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多器官功能障碍综合征 MODS 及其进展. 概念 • MODS 是指在严重感染、创伤、休克和大手术后两个或两个以上系统器官或脏器功能同时或序贯发生功能障碍的临床综合征。 • 受损器官包括肺、肾、肝、胃肠、 心、脑、凝血及代谢功能等. MODS 概念上强调:. - PowerPoint PPT Presentation
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MODS
MODS
MODS MODS MODS(24h) MODS60%100%
1 .,,, 2 .(>24h),24h 3 ., 4 . 5 .
1,++ ,, 1 2 3 4() 5 6,
MODS systemic inflammatory response syndrome, SIRS 1 disseminated activation of inflammatory cells - C3a C5a - TNF IFN IL-1 IL-6 IL-8 PAF LTB4 TXA2 PF3-4 ADP P L adhesion molecule, AM
2 (proinflammatory mediator spillover) - priming TNF DIC .
- 02-Ca2+
MODS 1 - SIRS 2 DIC 3
1 1 hypermetabolism TNF IL-1 MODS 2
2 1 MODS 2 SIRS MODS
Fry Knaus MODS Mashall
FryMOF 5 >34.2mol/L (20mg/dl)GOTLDH1 24600ml >166.7mol/L(20mg/dl) MOF CVP20cmH2O1.96kPa >51.3mol/L (30mg/dl) GOTGPT>100U BUN18mmol/L250mol/L(3mg/dl)
KnausMOF 1HR54/min 2MAP6.53kPa49mmHg 3/ 4pH7.24PaCO26.54kPa49.49mmHg 1R5/min49/min 2PaCO26.67kPa50mmHg 3A-aDO246.7kPa350mmHg 44 1479ml/24h195ml/8h 2BUN35.7mmol/L100mg/dl 3Cr309.4mol/L 3.5mg/dl 1WBC30109/L 2PLT10109/L (320% Glasgow624h
() 2d( 3d5d7d) () >mol/L)2mg(177 2600mld>600mld >50mg(18mmolL) () >2mg (34mmolL) ALTASTLDH2 () 1 2 3 ( )
MarshallMODS PaO2/ FiO2mmHg 300 226~300 151~225 76~150 75 Crmol/L 100 101~200 201~350 351~500 >500 TBILmol/L 20 21~60 61~120 121~240 >240 PARbpm 10.0 10.1~15.0 15.1~20.0 20.1~30.0 >30.0 PLT109/L >120 81~120 51~80 21~50 20
Glasgow 15 13~14 10~12 7~9 6 1PAR/ 2PaO2/ FiO2PeepPeep 3 4GCS
MODSMarshall,9. 1.MODS 2.MODS 3. 4.
MODS .. 14-21 ...4 MODS PLTWBC
() ()CVPSwan-GanzPAWP(PCWP)PACO(CI) () 1(min) 2 3 TVIEPEEPFi02 () 1.pH 2. 3. 4.()
() ()(24h) () (LT) - AKPAFPLDH GT () 1 2 DICFIB 3PD- 3 () ()() ) () 1. 2. 3. () (K+Na+C1-Ca2+Mg2+P2+) (CuFeZnMg2+Ca2+Se) T3T4TSH VTV/QVO2-DO2 CrBUN ASTALT pHiD- PLTAPTTKPTT HRBP
MODSMODSMODS/MOF200210ESICM(ISF)MODS525%2004MODSC(APC)
1. MODS,40%
2. ALIARDSPaO2PEEP15cmH2060PaO2PaCO2PaO2ALIARDSNOLiquid ventilationECM0IVOX
3. CAVHD
(CRRT)(MODS) SIRMODS/--1-6MODSMOSF
MODSMODSCRRT--1-6MODSTNFLPS
4.MODS(BAL)(ALF)(MARS)MODSNO-6(IL-6)IL-8-(TNF-)-(INF-)Wang(LLC-PKI)ARF()MODS/MOF35.8%IL-10
5. MODSH2MODSMODSMODS310g231030gC
6.DIC MODSDIC
7. SIRSMODS
105kJ/kg5g/kg1.0g/kg1.52.0g/kgMODSMODSDalyw-3SIRS
8. MODSB BieskoMODSTNFILPAFSOD)MODSSDDMODS
9.MODSDong 2 390 MODS 85.2%76%MODS /Chai
10.MODS 80MODS33MODSLPSTNFIL-1PAF
MODSMODS(SIRS)ARDSMODSSIRSA2(PLA2)(PAF)MODSMODSMODS
TNFPGEC,E),
1. 2.SIRS 3.H2 4. 5. 6.
,(sirs)mods,,,,,,sirs,,modsmods,
1 2050irving,flemingnightingale,/deitch,,5 d;okada(sbs)3,sbs,,,,,
goris0,1,2/24 h,/,/2,,1,21995mods12(1)3,01,2,3,4
2 2.1 4IGM,-,,,/(),
:,,,,,,(gln),gln,,,,,,(paf)(tnf),,,,mods(lps),, ao3(dic)TNF(il)(ifn),,
,mods ,,,,,,mods mods,mods,,,
2.2 :101478%,,,1 kg,10121013,,,,,,,/,,,
,,,,
2.3 ,,,,,(), 2.4 3(galt)til-3il-5il-6ifn- IGAa(siga),siga,sigasiga,,leeuwen,70%,,,lps
3 3.1 3.2 (dao)dao,,95%,,,,,dao,dao,dao 3.3 d-:d-,d-,d-,,d-d-,
3.4 :,,,,,, 3.5 :24 h 3.6 ph(phi),co2,phiphi,phiphi,
4 4.1 :,,,,(tpn)mods,mods, 4.2 ,,,c
4.3 ,,,,phi,,,,,iga,,,,,,tnf
4.4 (sdd)sdd,,(),,,,,sdd:e:-,,:sdd(3 d),,
4.5 ,,,,,,,,,31,,,,-,,,,(),,,,,,,,,,,,,,,
4.6 4.6.1 h2,mods,,,,,,,mods 4.6.2 ,,,:,,,,,,: 4.6.3 -,,,,,,,,,5-,,
4.6.4 glngln,,gln,gln,gln,glngoetersglngln,9 d6gln,, 4.6.5 cd14cd14,tnf,
1 MODSMODSSwan-Ganz
2 MODS(DIC) MODSDICDICMODSDICMODS 3 045%5%231
4 K+Na+Ca2+Mg2+0.5 mmol/L
5 GHMODSGH 6 ENPNMODSENPNPN?1213 dENENMODS
7 MODS(ARDS)ARDSMODSMODS231 8 MODSICU
9 MODS10 10 H2H+-K+-ATPpH2pH4pH6MODSpH35 d 11 MODS2080
12 MODSARDS5 mg40 mg14 h 1ARDS50%MODS 13 BPCRRTMODSMODS
14 33 2000 15 ()ARDSO2CO2O2O2CO2O2CO2(PaO2)(PaCO2)CO2
16 ARDS(57 ml/kg)(PEEP)ARDSMODSICUMODS