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Alzheimers disease (AD) is a chronic disorder that slowly destroys neurons and causesserious cognitive disability. AD is associated with senile plaques and neurofbrillary tangles

(NFTs). Amyloid-beta, a major component o senile plaques, has various pathological eectson cell and organelle unction. Extracellular amyloid-beta oligomers may activate caspasesthrough activation o cell surace death receptors. Alternatively, intracellular amyloid-betamay contribute to pathology by acilitating tau hyper-phosphory lation, disrupting mitochondria

unction and triggering calcium dy sunction. To date, genetic studies have revealed our genesthat may be linked to autosomal dominant or amilial early onset AD (FAD). These ourgenes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) andapolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to anincrease in the production o amyloid- beta peptides, specifcally the more amyloidogenic orm,

amyloid-beta 42. FAD-linked PS1 mutation downregulates the unolded protein response and

leads to vulnerability to ER stress.

Alzheimers diseasesignaling pathway

For more inormation on all the antibodies eatured here or to view our extensive catalog,visit www.ptglab.com

ABAD / HSD17B10 10648-1-AP Rabbit poly ELISA, WB, IHC

ABAD / HSD17B10 60069-1-Ig Mouse mono ELISA, WB

APH1A 11643-1-AP Rabbit poly ELISA, WB

ApoE 18254-1-AP Rabbit poly ELISA

APP 10524-1-AP Rabbit poly ELISA, WB

APP-BP1 / NAE1 14863-1-AP Rabbit poly ELISA, WB

BACE1 /-secretase 12807-1-AP Rabbit poly ELISA, WB

BAD 10435-1-AP Rabbit poly ELISA, WB

BID 10988-1-AP Rabbit poly ELISA, WB, IHC

Calpain / CAPN1 10538-1-AP Rabbit poly ELISA

CASP7 10459-1-AP Rabbit poly ELISA

CASP8 13423-1-AP Rabbit poly ELISA, WB, IHC

CASP9 10380-1-AP Rabbit poly ELISA, WB, IF

CDK5 10430-1-AP Rabbit poly ELISA, WB

CHP 15834-1-AP Rabbit poly ELISA, WB

CytC (CYCS) 10993-1-AP Rabbit poly ELISA, WB, IHC

ERK1/2 / MAPK1 16443-1-AP Rabbit poly ELISA, WB, IHC

ERK1/2 / MAPK1 51068-1-AP Rabbit poly ELISA, WB, IHC

FADD 14906-1-AP Rabbit poly ELISA, WB

FAS / TNFR 13098-1-AP Rabbit poly ELISA, WB, IHC

Fe65 / APBB1 12526-1-AP Rabbit poly ELISA

GAPDH 10494-1-AP Rabbit poly ELISA, WB, IHC, IF

GAPDH 60004-1-Ig Rabbit poly ELISA, WB

GNAQ 13927-1-AP Rabbit poly ELISA, WB

GSK3 15113-1-AP Rabbit poly ELISA, WB

GSK3 51065-1-AP Rabbit poly ELISA, WB, IHC

IL-1 60136-1-Ig Mouse mono ELISA, WB

LPL 16899-1-AP Rabbit poly ELISA

NCSTN 14071-1-AP Rabbit poly ELISA, WB

NEP (MME) 18008-1-AP Rabbit poly ELISA, WB, IHC

NEP (MME) 60034-1-Ig Mouse mono ELISA, WB

nNOS 18984-1-AP Rabbit poly ELISA, WB

p35 / p25/ CDK5R1 18346-1-AP Rabbit poly ELISA

PEN2 / PSENEN 16144-1-AP Rabbit poly ELISA

PSEN1 16163-1-AP Rabbit poly ELISA, WB

SNCA 10842-1-AP Rabbit poly ELISA, WB, IHC

Tau / MAPT 10274-1-AP Rabbit poly ELISA, WB, IHC

TNF 17590-1-AP Rabbit poly ELISA, WB

OligomericA

Cu+ Fe2+

Neuronalinjury

H20

2

Nitricoxide

Protein OxidationApoptosisDNA damage

MITOCHONDRIA

Decreasedenergy

production?

APPprocessing

Apoptosis