СОВЕРШЕНСТВОВАНИЕ ТЕХНОЛОГИИ ПОЛУЧЕНИЯ ХИТОЗАНА

Embed Size (px)

Text of СОВЕРШЕНСТВОВАНИЕ ТЕХНОЛОГИИ ПОЛУЧЕНИЯ ХИТОЗАНА

  • . 11. 2011. 2 (2) 1 7

    .

    .,

    ..,

    2011

    663/66 36-9

    .. , ..

    . .

    : , , -, , , , -.

    I ., , - -. 1994 . 1 000 , 800 , - 150200 . . - , , , .

    15 , 70 - , - :

    1. - , - -; - , , , , , ; , , .

    [13] - . , - -, , , , .

    , - , -. , , - - , - - / , - , - . - - . , -, , -, - .

    , , - . , - , , - . -- - , -, - , - , . [6].

    2. , ,, , - , -, -

  • 1 8 .. , .. .

    , - , ; - , - ; ; , - , - .

    3. , , - , ,, [5], , , - .

    4. -, 2540 %, -, , ; , - , -, - - .

    5. , , , -, -, .

    , - [2; 4] , , - , - , - , , - , (

    ) , - .

    - : - - , - , - , - , . - -, , .

    -, , -, , , , - -, - (-), , -, - , , - , - , - , [9; 10; 14].

    , , - , , - .

    - , - N--2--2---D- [3] (. 1).

    . - ,

    OO

    N HH O

    C OC H 3

    C H 2O H

    O O

    N HH O

    C OC H 3

    C H 2O H

    . 1.

  • . 11. 2011. 2 (2) 1 9

    . - , - . - - - - . - . - - , - ( - ) , - , - - -. , , - , .

    , - . - , - , - - .

    , - Pandalus - , - Aspergillum.

    - , - . - - - .

    - - - 70 C, 20 C. , - 4 C, - .

    - - , - , - , - .

    (II) -(14)-2--2-D-, -, , 515 % , 1 % , - [12]. (I) 2 - (. 2).

    , - - ( ) 2 3 - , .

    , ,

    HO

    O

    NH

    CO

    CH3

    OCH2OH O

    NH

    HO

    +NaOH

    O

    CH2OH

    CO

    CH3

    -CH3COONa OHO

    CH2OHO

    NH2

    OCH2OH O

    NH2

    HO

    (I) (II). 2.

  • 2 0 .. , .. .

    - 4049%- NaOH 110140 C 46 - [9; 11].

    - , - , - , , . . [1; 8; 12].

    - [7].

    , - [9]. - , - , . -, , - , . - - . - - , - .

    , - , - , , .

    - ( 50 C), - - , , .

    -- (. ) -

    - -, - , , .

    , - , -, - ,, - - .

    - . 10 %- - , , - : -, -. - - - .

    0,1 M l. - - , .

    - 12 23 - , - - , 40%- NaOH ( - 1 : 20) 100 C - 12 .

    - -

    - . .

    % 10,0 9,40 1%- 2%-

    . 7,5 3,85

  • . 11. 2011. 2 (2) 2 1

    . 2001. . 7, 1. . 5156.

    4. , . . - / . . // . 2005. 5. . 2127.

    5. --. , , - / . . [ .] // . 2000. 6. . 1418.

    6. , . . - / . . , . . -, . . // . 2005. 6. . 2124.

    7. / .. . . . : . ., 1984. 255 .

    8. . 2116314 , 6 08 37/08. / . . -, . . , . . , . . -. 97104789/04 ; . 26.03.97 ; . 27.07.98// . 1998. 21. 220 .

    9. . , / . . . , . . -, . . . . : , 2002. 368 .

    10. Chitosan as antimicrobial agent: applicationsand mode of action / E. Rabea, M. Badawy, C. Stevens,G. Smagghe [et al.] // Biomacromol. 2003. Vol. 4, l. P. 1457.

    11. Chitosan Preparation from Persian Gulf ShrimpShells and Investigating the Effect of Time on the Degreeof Deacetylation / M. Shahabi Viarsaghl, M. Janmaleki,H. Reza Falahatpisheh1, J. Masoumi // Journal ofParamedical Sciences (JPS). 2009. Vol. 1. P. 27.

    12. Hoemann, C. Tissue engineering of cartilageusing an injectable and adhesive chitosan-based cell-delivery vehicle / C. Hoemann, J. Sun, A. Legare// Osteoarthritis Cartil. 2005. Vol. 13. P. 318329.

    13. Kyung, W. K. Antimicrobial activity of nativechitosan, degraded chitosan-carboxymethylatedchitosan / W. K. Kyung, R. I. Thomas, L. Chan // Journalof Food Protection. 2003. 66. P. 14951498.

    14. Ultrastructure of hybrid chitosan-glycerolphosphate blood clots by environmental scanning electronmicroscopy / M. Iliescu, C. D. Hoemann, M. S. Shive,A. Chenite // Microsc. Res. Technique. 2008. Vol. 71, 3. P. 236247.

    . -, 70 %. - 5055 .

    - Pandalus . - 8,6 %, 6,46 %, 43,8 %, 40,9 %.

    - , - ( 9289-067-00472124-03). - :

    : 13 .: .: ,

    .: ,

    .

    pH- - pH-150 .

    100105 .

    1. , . . - : , - / . . , . . // - . , . . : , 2002. C. 723.

    2. , - / .. [ .]// . 1995. 6. . 1822.

    3. , . . : -, , / . . // -

    IMPROVED TECHNOLOGY OBTAINING CHITOSAN

    M.P. Lyabin, P.S. Semenov

    The main applications of chitosan. The possibility of obtaining biopolymer new soft way.

    Key words: chitin, chitosan, medicine, biotechnology, bioengineering, production,deacetylation.