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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
1/12
HOENKG DN H^NQT\OQmmmFgrmtoc ORG]G DMO@EGQTMAG ] TN\ORN^TMAG
Yn|m9e; ?Q mhge Lg cm yo | COLG\OTG\MG ANET\OCM[ODG YMF(QMDOTOLCO
DN AGETNEMDG
?% GLKNTMYG
% YGAOL^CO\MG
9% RGCMTMAOQ @NEN\OCNQ DN O^TGAGET\GC
0% DNQO\\GCCG
6% HOT\M[ DN \NQRGEQOLMCMDODNQ
=% IC^KG@\OHO
?2%\N@MQT\GQ
??%OENVGQ
Ncolg|9; \ym9; z|| u~~ %%%% % iiii5||~rg I~eam eo dn
aocmKWolg|otg|mg Anet|o {odgYMF(mdo
A9dm`g; ODT(R\(111O(22?%%%%%%AOM%DMO HO]G\DNLG@GTOD3A
%%%%%%%%%% , %%u(u(##(((%(%FgggrPQ~elt%63%54th;3
Inafo; Gat~l|n dn
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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
2/12
HOENKG DN H^NQT\OQ A9dm`g; ODT(R\(111O(22?KFgrmtoc ORG]G
DMO@EGQTMAG ] TN\ORN^TMAGQmhge Lgcmyo| COLG\OTG\MG ANET\OCM[ODG
YMF(QMDO Yn|m9e; ?
%%%%%%AOCDmO HO]G\DN LG@GTOg%a%ctF%ggu,uu:u:'G::u',
?% GLKNTMYG;Dntn|hmeo| cg cmenohmnetg ro|o nc hoenkg dn tgdo co
h~nt|o |namlmdo nenc Colg|otg|mg Anet|ocm{odg YMF(Qmdo ro|o ~
oeocmm#
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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
3/12
A9dm g; ODT(R\(111O(22?OENKG DN H^NQT\OQMkc
Fgrmtoc ORG]G DMO@EGQTMAG ] TN\ORN^TMAGQmhge Lgcmyo| COLG\OTG\MG
ANET\O^[ODG YMF(QMDO Yn|m9e; ?
co orcmaoamgen ne ~e aog dn oyn|io ne nc dmag d~|g# ~e
lg||odgoaamdnetoc 2 ~e oaamdnetn mhr|nymtg% R\^NLO TOHM[; 2 r|~nlo
dn imct|oamge n ~e r|gandmhmnetghntgdgcgqmag q~n dmymdn o ~eo
rglcoamge dn nt~dmg age |nrnatg o ~eorotgcg`io meyntm odo# ne dg
`|~rg; ~eg age octo r|glolmcmdod dn tnen|co nein|hndod &r|~nlo
rgmtmyo- } gt|g age h~} octo r|glolmcmdod dn egtnen| dmafo
nein|hndod &r|~nlo en`otmyo- QN\GTNAO; c~`o| dgedn n ochoaneoe
lokg nt|mato agedmamgen dnlmgn`~|mdod } tnhrn|ot~|o aget|gcodo
&9(6A- h~nt|o dn ic~mdg#na|namgen ag|rg|ocn } tnkmdg% A\MGAOKO;
\namrmnetn rcotmag age toro } h~ctmrcn aghro|tmhnetg ne
dgedn n `~o|doe h~nt|o dn ic~mdg } na|namgen ag|rg|ocn ro|o
n|ochoaneodg o h~} loko tnhrn|ot~|o dn agen|yoamge rg|
co|`gtmnhrg%9% RGCiTMAOQ @NEN\OCNQ DN O^TGAGET\GC; Yn|mimao| co
tnhrn|ot~|o dn co enyn|o rg|totmc ne co q~n n t|oerg|to coh~nt|o%
cdnetmimaoamge aco|o dnc r~eto dn |nagcnaamge dn h~nt|o \nymmge
rn|mgdmao dn co tnhrn|ot~|o dn co enyn|o dn ochoaneohmnetgdn co
h~nt|o rg| ro|tn dn co loatn|mgcgqo dnccolg|otg|mg% \nocm{o| nc
loaj(~r dn cg |n~ctodg dnc mtnho dn colg|otg|mg% \nymmge dn co
aocmdod dn co h~nt|o cdnetmiiaoamge ag||nato c~n`g dn co
yn|mimaoamge dn co mdnetmdod dnc roamnetnage cg dga~hnetg \nymmge
dn cg dga~hnetg \nafo{g dn roamnetn q~n eg rn|tnenan o co rglcoamge
glkntg dnnt~dmg%
0% DNQO\\GCCG;0%? \NANRAMGE DN H^NQT\OQ;
NM O^VMCMO\ 2 CO LOATN\MGCG@O \NQRGEQOLCN; \namln co h~nt|o dn
ro|tn dnc |nr|nnetoetn dn co im|hot|oerg|todg|o% Yn|mimao co
tnhrn|ot~|o dn co enyn|o dn t|oerg|tn ro|o aodo r~etg dn|nagcnaamge
dn h~nt|o } co |n`mt|o ne co aomcco ho|aodo aghg T G dnccml|g dn
\NANRAMGE DN H^NQT\OQ# nrnamimaoedg co tnhrn|ot~|o dnco
amtghnt|mo%
Ro`meo 1 dn ?
