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流感疫苗 Q & A

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流感疫苗 Q & A. 衛生署 疾病管制局 中區傳染病防治醫療網 王任賢 指揮官. Q1: 流感疫苗是活的還是死的. 流感疫苗的製作是將活的流感病毒打入雞的胚胎中,待長出很多病毒後取出以福馬林殺死,最後以高科技將福馬林稀出後做成疫苗,所以疫苗是死的. Q2: 流感與新流感有何不同 ?. 流感又稱為 季節性流感 ,每年都會來,大家都有基礎抗體,通常很少死亡。新流感為世界衛生組織宣佈的,這種病毒以前都沒來過,大家都沒抗體 ,因此死亡率偏高. Q3: 流感疫苗與新流感疫苗是相同的嗎 ?. - PowerPoint PPT Presentation

Text of 流感疫苗 Q & A

  • Q & A

  • Q1:

  • Q2: ?

  • Q3: ?A H1N1, A H3N2, BAH1N1

  • Q4: ?2-329

  • Q5: 2009?2009

  • Q6:

  • Q7: ?H5N1cell base

  • Q8: ?

  • Q9: ?

  • Q10: ?

  • Q11: ? (AdimFlu) 15 mcg (Forcetria) 7.5 mcg (MF59)

  • Q12: ?

  • Q13: ?2009

  • Q14: ?

  • vs : 18-60

    HATotalN=120Seronegative at baselineN=98TotalN=132Seronegative at baselineN=50Seroprotective rate (day 22)92.5%92.9%96%98%GMR (day 22 to day1)32.641.41865Seroconversion or significant increase93.3%92.9%88%98%

  • vs : 60

    HATotalN=53Seronegative at baselineN=33TotalN=122Seronegative at baselineN=27Seroprotective rate (day 22)75.5%81.8%72%56%GMR (day 22 to day1)10.716.049.58Seroconversion or significant increase71.7%81.8%43%56%

  • vs : 18

    3 weeks after 1st vaccination (n/N), %(1-3 y: 7.5 mcg, >3 y: 15 mcg)(all 7.5 mcg with adjuvant)1-

  • vs :

    Event N=292 (15 mcg=177, 30 mcg=115) N=254 (7.5 mcg with adjuvant)Redness14.7%Very common (10-100%)Swelling16.4%Very common (10-100%)Fever (>38.3)0.7%Common (1-10%)Muscle aches/Myalgia17.5%Very common (10-100%)Headache13.4%Very common (10-100%)Nausea4.8%Common (1-10%)

  • Q15:

  • Q16: 30

  • Q17:

  • Q18:

  • Q19?Nichols et al. Arch Int Med, 1996;156:1546

    6.1

    19.4

    17.5

    5.7

    14.4

    24.1

  • Nichols et al. Arch Int Med, 1996;156:1546

    6.1

    6.2

    19.4

    18.9

    17.5

    16.0

    5.7

    6.2

    14.4

    10.8

    24.1

    63.8

  • Q20: ?: 1922 ?

  • Q21?6hives. 8Guillain-Barr syndromeOculorespiratory Syndrome (ORS)

  • Q22?

    :

  • *This presentation will address the risk factors for and the prevention of surgical site infections.This slide demonstrates the rates of local (sore arm) and systemic side effects in the week after injection in the largest randomized controlled trial of influenza vaccine in healthy working adults. Just over 1 in 20 people had a fever, nearly 1 in 5 were abnormally tired, and 6% complained of muscle aches.Before you make conclusions,however, you need to see the next slide - Here you can see that the data you were looking at were the data from the placebo group when you compare the adverse event rates in placebo and vaccine groups, you seen that vaccine is associated with sore arm in about 40% of people. Although fever occurs after vaccination, it is not CAUSED by vaccination because we vaccinate people in October and November, when many viruses which cause viral respiratory tract infections are circulating, it is not uncommon to develop illness after vaccine is given. This is a temporal, but not a causal association.

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