decelerate loss of allograft function

- prevent acute rejection in transplantation

VITAMIN D & TELOMERIC AGING

Vitamin D - a potent inhibitor of inflammation

The difference in telomere length between the highest and lowest tertiles of vitamin D was 107 base pairs (P = 0.0009), equivalent to 5.0 years of telomeric agingRichards JB et al Am J Clin Nutr 2007;86:1420-1425

VITAMIN D DEFICIENCY & DISEASE• Aging

• Allergy

• Alzheimer’s disease

• Asthma

• Athletic performance

• Autism

• Cancer

• Cavities

• Colds

• Crohn´s disease

• Cystic fibrosis

• Depression

• Diabetes 1 and 2

• Eczema

• Heart disease

• Hearing loss

• Hypertension

• Infertility

• Influenza

• Insomnia

• Maculardegeneration

• Migraines

• MultipleSclerosis

• Muscle pain

• Myopia

• Obesity• Periodontal disease

• Pre-eclampsia

• Psoriasis

• RheumatoiddiseasesSchizophrenia

• Seizures

• Septicemia

• Tuberculosis

• Vaginosis/fluor

VITAMIN D DEFICIENCY IN SURGERY

85 % of patients undergoing hip or knee replacement

Breijawi N et al Eur Surg Res 2009;42:1–10

77 % of chronic pancreatitis patients Dujsikova H et al Pancreatology 2008;8:583–586

57 % obesity surgery patients (79 % in black and Hispanic) Gemmel K et al Surg Obes Rel Dis 2009,5, 54–59

67 % of renal transplantation patients Ducloux D et al Transplantation 2008;85: 1755–1759

95% of Afro-Americans undergoing renal transplantation Tripathy SS et al Transplantation 2008;85: 767–770

VITAMIN D IN BABIESArnberg K et al Acta Paediatr 2011;100:1244-1248

A cross-sectional study in255 infants aged 9 months. 97% received vitamin D supplementation.

Mean plasma 25-hydroxyvitamin D:

77.2 ± 22.7 nM.

Association between vitamin D &

low HDL (p = 0.003), low cholesterol (p = 0.002) and low triglycerides (p = 0.010), low body mass index (p = 0.005) and low waist

circumference (p = 0.002).

VITAMIN D & BREAST CANCERMohr SB et al Breast J 2008;14:255-60

AUTISM & LATITUDE Grant WB, Soles CM (latitude)Dermatoendocrinol. 2009;1:223-228

VITAMIN D & CANCER GROWTHSwami S et al Endocrinology 2012;153:2576-2587

.Mouse models of breast cancer and prostate cancer, vitamin D(3)-supplemented in large dose (5000 IU/kg) & compared with a control diet (1000 IU/kg).

VITAMIN D & CHRONIC LYMPHOCYTIC LEUKEMIA PROGNOSISShanafelt TD et al Blood 2011;117:1492-1498

ALLERGY AND VITAMIN DSharief S et al J Allergy Clin Immunol 2011;127:1195-1202

VITAMIN D & ASTHMA IN CHILDREN

A significant positive correlation exists between forced vital capacity % vitamin D/s (P = .040)

Only 9.4% of children with asthma have a sufficient vitamin/s (> 30 ng/mL).

Children with well-controlled asthma have higher Vitamin D/s than children with un-controlled or partially controlled asthma (P = .023)

A positive correlation exists between vitamin D/s and so called Childhood Asthma Control Test (P = .011) Chinellato I et al J Pediatr 2011;158:437-441

VITAMIN D & CYSTIC FIBROSISRovner AJ et al Am J Clin Nutr 2007;86:1694 –1699

VITAMIN D & MATERNAL VAGINOSISBodnar LM et al J Nutr. 2009;139:1157-1161

VITAMIN D IN DEPRESSIONHögberg G et al Acta Paediatrica 2012;101:779-783

54 Swedish depressed adolescents. Mean serum 25OHD was 41 at baseline and 91 nmol/L (p<0.001) after oral supply of vitamin D during 3 months (4000 IU/d during 1 month and 2000 IU/d 2 months)

