0.96 1.06 0.98 1.15 1.18

Atchison, 2011 Carstensen, male, 2012

Carstensen, female, 2012 Chodick, male, 2010

Chodick, female, 2010 Ehrlich, 2010

Hall, 2005 Inoue, male, 2006

Inoue, female, 2006 Jee, male, 2005

Jee, female, 2005 Johnson, 2011

Khan, male, 2006 Khan, female, 2006

Lo, 2012 Luo, 2012

Ogunleye, 2009 Rapp, 2006

Stattin, 2007 Stocks, male, 2009

Stocks, female, 2009 Wotton, 2011 Wotton, 2011

Yeh, 2012 Attner, 2012 Driver, 2010

Steenland, male, 1995 Steenland, female, 1995

Bodmer, 2012 Kuriki, male, 2007

Kuriki, female, 2007 O'Mara, male, 1985

O'Mara, female, 1985 Rousseau, 2006

Study ommited

Meta-analysis random-effects estimates (exponential form)

eFigure 1. Sensitivity analysis by excluding one study at a time

eFigure 2. Begg’s regression asymmetry test (P = 0.002)

Begg's funnel plot with pseudo 95% confidence limits

log[

RR

]

s.e. of: log[RR]0 .5 1

-2

-1

0

1

2

eFigure 3. Contour-enhanced funnel plot using inverse standard error on the y axis