1

2

3

1.2. T3.B

1. B25% T75%

2. T25% B65% :

1. T

2. B

3. ADCC

Kupffer A: -

BCR/AbAntigen recognition and clearanceTCR Antigen recognition by T cellsMHC Antigen presentationCytokineImmunoregultation and effector functionComplementInnate immunity against pathogensCD moleculesImmune cell differentiation and function

1 :

:

2::

1 () 2 ()

+

1

2 10000Da3 10DaAA 5734Da AA

4.5.

- - - - ,() - ( ,) Th -TD Ag -TI Ag

(O)Ag 170 60,50 , AF (H)Ag 60 60,(a.b.c) , (1.2.3)Ag - , - (KAg) (Vi Ag) , 100,K88K99Ag -(,,,0.3-0.4%) -(,,)

()

A.heavy chainH 2 light chainL 2 B.variable region, V constant region, C

Ig

IgG (75%Ig) (2123) 35(8.017 mg/ml)

ADCC

IgM IgA IgE IgDIgM: IgA: IgE: IgD: B

IgMIgG

A. B. C. D. E. F.

polyclonal antibody B :

McAb B --- B --- --- HAT(H), (A)(T)

DNAIg -(chimeric antibody) (reshaped humanized antibody) Fab Fc Fv (bispecific antibody)

DNA DNA

1. 2. TB3. T

() () () ()

IgE

.() -- --- --- ---

() --- IgE Th2 IL-4 B IgEIgE(1000-10000)FcFcR ()IgE FcFcR FcR--- 112 () () FcR --- IgE

--- ---

(eosinophils) A. B.

IgGIgMNK

6h2448h