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ݩ[email protected] 㛫⏕≀Ꮫ Vol. 26, No. 1 (2020) 51 ੜি ఢ 叞 প৾ প৾৶৾௺ଢ଼ఐ েఐ৾௧వ ಟኈ 2 ᖺࡢኟࡀ⚾ࠊᡤᒓࡍ῝⏣◊✲ᐊࡢ Duke-NUS Medical School ࡢDavid M Virshup ᩍᤵ ඹ◊✲ࡢᡴデ ࠋࡓࡗ࠶ࡀᙼࡀసᡂࡓࡋኚ␗ ࢫ⾜ࡢࢬゎᯒࡋ࠸ࡋࡇ࠺࠸ ⚾ࠋ࠸ࡋࡀᡭᣲࡓࡆࡇ⏣῝ࠊᩍᤵ⚾ࡀ㐺௵ࡔ࠺ ࠊࡋᐇ㝿ᡭࡋࡇࡃ࠸ ࠋࡓࡗ࡞ඹ◊ ✲㛤ጞࡍࡓ࠶ࡢࡑࠊᗘࡑࠊࡒ 2 㐌 㛫⛬ᗘࡢᮇ㛫ࡗࡓࢩ ࡢVirshup ◊✲ ᐊゼ✲◊ࠊィ⏬ࡢᡴࡕࡏᙼࡢᐇ㦂ࡢᡭἲ ࠸ࡘሗ⾜ࡇ࠺ ࠋࡓࡗ࡞ᅇࡢΏ⯟ ࡣ⚾ࡗࡢᅜእ㐍ฟࡇ࠺࠸࠶ ࠊᐇ㝿᪥ ᖖⓗⱥㄒ࠼ࡢ ࠊᡭ⥆ࢺࡢ➼ࡁぢ⯙ ࠸࡞ࡓࡗ࠸ᚰ㓄ࡣከᑡ ࠊࡀࡓࡗ࠶ࢫ ࢺᚓ࠾ࠊࡋᅵ⏘ᦠ ࠊ࠼ពỴࡋࢳ ✵ࢠ 㣕 ࠋࡓࡗ❧ࡧࢩࡣ㉥㐨┤ୗ⨨ࡍᖖኟࡢᅜ ࠶ ࠋฟ❧๓ࡗࡍࡣᛀ ࠊࡀࡓ࠸ኟࡣᬬ ࠋ࠸㞳㝣 ࡣኟࡢ࠸╔࠼࠸ேࡕࡣࡋ ࠸࡞ࡓࡗᛮ╔ࠊࡀࡔࡢ࠺㝣ࡣࡢᐈ ࡀࡢࡘ࠸㛫⿇ࡗ࡞࠾╔ࠊ㝣ࡋ╔ ࠼ࡓ࠸ධᅜᑂᰝࡢฟ㐜ࡋ ࠋࡓࡗࢳ ✵ࢠᕷ⾤ᆅ ࡣMRT ࠺࠸㟁㌴ ࠋ࠺᪥ᮏᬑ㏻ษ➢࡞␗ࡣ ࠊMRT ⏝࠸ษ➢ࡣᅇ࠸ࡇࡍࡀࡁ ࠋ ࠺࠸࠸࠸࡞ࡉవィᩱ㔠ᡶࡇ࠺ ࡞ ࠋಀဨࡀࡓ࠸ࡣ㈙ࡅࡔ࠺࡞ᡭ㛫ࡢࡓࡗ ࠊ๓༑ศㄪ⾜ࡇࡃ࠾ࡍ ࠋࡈᏑࡢࡌ᪉ከ࠸ᛮࢩࠊࡀ࠺ࡣ ࡃ㏻ࡢせ⾪ࡓࡓࡗ࠶ ࠊᵝ࡞ࠎࡀΰࡊ ࠶ࡗ࠸ࠋWikipedia Ẹ᪘ᵓᡂࡋ⳹ࡣே ࡀ༨ ࠊḟ࠸⣔ ࠊࢻ⣔ࡀከ࠸ ࡋ ࠋ࠸㌴ෆࡢᐈࡢᵓᡂࡣయࡢࡑ࡞࠺༳㇟ ࡓࡅ ࠊࡀࡣほගᆅࡋேẼ ࠊࡃࡋࢫ࡞ࡁ ࢶࢣࢫᣢࡓࡗほගᐈከ⾤ࠋࡓࡗ୰ࡣᅪẖ ࡃศ࠾ ࠊṌ࠸࠸㞺ᅖẼࡢࡘ࠸ࡀ㛫 ኚࡀ⚾ࠋᅾࡓࡋࢸࢳࡣࢱࢼ ࡢ୰࠶ ࠊ୰⳹ᩱ⌮ᗑࡢ㛫ࢻࡢ ࠸࠾ࡍࡀ࠺࠸⌋⤒࠸ࡋ㦂 ࠋࡓࡋ᪥ᮏ᪥ᮏㄒࡀ㏻ ࡌࡇ࠸࡞ࡀ࠸↓ࡎ࠺ࢩࠊయ ࡢఫẸࡀⱥㄒ࠼ᛮࡗ ࠊࡀࡔࡢࡓ࠸㏆ࡢࡃ୰⳹ ᩱ⌮ᗑࡣⱥㄒࡀ㏻ࡇ࠸࡞ࡌ ࠋࡓࡗ࠶Virshup ◊✲ᐊࡣⱥㄒࡀࠊࡀࡓ࠸ ᢡ▱࠸࡞ゝㄒ⪺࠼ࡇ ࠋࡓࡁᅇࡢඹ◊✲┤ ᥋ ࡢࢡࢻࢫRajesh Narasimamurthy ༤ኈ ࡣࢻฟ㌟࠶ ࠊࡣࢻケࡢⱥㄒ ࡀ⪺ࡁࡇ࠸࡞ ࠊࡀࡓࡗ࠶ࡋࡤࡋ᰿Ẽࡃᑀ ᐇ㦂ᡭἲࡢㄝ㆟ㄽࡋࡃ࠾ࡓࡆ⚾ࡢⱥ ヰ⬟ຊ࡞ࡓࡗࡀᛮ ࠋ࠺ᐇ㦂ᐊ✲◊ࡣᐊẖศࡇ࠸࡞࠸࠶ ࠊ 㣗⥴⾜ࡍࢢ◊✲ᐊẖศ ࠸ࡅ࠸࡞ࡣ ࠋࡓࡗࡔ࠺㐃ࡗࡔ㏆ࡢࡃᗑ 㣗⾜ࡃே ࡀࡓ࠸㸦⚾ఱᗘࡈ⥴ࡏࡉ ࡓࡗ㸧 ࠊRajesh ࡣࢱࢪ࠺ࡑࡔࠊᐙᘚ ᙜᣢࡗࡁ㣗 ࠋࡓ࠸᪥ᮏẚࢱࢪ ࡣከ࡞࠺ࡑẼࡍࡀࢩࠊࡀ ࢱࢪࡀẼ㍍㣗⾜ࡅࢺࢫࡣከ ࡞ࡣࡃ࠸ࠋ࠸ࡋᅾ୰ᗘ Rajesh ࢱࢪ ࡅࡢࢺࢫ㐃⾜ࡗ ࠋࡓࡗᑠ㯏㇋ࡀ୰ ᚰࡢ㣗 ࠊീ௨㣗ᛂ⚾ࠋࡓࡗ࠶ࡀ࠼እ ࢱࢪ࡞ࡢࡋࡢࠋ࠸࡞㸲㐌㛫 ࠸▷࠺࠸ᮇ㛫ࢩࡀࡓࡗࡔᅾࡋ ࡞␗ࠊ⫼ᬒᣢࡓࡗேࡀࠎ㞟ࡗ࠸ศ⮬ࠊศ␗ ࡞ࡇᑐࡍ⌮ゎ࠶ࡀᅵᆅࡔឤ ࠋࡓࡌ࡞ࡕࠊᅇࡢඹ◊✲ࡣィࢱࢡ㉁ PER2 ࡢⅬኚ␗ࢫゎᯒࠋࡓࡋPER2 ࡣᵝ ࢭ࡞ࠎṧᇶࡢ㓟ࡗᏳᐃᛶࡀไᚚࡉ ࡇ▱ࡀࡢࡇࠊࡀኚ␗ࡢࡕ࠺ࡢࡑࡣࢫࡘ ࠶ 478 ࢭࡢ┠␒ࢽ⨨ࡓࡋࡢ ࠶ࡢࡇࠋṧᇶࡀ㓟ࡉ ࠊࢳ ࢮ࠶ș-TrCP ࡗㄆ㆑ࡉࠊPER2 ࡣ ৾৬ୡ੶ ३থफ़এ شঝ௰बथ
Ï þ ì avchronobiology.jp/journal/JSC2020-1-051.pdf · i [email protected] ì6ë#Õ"@ Û Vol. 26, No. 1 (2020) 51 \ ¿ " SÞ Â ª þ ª þ y ö þ ú ] ¢ Ç _
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[email protected]
Vol. 26, No. 1 (2020)
51
2Duke-NUS Medical School David M Virshup
2Virshup
MRT
MRT
Wikipedia
Virshup
Rajesh Narasimamurthy
Rajesh
Rajesh
PER2 PER2
478
-TrCP PER2
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Vol. 26, No. 1 (2020)
52
--TrCPVirshup PER2
FASP-TrCP PER2
Zhou et al., Mol. Cell, 2015 FASP
-TrCP
(CK1)
CK1 FASP -TrCP-
PER2
-TrCP PER2Virshup
PER2
Virshup
David M Virshup Rajesh Narasimamurthy
David M Virshup