Cytotoxicity evaluation of self-etching dentine bonding agents in a cell culture perfusion condition. Eur J Dentistry 6:408-414. Connective tissue Teeth Cytotoxicity Minuth WW,

德国 MinuCell& MinuTissue 体外脉管连续灌流式三维细胞、组织培养系统应用论文索引

Publication Basic tissue Organ/Site Application

Minuth WW, Denk L (2014). Detection of abnormal extracellular matrix in the interstitium of regenerating

renal tubules. Int J Mol Sci 15(12):23240-23254.

Epithelium Kidney Regeneration

Nandkumar MA, U A, Thomas LV, Nair PD (2014). Pulmonary surfactant expression analysis - role of cell-

cell interactions and 3-D tissue-like architecture. Cell Biology International xx:xx-xx.

Epithelium Lung Regeneration

Minuth W, Denk L (2014). Tannic acid label indicates abnormal cell development coinciding with

regeneration of renal tubules. BMC Clinical Pathology 14:34.

Epithelium Kidney Regenerative Medicine

Klettner A, Recber M, Roider J (2014). Comparison of the efficacy of aflibercept, ranibizumab, and

bevacizumab in an RPE/choroid organ culture. Graefes Arch Clin Exp Ophatalmol 252:1593-1598.

Neural tissue Eye Pharmacology

Wu Z, Zhou Q, Duan H, Wang X, Xiao J, Duan H, Li N, Li C, Wan P, Liu Y, Song Y, Zhou C, Huang Z, Wang Z

(2014). Reconstruction of auto tissue-engineered lamellar cornea by dynamic culture for transplantation:

a rabbit model. PLOS ONE 9(4):e93012.

Neural tissue Eye Tissue engineering

Dithmer M, Fuchs S, Shi Y, Schmidt H, Richert E, Roider J, Klettner A (2014). Fucoidan reduces secretion

and expression of vascular endothelial growth factor in the retinal pigment epithelium and reduces

angiogenesis in vitro. PLOS ONE 9(2):e89150.


Mollet BB, Comellas-Aragones M, Spiering AJH, S?ntjens SHM, Meijer EW, Dankers PYW (2014). A

modular approach to easily processable supromolecular bilayered scaffolds with tailorable properties. J

Materials Chemistry B 2:2483-2493.

Epithelium Kidney Biomaterial testing

Aberle T, Franke K, Rist E, Benz K, Schlosshauer B (2014). Cell-type specific four-component hydrogel.

PLOS ONE 9(1):e86740.

Connective tissue Cartilage Biomaterial testing

daSilva JMF, Rodrigues JR, Camargo CHR, Fernandes Jr VVB, Hiller KA, Schweikl H, Schmalz G (2013).

Effectivness and biological compatibility of different generations of dentin adhesives. Clin Oral Invest

18:607-613.

Connective tissue Tooth Dentin adhesives

ülker HE, ülker M, Botsali MS, Dündar A, Acar H (2013). Cytoxicity evaluation of dentin contacting

materials with dentin barrier test device using erbium-doped yttrium, aluminium, and garnet laser

treated dentin. Human and Experimental Toxicology 33(9):949-955.

Connective tissue Tooth Cytotoxicity testing

Minuth WW, Denk L (2013). Initial steps to stabilize the microenvironment for implantation of

stem/progenitor cells in diseased renal parenchyma. Transplantation Technology 1:2.

Epithelium Kidney Regeneration

ülker HE, ülker M, Gümüs H?, Yalcin M, Sengün A /2013). Cytotoxicity testing of temporary luting cements

with two- and three-dimensional cultures of bovine dental pulp-derived cells. BioMed Research

Connective tissue Tooth Repair



2 / 24

全文论文请通过电子邮箱 [email protected] 向我们索取

苏州乾芸仪器科技有限公司

www.genintech.com,

International xx: Article ID 910459.

Schiessl IM, Rosenauer A, Kattler V, Minuth WW, Oppermann M, Castrop H (2013). Dietary salt intake

modulates differential splicing of the Na/K/2Cl cotransporter NKCC2. Am J Physiol Renal Physiol

305:F1139-48.

Epithelium Kidney Adaption of epithelia

Campos DM, Soares GA, Anselme K (2013). Role of culture conditions on in vitro transformation and

cellular colonization of biomimetic HA-Col scaffolds. Biomatter 3:e24922.

Connective tissue Bone Tissue engineering

Miura Y, Huettmann G, Orzekowsky-Schroeder R, Steven P, Szaszak M, Koop N, Brinkmann R (2013). Two-

photon microscopy and fluorescence lifetime imaging of retinal pigment epithelial cells under oxidative

stress. Invest Ophthalmology & Vis Science. 54:3366-3377.

Neural tissue Eye Regenerative Medicine

Kim HS, Chang SW, Baek SH, Han SH, Lee Y, Zhu Q, Kum KY (2013). Antimicrobial effect of alexidine and

chlorhexidine against Enterococcus faecalis infection. Int J Oral Science 5:26-31

Connective tissue Tooth Adhesion of

microorganisms

Klettner A, Westhues D, Lassen J, Bartsch S, Roider J (2013). Regulation of constitutive vascular

endothelial growth factor secretion in retinal pigment epithelium/choroid organ cultures: p38, nuclear

factor kappa B, and the vascular endothelial growth factor receptor-2/phosphatidylinositol 3 kinase

pathway. Molecular Vision 19:281-291.

Epithelium Eye Regenerative Medicine

Wei F, Song T, Ding G, Xu J, Liu D, Fan Z, Zhang C, Shi S, Wang S (2013). Functional tooth restoration by

allogeneic mesenchymal stem cell-based bio-root regeneration in swine. Stem Cells and Development

22:1752-62.

Connective tissue Tooth Regenerative Medicine

Minuth WW, Denk L, Gruber M (2013). Search for chemically defined culture medium to assist initial

regeneration of diseased renal parenchyma after stem/progenitor cell implantation. Int J Stem Cell

Research and Transplantation 1:202.

Epithelium Kidney Tissue engineering

Glaum R and Wiedmann-Al-Ahmad M (2013). Cocultivation of human oral keratinocytes and human

osteoblast-like cells. Methods Mol Biol 946:423-9.

Epithelium and

connective tissue

Craniomaxillo

facial region

Tissue engineering

Schneider T, Kohl B, Sauter T, Kratz K, Landlein A, Ertel W, Schulze-Tanzil G (2012). Influence of fiber

orientation in electrospaun polymer scaffolds on viability, dahesion and differentation of articular

chondrocytes. Clinical Hemorheology and Microcirculation 52:325-336.

Connective tissue Cartilage Tissue engineering



3 / 24



www.genintech.com,

Korsuwannawong S, Srichan R, Vajrabhaya L (2012). Cytotoxicity evaluation of self-etching dentine

bonding agents in a cell culture perfusion condition. Eur J Dentistry 6:408-414.

Connective tissue Teeth Cytotoxicity

Minuth WW, Denk L (2012). Supportive development of functional tissues for biomedical research by the

MINUSHEET? perfusion system. Clinical and Translational Medicine 1:22.

Basic tissues Different

organs

Wide spectrum of

applications

Astasov-Frauenhoffer M, Braissant O, Hauser-Gerspach I, Daniels AU, Weiger R, Waltimo T (2012).

Isothermal microcalorimetry provides new insight into biofilm variability and dynamics. FEMS Microbiol

Let 337(1):31-37.

Bacteria Titanium Biomaterials

Kim M, Kim K, Lee Y, Kim K (2012). Cytotoxicity test of dentin bonding agents using millipore filters as

dentin susstitutes in a dentin barrier test. Clin Oral Invest 17:1489-96.

Connective tissue Dentin Cytotoxicity testing

Volkmer E, Otto S, Polzer H, Saller M, Trappendreher D, Zagar D, Hamisch S, Ziegler G, Wilhelmi A,

Schieker M (2012). Overcoming hypoxia in 3D culture systems for tissue engineering of bone in vitro using

an automated, oxygen-triggered feedback loop. J Mater Sci. 23(11):2793-2801.

Connective tissue Bone Regeneration

Mateescu M, Rguitti E, Ponche A, Descamps M, Anselme K (2012). Biomimetic evaluation of β tricalcium

phosphate prepared by hot isostatic pressing. Biomatter 2, 3: 1-11.

