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Universitat Autnoma de Barcelona

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________________________________________________________________________Resumen

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SNTOMAS TRATAMIENTOS

Sntomas primarios

Sntomas secundarios

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Sntomas terciarios

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CRITERIOS DE CLASIFICACIN DE LA EVOLUCIN CLNICA DE LA EM

Recadas y remisiones (RR) Brotes bien definidos, a menudo con recuperacin completa o casi completa. Sin progresin de la enfermedad entre ataques.

Recadas y progresin (RP) Avance de la enfermedad con recadas, sin recuperacin entre ellas.

Primariamente progresivo (PP) Empeoramiento continuo de los sntomas neurolgicos y deficiencias. Generalmente sin remisin o exacerbaciones agudas.

Secundariamente progresivo (SP) Agravamiento continuo de los sntomas. Aparece despus de una etapa de RR.

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Vector Material gentico Capacidad de empa-quetamiento

Tropismo Potencial inflamatorio Forma del genoma viral en la clula

Principales limitaciones

Principales ventajas

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Subgrupos de HAd Serotipos Tropismo natural predominante Receptores conocidos

A 12, 18, 31 gastrointestinal CAR

B1 3, 7, 16, 21, 50 respiratorio CD46, CD80/86, Receptor X, HSPG

B2 11, 14, 34, 35 renal CD46, CD80/86, Receptor X, HSPG

C 1, 2, 5, 6 respiratorio CAR, HSPG, MHC-I, VCAM-I, Integrinas

D 8, 9, 10, 13, 15, 17, 19, 20, 22-30, 32, 33, 36-39, 42-49, 51

ocular CAR, acido sialico, CD46

E 4 respiratorio, ocular CAR

F 40, 41 gastrointestinal CAR

G 52 gastrointestinal -----

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________________________________________________________________________Objetivos

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