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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
4/12
A9dm g; ODT(R\(111O(22?OENKG DN H^NQT\OQ_c
Fgrmtoc ORG]G DMO@EGQTMAG ] TN\ORN^TMAGQ mhge Lgcmyo|
COLG\OTG\MG ANET\OCM[ODG YMF(QMDO Yn|m9e; ?OCAOc%DMO HO]G\Dn LG@GTO
D%%%%((,%((((u#/t%M_, %%( ( %u$M5cG,uu
\n`mt|o ne nc cml|g \NANRAMGE DN H^NQT\OQ nc e~|en|g dn
h~nt|org| aodo r~etg dn |nagcnaamge nrnamimaoedg nc e~|en|g dn
t~lg|namlmdg ro|o aodo nvohne ne ro|tma~co| &amtghnt|mo# ao|`o
ym|ocn#nacmo-% Ho|ao co `|odmcco dn h~nt|o |namlmdo age nc eghl|n
dnc r~etg dn|nagcnaamge oc q~n rn|tnenane } co inafo dn |nanramge
dn co hmho% Ochoaneo co h~nt|o dn co m`~mnetn ig|ho;( NACcOQ;
&Q~n|g# t~lg toro oho|mcco- ochoaneo| ne enyn|o <
dnccolg|otg|mg( AO\@O YM\OC; &rcoho age NDTO- ochoaneo| ne
enyn|o < dnccolg|otg|mg( AMTGHNT\MOQ; &oe`|n tgtoc# t~lg
toro cmco- dnko| o tnhrn|ot~|oohlmnetn ne co `|odmcco dn co
qnaamge# Eg |ni|m`n|o|%
0%
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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
5/12
HOENKG DN H^NQT\OQ A9 dm `g ; ODT (R\ (111O(22?_ LFgqrmto c
ORG]G DMO@EGQTMAG ] TN\ORN^TMAGQmhge Lgc myo| COLG\O TG\MG
ANET\OCM[ODG YMF(QMDO Y n|qm9e ; ?
OCAOc%%DMOW]G\DNLG@GTOG%%a%%%%%%%%%% u#y%R #%%E; :pr fc Qcu %%
;M;|%gmHp
0%1 R\GANQOHMNETG DN COQ H^NQT\OQ; Co loatn|mgcgqo neao|`odo dn
aodo naam9e |nocm{o nc r|ganohmnetg dnco h~nt|o dn oa~n|dg age ? 2
medmaodg ne cg dga~hnetg; ODT(ME(111O(22?# ODT(ME(111O(22<
&Ro|o Nacmo rgmtmyn-# ODT(ME(111O(221%
-%( NACcOQ; n |nocm{o dn oa~n|dg o ? 2 ntmr~codg ne nc dga~hnetg
ODT(ME(111O(22?% @~o|do| tgdo co h~nt|o rgmtmyo ne co enyn|o ? ne
co `|odmccoho|aodo aghg Pntn|e(Lcgt ro|o ~ rgtn|mg| r|ganohmnetg
nq~eODT(ME(111O(22. dn co h~nt|o age|n~ctodg en`otmyg r|ganodo }
agen|yo|co o (02A# co `|odmcco dnochoaneohmnetg dn nto h~nt|o n
dnlne ho|ao| age nc e~hn|g dncoeg } agena~tmyg ociolntcag &.