Connective tissue Bone Biomaterial Research

Treumer F, Klettner A, Baltz J, Hassain AA, Brinkmann AA, Roider J, Hillenkamp J (2012). Vectorial release

of matrix metalloproteinases (MMPs) from poricine RPE-choroid explants following selective retina

therapy (SRT): Towards slowing the macular aging process. Exp Eye Res 97(1):63-72.

Epithelial-/Neural

tissue

Eye Regeneration

Rüder C, Sauter C, Becker T, Kratz K, Hiebl B, Jung F, Lendlein A, Zohlnhofer D (2012). Viability, proliferation

and adhesion of smooth muscle cells and human umbilical vein endothelial cells on eletrospun polymer

scaffolds. Clin Hemorheol Microcirc 50(1): 101-12.

Epithelial-/Muscular

tissue

Vessel Biomaterial research

Rath SN, Strobel LA, Arkudas A, Beier JP, Maier AK, Greil P, Horch R, Kneser U (2012). Osteoinduction and

survival of osteoblasts and bone marrow stromal cells in 3D biphasic calcium phosphate scaffolds under

static and dynamic culture conditions. J Cellular Molecular Medicine 16(10):2350-2361.

Connective tissue Bone Regeneration

Bruggeman LA, Doan RP, Loftis J, Darr A, Calabro A (2012). A cell culture system for the structure and

hydrogel properties of basement membranes: application to capillary walls. Cellular and Molecular

Bioengineering 5(2):194-204.

Epithelial tissue Kidney Regeneration



4 / 24



www.genintech.com,

Minuth WW, Denk L (2012). Interstitial interfaces show marked differences in regenerating tubules,

matured tubules and the renal stem/progenitor cell niche. J Biomedical Materials Research Part A 100(5):

1115-25.


Schneider T, Kohl B, Sauter T, Becker T, Kratz K, Schossig M, Hiebl B, Jung F, Lendlein A, Ertel W, Schulze-

Tanzil G (2011). Viability, adhesion and differentiated phenotype of articular chondrocytes of degradable

polymers and electro-spun structures therof. Macromol Symp 309/310:28-39.

Connective tissue Cartilage Regeneration

Klettner AK, Doths J, Roider J (2011). Nicotine reduces VEGF-secretion and phagocytotic activity in porcine

RPE. Graefes Arch Clin Exp Ophthalmol 250(1): 33-8.

Neural tissue Eye Regeneration

Glashauser A, Denk L, Minuth WW (2011). Polyester fleeces used as an artificial interstitium influence

the spatial growth of regenerating tubules. J Tissue Sci Eng 2: 105. DOI 10.4172/2157-7552.


Kalamarz-Kubiak H, Gozdowska M, Nietrzeba M, Kulcykska E (2011). A novel approach to AVT and IT

studies in fish brain and pituitary: in vitro perfusion technique. Journal of Neuroscience Methods

199(1):56-61

Neural tissue Brain Endocrinology

Farack J, Wolf-Brandstetter C, Glorius S, Nies B, Standke G, Quadbeck P, Worch H, Schwarnweber D

(2011). The effect of perfusion culture on proliferation and differentiation of human mesenchymal cells

on biocorrodible bone replacement material. Materials Science and Engineering B 176:1776-1772.

Connective tissues Bone Tissue engineering

Minuth WW and Denk L (2011). Advanced Culture Experiments with Adherent Cells. From single cells to

specialized tissues in perfusion culture. Open access publishing, University of Regensburg, ISBN Nr. 978-

3-88246-330-9, 414 pages. urn:nbn:de:bvb:355-epub-214847.

Specialized tissues Various

organs

Tissue culture

technology

Sengün A, Yalcin M, ülker HE, Oztürk B, Hakki SS (2011). Cytotoxicity evaluation of dentin bonding agents

by dentin barrier test on 3-dimensional pulp cells. Oral Surg Oral Pathol Oral Radiol Endod 112:e83-8.

Connective tissue Tooth Cytotoxicity

Yue S, Lee PD, Poologasundarampillai G (2011). Evaluation of 3D bioactive glass scaffolds dissolution in

a perfusion flow system with X-ray microtomography. Acta Biomaterialia 7(6):2637-43

Connective Tissue Bone Regenerative medicine

Dankers PY, Boomker JM, Huizinga - van der Vlag A, Wisse E, Smedts FM, Harmsen MC, Bosman AW,

Meijer W, van Luyn MJ (2011). Bioengineering of living renal membranes consisting of hierarchical,

bioactive supramolecular meshes and huma tubular cells. Biomaterials 32(3):723-33.

Epithelial tissue Kidney Regenerative medicine



5 / 24



www.genintech.com,

Hamilton RD, Leach L (2011). Isolation and properties of an in vitro human outer blood-retinal barrier

model. Methods Mol Biol 686:401-416.

Epithelial tissue Eye Regenerative medicine

Quadbeck P, Hauser R, Kümmel K, Standke G, Stephani G, Nies B, R??ler S, Wegener B (2010). Iron based

cellular metals for degradable synthetic bone replacement. PM2010 World Congress - PM Biomaterials

p 1-8.

Connective tissue Bone Biomaterials

Dankers PY, Boomker JM, Huizinga-van der Vlag A, Smedts FM, Harmsen MC, van Luyn MJ (2010). The

use of fibrous, supramolecular membranes and human tubular cells for renal epithelial tissue

engineering: towards a suitable membrane for a bioartificial kidney. Macromol Biosci 10(11):1345-54.


Minuth WW, Denk L, Roessger A (2010). Regenerating tubules for kidney repair. Stem Cell Engineering -

Principals and Applications, Eds. Artmann, Minger, Hescheler, Springer Verlag, pp 321-344.


Yeatts A, Fisher JP (2010). Bone tissue engineering bioreactors: Dynamic culture and the influence of

shear stress. Bone 48(2):171-81.

Connective tissue Bone Regenerative medicine

Bernhardt A, Lode A, Peters F, Gelinsky M (2010). Optimization of culture conditions for osteogenically-

induced mesenchymal stem cells in β-tricalcium phosphate ceramics with large interconnected channels.

J Tissue Eng Regen Med 5(6):444-53.


Minuth WW, Denk L, Glashauser A (2010). Promoting and harmful effects of steroid hormones on renal

stem/progenitor cell development. J Tissue Science Engineering 1:101


da Silva HM, Mateescu M, Damia C, Champion E, Soares G, Anselme K (2010). Importance of dynamic

culture for evaluating osteoblast activity on dense silicon-substituted hydroxyapatite. Colloids Surf B

Biointerfaces 80(2):138-44.


Steinhagen J, Niggemeyer O, Fuerst M, Rüther W, Schünke M, Kurz B (2010). Perfusion culture system:

Synovial fibroblasts modulate articular chondrocyte matrix synthesis in vitro. Tissue Cell 42(3):151-157.

Connective tissue Cartilage Regenerative medicine

Minuth WW, Denk L, Glashauser A (2010). Towards a guided regeneration of renal tubules at a polyester

interstitium. Materials 3:2369-2392.


Miess C, Glashauser A, Denk L, de Vries U, Minuth W (2010). The interface between generating renal

tubules and a polyester fleece in comparison to the interstitium of the developing kidney. Ann Biomed




6 / 24



www.genintech.com,

Eng 38(6):2197-209.

Heinemannn C, Heinemann S, Bernhardt A, Lode A, Worch H, Hanke T (2010). In vitro osteoclastogenesis

on textile chitosan scaffold. Eur Cell Mater 19:96-106.


Minuth WW, Denk L, Glashauser A (2010). Cell and drug-delivery therapeutics for renal tissue

regeneration. Advanced Drug Delivery Reviews 62(7-8):841-854.


Minuth WW, Denk L, Glashauser A (2010). A modular culture system for the generation of multiple

specialized tissues. Biomaterials 11:2945-2954.

All tissues Specialized

tissue

Regenerative medicine

da Silva HM, Mateescu M, Ponche A, Damia C, Champion E, Soares G, Anselme K (2010). Surface

transformation of silicon-doped hydroxyapatite immersed in culture medium under dynamic and static

conditions. Colloids and Surfaces B: Biointerfaces 75(1):349-55.

Connective tissue Bone Biomaterial research

Miura Y, Klettner A, Noelle B, Hasselbach H, Roider J (2010). Change of morphological and functional

characteristics of retinal pigment epithelium cells during cultivation of retinal pigment epithelium-

choroid perfusion tissue culture. Opthalmic research 43;122-133.

