!∀

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∗4∃&4(#0∋∗(#

,+∗4∃

,∗∋(∃ΦΗ∃%,2Η∃Χ#(:/∋Ι∃/;∃≅ϑ1#++#41#∃#(1Κ∃

– :∀∗(∃&(∃&.∃5∗4

,∗∋(∃ΦΗ∃%,2Η∃Χ#(:/∋Ι∃/;∃≅ϑ1#++#41#∃#(1Κ∃

#∃%∀&∋(∀)∗+∀

,  &∋(−∋∃./0∗1%2∀/∗1%∀∃0/3∗4.5∀

,  4∗∗3/∀06∀3∃%∀78∋9∀∋∃./0∗1%∀

,  &∋(2∀:4;1%∗1?≅3;Α∗6;Β∀4%?4%/%63;Α∗6∀∗:∀3∃%∀

∃≅1;6∀Χ∗∆.∀;/∀;6∀063%Ε4;3%∆Φ∀>∗1?Β%Γ∀;6∆∀∆.6;10>∀/./3%1∀∀

,  )∗+2∀>∗∗4∆06;Α∗6∀∗:∀%Η∗43/Φ∀0∆%6ΑΙ>;Α∗6∀∗:∀≅/%4∀6%%∆/Φ∀

/3;6∆;4∆/Φ∀∗63∗Β∗Ε0%/Φ∀3∗∗Β=03Φ∀;??Β0>;Α∗6Φ∀34;0606ΕΦ∀

∆0//%106;Α∗6∀

,  ϑ∗11≅603.∀Χ≅0Β∆06Ε∀;6∆∀#4;0606Ε∀

,  Κ∗6ΕΛ3%41∀/≅/3;06;Χ0Β03.∀Μ&∋(∀76/Α3≅3%Ν∀

∃Ο?2−−

&∋(Λ72∀Ρ04/3∀>;ΒΒ∀

Acronym Topic Project type

VPH NoE Networking N o E

VPHOP Osteoporo s i s I P

euHeart Heart/CV disease I P

ARTreat CV/Atheroschlerosi s I P

preDiC T Heart/CV disease STREP

ContraCancrum Cancer STREP

ARCH Vascular/AVF & haemodialys is STREP

PASSP O R T Liver/surgery STREP

Predic tAD Alzheimers/BM & diagnosis STREP

NeoMA R K Oral cancer/BM, D & T STREP

V P H 2 Heart/LVD surgery STREP

IMPPACT Liver cancer/RFA therap y STREP

HAMAM Breast cancer/diagnos is STREP

Action-Grid Grid access EU – LA & Balkans C A

RADICAL Security and privacy in V P H C A

!∀)∗+∀

Σ∀7∋/∀∀

Τ∀9#Υ+∋/∀

ς∀ϑΩ/∀

&∋(∀)∗+∀ϑ∗6/∗4Α≅1∀ΞΘ%4Θ0%%∀Μϑ)Υ9Φ∀7)Υ7ΩΦ∀+Υϑ7_Ν∀

ς∀9?;06∀Μ8∋ΡΦ∀7_7_Ν∀

!∀%41;6.∀Μ+_αΚ∀β+α7χΝ∀

!∀90;3%∀_%1Χ%4/∀

,  &∋(Λ76/Α3≅3%∀∀4%>%63Β.∀:∗≅6∆%∆∀;6∆∀6∗

#∃%∀&∋(∀#∗∗Β∴03∀

•  Ξ?%6∀1;4=≅?∀Β;6Ε≅;Ε%∀Μ]_ΚΝ∀/3;6∆;4∆/∀:∗4∀∆%/>40Χ06Ε∀∆;3;∀;6∆∀1∗∆%Β/∀;3∀/?;Α;Β∀/>;Β%/∀3∃;3∀4;6Ε%∀:4∗1∀?4∗3%06/∀3∗∀3∃%∀∃≅1;6∀∗4Ε;6∀

•  Ω??Β0>;Α∗6∀?4∗Ε4;1106Ε∀063%4:;>%/∀ΜΩ∋7/Ν∀:∗4∀01?Β%1%6Α6Ε∀3∃%/%∀&∋(∀/3;6∆;4∆/∀

•  γ∗4=η∗∃∀

•  γ%ΧΛ;>>%//0ΧΒ%∀4%?∗/03∗40%/∀:∗4∀∆;3;Φ∀1∗∆%Β/∀;6∆∀%∀>∗1?≅3;Α∗6;Β∀4∗≅Α6%/∀;6∆∀Ε4;?∃0>;Β∀≅/%4∀063%4:;>%/∀3∃;3Φ∀Θ0;∀3∃%∀Ω∋7/Φ∀>;6∀;>>%//∀3∃%∀∆;3;∀;6∆∀1∗∆%Β∀4%?∗/03∗40%/∀

!∀&∋(∀)∗+Φ∀ςΨΨΖ∀

Ζ∀

Τ,∆∃Υ∃(∀#∃≅ϑ#37+∗∋∃,∋/8#1(.∃

,  +Γ%1?Β;4∀∋4∗ι%>3/∀Μ+∋/ΝΦ∀;/∀>∗6>%0Θ%∆∀06∀⊥∗γ2∀∀

ϕ  %Γ0/Α6Ε∀?4∗ι%>3/Φ∀3/Ν∀

ϕ  λ/∗Β0∆∀%Γ;1?Β%/∀∗:∀∃∗40µ∗63;Β∀;6∆∀Θ%4Α>;Β∀1∗∆%Β−∆;3;∀063%Ε4;Α∗6λ∀

ϕ  ∆04%>3∀>∗11031%63∀3∗∀Β06=∀≅?∀%∀&∋(∀#∗∗Β∴03∀∆%Θ%Β∗?1%63Φ∀

:∗4∀∃∀3∃%.∀;4%∀Ε4;63%∆∀ςΩΦ∆∃,#∋./4?/4(∀.∃/;∃.)77/∋(∀:4∗1∀3∃%∀)∗+∀

,  +∋/∀1;063;06∀;∀3

Τ∀

&∋(∀)∗+∀+Γ%1?Β;4∀∋4∗ι%>3/∀

Name

seedEP1 SAPHIR: A multi-organ Core Model of arterial pressure and body fluids homeostasis

