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REFERAT

OSTEOSARCOMA

Presenter :

Rossi Monisa S.Ked

Pembimbing :

Dr. M.Tambah Thaibsyah Sp.B

Dr. Syafruddin Sp.B

Dr. Mufrizal Sp.B

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PENDAHULUAN

Osteosarkoma disebut juga osteogenik

sarkoma adalah suatu neoplasma ganas yang

berasal dari sel primitif (poorly differentiated

cells) di daerah metafise tulang panjang pada

anak-anak.

Radiografi diperlukan untuk mengetahui lokasi

dari lesi.

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Epidemiologi

Osteosarkoma 22% dari seluruhjenis tumor tulang.

Kanker tulang (osteosarkoma)sering

menyerang kelompok usia 1525tahun.

Etiologi masih belum jelas.

Lokasi osteosarkoma paling seringpada metafisis

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Tumor Frequency %

Telangiectatic 3.5-11

Parosteal 3-4

Periosteal 1-2

Gnathic 6-9

Small cell 1

Intraosseous, low grade

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Patofisiologi

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Gejala Klinis

Nyeri dan/ atau pembengkakan ekstremitasyang terkena.

Fraktur patologik.

Pembengkakan pada atau di atas tulang ataupersendian serta pergerakan yang terbata.

Teraba massa tulang dan peningkatan suhukulit di atas massa serta adanya pelebaran vena

Gejala-gejala penyakit metastatik meliputinyeri dada, batuk, demam, berat badanmenurun dan malaise.

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Predileksi Osteosarcoma

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Klasifikasi

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Klasifikasi

Osteosarkoma klasik.

Osteosarkoma hemoragi atau telangektasis

Parosteal osteosarkoma.

Periosteal osteosarkoma.

Osteosarkoma sekunder

Osteosarkoma intrameduler derajat rendah.

Osteosarkoma akibat radiasi.

Multifokal osteosarkoma.

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Stadium

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Laboratorium

RadiografiX-Ray, Ct-Scan, MRI,

Ultrasound, Nuclear Medicine

Patologi anatomi

Pemeriksaan Penunjang

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Perubahan periosteal berupa Codman triangles (white arrow) dan

masa jaringan lunak yang luas (black arrow).

X Ray

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Epitheloid Osteosarcoma

Telangiektasi Osteosarcoma

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Osteoblastoma like -

Condroblastoma like -

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Giant cell rich osteosarcoma

Osteosarcoma (fibrohistiocytic variant)

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Low-grade central osteosarcoma

Gnathic- Osteosarcoma

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Parosteal osteosarcoma

Multifocal osteosarcoma

Multifokal osteosarcoma

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Periosteal osteosarcoma

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Intracortical osteosarcoma.

High-grade surface osteosarcoma

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MRI

Gambaran MRI

menunjukkankortikal destruksi

dan adanya

massa jaringanlunak.

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Patologi Anatomi

Classic osteosarcoma in which there is abundant production of osteoid and bone

matrix in a lacy pattern into which the malignant cells are incorporated. Because

these sections usually are decalcified, the terms osteoid and immature bone are

interchangeable, especially if the imaging studies do not reveal the precise biopsy

site (H&E, 250).

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Diagnosa banding

1. Ewings sarcoma2. Osteomyelitis

3. Osteoblastoma

4. Giant cell tumor5. Aneurysmal bone cyst

6. Fibrous dysplasia

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Penatalaksanaan

Kemoterapi

Pembedahan

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