Significant increases observed: • Well-being (p<0.001)

• Depressed feeling (p<0.001)

• Irritability (p<0.05) (p<0.001)

• Tiredness (p<0.001)

• Mood swings (p<0.01)

• Sleep difficulties (p<0.01)

• Weakness (p<0.05)

• Ability to concentrate (p<0.05)

• Pain (p<0.05) &

• Significant amelioration of depression according to the MFQ-S (p<0.05)

VITAMIN D & INFECTION/INFLUENZA

TRAINING, VITAMIN D & MUSCLE POWERCarillo AE et al Clinical Nutrition 2012 E-pub

VITAMIN D DEFICIENCY – COSTSGant WB et al Prog Biophys Mol Biol 2009;99:104-113

36 % of direct and 28 % of indirect Health Costs are associated with vitamin D deficience:

Cardiovascular 13.5 and 7.5 resp

Infections incl influenza 7 and 6.5 resp

Type 2 diabetes 7 and 2.4 resp

Cancer 6.4 and 9.6 resp

Osteoporosis 1.5 and 0.5 resp

Multiple sclerosis 1 and 0.2 resp

SUBSTITUTING VITAMIN DGant WB et al Prog Biophys Mol Biol 2009, 99:104-113

to all European to 40 ng/mL would reduce

the direct economic burden of disease by

11.4%, or EUR 105,000 000 000

the indirect economic burden of disease by

6.4 % or EUR 82,000 000 000

the total reduction in economic

burden of disease by 17.7%, or

EUR 187,000 000 000

PORTAL VEIN, THORACIC DUCT, HEPATIC ARTERYPORTÅDERN, STORA LYMFGÅNGEN. LEVERARTÄREN

SATURATED FATTY ACID METABOLISMMCFA: Coconut Oil 85,2, Palm kernel oil 81,5, Palm Oil 45,3, Olive Oil 14.5 (70 % monosaturated)

LCFA: Animal fats

PRESENT THE ENTRANCE OF ENERGY PALEO

THE FRONT DOOR – SHORTCUT 1app 60 % are Sugar and Suger-like substanceswhich enters the body in upper jejunum via

mainly the arterial system < 15 %

THE BACK DOOR – THE DANGEROUS ROUTEapp 30 % animal fats & vegetable oil enters via

the the body via the lymphatic system and remains in circulation for hours > 10 %

THE MAIN DOOR< 20 % Raw greens, Vegetables, Fruits are foodsfor Microbiota and reaches the large intestine,

enhancing immune system, preventing inflammation- app 80 %

POSTPRANDIAL LIPIDEMIA & INFLAMMATION

Khor A et al Nutr Res. 2014;34:391-400.• Postprandial inflammatory activity is a strong risk factors

for atherosclerosis Ebenbichler CF Curr Opin Lipidol 1995;6:286–

290 (& other chronic diseases)

• increases content of endotoxin in blood (eqv to smoking 3 cigarettes) Erridge C et al Am J Clin Nutr 2007;86:1286 –1292

• leads to cascades of inflammatory and oxidative stress

• Ceriello A et al. Diabetes 2004;53:701–710

• release of tumor necrosis factor-α, a key proinflammatory cytokineErridge C et al Am J Clin Nutr 2007;86:1286 –1292

• increases numbers of & activates leukocytes Alipour A et al Arterioscler Thromb Vasc Biol 2008;28:792–797

• Inflammatory reaction potentiated by simultaneous intake of sugar Ceriello A et al. Diabetes 2004;53:701–710

POSTPRANDIAL INFLAMMATION & ENDOTOXEMIAErridge C et al Am J Clin Nutr 2007;86:1286 –1292

VINEGAR & POSTPRANDIAL METABOLISMMitrou P et al Eur J Clin Nutr 2015;69:734-739

Wein S. Diabetes Metab Res Rev 2009;25:185-194MCFAs: Coconut oil and palm kernel oil are the top sourcesLCFAs: C14, C16, C18 – mainly from dairy and meat