(CNRS, Evry)

seedEP2 IMUS: integrated multi-level modeling of the musculoskeletal system (ULB, IOR)

seedEP3 WHAM: "Modeling human disease in the presence of model and parameter

uncertainty" (KI)

seedEP4 Towards quantitative assessment of drug safety by multiscale and molecular simulation

tools (IMIM/GRIB)

seedEP5 Modeling and visualizing brain function and pathophysiology (ERCIM/ICS-Forth)

EP6 (Call 1) Establishing ontology-based methods to improve interoperability between data and

models for the VPH ToolKit: the Guyton case study (EBI, CNRS, UoA, Univ. Wash.)

EP7 (Call 2) CIGENE: Integrating genetic theory and genomic data with multiscale models in a

population context

EP8 (Call 2) The NoE, Infrastructure and the Challenge of Call6

EP9 (Call 2) VIP for VPH : Execution of medical image simulation workflows on DEISA through

workflow interoperability between the Virtual Imaging Platform and the VPH toolkit

EP10 (Call 3) Environment for Sexually Transmitted Infection Modelling

EP11 (Call 3) Vascular Tissue Modelling Environment (VTME)

&∋(∀#4;0606Ε∀;>ΑΘ0Α%/∀

&∋(Λ_7∋∀ΞΘ%4Θ0%;Β∀(≅1;6∀9>0%6Α/3/∀

76∆≅/34.ΛΩ>;∆%10;∀_%%Α6Ε∀

α;4>%Β∗6;Φ∀ςΤ3∃∀9%?3%1Χ%4∀ςΨ!!∀

&∋(Λ_7∋2∀_∗ΑΘ;Α∗6/∀

•  :(∋74∃6);4#∃/∀Μ&∋(Ν∀0/∀;6∀%1%4Ε06Ε∀∆0/>0?Β06%∀∃∀;01/∀;32∀

–  ?∋&∃2/%)∃)#&7;Β%∀;6∆∀1≅ΒΑΛ?∃./0>/∀∀

1∗∆%ΒΒ06Ε∀∗:∀∃≅1;6∀?∃./0∗?;3∃∗Β∗Ε.∀

!  901≅Β;Α∗6∀∗:∀>∗1?Β%Γ∀>Β060>;Β∀

&∋(Λ_7∋2∀Υ;Α∗6;Β%∀

•  76∀/≅>∃∀;∀1≅ΒΑ∆0/>0?Β06;4.∀Ι%Β∆Φ∀/3≅∆%63/∀1≅/3∀

4%>%0Θ%∀;∀/∗Β0∆∀/>0%6ΑΙ>∀Χ;>=Ε4∗≅6∆∀0:∀3∃%.∀;4%∀

3∗∀1;=%∀:≅3≅4%∀>∗6340Χ≅Α∗6/∀

•  #∃≅/Φ∀34;0606Ε∀/∃∗≅Β∆∀Χ%∀Χ;/%∆∀∗6∀%Γ0/Α6Ε∀

_;/3%4/∀?4∗Ε4;11%/∀06∀4%Β;3%∆∀∆0/>0?Β06%/∀

–  +ΕΠ∀α0∗06:∗41;Α>/Φ∀Χ0∗1%∆0>;Β∀%6Ε06%%406ΕΦ∀

1;3∃%1;Α>;Β∀1∗∆%Β06Ε∀

•  +Γ0/Α6Ε∀?4∗Ε4;11%/∀1≅/3∀Χ%∀>∗1Χ06%∆∀3∗∀

>∗1?Β%1%63∀%;>∃∀∗3∃%4Φ∀;6∆∀%Γ3%6∆%∆∀3∗∀

;∆∆4%//∀&∋(Λ/?%>0Ι>∀34;0606Ε∀6%%∆/∀

&∋(Λ_7∋2∀ϑ≅44%63∀9>%6;40∗∀

•  _;/3%4/∀?4∗Ε4;11%/∀

Χ%06Ε∀063%Ε4;3%∆∀063∗∀

3∃%∀:4;1%∗63%63∀

•  7∆%6Α:.∀%Γ0/Α6Ε∀∀&∋(Λ4%Β;3%∆∀1∗∆≅Β%/∀

•  7∆%6Α:.∀%//%6Α;Β∀Ε;?/∀

06∀34;0606Ε∀

•  :;>8?.∋&2∀∗6ΛΒ06%∀

1∗∆≅Β%/∀%//%6Α;Β∀:∗4∀

&∋(∀34;0606Ε∀

&∋(Λ_7∋2∀+Γ?%>3%∆∀Ξ≅3>∗1%/∀

