טבלת ממאירויות המטולוגיות

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a table of common hematologic malignancies - in hebrew

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CLL/SLL - CLL , %4 SLL- .NHL " 0004 ,CLL =.SLL -2 . 05. B .BM, PB, LN 5 - +CD ( )T + CD19,20,22,38 HLADR , . , .

ALL: pre-T . 4

ALL: pre-B

, ( ) (, ). , , , - %51 B 85%, T " , %07-05 54+CD1+ TdT+ CD2,3,4,5,8, CD " BM - PB -TdT+ Ig .02CD19+ CD10 CD45 CD )(=CALLA BM

( ), , . pure .red cell aplasia / BM ( ! " B .)T ' ( ,)NHL . ' .

( ). , - .BM , (), , , , ( ), ( CNS , ) AML , , , - .BM B .T , , (") - BM " BM "

. - SLL , . .SLL . , " " ( )smudge cells. - SLL - .CLL ". . ( ). Mab-Campath 25( CD )CLL + (-02+)CD () ( -6 , , /"-, LN ). . " Rai/Binet LN, , , ". (41)13q 21. 07 ZAP. 83 CD . ( ). %01 (" -.)large b-cell lymphoma

" " .TCR 1TAL , " 12;21()Ig. t - :AML , , . - ALL - AML - .PAS B/T. , , , . IHC-( TdT -%59). : ,)12;21(t ]'t(4;11) t(9;22)[Phil -3 : 1 L , . - PAS - 2 acid phosphatase. L , . - PAS - acid 3 phosphatase.L burkitt " . - PAS - ,acid phosphatase . , : - . ( ) (). " . . - .CNS - ,BBB . , . BM, . . , , BM, , , : .BM - BM . ( '), ( ) -. ( ,)flame cells , Mott . , ( Ig), ' ( Ig), . Ig - RBC (rouleaux )formations : , . ( ): --. , . - 6- ,IL ( .) ( , .). - (( )Velcade " )NF-b , - , . ' . BMT/- 56. +. . BMT . , . . EPO. 6- IL . . . alkylating agents -%07-05 , -3 . , .

MGUS , bence-jones

,

MGUS %1 (" )

ET , .TPO

CML , 1:100-200k. %02-51 . , , ( -.)ALL 06-52, 04-03, , . - ,BM -PB

PV RBC , 06. - .PB - B , , . . ( ), / , ( , - ) ", .gout PV , : : , . : , EPO, , .COPD (" >%29), (" %06-55), EPO (" 901*5.1, . ( . )., INF : 51-21 .

22;9)( )t) .ABL-BCR ALL , . (%01~) " . -35 P -%01 -.blast crisis -%001) BM %05), . PB BM . BM , /, , .sea-blue histiocytes ' ( , ). - :AML , - AML . , . %01 . - RBC- . ' ( ). ,Hydrea, INF. Allo-BMT