Neural tissue Eye Regenerative medicine

Glaum R, Wiedmann - Al-Ahmad M, Huebner U, Schmelzeisen R (2010). Cocultivation of human

keratinocytes and human osteoblast-like cells on laminin-coated polycarbonate membranes and equine

collagen membranes under different culture conditions. J Biomed Mater Res A 93A(2):704-715.

Epithelium/

Connective tissue

Composite

graft

Biomaterial research

Klettner A, Kruse ML, Meyer T, Wesch D, Kabelitz D, Roider J (2009). Different properties of VEGF-

antagonists: Bevacizumab but not Ranibizumab accumulates in RPE cells. Graefes Arch Clin Exp

Ophthalmol 247(12): 1601-8.


Hagedorn GM, Blank A, Weiland B, Spassov A, Lauer G (2009). Perfusion culture promotes differentiation

of oral keratinocytes in vitro. J Physiol Pharmacol 60(8):25-9.

Epithelial tissue Oral mucosa Regenerative medicine

Klettner A, Roider J (2009). Constitutive and oxidative-stress-induced expression of VEGF in the RPE are

differently regulated by different Mitogen-activated protein kinases. Graefs Arch Clin Exp Ophthalmol

247:1487-1492.


Xia L, Ng S, Han R, Tuo X, Xiao G, Leo HL, Cheng T, Yu H (2009). Laminar-flow immediate-overlay

hapatocyte sandwich perfusion system for drug hepatotoxicity testing. Biomaterials 30(30):5927-36.

Epithelium Liver Toxicity testing



7 / 24



www.genintech.com,

Heinemann C, Heinemann S, Lode A, Bernhardt A, Worch H, Hanke T (2009). In vitro evaluation of textile

chitosan scaffolds for tissue engineering using human bone marrow stromal cells. Biomacromolecules

10:1305-1310.


Ulker HE, Sengun A (2009). Cytotoxicity evaluation of self adhesive composite resin cements by dentin

barrier test on 3D pulp test. Eur J Dent 3(2):120-6.

Connective tissue Tooth pulp Cytotoxical research

Roessger A, Denk L, Minuth WW (2009). Potential of stem/progenitor cell cultures within polyester

fleeces to regenerate renal tubules. Biomaterials 30(22):3723-32.

Epithelium Kidney Stem cell research

Minuth WW, Denk L, Roessger A (2009). Gradient perfusion culture - simulating a tissue-specific

environment for epithelia in biomedicine. J Epithel Biology & Pharmacology 2:1-13.

Epithelium Gradient

perfusion

culture

Biomedicine

Minuth WW, Denk L, Meese C, Rachel R, Roessger A (2009). Ultrastructural insights in the interface

between generated tubules and a polyester interstitium. Langmuir 25(8):4621-4627.


Anders JO, Mollenhauer J, Beberhold A, Kinne RW, Venbrocks RA (2009). Gelatin-based haemostypic

Spongostan as a possible three-dimensional scaffold for a chondrocyte matrix? J Bone Joint Surg (Br)

91(B):409-16.


Lauer G (2009). Fundamentals of Tissue engineering and Regenerative Medicine, 27.6 Optimizingg the

Mucosa Graft: Developing Gingival Keratinocyte - Fibroblast Contact. pp 375 ed. by Ulrich Meyer et al.

Springer Verlag

Epithelium Mucosa Graft Tissue engineering

Vajrabhaya L, Koruwannawong S, Bosl C, Schmalz G (2009). The cytotoxicity of self-etching primer

bonding agents in vitro. Oral Surg Oral Med Oral Path Oral Radiol Endod 107:e86-e90.

Connective tissue Tooth pulp Cytotoxical research

Masungi C, Mensch J, Willems B, Van Dijck A, Borremans C, Noppe M, Brewster ME, Augustijns P (2009).

Usefulness of a novel Caco-2 cell perfusion system II. Characterization of monolayer properties and

peptidase activity. Pharmazie 64:36-42.

Epithelium Intestine Pharmacology

Hayashi M, Matsuzaki Y, Shimonaka M (2009). Impact of plasminogen on an in vitro wound healing

model based on a perfusion cell culture system. Mol Cell Biochem 322(1-2):1-13.

Epithelium Endothelial

repair

Regenerative medicine

Heinemann C, Heinemann S, Bernhardt A, Worch H, Hanke T (2008). Novel textile chitosan scaffolds Connective tissue Bone Biomaterial research



8 / 24



www.genintech.com,

promote spreading, proliferation and differentiation of osteoblasts. Biomacromolecules 9:2913-2920.

Dreesmann L, Hajosch R, Ahlers M, Nuernberger JV, Schlosshauer B (2008). Permeability testing of

biomaterial membranes. Biomed Mater 3:034119.

Connective tissue Regeneration Biomaterial research

Motz A, Bur M, Schaefer UF, Lehr CM (2008). Instrumented in vitro approaches to assess epithelial

permeability of drugs from pharmaceutical formulations. In: Drug Absorption Studies, Springer Verlag,

ISBN 978-0-387-74900-6, pp. 430-455.

Epithelium Lung Environmental

toxicology

Paur HR, Mülhopt S, Weiss C, Diabaté S (2008). In vitro exposure systems and bioassays for the

assessment of toxicity of nanoparticles to the human lung. J Verbr. Lebensm. 3:319-329.

Epithelium Lung Environmental

toxicology

Minuth WW, Denk L, Blattmann A, Castrop H (2008). Collagen type III is an important linking molecule

between generated renal tubules and an artificial interstitium. J Clinical Rehabilitative Tissue Engineering

Research (CRTER) 12,32:6201-08.

Epithelial tissue Kidney Stem cell research

Volkmer E, Drosse I, Otto S, Stanglmeyer A, Stengele M, Kallukalam BC, Mutschler W, Schieker M (2008).

Hypoxia in static and dynamic 3D culture systems for tissue engineering of bone. Tissue Engineering A

14,8:1331-40.

Connective tissue Bone Regenerative Medicine

Minuth WW, Denk L (2008). Aldosterone-dependent generation of tubules derived from renal

stem/progenitor cells. Transplantationsmedizin 20:42-47.


Kaempf S, Johnen S, Salz AK, Weinberger A, Walter P, Thumann G (2008). Effects of Bevacizumab (Avastin)

on retinal cells in organotypic culture. Invest Ophathalmol Vis Sci 49,7:3164-71.


Minuth WW, Blattmann A, Denk L, Castrop H (2008). Mineralocorticoid receptor, heat shock proteins and

immunophilins participate in the transmission of the tubulogenic signal of aldosterone. J Epithelial

Biology & Pharmacology 1:24-34.


Klettner AK, Roider J (2008). Comparison of Bevacizumab, Ranibizumab and Pegatanib in vitro: efficiency

and possible additional pathways. Invest Opathalmol Vis Sci 49,10:4523-7.


Demirci M, Hiller KA, Bosl C, Galler K, Schmalz G, Schweikl H (2008). The induction of oxidative stress,

cytotoxicity, and genotoxicity by dental adhesives. Dental Materials 24:362-371.

Connective tissue Dentin Biomaterial testing

Frerich B, Zückmantel K, Winter K, Müller-Dürwald S, Hemprich A (2008). Maturation of capillary-like Connective tissue Vessel Regeneration research



9 / 24



www.genintech.com,

structures in a tube-like construct in perfusion and rotation culture. Int J Oral Maxillofac Surg 37:459-

466.

Hammer M, Richter S, Kobuch K, Mata N, Schweitzer D (2008). Intrinsic tissue fluorescence in an

organotypic perfusion culture of the porcine ocular fundus exposed to blue light and free radicals.

Graefes Arch Clin Exp Ophtalmol Epub 246,7:979-88.


Blattmann A, Denk L, Strehl R, Castrop H, Minuth WW (2008). The formation of pores in the basal lamina

of regenerated renal tubules. Biomaterials 29:2749-2756.


Kobuch K, Hermann WA, Framme C, Sachs HG, Gabel VP, Hillenkamp J (2008). Maintenance of adult

porcine retina and retinal pigment epithelium in perfusion culture: Characterisation of an organotypic in

vitro model. Exp Eye Res 86:661-668.


Detsch R, Uhl F, Deisinger U, Ziegler G (2008). 3D-Cultivation of bone marrow stromal cells on

hydroxyapatite scaffolds fabricated by dispens-plotting and negative mold technique. J Mater Sci: Mater

Med 19,4:1491-6.