•  Ω∀:4;1%∃∀:4;1%∗6>%46/∀

•  Ξ4

≅Ζ∃Α,[∃,∋/8#1(∃∴]ΟΝΖΟ,Ξ⊥ΞΝ_Η∃=8#1>α#.∃Θ∃Ζ//7#∋∗>/4∃

!∀#∃%&∋&()∗∃+)(,(∃

!−.)/01∃)∃23(3/#∃−4∃5#0&6)∗∃78)()/1∃

16

ΦΓ  Η.)0∃∗74∋&)∃/5)34∃/2≅=)7&∃673∀

  α%Ε06/∀Ξ>3∗Χ%4∀ςΨ!!∀

  ϑ∗6/≅ΒΑ6Ε∀;/∀∃∀0:∀.∗≅θ4%∀063%4%/3%∆∀

  =Π1Π1>>∗41;>=ρ/∃%σ%Β∆Π;>Π≅=∀∀

17

  &∋(2∀;∀Ε4;6∆∀?Β;6∀3∗∀1;=%∀;ΒΒ∀∃≅1;6∀?∃./0∗Β∗Ε.∀>∗1?≅3;ΧΒ%∀

  #∃%∀>∗1?≅3%4∀1∗∆%Β/∀4%?4%/%63∀;6∀063%Ε4;Α∗6∀∗:5∀∀

  91;ΒΒ∀;6∆∀Β;4Ε%∀

  Ρ;/3∀;6∆∀/Β∗0?Β06%/∀

  ΩΒΒ∀1∗∆%Β/∀?%4/∗6;Β0/%∆Φ∀>;6∀Χ%∀063%4>∗66%>3%∆∀

  Ξ≅3?≅3/∀;4%∀%6∃;6>%∆∀∆0;Ε6∗/Α>∀φ∀34%;31%63∀∗?Α∗6/∀

  +Γ;1?Β%2∀/∃∗≅Β∆∀

Βα∗(∗∋.Η∃Β∃∋#3&4%63∀∗:∀;∀∆%03.∀

3∗∀3∃%∀%;43∃∀06>;46;3%Π∀

ςΠ∀Ρ4∗1∀∃2∀Ω6∀%1Χ∗∆01%63∀∗4∀

?%4/∗60Ι>;Α∗6Φ∀;/∀∗:∀;∀?406>0?Β%Φ∀;ϖ3≅∆%Φ∀∗4∀

Θ0%∃6∗Β∗Ε.2∀Ω∀Ε4;?∃0>;Β∀

4%?4%/%63;Α∗6∀∗:∀;∀?%4/∗6Π∀

Τ∀∗(∃.∀/)+

&∋(2∀9≅11;4.∀∗:∀∋;43∀!∀

•  Ω∀1;ι∗4∀+≅4∗?%;6∀;6∆∀063%46;Α∗6;Β∀%Η∗43∀:∗4∀>∗ΒΒ;Χ∗4;Α∗6∀;6∆∀063%4∗?%4;Χ0Β03.∀

–  &∋(∀)∗+Φ∀&∋(Λ7∀?4∗ι%>3/Φ∀&∋(∀76/Α3≅3%Φ∀78∋9∀∋∃./0∗1%∀

•  _∗∆%Β/Φ∀∆;3;Χ;/%/Φ∀4%?∗/03∗40%/Φ∀1;4=≅?∀Β;6Ε≅;Ε%/Φ∀4%:%4%6>%∀∗63∗Β∗Ε0%/∀

•  #4;0606Ε∀

–  &∋(Λ_7∋∀

–  &∋(∀#%Γ3Χ∗∗=∀

•  5∀

,∗∋(∃∆Η∃ΝΒ,2ΟΠ∃Θ∃Π#4∗+∃,∀−.&/3#∃

ΝΒ,2ΟΠΗ∃Ν1>Ψ1∃Ζ/4(#ϑ(∃

•  9Ω∋(7Υ2∀Ρ4%6>∃∀Ω)Υ∀;6∆∀;6∀+Γ%1?Β;4∀∋4∗ι%>3∀06∀3∃%∀&∋(∀

)%3%ΒΒ%6>%∀

•  ⊥%Θ%Β∗?∀;∀>∗ΒΒ;Χ∗4;ΑΘ%∀λ>∗4%∀1∗∆%ΒΒ06Ε∀%6Θ04∗61%63λ∀:∗4∀

1≅ΒΑΛ∗4Ε;6∀063%Ε4;3%∆∀?∃./0∗Β∗Ε.∀

–  3;4Ε%3∀?4∗ΧΒ%12∀4%Ε≅Β;Α∗6∀∗:∀ΧΒ∗∗∆∀?4%//≅4%∀;6∆∀η≅0∆/∀

∃∗1%∗/3;/0/∀

•  ϑ∗ΒΒ;3%4;Β∀6%%∆/2∀

–  1≅ΒΑΛ4%/∗Β≅Α∗6Φ∀1≅ΒΑΛ:∗41;Β0/1∀6≅1%40>;Β∀?;>=;Ε%∀

–  >∗11∗6∀Β;6Ε≅;Ε%∀:∗4∀1∗∆%Β∀∆%/>40?Α∗6−34;6/Β;Α∗6∀

–  ∆;3;Χ;/%∀3∗∀≅6∆%4?06∀?;4;1%3%4∀%/Α1;Α∗6∀;6∆∀1∗∆%Β∀Θ;Β0∆;Α∗6∀

–  ∗63∗Β∗Ε.∀∆%Θ%Β∗?1%63∀∀

•  3∗∀/3;6∆;4∆0µ%∀6∗1%6>Β;3≅4%∀

•  3∗∀%6;ΧΒ%∀;∆∗?Α∗6∀∗:∀4%:%4%6>%∀0∆%6ΑΙ%4/∀;>4∗//∀/>;Β%/−1∗∆%Β/−

⊥α/ΠΠΠ∀

BIOSYS 2006

!/:∗∋

(∀&∋.(∃

Β]2∃

1/4(∋/+∃

>..)#∃χ)&

ς[∀

• ∃∋#0)+∗(/∋−∃.−.(#3.∃∗1(∃

/α#∋∃3#∃.1∗+#.∃

from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.

Γ+///4Η∃3)+>Ω/∋0∗4∃&4(#0∋∗>/4∃

∃∃∃∃∃∃∃∃∃∃Ω∃3∗4−∃.−.(#3.∃∗∋#∃&4α/+α#

ςε∀

• ∃∋#0)+∗(/∋−∃.−.(#3.∃∗1(∃/α#∋∃

3#∃.1∗+#.∃

• ∀∗4/4∃

∃∃∃∃∃∃∃∃∃∃Ω∃3∗4−∃.−.(#3.∃∗∋#∃&4α/+α#

26

from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.