FAT UTILIZATION 72 HRSSoeters P et al Am J Physiol Endocrinal Metab 2012;303:E1397-1407

“CONTENT

FOOD

&

HEALTH

AMOUNT TIME

BENEFITS OF DIURNAL FASTING• Reduces oxidative stress

• Boosts mitochondrial energy efficiency

• Normalizes ghrelin "the hunger hormone“

• Normalizes fat, sugar and protein metabolism

• Normalizes espec insulin and leptin sensitivity

• Minimizes damage to cellular proteins, lipids & nucleic acids – hereby

• Reducing disease and premature aging

• Improves various biomarkers of disease

DIURNAL CONTROL OF

GENE ACTIVITY

Plikus MV et al J Biol Rhythm 2015 E-pub

MICROBIOTA & DIURNAL RHYTMFeehley T, Nagler CR Nature 2014;514:176-177

MICROBIOTA, METABOLISM & DIURNAL RHYTMThaiss CA et al Cell. 2014;159:514-529

DIURNAL RHYTHM

&MICROBIOTIC FUNCTIONS

Liang X et alCell. 2014;159:469-70

DIURNAL RHYTHM MICROBIOTIC FUNCTIONS

&FECAL

TRANSPLANTATION

Liang X et al. Cell. 2014;159:469-70

GUT MICROBIOTA & DERANGED METABOLISMVrieze A et al Diabetologia 2010;53:606-613

• ↓ FFA oxidation

• ↑ endotoxin/s

• ↑SCFA production

• ↓incretin secretion

• ↓ butyrate production

• ↑FFA oxidation

• ↓ endotoxin/s

• ↓ SCFA production

• ↑Incretin secretion

• ↑butyrate production

DAILY FASTING REDUCES OBESITY & IMPROVES HEALTH

Hatori M et al Cell Metabolism 2012;15: 848-860

INTERMITTENT FASTING & WEIGHTHatori M et al Cell Metabolism 2012;15: 848-860

NA=normal diet, free access, FA= free access to fat diet, NT & FT=time-restricted normal or fat diet

DIURNAL CHRONOBIOTICS PREVENTS & DELAYS ALZHEIMERS DISEASELaundry G, Liu-Ambrose T Front. Aging Neurosci 2014 E-pub BLT = Bright light therapy

DAILY FASTING –AVOIDING LATE

NIGHT EATING AND SKIPPING

BREAKFAST – long-term effects

Zilberter T, Zilberter EYFront Public Health 2014;2:59

BREAKFAST – NOT YOUR MOST IMPORTANT MEAL?

14 Forskare: ”Nu krävs kraftfulla åtgärder mot nötkött och flygresor”

Publicerad DN 2015-02-27

Svenskarnas globala utsläpp från köttkonsumtion och flygresor motsvarar hälften av de totala utsläppen på hemmaplan. I vår rapport till Naturvårdsverket föreslår vi tydliga styrmedel – som nya skatter – för att begränsa konsumtionen på dessa områden, skriver 14 miljö- och energiforskare.

Naturvårdsverket redovisar att de totala utsläppen orsakade av svensk konsumtion har ökat med 17 procent den senaste 20 åren. Konsumtionsvolymerna har stigit kraftigt och åtgärderna för att minska utsläppen har varit otillräckliga. Rapporten ”Hållbara konsumtionsmönster”Naturvårdsverket publicerar med bidrag från 14 forskare. http://www.dn.se/debatt/nu-kravs-kraftfulla-atgarder-mot-notkott-och-flygresor/

A better way - less energy,

less pollution

•App 56 billion animals are reared and slaughtered for annual human & pet consumption each year•expected to double by 2050

(About 10 animals per individual! )

•most increases will occur in the developing world Steinfeld et al. 2006

ATT BETÄNKA:Cirka 25 procent av svenskens klimatavtryck kommer från maten.