Connective tissue Bone Tissue engineering

Minuth WW, Denk L, Castrop H (2008). Generation of tubular superstructures by piling of renal

stem/progenitor cells. Tissue engineering 14,1:3-13.

Stem cells Kidney Tissue engineering

Du Y, Han R, Wen F, Ng San San S, Xia L, Wohland T, Leo HL, Yu H (2008). Synthetic sandwich culture of

3D hepatocyte monolayer. Biomaterials 29:290-301.

Epithelium Liver Biomaterial research

Bernhardt A, Lode A, Boxberger S, Pompe W, Gelinsky M (2008). Mineralised collagen – an artificial,

extracellular bone matrix – improves osteogenic differentiation of bone marrow stromal cells. J Mater

Sci-Mater Med: 19,1: 269-275.


Maier KL, Alessandrini F, Beck-Speier I, Hofer TP et al. (2008). Health effects on ambient particulate

matter - biological mechanisms and inflammatory responses to in vitro and in vivo particle exposures.

Inhal Toxicol 20(3):319-37.

Epithelial tissue Lung Environmental health

Minuth WW, Denk L, Hu K (2007). Kontrolliertes Environment für die Entwicklung von Stammzellen zu

renalen Tubuli. Regenerative Medizin 1:22-27.

Stem cells Kidney Tissue engineering

Constantinescu R, Constanntinescu AT, Reichmann H, Janetzky B (2007). Neuronal differentiation and Neural tissue Dopaminergic Tissue engineering



10 / 24



www.genintech.com,

long-term culture of the human neuroblastoma line SH--SY5Y. J Neural Transm 72: 17-28. cells

Minuth WW, Hu K, Denk L (2007). Kontrolliertes Environment für Stammzellen – Generierung renaler

Tubuli in chemisch definiertem Kulturmedium. BIOforum 4:28-29.

Epithelia Stem cell

research

Tissue engineering

R?pke E, Sch?n I, Vogel J, Jamali J, Bloching M, Berghaus A (2007). Screening von modifizierten

Polyethylenoberfl?chen für das Tissue engineering von Chondrozyten. Laryngo-Rhino-Otol 86:37-43.

Connective tissue Biomaterial

testing

Tissue engineering

Minuth WW, Denk L, Hu K, Castrop H, Gomez-Sanchez C (2007). Tubulogenic effect of aldosterone is

attributed to intact binding and intracellular response of the mineralocorticoid receptor. Central Eur J

Biol - CEJB 2(2):307-325.


Minuth WW, Denk L, Hu K (2007). The role of polyester interstitium and aldosterone during structural

development of renal tubules in serum-free medium.Biomaterials 28:4418-28.


Zheng W, Jimenez-Linan M, Rubin BS, Halvorson LM (2007). Anterior pituitary gen expression with

reproductive aging in the femal rat. Biol Reprod 76:1091-1102.

Epithelium Endocrinolog

y anterior

pituitary

Gen research

Hauser-Gerspach I, Kulik EM, Weiger R, Decker EM, von Ohle C, Meyer J (2007). Adhesion of

Streptococcus sanguinis to dental implant and restorative materials in vitro. Dental Materials J

26(3):361-366.

Connective tissue Enamel Biomaterial research

Hu K, Denk L, deVries U, Minuth WW (2007). Chemically defined medium environment for the

development of renal stem cells into tubules. Biotechnology J 2:992-995.


Seitz S, Ern K, Lamper G, Docheva D, Drosse I, Milz S, Mutschler, W, Schieker M (2007). Influence of in

vitro cultivation on the integration of cell-matrix constructs after subcutaneous implantation. Tissue

engineering 13,5:1059-1067.

Connective tissue Stem cells Tissue engineering

Jian GE, Jingbo L (2007). The stem cell and tissue engineering research in chinese ophthalmology. Front

Med China 1(1):6-10.

Nervous tissue Eye Stem cell research

Hamilton RD, Foss AJ, Leach L (2007). Establishment of a human in vitro model of the outer blood-retinal

barrier. J Anat 211(6):707-16.

Nervous tissue Eye Regenerative medicine

Minuth WW, Strehl R (2007). Technical and theoretical considerations about gradient perfusion culture Epithelium Barrier Biomaterials/



11 / 24



www.genintech.com,

for epithelia used in tissue engineering, biomaterial testing and pharmaceutical research. Biomed Mater

2:R1-R11.

Pharmacology

Heber S, Denk L, Hu K, Minuth WW (2007). Modulating the development of renal tubules growing in

serum-free culture medium at an artificial interstitium. Tissue Eng 13:2.


Schumacher K, Khong YM, Chang S, Ni J, Sun W, Yu H (2007). Perfusion culture improves the maintenance

of cultured Liver Tissue slices. Tissue Eng 13:197-205.

Epithelium Liver Pharmacology

Yang SE, Cha JH, Kim ES, Kum KY, Lee CY, Jung IY (2006). Effect of smear layer and cholhexidine treatment

on the adhesion of Enterococcus faecalis to bovine dentin. J Oral Endodont/JOE 32,7:663-667.

Connective tissue Tooth, Dentin Biomaterial research

Shearer H, Ellis MJ, Perera SP, Chaudhuri JB (2006). Effects of common sterilization methods on the

structure and properties of poly(d,l lactic-co-glycolic acid) scaffold. Tissue Engineering 12,10:2717-27.

Connective tissue Cartilage,

Bone

Biomaterial research

Minuth WW (2006).. Patent Nr. DE 10 2005 002 938: Verfahren zum Versorgen von Zellen oder Geweben. ? ? ?

Ng S, Han R, Chang S, Ni J, Hunziger W, Goryachev B, Ong SH, Yu H (2006). Improved hepatocyte excretory

function by immediate presentation of polarity cues. Tissue Eng 12,8:2181-2191.

Epithelium Liver Pharmacology

Saikia P, Maisch T, Kobuch K, Jackson TL, B?umler W, Szeimies RM, Gabel VP, Hillenkamp J (2006). Safety

testing of Indocyanine Green in an ex vivo porcine retina model. Investigative Ophalmology & Visual

Science 47,11:4998-5003.

Nervous tissue Eye Pharmacology

Frerich B, Zückmantel K, Hemprich A (2006). Microvascular engineering in perfusion culture:

immunohistochemistry and CLMS findings. Head & Face Medicine 2:26.

Microvessels Adipose

tissue

Vascular supply

Minuth W, Denk L (2006). From the renal stem cell niche to functional parenchyme. 41. Congress of the

European Society for surgical research in Rostock, Medimont, International Proceedings, Editor Brigitte

Vollmar, ISBN 88-7587-244-9, pp 9-17.


Bitterle E, Karg E, Schroeppel A, Kreyling WG, Tippe A, Ferron GA, Schmid O, Hexder J, Maier KL, Hofer T

(2006). Dose-controlled exposure of A549 epithelial cells at the air-liquid interphase to airborne ultrafine

carbonaceous particles. Chemospehre 65,10:1784-1790.

Epithelium Lung Test of Biomaterials

Minuth WW, Strehl R (2006). 3D Kulturen - Zellen, Kultursysteme und Environment. Pabst Science

Publishers, Lengerich, ISBN 10:3-89967-316-6 und ISBN 13:978-3-89967-316-6, 471 Seiten.

? ? General



12 / 24



www.genintech.com,

Yamagishi K, Enomoto T, Ohmiya Y (2006). Perfusion-culture-based secreted bioluminescence reporter

assay in living cells. Analytical Biochemistry 354:15-21.

Nervous Tissue Circadian

clock gene

Reporter assay

Minuth WW (2006). Patent Nr. DE 199 52 847: Vorrichtung zum Kultivieren und/oder Differenzieren

und/oder Halten von Zellen und/oder Geweben.

? ? ?

Gille J, Meisner U, Ehlers EM, Müller A, Russlies M, Behrens P (2005). Migration pattern, morphology and

viability of cells suspended in or sealed with fibrin glue: a histo-morphological study. Tissue and Cell

37:339-348.

Connective Tissue Cartilage Regenerative Medicine

Leukers B, Gülkan H, Irsen SH, Milz S, Tille C, Schieker M, Seitz H (2005). Hydroxyapatite scaffold for bone

tissue engineering made by 3D printing. J Materilas Scienc: Materials in Medicine 16:1121-1124.