Ο4∃(∀#∃+/40Ω(#∋39∃:#∃3).(∃=#∃&4∃:∗(#∋∃∗4

from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders. ςω∀

Defects of renal transporters are implicated in health problems.

These are pharmacological targets with inter-connected relationships.

ςΖ∀

Μ_%6%3∗6Φ∀∋Π∀%3∀;ΒΠ∀ΜςΨΨεΝΠ∀∋∃./0∗Β∀Υ%Θ∀ΖεΜςΝ2∀ξωΤΛω!εΠΝ∀

Gittelman’s syndrome: PA↓, RAAS ↑ compensation par ENaC Gordon’s syndrome:

(PHA typeII)

PA ↑ PRA & Aldo ↓

Bartter’s syndrome:

PA ↓ , PRA ↑ & Aldo ↑

α-adducin: essential hypertension

!∗∋0#(∃.1#4∗∋&/Η∃2−7#∋(#4.&/4γ]#;#1(.∃/;∃]&.(∗+∃!)=)+#∃Χ∗Ζ+∃∋#∗=./∋7>/4Κ∃

2/:∃(/∃3//4.∀&7Μ∃

Τ#∃3).(∃∗11/)4(∃;/∋Η∃

•  3∃%∀>∃;6Ε%∀∗:∀:≅6>Α∗6∀;3∀3∃%∀1∗Β%>≅Β;4−∀>%ΒΒ∀1%1Χ4;6%∀

Β%Θ%Β∀

–  3∃%4;?%≅Α>∀3;4Ε%3∀

•  3∃%∀01?;>3∀∗6∀ΧΒ∗∗∆∀Θ∗Β≅1%Φ∀Θ0;∀);ϑΒ∀4%;Χ/∗4?Α∗6∀

•  3∃%∀4%/≅ΒΑ6Ε∀%Η%>3∀∗6∀ΧΒ∗∗∆∀?4%//≅4%∀

•  ∃∗41∗6;Β∀;6∆∀6%4Θ∗≅/∀/./3%1∀:%%∆Χ;>=/∀

–  Μ06>Β≅∆06Ε∀?∗//0ΧΒ%∀%Η%>3/∀∗6∀%Γ?4%//0∗6∀∗:∀3∃%∀3;4Ε%3∀Ε%6%ψΝ∀

ΓΞ!∃Ι##7∃#ϑ#1)>/4∃>3#∃3∗4∗0#∗=+#η∀

_ς9Κ2∀1462≅.∋#∃6(−#)14626&∆&6−)Λ(#46∃2./)Μ(Χ∋∃∋=Ν∀∀∀ΩΠ∀(%46;6∆%µΜΥ%66%/Ν∀

Ξ⊥+−∋⊥+∀

Ρ+_∀

_≅ΒΑΛΩΕ%63∀_∗∆%Β/∀

ϑ%ΒΒ≅Β;4∀Ω≅3∗1;3;∀

_ς9Κ∀

Κ#97∀

Synchronisation & simulation

adaptatives

Synchronisation &

simulation à pas fixe

Synchronisation à pas fixe &

simulation adaptative

#%1?∗4;Β∀∀

9.6>∃4∗60µ;Α∗6∀

76?≅3−∗≅3?≅3∀

>∗≅?Β06Ε∀

temps

O2 I1

M2 M1

I1 O2

?)+>Ω;/∋3∗+&.3∃3//4∀

, ∀(0%4;4>∃0>;Β∀/34≅>3≅4%∀∀

, ∀ΞΧι%>3Λ∗40%63%∆∀∀

, ∀⊥0/340Χ≅3%∆∀;??4∗;>∃∀

Modèle

couplé Coordinateur

Modèle

couplé

Modèle

atomique

Modèle

atomique

Modèle

atomique Coordinateur

Simulateur Simulateur

Simulateur

Ρ∗41;Β0/1%∀ϑ∗6Α6≅∀ Ρ∗41;Β0/1%∀⊥0/>4%3∀

(0ζ4;4>∃0%∀∆%∀1∗∆{Β%/∀ (0ζ4;4>∃0%∀∆%∀/01≅Β;3%≅4/∀

_ς9Κ2∀1462≅.∋#∃6(−#)14626&∆&6−)Λ(#46∃2./)Μ(Χ∋∃∋=Ν∀∀∀ΩΠ∀(%46;6∆%µΜΥ%66%/Ν∀

α%6>∃1;4=∀ϕ∀Ω∆;?ΑΘ%∀∗≅?Β06Ε∀

⊥#∀060Α;Β0µ%∆∀3∗∀!%Λ[Φ∀>∗≅?Β06Ε∀|∀ςΠε%Λ[Φ∀1;Γ∀;Χ/Π∀+44∀|∀ε%Λ!Σ∀

+Γ%>≅Α∗6∀Α1%∀ιΚ∆∃.#1.∃Η∀ϕ∃ι∃>3#.∃;∗.(#∋∃(∀∗4∃∗∃.(∗4

?∆Ν⊥∃Ξ.#∋∃Ο4(#∋;∗1#∃

• ∀Ζ/4(∋/+∃?∆Ν⊥∃.&3)+∗>/4Κ∃

• ∀_;60?≅Β;3%∀_ς9Κ∀/01≅Β;Α∗6∀?;4;1%3%4/Π∃

• ∀ϑ∃;6Ε%∀1∗∆%Β∀?;4;1%3%4/∀Χ%:∗4%∀;6∆∀∆≅406Ε∀/01≅Β;Α∗6Π∀

• ∀ΞΧ/%4Θ%∀1∗∆%Β∀∃0%4;4>∃.∀;6∆∀Θ;40;ΧΒ%/∀Μ06?≅3/Φ∀∗≅3?≅3/Φ∀?;4;1%3%4/Ν∀06∀4%;ΒΛΑ1%Π∀

• ∀9%;4>∃∀Θ;40;ΧΒ%/∀Χ.∀6;1%Π∀

• ∃⊥/∗

