Autoimmune Liver Diseases

*WANG, GQ

AIHPBCPSCAIC (Overlap Syndromes)

*WANG, GQ

AILD

*WANG, GQ

AIHPBCPSC60%HLADR3DR4dsDNA

*WANG, GQ

*WANG, GQ

*WANG, GQ

Autoimmune Hepatitis (AIH)- (4:1)Czaja AJ & Freese DK. Diagnosis and treatment of AIH. Hepatology 2002; 36:479-497

*WANG, GQ

AIHMcFarlane IG. Pathogenesis of autoimmune hepatitis. Biomed & Pharmacother. 1999; 53:255

*WANG, GQ

Potential mechanisms of immune-mediated damage in AIH

*WANG, GQ

AIH

*WANG, GQ

AIH-Interface hepatitis

*WANG, GQ

AIH-Plasma cell infiltration

*WANG, GQ

AIH N IH/PN BN LH RLC CN PPI (%) (%) (%) (%) (%) (%)

I 21 100 57.1 95.2 71.4 33.3 95.2

II 5 100 80.0 100 100 80.0 20.0

IH/PN/ RLC LH PPI CN 2002162730

*WANG, GQ

AIHSLE

*WANG, GQ

AIH N ALT AST Glo ANA LKM1 (F/M) (U/L) (U/L) (%) SMA (%)

I 21 19/2 40.5 287.2 206.1 42.6 95.2 0 18.6 II 5 5/0 12.5 389.6 319.8 26.1 0 100 19.1

IIIIII 2002162730

*WANG, GQ

AIHANASMA ILKM-1 /SLA/LP pANCA ASGPR ILC-1

*WANG, GQ

ANAANAAIH6713SMA54AIHANA 1:320 (1:40~1:16384)74ANA 1:40ANARNADNAHepG2ANAPBCPSC

*WANG, GQ

SMA SMAAIH8733ANA54SMA1:160(1:40~1:5120)80AIH1:40SMAF-tubulindesminvimentin

*WANG, GQ

(LKM1)LKM1ANASMAAIH

LKM1LKM1P-450CYP 2D6P450 2D650Kda

*WANG, GQ

/SLA/LP/SLA/LPAIH50KdatRNP(Ser)Sec) SLA/LPAIHAIH

*WANG, GQ

pANCA pANCAAIH90pANCAAIHpANCAAIHAIH

*WANG, GQ

ILC1ILC1AIHLC140AIH2032LC1LKM1LC1HCVAIH

*WANG, GQ

(-actin)AIHSMAAIHHLA DR3SMASMAAIH

*WANG, GQ

ASGPRASGPRANASMALKM1ASGPR

*WANG, GQ

AIH

ALTIgG1.5 ANASMALKM1180, 120AMA

*WANG, GQ

AIH1- AECMV EBV