http://www.acro-scale.co.jp/Acroscale Inc. Sendai laboratory +81-22-752-2211 acro-docketing@acro-scale.co.jp

Saito, F. ; Sakamoto, I. ; Kanatani, A. ; Chiba, Y. Biochimica et Biophysica Acta, 2016, 1860, 1809-1820. Sakamoto, I. ; Tezuka, K. ; Fukae, K. ; Ishii, K. ; Taduru, M. ;Maeda, M. ; Ouchi, K. ; Yoshida, Y. ; Nambu, Y. ; Igarashi, J. ; Hayashi,N. ; Tsuji, T. ; Kajihara, Y. J. Am. Chem. Soc., 2012, 134, 5428-5431.

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R E S E A R C H R E S U LT S

CHEMICAL APPROACH TOWARD GLYCOPROTEINS

Academic paper

65th ASMS Conference on Mass Spectrometry and Allied Topics, (2017, 6), Indianapolis. 137th Annual Meeting of the Pharmaceutical Society of Japan, (2017, 3), Sendai. PepTalk: The Protein Science Week, (2014, 1), Palm Springs.

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Conference presentat ion

HPLC profiles of chemical ly synthes ized and recombinant INF-β

HILITE 1

Our chemica l s ynthes i s method can produce any des i red g lycoprote in in h igh pur i t y and with homogeneous o l igosacchar ides

Synthetic homogeneous sialyl-IFN-β

Sakamoto, I., et al. J. Am. Chem. Soc. 2012, 134, 5428-5431

C o nt r o l ove r e xa c t q u a nt i t y a n d p u r i t y

S y nth e t i c I N F-β-1 a ( n o n-f u c o s y l a te d )

C o m m e rc i a l 1

C o m m e rc i a l 2

Unpublished data

Treatment for multiple sclerosis

Treatment for glioblastoma as well as hepatitis B and C

http://www.acro-scale.co.jp/Acroscale Inc. Sendai laboratory +81-22-752-2211 acro-docketing@acro-scale.co.jp

ACROSCALE GLYCAN STANDARDS

Sugar chain synthesis and structure confirmation using flexible derivatization technology

HILITE 2

Allowing us to provide HIGH PURIT Y STANDARDS for the qualitative and quantitative determination of glycans

ANALYSIS OF CHEMICALLY SYNTHESIZED GLYCOPEPTIDESMonitoring Q-TOF systems : Hydrogen/Deuterium Exchange (HDX)/MS for Verifying Racemization

HILITE 3

Deuter ium at tached v ia eno l i zat ion of the carbony l Cα-H were monitored by th i s s y s tem.

A glycopeptide was treated with sodium deuteroxide solution for deprotection. After treatment of the reaction mixture with H2O, hydrogen/deuterium exchange (HDX) via enolization of the carbonyl Cα-H was monitored by ESI-QTOF-MS.

Removal the sialic acid benzyl groups under alkaline conditions

Variation Structural analysis

glycan