Connective Tissue Bone Biomaterial test

Shearer H, Ellis MJ, Perera SP, Chaudhuri JB (2005). Sterilisation of PLGA flat sheet and hallow fiber tissue

engineering scaffolds. Eur Cells and Materials 10,2:4.

Connective Tissue Bone Biomaterial test

Galler K, Hiller KA, Ettl T, Schmalz G (2005). Selective influence of dentin thickness upon cytotoxicity of

dentin contacting materials. J Endod 31,5:396-399.

Connective Tissue Dentin Toxicology

Minuth WW, Strehl R, Schumacher K (2005). Microreactor optimization for functional tissue engineering.

In Chapter 2 (pp 19-45) of Bioreactors for Tissue engineering, Principles, Design and Operation ed. by

Chaudhuri J and Al-Rubeai M, Springer Biotechnology, ISBN 1-4020-3740-6.

? ? ?

Tiemann U, Bücher K, Pfarrer Ch, P?hland R, Becker F, Kanitz W, Schmidt P (2005). Influence of ovarian

steroid hormones or platelet-activating factor receptor in endometrial explant perfusion cultures from

ovariectomized bovine. Prostaglandins & other Lipid Mediators 76:35-47.

Epithelium Femal

Reproductive

Tract

Pharmacology

Minuth WW, Denk L, Heber S (2005). Growth of embryonic renal parenchyme at the interphase of a

polyester artificial interstitium. Biomaterials 26:6588-6598.

Epithelium and

Mesenchyme

Kidney Improved Tissue Culture

Leukers B, Gülkan H, Irsen SH, Milz S, Tille C, Seitz H, Schieker M (2005). Biocompatibility of ceramic

scaffolds for bone replacemant made by 3D printing. Mat Wiss Werkstofftechnik 36(12):781-787.

Connective tissue Biomaterial

testing

Tissue engineering

Steuer H, Jaworsky A, Elger B, Kaussmann M, Keldenich J, Schneider H, Stoll D, Schlosshauer B (2005).

Functional characterization and comparison of the outer blood-retina barrier and the blood-brain barrier.

Invest Ophtalmology & Visual Science 46,3:1047-1053.

Nervous Tissue Blood brain

barrier

Pharmacology



13 / 24



www.genintech.com,

Minuth WW, Strehl R, Schumacher K (2005). Tissue Engineering - Essentials for Daily Laboratory Work.

WILEY-VCH Verlag, ISBN 3527311866, 350 pages.

? ? ?

Dimova S, Vlaeminck V, Brewster ME, Noppe M, Jorissen M, Augustijns P (2005). Stable ciliary activity in

human nasal epithelial cells grown in perfusion culture. Int J Pharmaceutics 292:157-168.

Epithelium Respiratory

Tract

Pharmacology

Strehl R, Tallheden T, Sj?gren-Jansson E, Minuth WW, Lindahl A (2005). Long-term mainteance of human

articular cartilage in culture for biomaterial testing. Biomaterials 26:4540-4549.

Connective Tissue Cartilage Test of Biomaterials

Minuth WW, Schumacher K, Strehl R (2005). Renal epithelia in long term gradient culture for biomaterial

testing and tissue engineering. Biomed Mater Eng. 15(1-2):51-63.

Epithelium Kidney Test of Biomaterials

Bakowsky U, Ehrhardt C, Loehbach C, Li P, Kneuer C, Jahn D, Hoekstra D, Lehr CM (2005). Adhesion

molecule-modified cardivasculare prothesis: Characterization of cellular adhesion in a cell culture model

and by cellular force spectroscopy. Pp 157-173, Kapitel 11 in Adhesion: Current Research and Applications

ed. W. Possart, Wiley-VCH.

Epithelium Vascular

protheses

Tissue engineering

Bruckner H (2004). Tissue engineering: Gewebe aus der Retorte LaborPraxis 4: 62-65. All tissues Missing

regeneration

Tissue engineering

Sternberg K, Selent C, Hakan?on N, T?llner J, Langer T, Seiter H, Schmiitz KP (2004). Bioartifizielle

Materialien in der Urologie. Urologe 10: 1200-1207.

Epithelium Urogenital

tract

Tissue engineering

Rothamel D, Schwarz F, Sculean A, Herten M, Scherbaum W, Becker J (2004). Biocompatibility of various

collagen membranes in cultures of human PDL fibroblast and human osteoblast-like-cells. Clin Oral Impl

Res 15,4:443-9.


Steuer H, Jaworski A, Stoll D, Schlosshauer B (2004). In vitro model of the outer blood-retina barrier. Brain

Research Protocols 13:26-36.

Nervous Tissue Eye Pharmacology

Gelinsky M, K?nig U, Sewing A, Pompe W (2004). Por?se Scaffolds aus mineralisiertem Kollagen - ein

biomimetisches Knochenersatzmaterial. Mat.-wiss und Werkstofftech 35,4:229-233.

Connective Tissue Bone Tissue engineering

Duda GN, Kliche A, Kleemann R, Hoffmann JE, Sittinger M, Haisch A (2004). Does low-intensity pulsed

ultrasound stimulate maturation of tissue-engineered cartilage? J Biomed Mater Res Part B: Appl

Biomater 68B:21-28.

Connective Tissue Cartilage Tissue engineering



14 / 24



www.genintech.com,

Jennings P, Koppelstaetter, C, Pfaller W, Morin JP, Hartung T, Ryan MP (2004). Assessment of a new cell

culture perfusion apparatus for in vitro toxicity testing. Part 2: toxicological evaluation. ALTEX 21,2:61-

66.

Epithelium Kidney Pharmacology

Koppelstaetter C, Jennings P, Ryan MP, Morin JP, Hartung T, Pfaller W (2004). Assessment of a new new

cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 1: technical description. ALTEX

21,2?:51-60.

Epithelium Kidney Pharmacology

Strehl R, Schumacher K, Minuth W (2004). The current state of engineering tissues and organ parts. In

Ethical, Legal, and Social Issues in Organ Transplantation, Editors T. Gutmann, AS Daar, RA Sells, W Land,

Pabst Publishers, Lengerich, ISBN 3-89967-017-5 (Europe), ISBN 1-59326-063-6 (USA), pp. 405-422.

? ? ?

Masungi C, Borremans C, Willems B, Mensch J, Dijck AV, Augustijns P, Brewster ME, Noppe M (2004).

Usefulness of a novel Caco-2 cell perfusion system. I. in vitro prediction of the absorption potential of

passively diffused compounds. J Pharm Sci 93,10:2507-2521.

Epithelium Digestive

Tract

Pharmacology

Minuth WW, Sorokin L, Schumacher K (2004). Generation of renal tubules at the interface of an artificial

interstitium. Cell Physiol Biochem 14,4-6:387-394.

Epithelium Kidney Improved Tissue Culture

Strehl R, Schumacher K, Minuth WW (2004). Controlled respiratory gas delivery to embryonic renal

epithelial explants in perfusion culture. Tissue Engineering 10,7:1196-1202.


Fiegel HC, Havers J, Kneser U, Smith MK, Moeller T, Kluth D, Mooney DJ, Rogiers X, Kaufmann P (2004).

Influence of flow conditions and matrix coatings on growth and differentiation of three-dimensionally

cultured rat hepatocytes. Tissue Engineering 10,1-2:165-174.

Epithelium Liver Conceptual Tissue

Culture

Minuth WW, Strehl R, Schumacher R (2004). Tissue factory - Conceptual design of a modular system for

the in-vitro generation of functional tissues. Tissue Engineering 10,1/2:285-294.

All Tissues ? ?

Minuth WW, Schumacher K (2004). Tissue Engineering - Schwierigkeiten und Chancen bei der Herstellung

künstlicher Gewebe. Journal DGPW 29:20-22.

Tissues Regeneration Tissue engineering

Minuth WW (2003). Hat die Zukunft schon begonnen? Zellbiologie 1: 16-17. All Tissues Missing

regeneration

Tissue engineering

Decker EM, Weiger R, von Ohle C, Wiech I, Brecx M (2003). Susceptibility of planktonic versus attached Connective Tissue Enamel Biomaterial test



15 / 24



www.genintech.com,

Streptococcus sanguinis cells to chlorhexidine. Clin Oral Invst 7:98-102.

Minuth WW, Schumacher K (2003). From the renal stem cell niche to functional tubule. Med Klin 15,98

Suppl2:31-35.