dnh~nt|o en`otmyo%
CO LOATN\M9CG@O NEAO\@ODO DNC R\GANQOHMNETG DNNACMOQ NQ
\NQRGEQOLCN DN; \nocm{o| co yocmdoam9e } co mhr|nm9e dn cg |n~ctodg
en`otmyg% &Yn|oenvg hoenkg dnc mtnho dn colg|otg|mg%- Cg
|n~ctodg mhr|ng o||gkodg rg| nc nq~mrg rn|tnenamnetn oc hnoat~oc n
`~o|doe ne nc O[ % dneghmeodg \NQ^CTODGQ NACMOQ Cg |n~ctodg dn
Nacmo dn hnn oetn|mg|n n `~o|doe ne nc o|afmygdnc colg|otg|mg%
-%( PNQTN\E LCGT; n |nocm{o o tgdo co h~nt|o rgmtmyo# aghg
r|~nloageim|hotg|mo ne nc hmhg t~lg dnc NACcO# age ageim|hoam9e ne
n`~edoh~nt|o# gcmamtodo rg| hndmg dn gimamg oc r~etg dn tgho dn
h~nt|o|nrgeolcn%
Co loatn|m9?2`o neao|`odo dn co naam9e n |nrgeolcn dn; \nocm{o|
co r|~nlo ageim|hotg|mo dnet|g dn cg dg dmo m`~mnetn o cogltneam9e
dnc |n~ctodg |noatmyn dn co r|~nlo tohm{ &NACcO- @~o|do| ne
|ni|m`n|oam9e
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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
6/12
HOENKG DN H^NQT\OQ A9dm g; ODT(R\(111O(22?mmmFgrmtoc ORG]G
DMO@EGQTMAG ] TN\ORN^TMAGQmhge Lgcmyo| COQG\O TG\MG ANET\OCM[ODG
YMF(6MDO Yn|m9e; ?
Om%%AOc%%DMO HO]G\DN MKG@Gc ',O M-%A
% % % % %uuM*:prl4A||5tSe;c:t;:cm m%W
\n`mt|o| ne nc cml|g PNQTN\E(LCGT# tgdo co h~nt|o q~n yoe o
n|r|ganodo R|gano| co h~nt|o } cg aget|gcn dn oa~n|dg oc
dga~hnetg;ODT(ME(111O(22< \n`mt|o| ne nccml|g PNQTN\E LCGT cg
|n~ctodg gltnemdg% Me`|no|# yocmdo| n mhr|mhm| cg |n~ctodg ne nc
mtnho dn Colg|otg|mg&yn| oenvg# hoenkg dnc mtnho dn
Colg|otg|mg-% C~n`g dnc r|ganohmnetg co h~nt|o n nro|oe ne ymocn
ro|o ~ochoaneohmnetg rg| > ocmg ne enyn|o ? dnc colg|otg|mg# dn
oa~n|dg o com`~mnetn nrnamimaoamgen;
\NQ^CTODG YMOCRGQMTMYG \GKGMEDNTN\HMEODG OHO\MCCGEN@OTMYG
O[^C
u AMTGHNT\MOQ; co h~nt|o dnlne r|gano|n oetn dn
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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
7/12
A9dm`g; ODT(R\(111O(22?OENKG DN H^NQT\OQ
uFgrmtoc ORG]G DMO@EGQTMAG ] TN\ORN^TMAGQmhge Lgcmyo|
COLG\OTG\MG ANET\OCM[ODG YMF(QMDO Yn|m9e; ?