87/∀:∗4∀⊥Ω+_Κ∀φ∀_ς9Κ∀

%6%4;Α∗6∀∗:∀;6∀

]_Κ∀Μ⊥Ω+_ΚΝ∀ΙΒ%∀

]9Κ#∀

_ς9Κ∀ΜϑυυΝ∀ α_∀

_;=%ΙΒ%∀∀

_ς9Κ2∀

);ΑΘ%∀Β0Χ4;4.∀

(#_Κ∀

_;3Β;Χ∀

_∗∆≅Β;4∀/./3%1/Λ1∗∆%Β∀∗:∀ΧΒ∗∗∆∀?4%//≅4%2∀Χ4%;=∆∗%1%63∀1∗∆%Β/∀:∗4∀

06∆0Θ0∆≅;Β∀1∗∆≅Β%/2∀∀

∀,∀ϑ&9Φ∀Β≅6ΕΦ∀=0∆6%.∀

Model

Properties

Operations

TissueE!ect

Properties

Operations

ThirstDrinking

Properties

Operations

RedBloodCells

Properties

Operations

PulmonaryDynamics

Properties

Operations

PlasmaTissue

Properties

Operations

MuscleBloodFlow

Properties

Operations

LocalBloodFlowControl

Properties

Operations

KidneySaltOut

Properties

Operations

Kidney

Properties

Operations

Hemodynamics

Properties

Operations

HeartViciousCycle

Properties

Operations

HeartRate

Properties

Operations

HeartHypertrophy

Properties

Operations

Guyton

Properties

Operations

GelProtein

Properties

Operations

GelFluid

Properties

Operations

Electrolytes

Properties

Operations

CapillaryMembrane

Properties

Operations

BloodViscosity

Properties

Operations

AutonomicControl

Properties

Operations

AntidiureticHormone

Properties

Operations

AngioControl

Properties

Operations

AldoControl

Properties

Operations

AdaptBaroreceptor

Properties

Operations

VascularStressRelax…

Properties

Operations

]#(∗&+#Ω.1∗+#∃#ϑ(#4.&/4.∃∗4

_∗∆≅Β;4∀/./3%1/Λ1∗∆%Β∀∗:∀ΧΒ∗∗∆∀?4%//≅4%2∀∀

∴0∆6%.∀1∗∆≅Β%∀

≅.3∗6Φ∀ΩΠϑΠΦ∀#ΠΠ∀ϑ∗Β%1;6Φ∀;6∆∀(Π}Π∀4;6Ε%4Φ∀λϑ04>≅Β;Α∗62∀ΞΘ%4;ΒΒ∀4%Ε≅Β;Α∗6Πλ∀∀

Ω66≅;Β∀Υ%Θ0%1∃

α∗./1/4.(∋&1(/∋∃#Ρ#1(∃/4∃

∗∋(#∋.∃

%Ο?Η∃Γ+//1∃7∋#..)∋#∃

,,ΖΗ∃7+∗.3∗∃Ζ,∃

ΠΓΑΗ∃Π#4∗+∃Γ+///4∃

ΖΧ≅Η∃(∀&∋7+∋∃

Β?Η∃∗+7+∋∃

Ξ!,Ξ!Ν∃

Χ]Η∃∋∗(#∃/;∃∋#4∗+∃Χ∗µ∃

#ϑ1∋#>/4∃

%Ξ]Η∃∋∗(#∃/;∃)∋&4#∃/)(7)(

%Ο?∃,Β∃

,,Ζ∃ΠΓΑ∃ Π≅β∃ Χ]∃

%Ξ]∃

ΖΧ≅Β2?∃Β?∃

ΒΞ?∃

afferent,

efferent, &

resistance

glomerular

volume

sodium

reabsorption/

excretion

renal blood flow

_∗∆≅Β%∀ΥΩΩ9∀∀ΜΥ%606ΛΩ6Ε0∗3%6/06ΛΩΒ∆∗/3%4∗6%Λ9./3%1Ν∀

ΡΠ∀≅0ΒΒ;≅∆∀φ∀∋Π∀(;66;%43∀Μ∋∗0Α%4/Ν∀

∋406>0?;Β∀9∗≅4>%/2∀αΥ+)⊥Ω∀∼∀9>∃.6#&∋)&7)∃6ΓΟ)ΩΞΞΘ)Ρ)Τ.∗∗)&7)(Σ./∃Ο)ΩΞΞΖ)Ρ)Σ64#&/≅&65)&7)∃6ΓΟ)

ΩΞΞΞ)Ρ);&∋−−./)&7)∃6ΓΟ)ΦΠΠα)Ρ)Σ∃5&∋)&7)ς∃/7&/Ο)ΦΠΠΠ)Ρ)ς∋β/Χ&∋%&∋)&7)∃6ΓΟ)ΦΠΠ_)Ρ)χ∋2δ8?∃∗(−∃/.)&7)∃6ΓΟ)ΦΠΠ_)Ρ)χ∋2δ8?∃∗(−∃/.)&7)∃6ΓΟ)ΦΠΠΘ)Ρ);&28;&7&∋5()&7)∃6ΓΟ)ΦΠΠα)Ρ)

