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Luis Jose Fernández Yepez
Estudiante de posgrado primer año de Neurología Clínica
Universidad del Sinú-Seccional Cartagena
Cartagena, Colombia
17 Junio 2015
1990: Primer caso descrito en Estados Unidos
AGH: se ha reconocido cada vez más en Estados Unidos, Europa y Asia
>5.000 casos reportados
Center for Disease Control (Atlanta) : Notificación obligatoria
Jin H, Wei F, Liu Q, Qian J. Epidemiology and Control of Human Granulocytic Anaplasmosis: A Systematic Review.
Vector-Borne and Zoonotic Diseases. 2012 Apr;12(4):269–74.
Es una enfermedad zoonótica emergentecausada por la rickettsia Anaplasmaphagocytophilum transmitida porgarrapatas Ixodes en todo el mundo.
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Pacientes con AGH:
36% hospitalización
3% complicaciones mortales
17% hospitalizados : UCI
0,2% meningitis o encefalitis
1% fallecen
Jin H, Wei F, Liu Q, Qian J. Epidemiology and Control of Human Granulocytic Anaplasmosis: A Systematic Review.
Vector-Borne and Zoonotic Diseases. 2012 Apr;12(4):269–74.
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Koebel C, Kern A, Edouard S, Hoang AT, Celestin N, Hansmann Y, et al. Human granulocytic anaplasmosis in
eastern France: clinical presentation and laboratory diagnosis. Diagnostic Microbiology and Infectious Disease.
2012 Mar;72(3):214–8.
Ohashi N, Gaowa, Wuritu F, Kawamori D, Wu Y, Yoshikawa S, et al. Human Granulocytic Anaplasmosis, Japan.
Emerging Infectious Diseases. 2013 Feb;19(2):289–92.
García JC, Núñez MJ, Portillo A, Oteo JA. Anaplasmosis humana: comunicación de 2 casos. Enfermedades
Infecciosas y Microbiología Clínica. 2015 Jan;33(1):68–9.
García JC, Núñez MJ, Portillo A, Oteo JA. Anaplasmosis humana: comunicación de 2 casos.
Enfermedades Infecciosas y Microbiología Clínica. 2015 Jan;33(1):68–9.
Parra M, Mattar S. Detección de anticuerpos contra Anaplasma, Bartonella y Coxiella en habitantes rurales de un
área del Caribe colombiano. Revista MVZ Córdoba. 2006;11:781-9.
Parra M, Mattar S. Detección de anticuerpos contra Anaplasma, Bartonella y Coxiella en habitantes rurales de un
área del Caribe colombiano. Revista MVZ Córdoba. 2006;11:781-9.
Ríos R, Franco S, Mattar S, Urrea M, Tique V. Seroprevalencia de leptospira sp., Rickettsia sp. Ehrlichia sp. en
trabajadores rurales del departamento de Sucre, Colombia. Infectio. 2008; 12(2): 90-95
3,3% para Ehrlichia sp.
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Formas de transmisión:
• Picadura de garrapata
• Transplacentaria
• Exposición directa a la sangre devenado(carniceros)
• Transfusiones
• Exposición nosocomial(China) : sangre –secreciones respiratorias
Horowitz HW, Kilchevsky E, Haber S, Aguero-Rosenfeld M, Kranwinkel R, James EK, et al. Perinatal Transmission
of the Agent of Human Granulocytic Ehrlichiosis. New England Journal of Medicine. 1998 Aug 6;339(6):375–8.
Bakken JS, Krueth JK, Lund T, Malkovitch D, Asanovich K, Dumler JS. Exposure to Deer Blood May Be a Cause of
Human Granulocytic Ehrlichiosis. Clinical Infectious Diseases. 1996 Jul 1;23(1):198–198.
Townsend RL, Moritz ED, Fialkow LB, et al. Probable transfusion-transmission ofAnaplasma phagocytophilum by
leukoreduced platelets. Transfusion 2014; 54(11):2828–32..
Zhang L. Nosocomial Transmission of Human Granulocytic Anaplasmosis in China. JAMA. 2008 Nov
19;300(19):2263.
Rikihisa Y. Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells. Nature
Reviews Microbiology. 2010 Apr 7;8(5):328–39.
Rikihisa Y. Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells. Nature
Reviews Microbiology. 2010 Apr 7;8(5):328–39.
Rikihisa Y. Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host
cells. Nature Reviews Microbiology. 2010 Apr 7;8(5):328–39.
Rikihisa Y. Mechanisms of Obligatory Intracellular Infection with Anaplasma phagocytophilum. Clinical
Microbiology Reviews. 2011 Jul 1;24(3):469–89.
Rikihisa Y. Mechanisms of Obligatory Intracellular Infection with Anaplasma phagocytophilum. Clinical
Microbiology Reviews. 2011 Jul 1;24(3):469–89.