u AO\@O YM\OC; co h~nt|o |nanramgeodo ne t~lg cmco q~n eg
fo}oemdn anet|mi~`odo ne nc r~etg dn tgho dn h~nt|o# n dnlne
anet|mi~`o|} nro|o| nc rcoho ag||nrgedmnetn: ntg rcoho n hoetmnene
ne|ni|m`n|oam9e ne enyn|o < dndn nc hghnetg dn co |nanram9e foto
nc dcodnc r|ganohmnetg%Co loatn|tgcgqo neao|`odo dn co naam9e n
|nrgeolcn dn;
Mhr|mhm| cmto dn t|olokg o||gkodo rg| nc mtnho dn colg|otg|mg%
\nocm{o| nc r|ganohmnetg dn co h~nt|o# nc aget|gc dn aocmdod }
cgr|gandmhmnetg dn hoetnemhmnetg dnc nq~mrg dn ao|`o ym|oc dn
oa~n|dg ocg dga~hnetg; ODT(ME(111O(224 } ODT(ME(111O(220 Qn`~m| co
hndmdo dn lmgn`~|mdod |naghnedodo% @~o|do| tgdo co h~nt|o ne
age`ncoam9e ne co enyn|o ?# nro|odone ymocn% Dnao|to| cg t~lg }
dnnafg dnc r|ganohmnetg mehndmotohnetndnr~n dn gltnen| cg |n~ctodg#
dn oa~n|dg oc dga~hnetg; ODT (HO(111O(22< \nocm{o| co yocmdoam9e
n mhr|nm9e dn tgdg cg |n~ctodg% @~o|do| cg |n~ctodg mhr|ng o||gkodg
rg| nc nq~mrg ne nc O[dneghmeodg AO\@O YM\OC# ne nc oro|todg
ho|aodg aghg\NQ^CTODGQ% Cg |n~ctodg dn cg hnn oetn|mg|n n dnlne
ochoaneo| ne nc o|afmygdnc colg|otg|mg%0%4 OCHOANEOHMNETG DN COQ
H^NQT\OQ;o% H^NQT\OQ EG \NOATMYOQ; n ochoaneoe rg| dg hnn%
NM o~vmcmo| dn colg|otg|mg n |nrgeolcn dn; G|`oem{o| tgdo co
h~nt|o eg |noatmyo ne `|odmcco dn magrg|ho|aodo age nc metn|yocg dn
h~nt|o q~n agetmnen# nc hn } nc e~|en|gdn co `|odmcco
ag||nrgedmnetn% Nto h~nt|o n ochoaneoe ne co enyn|o 1 dnc
colg|otg|mg% C~n`g dn t|oea~||mdg nc tmnhrg dn ochoaneohmnetg# co
h~nt|o gednao|todo m`~mnedg co medmaoamgen dnc dga~hnetg
ODT(HO(111O(22. dn coh~nt|o eg |noatmyo r|ganodo dn aodo hn# nto
h~nt|on agen|yoe rg| > ommg%
Co loatn|cgcgqo dn co naam9e n |nrgeolcn dn;
Ro`meo 0 dn ?
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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
8/12
Ot%%AOC%MK&O HO]G\DNLG@GTO D%uuuu(u$Mc~G,D3%?5Mjh
A9dm`g; ODT(R\(111O(22?OENKG DN H^NQT\OQzDFgrmtoc ORG]G
DMO@EGQTMAG ] TN\ORN^TMAGQ mhge Lgcmyo| COLG\OTG\MG ANET\OCM[ODG
YMF(QMDO Yn|m9e; ?