Nötkött orsakar 40 ggr högre utsläpp än t.ex. bönor - jmf kyckling ”bara” 4 ggr.

Av den energi som nötkreatur konsumerar blir ytterst litet kvar: nöt %, grisar 10 %, kyckling 15 %.

Resten försvinner bl. a. för djurens tillväxt och som kroppsvärme hos djuren.

IMPACT OF AGRICULTURE 1Tilman D, Clark M Nature 2014;515:518-522

• About half of the ice-free land on Earth is used as cropland or pasture land.

• Global agriculture & food production release > 25% of all greenhouse gases, pollute, land, ocenas & fresh waters

• Ruminant meats (beef & lamb) have emissions per gram food protein that are about 250 times those of legumes.

• Future global land clearing for agriculture could threaten species with extinction

Agriculture, particularly meat & dairy products, accounts for: •70 % of global freshwater

consumption

•38 % of the total land use &

•21 % of the world's greenhouse gas emissions

IMPACT OF AGRICULTURE 2Tilman D, Clark M Nature 2014;515:518-522

• Diets high in processed foods: refined sugars, refined fats, oils and meats has contributed to 2.1 billion people becoming overweight or obese

• Still will almost a billion people still suffer from inadequate diets & insecure food supplies

2050: IMPACT OF FOODS ON EMISSION Tilman D, Clark M Nature 2014;515:518-522

The income dependent diet requires from 370 to 740 million (mean 540) hectares more cropland than the alternative diets

THE PROBLEM OF WATER SHORTAGE

More than half of the water used in the United States goes to livestock production L. Beckett & J. W. Oltjen J Animal Science 1992;71:818-8268

4000 lit (18000?) of water is needed to produce 1 kg of meat compared to 14 lit to produce one kg of grain Audubon News Jan 2000

Every kg of beef that is avoided can save up to 4000 (18000?) liters of water Boyan S: How Our Food Choices can Help Save the Environment.

”COSTS” OF LIFESTOCK PRODUCTION• 70% of United States grain goes to

feeding farm animals USDA 1991

• It takes almost 7 kg of corn and soy to produce one kg of pork.Cattle-Fax 1989

• Nearly 800 million people could be fed by all the grains currently fed to US livestock Professor David Pimental NY

REMEMBER 1Every second of every day,

one “football field” of tropical rainforest is

destroyed in order to

produce 257 hamburgersBoyan S. How Our Food Choices can

Help Save the Environment

REMEMBER 2Food production will need to increase by

100 per cent by the year 2050

LIFESTOCK & GREEN HOUSE EMISSION

Greenhouse-gas emissions from the agriculture sector account for about 22% of global total emissions, similar to that of industry and 50 % greater than that of transport.

Livestock production accounts for nearly 80% of the sector's emissions. McMichael AJ et al Lancet 2007; 370: 1253–63

THE BURDEN OF METHANE

Over the last 300 years, the atmospheric methane burden has grown 2.5-fold 97% of livestock greenhouse emissions arise from enteric rumen fermentation Hegerty, 2001

GLOBAL WARMING – CONSEQUENCES OF AGRICULTURE Steinfeld H et al 2006

• 37 % percent of produced methane gases, a gas that has 22 times more global warming potential than carbon dioxide

• 65 % of produced nitrous oxide comes from manure, a gas that has 296 times more global warming potential of carbon dioxide

• 64 % of produced ammonia emissions, which contributes to acid rain and destruction of eco-systems

FOOD & GREENHOUSE EFFECTSHeller MC, Keolaian GA J Indust Ecol 2014 E-pub

RUMINANTS & GREENHOUSE-GAS EMISSIONSMcMichael AJ et al Lancet 2007; 370: 1253–63

REMEMBER 4App 80% of health care

costs are due to overconsumption of

mainly

agriculture-produced

Western-type diet.

