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ALZHEIMER’S DISEASE: PATHOGENESIS, DIAGNOSIS AND TREATMENTDevashish Mehta*, Amar Goyal, Kuldeep K. Sharma.
devashishmehta7754@gmail.com
ALZHEIMER’S DISEASEINTRODUCTIONAlzheimer's disease is a
neurodegenerative brain disorder.It is the most common form of dementia.It usually starts in late middle age or in
old age(above 65years).It is characterized by progressive
memory loss.Formation of Neurofibrillary tangles and
plaques containing beta-amyloid cells.
CAUSES OF ADIncreasing ageHistory of a head injuryRisk factors for blood vessel
disease such as smokingHeredityObesityHigh blood pressureHigh cholesterol
Signs and SymptomsAt early stages of AD :Impairment in MemoryAphasiaApraxiaAgnosiaMood changesLoss of spontaneity and
initiative
At progressive AD:Increasing short-term
memory loss and confusionFeelings of restlessnessLoss of appetitePersonality changes
Stages of ADStage 1: NormalStage 2: Normal aged forgetfulnessStage 3: Mild cognitive impairmentStage 4: Mild Alzheimer’sStage 5: Moderate Alzheimer’s
diseaseStage 6: Moderately severe
Alzheimer’s diseaseStage 7: Severe Alzheimer’s disease
PATHOGENSIS
PathophysiologyR.O.S.( Reactive oxygen species)
generation.Deposition of Amyloid β( Aβ42)Hyperphosphorylation of Tau
ProteinNeurofibrillary Tangles (NFT)
FormationInflammation
Healthy Brain vs AD Brain
DIAGNOSIS OF AD• Psychiatric assessments. • Mental status examination and
neuro psychological assessment. • Laboratory tests. • Brain imaging : CT scan, MRI • CSF Examination • Electro-encephalogram (EEG)
TREATMENT STRATGIESNon – Pharmacological
Meditation YOGA Panchkarma
Pharmacological Allopathic Ayurvedic
Allopathic TreatmentCholinesterase inhibitor( eg.-
Donepezil, Galantamine, Tacrine)HMG Co A reductase
inhibitor(eg.- Simvastatin, Atorvastatin, Lovastatin)
Non- Statin Hypolipidaemics (eg.- Probucol)
NMDA receptor antagonist
Ayurvedic TreatmentBrahmi VatiShunkhpushpiJatamansiBadam
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