Η∃4%/&∋)&7)∃6ΓΟ)ΩΞ⊥Ω)Ρ)Η∃4%/&∋)&7)∃6ΓΟ)ΩΞ⊥α)Ρ)Λ&34&(∋∃)Με∗&δ)&7)∃6ΓΟ)ΦΠΠα)Ρ);&/7δ)&7)∃6ΓΟ)ΦΠΠΘΓΓΓ))

:4∗1∀δ)&++∗)04>≅Β;Α6Ε∀4%606Λ

;6Ε0∗3%6/06∀/./3%1∀;6∆∀ΧΒ∗∗∆∀?4%//≅4%∀4%Ε≅Β;Α∗6Πλ∀Ω>3;∀α0∗3∃%∗4∀εΖΜςΛΣΝ2∀![ΣΛ!ωΨΠ∀

ως∀Θ/Π∀Τς∀Θ/Π∀ΥΩΩ9∀1∗∆%Β∀

(0Ε∃%4ΛΥ%/∗Β≅Α∗6∀1∗∆%Β/2∀∀

∋≅Β/;ΑΒ%∀1∗∆%Β/∀∗:∀3∃%∀∃%;43∀ΜΚ#97Ν∀

–  +;>∃∀Θ%6340>Β%∀0/∀4%?4%/%63%∆∀;/∀;∀/06ΕΒ%∀

>∗634;>ΑΒ%∀%Β%1%63Φ∀Χ.∀1%;6/∀∗:∀;∀Θ;40;ΧΒ%∀

%Β;/3;6>%∀1∗∆%Β∀

•  8/06Ε∀1∗Θ06Ε∀;Θ%4;Ε%∀063%4:;>%∀>∗1?∗6%63/∀

:∗4∀06?≅3Λ∗≅3?≅3∀>∗≅?Β06Ε∀3∀>∗≅?Β06Ε∀:∗4∀;∀:≅ΒΒΛ?≅Β/;ΑΒ%∀Θ%4/0∗6∀

Μ4%ν≅0406Ε∀4%Λ0∆%6ΑΙ>;Α∗6∀∗:∀3∃%∀ως∀

?;4;1%3%4/Ν∀

Ω∀∃0Ε∃%4Λ4%/∗Β≅Α∗6∀Ρ+_∀1∗∆%Β∀∗:∀3∃%∀Κ&∀

063%Ε4;Α6Ε2∀

Ω∀?;Α%63Λ/?%>0Ι>∀Ε%∗1%34.∀∗Χ3;06%∆∀:4∗1∀ϑ#∀01;Ε%/∀

Ω∀1∗4%∀∆%3;0Β%∆∀%Β%>34∗Λ1ζ>;6∗Λ∃.∆4;≅Β0>∀1∗∆%Β∀

_∗Θ06Ε∀;Θ%4;Ε%∀063%4:;>%∀

Τς∀9%6/0ΑΘ03.∀;6;Β./0/∀;6∆∀

Ε%6%4;Α∗6∀∗:∀;∀&043≅;Β∀∋∗?≅Β;Α∗6∀

• )#∗∀%6;ΧΒ%∀>∗1?;40/∗6∀∗:∀;Β3%46;ΑΘ%∀∗4∀1∗4%∀∆%3;0Β%∆∀

1∗∆≅Β%/)

• ∀Ω/∀;∀Ε≅0∆%∀:∗4∀(/)−(6(0.∀%Γ?Β∗4;Α∗6∀∗:∀∆4≅Ε∀%Η%>3/Φ∀Ε%6%Α>∀?∗Β.1∗4?∃0/1/Φ∀%3>Π∀

• ∃Ολ∃3∗7.∃/;∃(∀#∃∆ν∃3/∃∀1∗∆≅Β%2∀?Β∗3/∀∗:∀;ΒΒ∀∗≅3?≅3∀Θ;40;ΧΒ%/∀;/∀:≅6>Α∗6∀∗:∀%;>∃∀06?≅3Φ∀

∗Θ%4∀;∀4%Β%Θ;63∀?∃./0∗Β∗Ε0>;Β∀4;6Ε%∀∗:∀Θ;Β≅%/∀

• ∀Ζ/37∋#∀#4.&α#∃.#4.&>α&(−∃∗4∗+−.&.∀Μ7α79ϑ∀3%;1Ν∀

• 9%6/0ΑΘ03.∀∗:∀ςΤω∀/./3%1∀Θ;40;ΧΒ%/∀3∗∀%;>∃∀∗:∀Τξ∀/%Β%>3%∆∀?;4;1%3%4/∀;3∀

ε∀106ΠΦ∀!∃Φ∀!∆;.Φ∀;6∆∀[∀;Β>≅Β;3%∆∀

• ∀#∃0/∀0/∀∆∗6%∀:∗4∀/.∋#∃6∀/3%;∆.∀/3;3%∀;6∆∀;Β/∗∀Μ3%Ν∀:∗4∀!ΨΨΨ∀Γ∀Τξ∀

4;6∆∗10µ%∆∀λ06∆0Θ0∆≅;Β/λ∀ΜMorris. 1991. "Factorial Sampling Plans for Preliminary Computational Experiments." Technometrics, 33(2): 161-174)∀