Rikihisa Y. Mechanisms of Obligatory Intracellular Infection with Anaplasma phagocytophilum. Clinical
Microbiology Reviews. 2011 Jul 1;24(3):469–89.
Rikihisa Y. Mechanisms of Obligatory Intracellular Infection with Anaplasma phagocytophilum. Clinical
Microbiology Reviews. 2011 Jul 1;24(3):469–89.
Retraso de la apoptosis espontánea
Degranulación prolongada de mediadores proinflamatorios o citokinas
respuesta antimicrobiana fagocitosis defectuosa
migración celular transendotelial
adhesión celular para activar al endotelio
Proteína inmunodominante llamada (msp2)
Unión a la superficie de los neutrófilos
Truchan HK, Seidman D, Carlyon JA. Breaking in and grabbing a meal: Anaplasma phagocytophilum cellular
invasion, nutrient acquisition, and promising tools for their study. Microbes and Infection. 2013 Dec;15(14-15):1017–
25.
Rikihisa Y. Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells. Nature
Reviews Microbiology. 2010 Apr 7;8(5):328–39.
Rikihisa Y. Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells. Nature
Reviews Microbiology. 2010 Apr 7;8(5):328–39.
Rikihisa Y. Mechanisms of Obligatory Intracellular Infection with Anaplasma phagocytophilum. Clinical
Microbiology Reviews. 2011 Jul 1;24(3):469–89.
Rikihisa Y. Mechanisms of Obligatory Intracellular Infection with Anaplasma phagocytophilum. Clinical
Microbiology Reviews. 2011 Jul 1;24(3):469–89.
Severo MS, Stephens KD, Kotsyfakis M, Pedra JH. Anaplasma phagocytophilum : deceptively simple or simply
deceptive? Future Microbiology. 2012 Jun;7(6):719–31.
Truchan HK, Seidman D, Carlyon JA. Breaking in and grabbing a meal: Anaplasma phagocytophilum cellular
invasion, nutrient acquisition, and promising tools for their study. Microbes and Infection. 2013 Dec;15(14-15):1017–
25.
Ismail N, Bloch KC, McBride JW. Human Ehrlichiosis and Anaplasmosis. Clinics in Laboratory Medicine.
2010 Mar;30(1):261–92.
Severo MS, Stephens KD, Kotsyfakis M, Pedra JH. Anaplasma phagocytophilum : deceptively simple or simply
deceptive? Future Microbiology. 2012 Jun;7(6):719–31.
> Frecuencia enfermedad febril
inespecífica
Enfermedad asintomática
Enfermedad fatal: edad, comorbilidades
y gravedad
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Exposición a garrapatas:
1 a 2 semanas previas antes del inicio
Fiebre Diaforesis
Cefalea Mialgias Artralgias
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North
America. 2015 Jun;29(2):341–55.
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North
America. 2015 Jun;29(2):341–55.
Examen de sangre periférica de Wright-Giemsa
PCR
Cultivo en HL-60 (leucemia promielocitica)
IFI para A. phagocytophilum IgG > cambio de 4 veces-IgM primeros 40 días
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Mandell GL, Bennett JE, Dolin R. Mandell, Douglas y Bennett, enfermedades infecciosas. Barcelona: Elsevier; 2012.
Koebel C, Kern A, Edouard S, Hoang AT, Celestin N, Hansmann Y, et al. Human granulocytic anaplasmosis in
eastern France: clinical presentation and laboratory diagnosis. Diagnostic Microbiology and Infectious Disease.
2012 Mar;72(3):214–8.
Mandell GL, Bennett JE, Dolin R. Mandell, Douglas y Bennett, enfermedades infecciosas. Barcelona: Elsevier; 2012.
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Aspergilosis pulmonar invasiva
Esofagitis y neumonitis por candida albicans
Esofagitis por herpes simple
Infecciones oportunistas graves , casos fatales de:
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Mortalidad : 1%Síndrome de shock
tóxico
Síndrome de dificultad
respiratoria aguda
Infecciones oportunistas invasivas con agentes tanto
víricas y fúngicas
Rabdomiólisis Pancarditis
Insuficiencia renal aguda
Hemorragias
Bakken JS, Dumler JS. Human Granulocytic Anaplasmosis. Infectious Disease Clinics of North America. 2015
Jun;29(2):341–55.
Plexopatía braquial
Polineuropatía desmielinizante
Pérdida auditiva neurosensorial
transitoria aguda
Kaphle U, Kheir F, Thammasitboon S. A Rare Case of ARDS From Human Anaplasmosis. Respiratory Care
[Internet]. 2015 Feb 10 [cited 2015 Jun 6]; Available from: http://rc.rcjournal.com/cgi/doi/10.4187/respcare.03714
Kaphle U, Kheir F, Thammasitboon S. A Rare Case of ARDS From Human Anaplasmosis. Respiratory Care
[Internet]. 2015 Feb 10 [cited 2015 Jun 6]; Available from: http://rc.rcjournal.com/cgi/doi/10.4187/respcare.03714
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