Wang Y, Uemura T, Dong J, Kojima H, Tanaka J, Tateishi T (2003). Application of perfusion culture system

improves in vitro and in vivo osteogenesis of bone marrow-derived osteoblastic cells in porous ceramic

materials. Tissue Engineering 9,6:1205-1214.

Connective Tissue Cartilage and

Bone

Improved Tissue Culture

Bücheler M, Haisch A (2003). Tissue engineering in Otorhinolaryngology. DNA and Cell Biology 22,9:549-

564.

Connective Tissue Respiratory

System


Schumacher K, Strehl R, Minuth WW (2003). Urea restrains aldosterone-induced development of peanut

agglutinin-binding on embryonic collecting duct epithelia. J Am Soc Nephrol 14:2758-2766.


Uemura T, Dong J, Wang Y, Kojima H, Saito T, Iejima D, Kikuchi M, Tanaka J, Tateishi T (2003).

Transplantation of cultured bone cells using combinations of scaffolds and culture techniques.

Biomaterials 24:2277-2286.

Connective Tissue Cartilage and

Bone


Minuth WW, Strehl R, Schumacher K (2003). Zukunftstechnologie Tissue engineering - Von der

Zellbiologie zum künstlichen Gewebe. WILEY-VCH Verlag, ISBN 3-527-30793-1.

? ? ?

Stern S, Lindenhayn K, Perka C (2003). Die Knorpeltransplantation mit bioresorbierbaren Polymeren im

tierexperimentellen Modell. Kapitel 9, pp 52 - 59. Fortbildung Orthop?die - Traumatologie, Springer

Verlag, edited by J?rg Jerosch.


Minuth WW, Schumacher K, Strehl R, de Vries U (2002). Epithelia -Biomateriaux- Genie tissuelaire.

BIOforum International Edition francaise 1: 28-30.


Guarnizo AC, Rodriguez EV, Albaladejo JMO, Carrasquer TC, Manzano JAC, Cacha JPM, Gasso CS (2002).

Autoinjerto subcutaneo de cartilago neosintetizado utilizando el polimero ETHISORB en conejos. Acta

Otorrinolaringol Esp 53:631-636.

Connective tissue Cartilage Biomaterial research

von Woedtke T, Jülich WD, Alhitari N, Hanschke R, Abel PU (2002). Biosensor-controlled perfusion culture

to estimate the viability of cells. Medical & Biological Engineering & Computing 40:704-711.

Epithelium Biotest Biofilm/ Fouling

Luppens SBI, Reij MW, van der Heijden RWL, Rombouts FM, Abee T (2002). Development of a standard Microorganisms Biotest Biofilm/ Fouling



16 / 24



www.genintech.com,

test to assess the resistance of Staphylococcus aureus biofilm cells to desinfectants. Applied Environ

Microbiology 68,9:4194-4200.

Camps J, About L, Thonneman B, Mitsiadis TA, Schmaltz G, Franquin JC (2002). Two- versus three-

dimensional in vitro differentiation of human pulp cells into odontoblastic cells. Connective Tissue Res

43:396-400.

Connective Tissue Dentin Test of Biomaterials

Risbud MV, Sittinger M (2002). Tissue engineering: advances in vitro cartilage generation. Trends in

Biotechnology 20,8:351-356.

Connective Tissue Cartilage Bioengineering

Schumacher K, Strehl R, De Vries U, Groene HJ, Minuth WW (2002). SBA-positive fibers between the CD

ampulla, mesenchyme and renal capsule. J Am Soc Nephrol 13:2446-2453.

Epithelium and

Mesenchyme

Kidney Improved Tissue Culture

Spiegel D, Schefthaler M, Kobuch K (2002). Outflow facilities through Descemet's membrane in rabbits.

Graefe's Arch Clin Exp Ophthalmol 240:111-113.

Nervous Tissue Eye Improved Tissue Culture

Schumacher K, Castrop H, Strehl R, de Vries U, Minuth WW (2002). Cyclooxygenases in the collecting

duct of neonatal rabbit kidney. Cellular Physiol Biochem 12:63-74.


Woedke T, Lindequist U, Alhitari N, Kusnick C, Jülich W-D, Abel PU (2002). The usefulness of a biosensor

controlled perfusion cell culture for the investigation of new drugs demonstrated with the marine fungus

Kirschsteiniothelia maritima. Pharmazie 57:270-274.

Epithelium General Bioengineering

Framme C, Kobuch K, Eckert E, Monzer J, Roider J (2002). RPE in Perfusion tissue culture and ist response

to laser application. Ophthalmologica 216:320-328.

Epithelium Eye Regeneration

Haisch A, Kl?ring S, Gr?ger A, Gebert C, Sittinger M (2002). A tissue-engineered model for the

manufacture of auricular-shaped cartilage implants. Eur Arch Otorhinolaryngol 259:316-321.


Schmalz G, Schuster U, Koch A, Schweikl H (2002). Cytotoxicity of low pH dentin-bonding agents in a

dentin barrier test in vitro. J Endodontics 28,3:188-192.


Strehl R, Schumacher K, de Vries U, Minuth WW (2002). Proliferating cells versus differentiated cells in

tissue engineering. Tissue Eng. 8(1):37-42.

All Tissues ? ?

Minuth WW, Strehl R, Schumacher K (2002). Von der Zellkultur zum Tissue engineering. Pabst Science

Publishers ISBN 3-936142-32-7.

? ? ?



17 / 24



www.genintech.com,

Minuth WW, Schumacher K, Strehl R, de Vries U (2002). Mikroreaktortechnik für Tissue engineering in

Medizintechnik mit biokompatiblen Werkstoffen und Verfahren. E. Wintermantel, Suk-Woo Ha, Springer

Verlag, pp 305-319.

? ? ?

Schumacher K, Strehl R, de Vries U, Minuth WW (2002). Advanced technique for long term culture of

epithelia in a continuous luminal - basal medium gradient. Biomaterials 23,3:805-815.

Epithelium Kidney Gradient Culture

Tippe A, Heinzmann U, Roth C (2002). Deposition of fine and ultrafine aerosol particles during exposure

at the air / cell interface. Aerosol Science 33:2007-218.

Epithelial tissue Lung Environmental health

Minuth WW, Schumacher K, Strehl R, de Vries U (2001). Epithelia - Biomaterials - Tissue engineering.

BIOforum International 2: 74-76.


Minuth WW (2001). Patent Nr. US 6 187 053: Process for producing a natural implant. ? ? ?

Schmalz G, Schuster U, Thonemann B, Barth M, Esterbauer S (2001). Dentin barrier test with transfected

bovine pulp-derived cells. J Endodontics 27,2:96-102.


Kremer M, Lang E, Berger A (2001). Organotypical engineering of differentiated composite-skin

equivalents of human keratinocytes in a collagen-GAG matrix (INTEGRA Artifial Skin) in a perfusion

culture system. Langenbeck?s Arch Sur 386:357-363.

Epithelium Skin Bioengineering

Minuth WW, Strehl R, Schumacher K, de Vries U (2001). Long term culture of epithelia in a continuous

fluid gradient for biomaterial testing and tissue engineering. J Biomater Sci Polymer Edn 12,3:353-365.

Connective Tissue Kidney Gradient Culture

Bonn E (2000). Organe aus dem Reagenzglas. Via medici 2: 48-51. All tissues Missing

regeneration

Tissue engineering

Fu? M, Ehlers EM, Russlies M, Rohwedel J, Behrens P (2000). Characteristics of human chondrocytes,

osteoblasts and fibroblasts seeded onto a type I/III collagen sponge under different culture conditions.

Annals anatomy 182:303-310.

Connective Tissue Cartilage Tissue engineering

Duda GN, Haisch A, Endres M, Gebert C, Schroeder D, Hoffmann JE, Sittinger M (2000). Mechanical

quality of tissue engineered cartilage: Results after 6 and 12 weeks in vivo. J Biomed Mat Res 53,6:673-

677.


Hoener MC (2000). Role played by sodium in activity-dependent secretion of neutrophins ? revisited. Eur Nervous tissue Brain Pharmacology



18 / 24



www.genintech.com,

J Neuroscience 12:3096-3106.

Kloth S, Kobuch K, Domokos J, Wanke C, Monzer J (2000). Polar application of test substances in an

organotypic environment and under continous medium flow: a new tissue-based test concept for a broad

range of applications in pharmacotoxicity. Toxicology in vitro 14:265-274.

