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hi Lb ©K i hi Lb Lb ©K i hi L 研究概要 1/4 © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L 細胞の生命活動 細胞の生命活動 神経細胞 イオン イオン 電気信号 ピペット 検出電極 © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L 心筋細胞 イオン イオン <単一細胞> <細胞群> パッチクランプ法 細胞 観測 観測 © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L Mi Ch l A MCA課題点 課題点 ・ ロースループット ・ ピペット製作、操作が困難 MEMS技術 © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L 細胞吸引孔 電極 一体化 した 構造 M icro C hannel A rray MCA絶縁膜開口部: Φ10 μm © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L 5 mm 吸引固定 による 細胞選択性 S/N向上 © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. -Lab. © Konishi-L Micro / Nano Mechatronics LAB. Micro / Nano Mechatronics LAB. Konishi Konishi LAB. LAB. Group Cell Group Cell 5 mm 吸引孔:Φ4 μm 所望の組織形成 ・定量解析 に向けた 基本構造

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Page 1: -Lab. 研究概要 細胞の生命活動konishi/mems/GBC/ja-gbc.pdf-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab

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研究概要 1/4

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© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

細胞の生命活動細胞の生命活動

神経細胞

イオンイオン

電気信号ピペット

検出電極

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© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L心筋細胞

イオンイオン

<単一細胞><細胞群> パッチクランプ法

細胞観測観測

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Mi Ch l A (MCA)

課題点課題点 ・ ロースループット・ ピペット製作、操作が困難

MEMS技術

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細胞吸引孔 と 電極 を一体化 した 構造

Micro Channel Array (MCA)絶縁膜開口部:

Φ10 μm

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© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L5 mm

吸引固定 による 細胞選択性 と S/N比の向上

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Micro / Nano Mechatronics LAB.Micro / Nano Mechatronics LAB. KonishiKonishi LAB.LAB.Group CellGroup Cell

5 mm

吸引孔:Φ4 μm 所望の組織形成・定量解析 に向けた 基本構造

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研究目的 2/4

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細胞外解析細胞外解析細胞外解析細胞外解析

MCA を基本構造とした 細胞操作細胞操作 ・・ 定量解析定量解析 ツール の 開発

細胞 解析細胞 解析細胞 解析細胞 解析© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

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細胞外解析用ツール細胞外解析用ツール細胞外解析用ツール細胞外解析用ツール 細胞内解析用ツール細胞内解析用ツール細胞内解析用ツール細胞内解析用ツール

電極針 バネ支持梁細胞 絶縁膜

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© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L支援ポール 吸引孔

ラッチ

ガイド構造陰圧

電極

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細胞内挿入用針電極型細胞内挿入用針電極型 MCAMCA細胞 溶液溜

細胞ネットワーク解析用細胞ネットワーク解析用 MCAMCA陰圧

細胞(磁性粒子)

空気圧

磁路一体化微小孔

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© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L電極ON OFF電磁石

冶具

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Micro / Nano Mechatronics LAB.Micro / Nano Mechatronics LAB. KonishiKonishi LAB.LAB.Group CellGroup Cell

空気圧空気圧 ++ 磁気誘導磁気誘導 MCAMCA 化学的細胞膜穿孔用化学的細胞膜穿孔用 MCAMCA

電極ON OFF電磁石

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研究成果 3/4

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細胞外解析用ツール細胞外解析用ツール細胞外解析用ツール細胞外解析用ツール 細胞内解析用ツール細胞内解析用ツール細胞内解析用ツール細胞内解析用ツール

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駆動源(プローブ) 吸引孔

ガイド構造

1 sec 1 sec

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電極針

ラッチ

1 sec 1 sec 細胞内挿入用針電極型 MCA の駆動の様子© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

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スライス自発活動電位の多点同時観測結果

hv細胞培地

1. 培地充填 2. 細胞吸引 3. 溶液交換 4. 細胞膜穿孔

OFF

磁性細胞(Φ10-20 μm)

流れ (40 nl / s)

OFF

(磁気)流れ (40 nl / s)

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光増感剤+ Lucifer Yellow 電極陰圧

吸引孔吸引孔 細胞細胞((PC12PC12)) LYLY染色された染色された細胞細胞

(Φ10 20 μm)

200 μm

磁路一体化

OFF

ON

OFF

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Micro / Nano Mechatronics LAB.Micro / Nano Mechatronics LAB. KonishiKonishi LAB.LAB.Group CellGroup Cell

単一細胞の磁気操作

30 μm

化学的細胞膜穿孔の実験結果

ON磁路 体化微小孔

磁気誘導@ 70 mA

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まとめ 4/4磁路一体化

微小孔© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

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細胞操作・解析用ツール細胞操作・解析用ツール のの 開発開発

細胞外10

パーマロイ

Φ20 μm

200 μm

微小孔

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細胞ネットワーク解析用MCA

空気圧+磁気誘導MCA

細胞内

細胞ネットワーク解析用細胞ネットワーク解析用 MCAMCA空気圧空気圧 ++ 磁気誘導磁気誘導 MCAMCA

10 mm

染色された細胞

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細胞内

細胞内挿入用針電極型細胞内挿入用針電極型 MCAMCA化学的細胞膜穿孔用化学的細胞膜穿孔用 MCAMCA

Suction hole

Needle probe

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細胞内挿入用針電極型MCA

細胞・細胞ネットワーク定量解析への応用細胞・細胞ネットワーク定量解析への応用hole 30 μm

化学的細胞膜穿孔用MCA

© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

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関連発表

○T.Hiranishi, W.Tonomura, K.Ino, M.Okochi, H.Honda and S.Konishi, “Both Pneumatic and Magnetic Induction of Scattered Cells on Micro Channel Arrayfor Cellular Analysis”, IEEE International Conference on Micro Electro Mechanical Systems (MEMS2008), pp.284-287, Tucson, Arizona, USA, 2008.

○W.Tonomura, T.Kurashima, Y.Takayama, H.Moriguchi, Y.Jimbo and S.Konishi, “Simultaneous Multipoint Measurement of Cellular Network by IsolatedMicro Channel Array with Pt-Black Electrodes”, IEEE International Conference on Transducers & Eurosensors, pp.1793-1796, Lyon, France, 2007. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.-Lab. © Konishi-L

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○K.Iso, T.K.Saito, H.Muguruma, H.Tabata and S.Konishi, “Photodynamic Perforation of Cell Membrane on Micro Channel Array toward Intracellular Technology”, IEEE International Conference on Micro Electro Mechanical Systems (MEMS2007), pp.445-448, Kobe, Japan, 2007.