IMPACT OF AGRICULTURE 3Tilman D, Clark M Nature 2014;515:518-522

Increases in body mass indices (BMI) will increase global incidences of chronic diseases, such as type II diabetes, coronary heart disease and some cancers, - these three predicted to become two-thirds of the global burden of disease by 2050

DIET AND REDUCED RISK

OF DISEASE

Tilman D, Clark M Nature 2014;515:518-522

TYPE OF FOOD & GREENHOUSE GAS EMISSION

(GHG)

Tilman D, Clark M Nature 2014;515:518-522

AGRICULTURE, HEALTH, GREEN-HOUSE EFFECTSFrid S et al Lancet 2009; 374: 2016–2025

ENVIRONMENTAL FOOTPRINTSB & R Vale Time to eat your dog, Guide to sustainable living 2009

Cow ,milking 30 lit/day 19.6 gha *Sheep 1.6 ghaHuman –developed world 6 ghaLarge dog 1.1 ghaHuman being developing world 1 ghaPig 0.6 ghaJeep/SUV 0.41 ghaSmall dog 0.3 ghaCat 0.15 ghaHamster 0.014 gha

* = global hectare, one gha = 10000 sqmet, total app 15 bill gha

One average dog eats the same amount of meat as

4 average Humans

The estimated 500 000 000 dogs on Earth

eat as 2 billion average Humans

REMEMBER 5

WHAT CAN WE DO? “A substantial contraction in meat consumption in high-income countries should benefit health, reducing the risk of ischaemic heart disease obesity, colorectal cancer etc”.McMichael AJ et al Lancet 2007; 370: 1253–63

THE EASIEST WAY?“Halting the increase of greenhouse-gas emissions from agriculture, especially livestock production, should therefore be a top priority, because it could curb warming fairly rapidly.”McMichael AJ et al Lancet 2007; 370: 1253–63

GOVERNMENTAL SUBSIDIESGood Medicine 2007;16, number 4

http://www.zamzar.com/convert/ppt-to-tiff/#http://www.zamzar.com/convert/ppt-to-tiff/#

Leonardo Dicaprio i filmen Cowspirary

1. 51 procent av världens koldioxidutsläpp orsakas av boskap och deras biprodukter, endast 13 procent orsakas av transporter med bilar, båtar, tåg och flyg.2. Du kan halvera ditt koldioxidavtryck genom att byta kött mot frukt och

grönsaker i din kost.3. Det går åt 3000 liter vatten för att tillverka en hamburgare, det är lika

mycket som går åt när man duschar i två månader.4. 4000-8000 kvadratmeter regnskog avverkas varje sekund, köttindustrin

ligger bakom 91 procent av avverkningen.5. Kött- och mjölkindustrin använder 1/3 av jordens tillgångar av

dricksvatten.6. En köttgård med 2500 kor skapar lika mycket avfall som en stad med

411000 invånare.7. 110 djur- och insektsarter försvinner varje dag till följd av skövlingen av

regnskog.8. Varje år fiskas 80,4 ton fisk upp från jordens hav – och för varje kilo som

fiskas upp kastas 5 kilo av andra marina arter som fångats av misstag.9. Boskap täcker 45 procent av jordens landyta.

STÖD – JORDBRUK, EUefter Grönvall A, Johansson M, Jönrup H Statistikenheten 1990

STÖD – JORDBRUK, SVERIGEefter Grönvall A, Johansson M, Jönrup H Statistikenheten 1990

David Perlmutter, MD,FACN, ABIHM is a Board-Certified Neurologist and Fellow of the American College of Nutrition

• Richard J Johnson, MD Professor and Chief of nephrology, University of Colorado, Denver

Gut microbiota,

immune development and function

Bengmark S.

Pharmacological

Research

2013 March;69:87-113

SonnenburgJustin & Erica

The Good Gut- Your weight

- Your mood- Your health

www.bengmark.com

stig@bengmark.se

”Hedra Dina tarmbakterier på det att det må gå Dig väl och Du må länge leva

på jorden”

Thank you!