G|`oem{o| co h~nt|o q~n n nea~net|oe ne co enyn|o ho|aodo
aghgQN\GTNAO% Qnro|o| nhoeochnetn co h~nt|o ne ymocn# ho|ao| cg
ymocn age ncagdmqg dn lo||o dn co h~nt|o ag||nrgedmnetn }
g|`oem{o|cg ne coa|mgaoko% Ho|ao| co a|mgaoko age nc metn|yocg dn
h~nt|o q~n agetmnen } agee~hn|g agena~tmyg dn oa~n|dg o co a|mgaoko
mehndmotohnetn oetn|mg|% Ochoaneo| co `|odmcco ne nc tn|an|
aghro|tmhmnetg dn co enyn|o ? dnccolg|otg|mg% Oat~ocm{o| co lon dn
dotg dn ochoaneohmnetg dn h~nt|o ne ncmtnho dn colg|otg|mg%
Co loatn|cncgqo neao|`odo dnc r|ganohmnetg dn NCMQOQ
]PNQTN\E(LCGT# n |nrgeolcn dn; Qnro|o| tgdo co h~nt|o dn
Pntn|e(Lcgt ne cg ymocnag||nrgedmnetn aghg n medmag ne nc e~hn|oc
0%1 dn ntn dga~hnetg% Ho|ao| co a|mgaoko age nc metn|yocg dn h~nt|o
ag||nrgedmnetn }ochoaneo|co ne nc n`~edg aghro|tmhmnetg dn co
enyn|o ? dnccolg|otg|mg% Co loatn|mgcgqo neao|`odo dn co naamge dn
AO\@O YM\OC ]AMTGHNT\MO n |nrgeolcn dn; Qnro|o| tgdo co h~nt|o dn
AO\@O YM\OC ne ymocn ntn|mcn } me
odmtmyg dnlmdohnetn ho|aodg% G|`oem{o|cg ne a|mgaoko# ho|ao|co
age nc e~|en|g agena~tmygag||nrgedmnetn } ochoaneo|cg ne nc ~ctmhg
aghro|tmhmnetg dn co enyn|o? dnccolg|otg|mg%a% H^NQT\OQ RO\O
AGET\GC DN AOCMDOD;
Co loatn|cncg`o neao|`odo dnc r|ganohmnetg dn NCMQOQ
]PNQTN\E(LCGT# n |nrgeolcn dn; Qnro|o| co h~nt|o ro|o nc aget|gc dn
aocmdod dn aodo naamgemednrnedmnetnhnetn } |nocm{o| nc neycg dn
oa~n|dg o cg cmenohmnetggtg| odg rg| nc colg|otg|mg dn Qoc~d
R~lcmao% Nag`n| co h~nt|o eg |noatmyo q~n n yoe o neymo| ro|o
aget|gc dnaocmdod nvtn|eg dn oa~n|dg o cg cmenohmnetg gtg|`odg rg|
nccolg|otg|mg dn Qoc~d R~lcmao% Neymo| co h~nt|o age gimamg
|nhmg|mg dnet|g dn cg ?> r|mhn|g dcodn cg hnn ag||nrgedmnetn#
nrnamimaodg rg| nc a|geg |oho neymodgrg| nc Colg|otg|mg dn Qoc~d
R~lcmao Qnro|o| co h~nt|o eg |noatmyo dn NACMOQ nag`mdo rg|
coloatn|mgcgqo# ne ymocn dnlmdohnetn ho|aodg } ochoaneo|cg ne
Ro`meo 6 dn ?
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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
9/12
Mm-Fgqrmto c ORG]G DMO@EGQTMAG ] TN\ORN^TMAGQmhgeLgc myo|
COLG\OTG\MG ANET\OCM[ODG YMF(QMDO Yn|qm9e ; ?
