May 24, 2016

ISPOR 2016 • Washington, DC

Social Listening For Safety Outcomes &Pharmacoeconomic Considerations:

Has The Time Come?

Proto-AEPosts with resemblance to Adverse

Events

AstheniaMedDRA: 10003549

DizzinessMedDRA: 10013573

Data Processing

Collect unstructured data fromsocial media APIs, third-partyauthorized resellers, andautomated scraping.

Acquire

detectsentiment

languagetranslation

statistics consolidatemultiples

detectadverseevents

detectbenefits

de-identifygeo-tag

Data are passed through a seriesof apps, emerging as meaningfulbits of information.

Process

detectsentiment

languagetranslation

statistics consolidatemultiples

detectadverseevents

detectbenefits

de-identifygeo-tag API mobile RSS tables reportsCSV

,visuals

Relevant data are passed to anotherseries of apps in preparation forhuman interpretation and analysis.

Export

API mobile RSS tables reportsCSV

,visuals

Relevant data are passed to anotherseries of apps in preparation forhuman interpretation and analysis.

Export

Internet VernacularTranslation

lost their eyesight

seeing weird colorseeing weird colour

doublevision

couldn’t seevisión doble

blindgoogley eyed

blurry vision

changes in visioncross eyedseeing weird

vision changeblindness

cross visionvisual snow

googly eyedseeing double

making me eat like a mouselost appetite

#notevenhungryappetite is nonexistent

apetite surpressed

didn’t get hungry

dont want to eat

killed my apetite

miss feeling hungry

killed my appetitecan’t eatsin hambre

lost my appetiteno appetitey

lack of apetitestomach small

lost teh appetite

never hungrynever want to eat

cant eat

couldnt seecrosseyed

blurryanorexic

apetite surpressed

lack of apetite

killed my apetite lost teh appetite

making me eat like a mouse

never want to eat

Implied

#notevenhungry

no appetitey

Invented words and hashtags

googley eyed

googly eyed

seeing weird colourseeing weird color

Varied Spelling

sin hambre

visión doble

Other Languages

blurry vision

Emoticons

Typos

making me eat like a mouseanorexic

lost appetite

#notevenhungryappetite is nonexistent

apetite surpressed

didn’t get hungry

dont want to eat

miss feeling hungry

killed my appetitecan’t eatsin hambre

lost my appetiteno appetitey

lack of apetitestomach small

lost teh appetite

never hungrynever want to eat

cant eat

lost their eyesight

seeing weird colorseeing weird colour

doublevision

couldn’t seevisión doble

blindgoogley eyed

changes in visioncross eyedseeing weird

vision changeblindness

cross visionvisual snow

googly eyedseeing double

couldnt seecrosseyed

blurry

killed my apetite

blurry vision

Decreased appetiteMedDRA 10061428

Loss of appetiteSNOMED 79890006

Visual impairmentMedDRA 10047571Visual impairment

SNOMED 397540003

Machine Learningvs.

Natural Language Processing

Machine LearningFind reports of importance.

Natural Language ProcessingExtract the most relevant elements.

How to build a machine learning

classifier

Proto-AE Trash

Medicine Prozak® (Fluoxetine) for the treatment of bulimia nervosa . Buy now Prozac-20mg "Fluoxetine" ...

Benefit

81%27%74%4%2%75%92%

Instant Feedback: % Confidence that this is a Proto-AE

You just trained the classifier.

Congratulations!

Natural Language Processing

An interactive example