教育講演9 ここまで分かった樹状細胞の機能と役割 ZUA JID 2003 卵黄嚢由来前駆細胞 胎児肝臓由来単球 免疫感作 ランゲルハンス細胞は何を食べて育つか

{

COICOI

1.

2.

3.

4.

5.

6.

b a

dermal DC

Factor XIIIa staining

GM-CSF LCsM-CSF LCs Birbeck granules

M-CSF LCs Mollar ZUA JID 2003

b

Langerhans cells

CD1a+

CD207+

CD1c+ dDC

CD207-

CD1a+

CD141high dDC

XCR1+

(dDC)

York sac-derived myeloid precursors

Langerhans cells

CD207

CD11c

Pre-cDC

Blood LY6C++ monocyte

Monocyte-derived DC

CD64low/+

MERTK-/low

CCR2+

Macrophage

CD64+

MERTK+

CCR2-

XCR1+ dDC

DN dDC

CD11b+ dDC

Langerhans cells

CD1a+

CD207+

CD1c+ dDC

CD207-

CD1a+

CD141high dDC

XCR1+

inflammatory DC ()

IL-34-/- Wang et al. Nature Immunol, 2012

L14-OVAp model

(7,12-dimethylbenz[a]anthracene (DMBA))

DMBA-trans-3,4-diol

Chronic UVB Tape stripping

TPA

Clonal proliferation of p53 + keratinocytes Epidermal hyperplasia

20 IL-8 Luc

assay IL-8

ELISA

Nrf-2

Keratinosens

TG442D

TG442C

1.

2.

3.

4.