HOENKG DN H^NQT\OQ A 9d m` g; O D T(R \
(111O(22?OCAOM%%M;V%G%HO]G\Dn; LG@GTO
g#a%%u#W%W%,HgM%%HuuQfeG#%D3%;%MEH
a|mgaoko ho|aodo aghg AGET\GC DN AOCM DOD% ro|o ~
rgtn|mg|neyig%0%> G\@OEM[OAM9E ] NEYMG DN \NQ^CTODGQ;
NM o~vmcmo| odhmemt|otmyg n |nrgeolcn dn; \nag`n| cg |n~ctodg dn
co mhr|ng|o } g|`oem{o|cg rg| r~etg dn|nagcnaam9e dn h~nt|o% Ho|ao|
nc gl|n age nc eghl|n dn co metmt~am9e ag||nrgedmnetn } ncco|cgro|o
~ neyig @~o|do| cg gl|n nccodg ne co lgco dn neyig ag||nrgedmnetn
&aodo~eo nto ho|aodo age nc eghl|n dnc r~etg dn |nagcnaam9e dn
h~nt|o- Dmcm`neamo| nc ig|hotg ODT(IG(111O(2?< ro|o aodo r~etg
dn |nanram9edn |n~ctodg Net|n`o| oc i~eamgeo|mg dn co im|ho
t|oerg|todg|o |nrgeolcn dn aodo|~to cg |n~ctodg } g|m`meoc } agrmo
dnc ig|hotg hneamgeodgdnlmdohnetn dmcm`neamodg% NM i~eamgeo|mg dn
co im|ho t|oerg|todg|o net|n`o cg |n~ctodg ne ncr~etg dn otneam9e }
co rn|geo q~n cg |namln im|ho co agrmo dnc ig|hotg% Co agrmo
dnlmdohnetn im|hodo n o|afmyodo ne nc O[ ag||nrgedmnetn%
6% HOT\M[ DN \NQRGEQOLMCMDODNQ;
Eg Oatmymdod Nvrcmaoam9e dn co \n`mt|g Gln|yoamgenoatmymdod
\nrgeolcn |mn`g } aget|gcnQn |namlne co \nymo| coh~nt|o ne nc
O~vmcmo| Cml|g dn h~nt|o ro|o? \nanram9e colg|otg|mg anet|ocm{odg
odhcect|otcya }'g |nanram9e yn|mimao| codn h~nt|o r|gynemnetn dn
tgdg dn agedmamgen dncg fgrmtocn Loatn|mgcgqo% h~nt|o tnhrn|ot~|o
}rn|tnenamnetn o co |nd% nhlocokn
\nymm9e dncMe`|ng dn Ao|`o| co 9|dnen oc o~vmcmo| mtnho
a~hrcmhmnetg dn cg< dn colg|o a|mtn|mg dng|dnen mtnho dn
colg|otg|mg% Odhmemt|otmyg% tg|mg oanrtoam9e dnh~nt|oMdnetmimao|
aodo \nymm9e dn coMdnetmimaoam9e ageag|doeamo dn cg1 dn co h~nt|o
age nc a9dm g Loatn|mgcgqo dotg age co g|dne }dn lo||oh~nt|o
ag||nrgedmnetn% cg dga~hnetg dncroamnetn
Ro`meo = dn ?
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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
10/12
_?Fgrmtoc ORG]G DMO@EGQTMAG ] TN\ORN^TMAGQmhge Lgcmyo|
COLG\OTG\MG ANET\OCM[ODG YMF(QMDO Yn|m9e; ?
HOENKG DN H^NQT\OQ A9dm`g; ODT(R\(111O(22?OCAOC%DiOW]G\DN
LG@GTOg%a%%% % % % % % % % % % % % % % % % % % u
%FoKrlgMW,,,,^p(
Eg Oatmymdod Nvrcmaoamge dn co \n`mt|g Gln|yoamgenoatmymdod
\nrgeolcn |mn`g } aget|gcnCo loatn|cgcgqo Fgko dnneao|`odo dn aodo
t|olokg#naamge |nocm{o nc mhr|nmge \nymmge dnr|ganohmnetg dn co n
dn cg |n~ctodg oetn dnR|ganohmne |n~ctodg4 tg dn h~nt|o dn oa~n|dg
Loatn|mgcgqo dn cg n| yocmdodg%age ? 2 medmaodg ne cg Ageag|doeamo
dnh~nt|o met|~atmyg ODT(ME( nq~mrg% nvo|enen111O(22?# ODT(ME( Cml|g
dn |nocm{odg%111O(22 etgdn dga~hnetg} Loatn|mgcgqo Qn|gtnao dmo|mg
dn |oe`g dn
h~nt|o hoetnemnedg co tnhrn|ot~|o dnagedmamgen ro|o
enyn|oon`~|o| ~ ymolmcmdod ot|oyn dnc tmnhrg%\nocm{o| co oatmymdodn
o~vmcmo| ODT(IG( \nymmge dn cg
G|`oem{oamge dna|mto ne ntn odhmemt|otmyg 111O(2?< |n~ctodg
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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
11/12
HOENKG DN H^NQT\OQ A9 dm` g; ODT(R\ (111O(22?MeFgqrmtoc ORG]G
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8/2/2019 ADT-PR-333A-001 Manejo de Muestras
12/12
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