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教育講演9 ここまで分かった樹状細胞の機能と役割 ZUA JID 2003 卵黄嚢由来前駆細胞 胎児肝臓由来単球 免疫感作 ランゲルハンス細胞は何を食べて育つか

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  • {

    COICOI

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    6.

  • b a

  • dermal DC

    Factor XIIIa staining

  • GM-CSF LCsM-CSF LCs Birbeck granules

    M-CSF LCs Mollar ZUA JID 2003

  • b

  • Langerhans cells

    CD1a+

    CD207+

    CD1c+ dDC

    CD207-

    CD1a+

    CD141high dDC

    XCR1+

    (dDC)

  • York sac-derived myeloid precursors

    Langerhans cells

    CD207

    CD11c

    Pre-cDC

    Blood LY6C++ monocyte

    Monocyte-derived DC

    CD64low/+

    MERTK-/low

    CCR2+

    Macrophage

    CD64+

    MERTK+

    CCR2-

    XCR1+ dDC

    DN dDC

    CD11b+ dDC

  • Langerhans cells

    CD1a+

    CD207+

    CD1c+ dDC

    CD207-

    CD1a+

    CD141high dDC

    XCR1+

    inflammatory DC ()

  • IL-34-/- Wang et al. Nature Immunol, 2012

  • L14-OVAp model

  • (7,12-dimethylbenz[a]anthracene (DMBA))

    DMBA-trans-3,4-diol

    Chronic UVB Tape stripping

    TPA

    Clonal proliferation of p53 + keratinocytes Epidermal hyperplasia

  • 20 IL-8 Luc

    assay IL-8

    ELISA

    Nrf-2

    Keratinosens

    TG442D

    TG442C

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