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第四十六章 作用于免疫系统的药物. 作用于免疫系统的药物统称为免疫调节药. (immunomodulator) 包括:免疫抑制剂( immunosupressive agents ) 免疫增强剂( immunopotentiating agents ) 免疫抑制剂是一类可抑制免疫系统作用的药物 肾上腺皮质激素 钙调磷酸酶抑制剂 抗增殖 / 抗代谢药和抗体制剂 免疫增强剂主要指具有免疫刺激、兴奋和恢复作用的药物 - PowerPoint PPT Presentation
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(immunomodulator)
immunosupressive agents immunopotentiating agents / immnuoadjuvants (immunonormalizing agents) (immunosubstituting agents)
innate immune response/adaptive immune responseBT
1. hypersensitivity2. autoimmune diseasessystemic lupus erythematosus1type 1 diabetes mellitus3. immunoproliferative diseasemultiple myeloma
4. immunodeficiency diseaseHIVsolid tumorshematological malignanciesinfectious diseases5. graft rejection6. tumor
1 2 3/
1.immunosuppressive agents2.3.4.24~48h5.
/
1. 2. 3. /4. 5.
TTIL-1IL-2IL-6-GREnGRE-IBNFB
calcineurinTFK506-FKBPTNFATIL-2TIL-2FKBPmTOR
cyclosporinCsATIL-1-transforming growth factor-TGF-cyclophilincalcineurinT(nuclear factor of activated T cellsNFAT)NFAT
( systemic lupus erythematosusSLE)(lupus nephritisLN)(myelodysplastic syndromeMDS)(nephrotic syndromeNS)
B
tacrolimusFK506FK506FKBPNFATTFK506G0ATCD3IL-2FK506Ca2+TBTB
-FK506FK506
mycophenolate mofetilMMF MMFMPAMPAinosine monophosphate dehydrogenaseIMPDHde novo synthesis pathwaysalvage pathwayIMPDHMPAIMPDH4~5TBIMPDHMPA
MMFIgA
MMFMPAMPAGMMFMPAMPA
ATG
ATGTCD2. CD3. CD4. CD8CD11aCD18CD25CD44CD45TBT
Aza10%~15%TATG
-CD3 (Muromonab-CD3)-CD3TCD3TTT
tripterygium glycosidesIL-2
immunopotentiating agents
1 Q102 3 NPT-15392poly ICpoly AU4 5 PHAAConA
1 -2. AIDSataxia-telangiectasia syndrome2 3
(bacillus calmette-guerin vaccine ,BCG) TBNKBCGBCG BCG
levamisoleLMS LMST/TEPHAcAMPTIL-2
LMSLMSLMS
-2 aldesleukin IL-2IL-2IL-2ThTcNKBIL-2IL-1
interferonIFN-NKIFNIFNKaposi
transfer factorTFTFRNAreverse transcriptaseTFDNATFTTFIgG
1 thymosin 1T1 T1TT1TdTIFNIL-2IL-2IFN- HBsAgHBeAgT1CD3CD4HBVIFN-T1
1.2. 3.4.5.-CD3
/
immnuoadjuvants (immunonormalizing agents) (immunosubstituting agents)1.
1.immunosuppressive agents2.3.4.24~48h5.2.
3.
/
4. TIL-1-transforming growth factor-TGF-cyclophilincalcineurinT(nuclear factor of activated T cellsNFAT)NFAT
5.-CD3
-CD3TCD3TT