Vascular System Kidney Improved Tissue Culture

Kloth S, Suter-Crazzolara C (2000). Modulation of renal blood vessel formation by glial cell line derived

neurotrophic factor. Microvasular Res 59:190-194.


Prem C. and Pelster B (2000). Swimbladder gas gland cells of the European eel cultured in a superfusion

system. Methods in Cell Science 22:125-132.

Epithelium Barrier Gradient Culture

Minuth WW, Schumacher K, Strehl R, Kloth S (2000). Physiological and cell biological aspects of perfusion

culture technique employed to generate differentiated tissues for long term biomaterial testing and

tissue engineering. J Biomater Sci Poymer Edn 11,5:495-522.


Perka C, Schultz O, Sittinger M, Zippel H (2000). Chondrozytentransplantation in PGLA/Polydioxanon-

Vliesen. Orthop?de 29:112-119.

Connective Tissue Cartilage Tissue Engineering

Kloth S, Kobuch K, Domokos J, Wanke Ch, Minuth WW (1999). Interaktive Tissue Culture Systems:

Innovative Tools for Toxicity Testing. BIOforum International 3: 70-72.

Epithelium Kidney Toxicity testing

Minuth WW (1999). Patent Nr. DE 196 48 876: Verfahren zum Herstellen eines natürlichen Implantates. ? ? ?

Rotter N, Aigner J, Naumann A (1999). Behaviour of tissue-engineered human cartilage after

transplantation into nude mice. J Mat Sci: Materials in Medicine 10:689-693.


Reischl J, Prelle K, Schol H, Neumuller C, Einspanier R, Sinowatz F, Wolf E (1999). Factors affecting

proliferation and dedifferentiation of primary oviduct epithelial cells in vitro. Cell Tissue Res 296:371-383.

Epithelium Female

Reproductive

System


Griesbeck O, Canossa M, Campana G, G?rtner A, Hoener MC, Nawa H, Kolbeck R, Thoenen H (1999). Are

there differences between the secretion characteristics of NGF and BDNF? Implications fort he

modulatory role of neurotrophins in activity-dependent neuronal plasticity. Microscopy Res Technique

45:262-275.

Nervous tissue Transmitter Pharmacology

Schumacher K, Strehl, R, Kloth S, Tauc M, Minuth WW (1999). The influence of culture media on Epithelium Kidney Improved Tissue Culture



19 / 24



www.genintech.com,

embryonic renal CD cell differentiation. In vitro Cell Dev Biol Animal 35:465-471.

Minuth WW, Steiner P, Strehl R, Schumacher K, de Vries U, Kloth S (1999). Modulation of cell

differentiation in perfusion culture. Exptl. Nephrology 7:394-406.


Schmalz G, Schuster U, Nuetzel K, Schweikl H (1999). An in vitro pulp chamber with three-dimensional

cell cultures. J Endodontics 24-29.


Kreklau B, Sittinger M, Mensing MB, Voight C, Berger G, Burmester GR, Rahmanzahdeh R, Gross U (1999).

Tissue engineering of biphasic joint cartilage transplants. Biomaterials 20:1743-1749.


Jülich WD, Hanschke R, Alitari N (1998). Schonende Sterilisation von biologisch aktiven Implantaten. Hyg

Med 23,11:465-472.

? ? ?

Kloth S, Eckert E, Klein S, Monzer J, Wanke C, Minuth WW (1998). Gastric epithelium under organotypic

perfusion culture. In vitro Cell Dev Biol Animal 34:515-517.

Epithelium Digestive

Tract


Ramsauer M, Kunz J, Krause D, Dermietzel R (1998). Regulation of blood-brain barrier –specific enzymes

expressed by cerebral pericytes (pericytic aminopeptidase N/pAPN) under cell culture conditions. J Cereb

Blood Flow Metab 18(11):1270-81.

Nervous tissue Blood brain

barrier

Pharmacology

Kloth S, Gerdes, J, Wanke C, Minuth WW (1998). Basic fibroblast factor is a morphogenic modulator in

kidney vessel development. Kidney Int 53:970-978.

Vascular Tissue Kidney Improved Tissue Culture

Rotter N, Aigner J, Naumann A, Planck H, Hammer C, Burmester G, Sittinger M (1998). Cartilage

reconstruction in head and neck surgery: comparison of resorbable polymer scaffolds for tissue

engineering. J Biomed Mat Res 42:347-356.


Minuth WW, Sittinger M, Kloth S (1998). Tissue engineering - Generation of differentiated artificial

tissues for biomedical applications. Cell Tissue Res 291:1-11.

Epithelium/

Connective Tissue/

Vascular Tissue

? ?

Minuth WW (1998). Patent Japan Nr. 329 434/95: Kammer zur Kultivierung von Zellen, insbesondere

Mikroskopkammer.

? ? ?

Minuth WW, Strehl R, Kloth S (1997). Von der Zellkultur zum Tissue engineering. Bioscope 4/5: 19-24. All tissues Cell/ Tissue

simulation

Improved culture

technique



20 / 24



www.genintech.com,

Ro?teuscher J (1997). Neue Zellen fürs Labor. Aviso 2: 36-38. All tissues Cell/ Tissue

simulation

Tissue engineering

Minuth WW (1997). US- Patenterteilung Nr. 5 665 599: Chamber for Cultivating Cells. ? ? ?

Minuth WW, Steiner P, Strehl R, Kloth S, Tauc M (1997). Electrolyte environment modulates differentiation

in embryonic renal collecting duct epithelia. Exp Nephrol 5:414-422.


Schultz O, Keyszer G, Zacher J, Sittinger M, Burmester GR (1997). Development of an in vitro model system

for destructive joint diseases. Arthritis and Rheumatism 40:1420-1428.


Lehmann P, Kloth S, Aigner J, Dammer R, Minuth W (1997). Lebende Langzeitkonservierung von humaner

Gingiva in der Perfusionskultur. Mund Kiefer GesichtsChir 1:26-30.

Epithelium Gingiva Improved Tissue Culture

Steiner P, Strehl R, Kloth S, Tauc M, Minuth WW (1997). In vitro development and preservation of specific

features of collecting duct epithelial cells from embryonic rabbit kidney are regulated by the electrolyte

environment. Differentiation 62:193-202.


Strehl R, Kloth S, Aigner J, Steiner P, Minuth WW (1997). P CD Amp 1, a new antigen at the interface of

the embryonic collecting duct epithelium and the nephrogenic mesenchym. Kidney Int 52:1469-1477.

Epithelium and

Mesenchyme

Kidney Gradient Culture

Sittinger M, Schulz O, Keyszer G, Minuth WW, Burmester GR (1997). Artificial connective tissues in

perfusion culture. Int J Artificial Org 20:57-62.


Minuth WW, Aigner J, Kubat B, Kloth S (1997). Improved differentiation of renal tubular epithelium in

vitro: Potential for tissue engineering. Exp Nephrol 5:10-17.


Minuth WW, Aigner J, Kloth S, Steiner P, Tauc M, Jennings ML (1997). Culture of embryonic renal

collecting duct epithelia in a gradient container. Pediatr Nephrol 11:140-147.


Canossa M, Griesbeck O, Berninger B, Campana G, Kolbeck R, Thoenen H (1997). Neurotrophin release

by neurotrophins: Implication for activity-dependent neuronal plasticity. Proc. Natl Acad Sci 94:13279-

13286.

Nervous Tissue Mesencephal

on


Minuth WW, Kloth S, Aigner J, R?ckl W (1996). Approach to an organo-typical environment for cultured

cells and tissues. Biotechniques 20: 498-501.

All tissues Missing

regeneration

Tissue engineering

Minuth WW, Sittinger M, Kloth S (1996). Tissue engineering - Herstellung von künstlichen Geweben für All tissues Cell/ Tissue Tissue engineering



21 / 24



www.genintech.com,

die Biomedizin. Bioscope 4, 5: 36-41. simulation

Minuth WW (1996). Patent Nr. 195 30 55.6: Verfahren zur Kultivation von Zellen, insbesondere

Organzellen des menschlichen und tierischen K?rpers.

? ? ?

Bl?chl A, Sirrenberg C (1996). Neurothrophins stimulate the release of dopamine from rat mesencephalic

neurons via Trk and p75Lntr receptors. J Biological Chemistry 271,35:21100-21107.

