Диффузная передача сигнала

4

-

-- - (, )

,

,

4.1

( mGluR, ) ( , NMDA, )

( , NMDA )

( ) NMDA AMPA ,

(spill , over : )

Po,max cleft - D NMDA , AMPA

() (b) ()

NMDA () : , NMDA

. , .600 nm

LTP (A) NMDA, AMPA . LTP AMPA . (B) () , NMDA ( AMPA) . - , LTP .

- , , - ,

4.2

( )

( )

- ( ) ()

? !300

,

: = /

( )

Na+ K+ () Na+ Cl- (, , , , )

() ()

, . . , , , 2005

( ) ( ) .

kon koff: , .

, 2005

()

4.3

Ca2+ Ca2+ ,

Ca2+, Ca2+ 2+

4.4

(a) . (b) , . .(c) . .

CA 1CA 3DG+ in vivo

+ (, , )

+

+ ( )

1. 2. 150 mM [Cl-]oIR-DIC image

D-APV (50 M) NMDA

NBQX (25 M) AMPA/

CGP52432 (5 M) B

Semyanov et al. Nature Neurosci. 2003

Semyanov et al. Nature Neurosci. 2003

, :

Semyanov et al. Nature Neurosci. 2003 ++ ,

.

:

5- (5-DHP)

3,5- (3,5-THP; )

3,5-THP .

(THDOC) , .

THDOC ,

,

Diffuse signalling together with intracellular reactions determines the state of neuronal membrane (e.g conductance, signal to noise ratio of neuronal firing pattern, phase portrait of firing pattern, integration time window, input-output function etc).