• ∀γ%∀∃;Θ%∀3∃≅/2∀

• ∀Θ043≅;Β∀?∗?≅Β;Α∗6∀∗:∀%6ΘΠ∀εΨΨ∀ΨΨΨ∀4;6∆∗10µ%∆∀06∆0Θ0∆≅;Β/Φ∀;6∆∀

• ∀1%;6∀∀9⊥∀∗:∀3∃%∀%Η%>3∀∗:∀%;>∃∀?;4;1%3%4∀∗6∀%;>∃∀Θ;40;ΧΒ%Φ∀;6∆∀

;Β/∗∀%/Α1;3%/∀063%4;>Α∗6/∀;1∗6Ε∀3∃%∀?;4;1%3%4∀%Η%>3/∀Μ>∗Θ;40;6>%∀

;6;Β./0/∀?4∗Θ0∆%/∀∆%3;0Β/Ν∀

δ)−(/4∃5δε∆6Η∃Ζ/37∋#∀#4.&α#∃Ν#4.&>α&(−∃∗4∗+−.&.ΚΚΚ∃

δε∆∃0+/=∗+∃.#4.&>α&(−∃∗4∗+−.&.∃λ∃%;3?Β∗3/λ∀∗:∀1%;6/∀∗:∀%Β%1%63;4.∀%Η%>3/∀

[Σ∀

Θ;40;ΧΒ%/∀

?;4;1%3%4/∀

?;4;1%3%4/∀

Θ;40;ΧΒ%/∀

?#∗4∃α∗+)#.∃/;∃(∀#∃4/∋3∗+&ο#∃;6Ε%∀∗:∀Θι∀∃;6Ε%∀∗:∀%;>∃∀?;4;1%3%4∀Μ∗6%Λ;3Λ;ΛΑ1%Φ∀!Ψ∀

∗:∀;ΒΒ∗3/∀;4%∀/∃∗∃;6Ε%Φ∀;/∀1;4=%∆Π∀#∃%∀Ε4;?∃∀0/∀34≅6>;3%∆∀;3∀∀!Π∀∀

∀∀∀ϑΒ%;4Β.Φ∀3∃%∀?;Ο%46/∀>∃;6Ε%∀∃∀?;4;1%3%4∀Μ∗6%Λ;3Λ;ΛΑ1%Φ∀!Ψ∀

∗:∀;ΒΒ∗3/∀;4%∀/∃∗∃;6Ε%Φ∀;/∀1;4=%∆Π∀#∃%∀Ε4;?∃∀0/∀34≅6>;3%∆∀;3∀∀!Π∀∀

∃∃∃Ζ+#∗∋+−9∃(∀#∃7∗π#∋4.∃1∀∗40#∃:&(∀∃>3#∃∗θ#∋∃(∀#∃7∗∋∗3#(#∋∃7#∋()∋=∗>/4.Κ∃∃

λ_∗440/∀?Β∗3/λ∀∗:∀1%;6/∀;6∆∀/3;6∆;4∆∀∆%Θ0;Α∗6/∀Μ9⊥+&Ν∀∗:∀

6∗41;Β0µ%∆∀%Η%>3/∀∗:∀;ΒΒ∀?;4;1%3%4/∀∗6∀3∃%∀Θ;40;ΧΒ%∀

λ∋Ωλ∀∗(∃;/)∋∃>3#.∃∗θ#∋∃7#∋()∋=∗>/4∃

≅ϑ∗37+#∃/;∃.#4.&>α&(−∃∋#.)+(.∃;/∋∃∃

(∀#∃α∗∋&∗=+#∃ρ,Βρ∃5∗∋(#∋&∗+∃=+///4∃/;∃∗++∃ες∃3/

λ_∗440/∀?Β∗3/λ∀∗:∀1%;6/∀;6∆∀/3;6∆;4∆∀∆%Θ0;Α∗6/∀Μ9⊥+&Ν∀∗:∀

6∗41;Β0µ%∆∀%Η%>3/∀∗:∀;ΒΒ∀?;4;1%3%4/∀∗6∀3∃%∀Θ;40;ΧΒ%∀λ∋Ωλ∀∗(∃

;/)∋∃>3#.∃∗θ#∋∃7#∋()∋=∗>/4∃Μϑ)Υ2∀4%:%4%6>%∀/∗∆0≅1∀>∗6>%634;Α∗6∀3∗∀∆%3%4106%∀Ω⊥(∀/%>4%Α∗6∀4;3%Ν∀

≅ϑ∗37+#∃/;∃.#4.&>α&(−∃∋#.)+(.∃;/∋∃∃

(∀#∃α∗∋&∗=+#∃ρ,Βρ∃5∗∋(#∋&∗+∃=+///4∃/;∃∗++∃ες∃3//4.∃:&(∀∃/(∀#∋∃

7∗∋∗3#(#∋.∃∀

ΨΠΨ∀1%;6/∀∀9⊥+&∀

?;4;1%3%4/∀

#Ρ#1(.∃/4∃,Β∀

ϑ)Υ∀

1/α∗∋&∗41#∃/;∃ΖΧΠ∃

#Ρ#1(.∃:&(∀∃∗++∃

/(∀#∋∃7∗∋∗3#(#∋.∀

76∀;∆∆0Α∗6∀3∗∀3∃%∀/%6/0ΑΘ03.∀;6;Β./0/2∀

Κ;4Ε%∀∋∗?≅Β;Α∗6∀∗:∀∀

λ&043≅;Β∀Μ≅.3∗6Ν∀76∆0Θ0∆≅;Β/λ∀

Υ;6∆∗10µ%∆∀?;4;1%3%4/∀"∀;6;Β∗Ε∗≅/∀3∗∀λ%&/.7=∗&λ∀

#∃0/∀4%/≅Β3/∀06∀;∀Θ;40%3.∀∗:∀Θ043≅;Β∀λ∗

_≅ΒΑ?Β∗3/∀3∗∀Θ0/≅;Β0µ%∀/%6/0ΑΘ03.∀4%/≅Β3/∀

%&∋()∗+∃ρδ)−(/4Ω7/7)+∗>/4ρΗ∃∃,∗∋∗3#(#∋.∃3/.(∃&37+&1∗(#/4∃

∀!Τς∀ΨΨΨ∀λΘ043≅;Β∀06∆0Θ0∆≅;Β/λ∀/4∃;/∋∃7∋/(#&4∃/4∃

βΠδΧ ∃0∗&4∃/;∃7/.&>α#∃;##

• ∀Θ043≅;Β∀?∗?≅Β;Α∗6∀

∗:∀ςΨΨ∀ΨΨΨ∀Θ043≅;Β∀

06∆0Θ0∆≅;Β/∀"∀

%Γ?Β∗4;Α∗6∀∗:∀6∗Θ%Β∀

4%Β;Α∗6/∃0?/∀;1∗6Ε∀

3∃%∀?Β%3∃∗4;∀∗:∀

?;4;1%3%4/∀φ∀

Θ;40;ΧΒ%/∀

γ%Χ∀063%4:;>%∀:∗4∀∆;3;Χ;/%∀∗:∀/%6/0ΑΘ03.∀4%/≅Β3/∀

∗6/34≅>Α∗6∀∗:∀;∀Ε4;?∃∀∗:∀1∗∆%ΒΛ/34≅>3≅4%∀

QKDB (Quantitative Kidney DataBase)