Nervous Tissue Mesencephal

on


Gueven N., Glatthaar B., Manke H.G., Haemmerle H. (1996). Co-cultivation of rat pneumocytes and

bovine endothelial cells on a liquid-air interface. Eur Respir J 9:968-975.

Epithelium Lung Gradient Culture

Schmalz G, Garhammer P, Schweiki H (1996). A commercially available cell culture device modified for

dentin barrier tests. J Endodontics 22,5:249-252.


XX (1995). Ohren aus der Retorte. Spiegel 17: 234-238. All tissues Cell/ Tissue

simulation

Tissue engineering

Kuhn L (1995). Transplantate - Kultivierte Nase. Wirtschaftswoche 18: 112-115. All tissues Cell/ Tissue

simulation

Tissue engineering

Minuth WW, Kloth S, Aigner J, Steiner P (1995). MINUSHEET - Perfusionskultur: Simulierung eines

gewebetypischen Milieus. Bioscope 3, 4: 20-25.

All tissues Cell/ Tissue

simulation

Improved tissue culture

technique

Minuth WW (1995). Patent Nr. P 44 43 902: Kammer zur Kultivierung von Zellen, insbesondere

Mikroskopkammer.

? ? ?

Sittinger M, Buija J, Rotter N, Reitzel D, Minuth WW, Burmester GR (1996). Tissue engineering and

autologous transplant formation. Biomaterials 17:237-242.


Aigner J, Kloth S, Minuth WW (1995). Transitional differentiation pattern of principal and intercalated

cells during renal collecting duct development. Epith Cell Biol 4:121-130.


Bujia J, Rotter N, Minuth WW, Burmester GR, Hammer C, Sittinger M (1995). Züchtung menschlichen

Knorpelgewebes in einer Perfusionskulturkammer. Laryngo Rhino Otol 74:559-563.


Kloth S, Ebenbeck C, Kubitza M, Schmidbauer A, Weich HA, Minuth WW (1995). Stimulation of renal

microvasculature development under organotypical culture conditions. FASEBJ 9:963-967.


Kloth S, Kubitza M, R?ckl W, Schmidbauer A, Gerdes J, Moll R, Minuth WW (1995). Development of renal Epithelium Kidney Improved Tissue Culture



22 / 24



www.genintech.com,

podocytes cultured under medium perifusion. Lab Invest 73:294-301.

Bujia J (1995). Die Züchtung von autologem Knorpelgewebe für die rekonstruktive chirurgie:

M?glichkeiten und Grenzen. Laryngo Rhino Otol 74:205-210.

Connective Tissue Cartilage Improved Tissue Culture

Sittinger M (1995). Tissue Engineering: Künstlicher Gewebeersatz aus vitalen Komponenten. Laryngo

Rhino Otol 74:695-699.


Bujia J, Sittinger M, Minuth WW, Hammer C, Burmester G, Kastenbauer E (1995). Engineering of cartilage

tissue using bioresorbable polymer fleeces and perfusion culture. Acta Otolaryngol 115:307-310.


Minuth WW, Aigner J, Kubat B, Kloth S, R?ckl W, Kubitza M (1995). In vitro Alternativen zum Tierversuch

- M?glichkeiten und Probleme, Pabst Verlag, pp 76-87.

? ? ?

Minuth WW (1994). Kultivierte Zellen - Eine neue Technik zur Simulierung eines organspezifischen

Milieus. Blick in die Wissenschaft 5:30-33.


simulation

Tissue engineering

Minuth WW (1994). Perfusionszellkultur - eine neue Methode für organspezifische, pathologische und

toxikologische Fragestellungen. MTA 9: 10-13.


simulation

Improved tissue culture

technique

Bujia J, Sittinger M, Hammer C, Burmester G (1994). Züchtung menschlichen Knorpelgewebes mit Hilfe

einer Perfusionskammer. Laryngo Rhino Otol 73:577-580.


Minuth WW (1994). US - Patent 5, 316, 945: Cell carrier arrangement. ? ? ?

Minuth WW (1994). Patent Nr. P 42 00 446: Zelltr?geranordnung. ? ? ?

Aigner J, Kloth S, Dermietzel R, Minuth WW (1994). Maturation of renal collecting duct cells in vivo and

under perfusion culture. Epithelial Cell Biol 3:70-78.


Minuth WW (1994). MINUSHEET - Mehr Effizienz beiZellkulturen. Fremdstoffmetabolismus und Klinische

Pharmakologie - Eds. Dengler und Mutschler, Gustav Fischer Verlag, pp. 197-205.

? ? ?

Minuth WW, Kloth S, Aigner J, Sittinger M, R?ckl W (1994). Organ-spezifisches Environment für kultivierte

Zellen und Gewebe. BIOFORUM 17:412-416.

? ? ?

Sittinger M, Buija J, Minuth WW, Hammer C, Burmester GR (1994). Engineering of cartilage tissue using

bioresorbable polymer carriers in perfusion culture. Biomaterials 15:451-456.


Kloth S, Schmidbauer A, Kubitza M, Minuth WW (1994). Developing renal microvasculature can be Vascular System Kidney Improved Tissue Culture



23 / 24



www.genintech.com,

maintained under perfusion culture conditions. Eur J Cell Biol 63:84-95.

Minuth WW, Kloth S, Majer V, Dermietzel R (1994). Growth of MDCK cells on non-transparent supports.

In vitro Cell Dev Biol 30A:12-14.

Epithelium Kidney Test of Biomaterials

Minuth WW (1993). Gebrauchsmuster G 89 08 58.3: Tr?ger für die Zellkultivation. ? ? ?

Minuth WW (1993). US-Patent 5,190,878: Apparatus for cultivating cells. ? ? ?

Minuth WW (1993). Die Kultur von Epithelzellen unter organtypischen Bedingungen. Alternativen zu

Tierversuchen in Ausbildung, Qualit?tskontrolle und Herz- Kreislaufforschung. Springer Verlag Wien -

New York: pp 238-245.

? ? ?

Minuth WW, Fietzek W, Kloth S, Aigner J, R?ckl W, Kubitza M, Dermietzel R (1993). Aldosterone modulates

the development of PNA binding cell isoforms within renal collecting duct epithelium kept in perfusion

culture. Kidney Int 44: 337-344.


Herter P, Laube G, Gronczewski J, Minuth WW (1993). Silver enhanced colloidal gold labelling of rabbit

kidney collecting duct cell surfaces imaged by SEM. J Microscopy 171:107-115.


Minuth WW, St?ckl G (1992/1995). Gebrauchsmuster und Patent Nr. G 9107 283.2 / DE 42 08 805 C2:

Vorrichtung zur Behandlung, insbesondere zur Kultivierung von Biomaterial mit wenigstens einem

Behandlungsmedium.

? ? ?

Minuth WW, Dermietzel R, Kloth S, Henerkes B (1992). A new method culturing renal cells under

permanent superfusion and producing a luminal-basal medium gradient. Kidney Int 41:215-219.


Minuth WW (1992). MINUSHEET - ein neuer Weg zur organspezifischen Zellkultur. Spektrum der

Wissenschaften 11:15-17.

? ? ?

Minuth WW, St?ckl G, Kloth S, Dermietzel R (1992). Construction of an apparatus for perfusion cell

cultures which enables in vitro experiments under organotypic conditions. Eur J Cell Biol 57:132-137.


Minuth WW (1991). Erster Schritt auf dem Weg zur künstlichen Leber. ?rztliche Praxis 98:27-29. Epithelium Liver Tissue engineering

Minuth WW (1991). Eine neue Kulturmethode für anhaftende Zellen unter natürlichen Bedingungen.

ALTEX 15:18-30.


Minuth WW (1991). MINUSHEET - eine neue Methode um differenzierte Zellen unter nahezu natürlichen ? ? ?



24 / 24



www.genintech.com,

Bedingungen zu kultivieren. Bioengineering 5:66-69.

Minuth WW (1990). Prof. Minuth geht neue Wege bei der Kultivation von hochspezialisierten Zellen.

Regensburger Universit?tszeitung 6:7-9.

All tissue Cell/ Tissue

simulation

Tissue engineering

Documents

Cytotoxicity evaluation of self-etching dentine bonding agents in a cell culture perfusion condition. Eur J Dentistry 6:408-414. Connective tissue Teeth Cytotoxicity Minuth WW,