2. 2014-07-2210025100K25K 3. : 4. : 5. , ? ? ?? ? 6. 7. ( Gout )
: 8. 7.0 (mg/dL)2007 9. 1.2.3.A : B : 2007 10. 11. = 12. 1988 : 30
17.3%20.3%14.6% 1991-1992 : 20.1%25.8%15.0% 1993-1996 :
1926.1%17.0% 2007 13. 90% 2007 14. vs Nucleosides Nucleotides
Nucleic Acids. 2008 Jun;27(6):620-3. 15. 9 mg/dl: 4.9 % 7-8.9
mg/dl: 0.5 % < 7 mg/dl: 0.1 %Am J Med 1987; 82:421-6 16. ( I/IV
)1. : ( 85% ): > > > > > > > 17. ( II/IV )2.
Monosodium urate crystal ( MSU ): ( strong negative birefrigent )
20000 -100,000 /mm3 18. 19. ( III/IV )3. : Lesch-Nyhan
Syndrome,Glycogen storage disease. ( / 7-9/1 ): , , : (,, , ) 20. (
IV/IV4. > 7 mg/dl, > 6 mg/dl 30%, 21. X 22. -Double Contour
Sign Snow-Storm Sign 23. CANT LEAPCyclosporine LasixAlcohol
EthambutolNicotinic acid AspirinThiazide Pyrazinamide,, 24. (3-5) /
25. : , : : : , , 26. : : 27. .. 28. 1. 2. 3. 4. 50% 29. )100
X(:150-1000/100 )?(:25-150/100 )(:0-25/100 ) () 30. )100
X(:150-1000/100 )?(:25-150/100 )(:0-25/100 ) () 31. :1.2. 32. ::
6.0 33. :- ,, )- - 34. Celebrex ( 200 mg) Mobic ( 15 mg)Acemet ( 90
mg) Votan ( 100 mg) 35. 1. 2. 3. 36. :1. Allopurinol: 37. (100mg)
38. Allopurinol (allopurinol
hypersensitivitysyndrome,AHS)allopurinol Steven-Johnson syndrome /(
TEN) 1 728(47 )2025% Allopurinol allopurinolampicillin, thiazide,
ACEI 39. :2. Benzbromazone:1500 c.c 40. (50mg) 41. :3.
Sulfinpyrazone::, 42. (100mg) 43. :4. Febuxostat : 44. Feburic 80
mg benzbromarone6.0 mg/dL (eGFR45 mL/min/1.73m2serum
creatinine1.5mg/dL 45. , ? ? ?? ? 46. III. 47. Take Home Message
:< 6 mg/dL Febuxostat 48.