Ζ+&1Ι&40∃/4∃/4#∃/;∃(∀#∃∋#;#∋#41#.∃

=∋&40.∃)7∃∗∃;Β∀:%;3≅4%/Φ∀34;6/?∗43∀?;4;1%3%4/Φ∀η∗∗6>%634;Α∗6/Φ∀34;6/?∗43%4∀=06%Α>/Φ∀%3>Π∀

⊥.6;10>∀/>4∗ΒΒΛ∆∗∗6340Χ≅3%∆∀Χ.∀

3∃%∀∃∀>∗11≅603.∀

QKDB : what's there?

QKDB (Quantitative Kidney DataBase) %∀

•  Χ%Ο%4∀063%Ε4;Α∗6∀063∗∀∗3∃%4∀4%/∗≅4>%/∀

•  6%/Θ∀ΙΒ%/∀

–  ;≅3∗1;Α>;ΒΒ.∀Ε%6%4;3%∀Ε4;?∃/∀∗:∀/%;4>∃∀4%/≅Β3/∀

–  76>∗4?∗4;Α∗6∀∗:∀6%Β%/∀

Ω≅3∗1;Α>∀06:∗41;Α∗6∀%Γ34;>Α∗6∀Χ;/%∆∀∗6∀ο∴⊥α∀∆%/>40?3∗4/∀Ω66%ΛΚ0/%∀_06;4∆Φ∀Υζ10∀⊥%Β∗41%Φ∀α40Ε0Ο%∀4;≅Φ∀Ω66%ΛΚ;≅4%∀Κ0Ε∗µ;3∀Μ+)977+Ν∀

ΞΧι%>ΑΘ%/2∀

Α∋/3∃3∗4−∃0//;Βλ∀1∗∆%Β/∀∗:∀=0∆6%.∀:≅6>Α∗6∀• ∀≅.3∗6∀1∗∆%Β/∀∗:∀α∋∀4%Ε≅Β;Α∗6∀

• ∀7=%∆;∀1∗∆%Β∀∗:∀;>0∆ΛΧ;/%∀4%Ε≅Β;Α∗6∀

• ∀∆;3;∀:4∗1∀>Β060>;Β∀340;Β/∀;6∆∀?∗?≅Β;Α∗6∀/3≅∆0%/∀• ∀:≅6>Α∗6;Β∀∆;3;∀:4∗1∀%Γ?%401%63;Β∀1∗∆%Β/∀

• ∀?∗;Β∀3∗∗Β/∀Μ5∀_ς9Κ5Ν∀• ∀3;Β%63%∆∀>∗ΒΒ;Χ∗4;3∗4/∀

• ∀5∀

!/:∗∋0%/∀∗:∀%Γ?%401%63;Β∀1∗∆%Β/Ν∀

• ∀λ4%Λ≅/%;ΧΒ%λΦ∀≅1%63%∆Φ∀/3;6∆;4∆/ΛΧ;/%∆Φ∀%3>ΠΦ∀:∗4∀3∃%∀∋∃./0∗1%−&∋(∀

763%4;>ΑΘ%∀87∀:∗4∀_ς9Κ∀1∗∆%Β/∀

Modèle

couplé Coordinateur

Modèle

couplé

Modèle

atomique

Modèle

atomique

Modèle

atomique Coordinateur

Simulateur Simulateur

Simulateur

Formalisme Continu Formalisme Discret

Hiérarchie de modèles Hiérarchie de simulateurs _ς9Κ∀∀

tubule transport models built-up from kinetic descriptions of transporters

counter-current recycling in medullary nephron loops and blood vessels

=0∆6%.∀1∗∆%Β/∀;3∀1;6.∀/>;Β%/∀

SAPHIR & BIMBO collaborators

IBISC (FRE 3190) & IR4M UMR8081

•  SR Thomas

•  Thibault Grosse (CDD VPH) •  Rob Moss (postdoc BIMBO) •  Stana Agnes (Ing IGR) •  Pierre Mazière (postdoc SAPHIR) •  Jérôme Bazin (CDD VPH NoE)

MC ENSIIE : Brigitte Grau, Anne-Laure Ligozat, Amel Bouzeghoub, Anne-Lise Minard

MC IBISC : Fariza Tahi, Farida Zehraoui, Nadia Abchiche, Tarek Melliti

http://saphir.ibisc.fr/

LTSI INSERM U.642 Rennes

Alfredo Hernandez Virginie LeRolle, David Ojeda, Guy

Carrault, Mireille Gareau

TIMC/PRETA UMR 5525 CNRS Grenoble

Pierre Baconnier Julie Fontecave-Jallon, Pascale Calabrese,

Enas Abdulhay

INSERM U927, Poitiers

Patrick Hannaert François Guillaud

U. Paris VI Jean-Pierre Françoise

NASA Ron White∀

BIMBO team (Lyon)

François Gueyffier Ivanny Marchand, Alexandra Laugerotte, Thierry Dumont