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THROMBOCYTOPENIA IN PLASMODIUM FALCIPARUM MALARIA
Shuaib Ansari, Haji Khan Khoharo*, Allauddin Abro**, Israr Ahmd
Akhund, Fatima Qureshi*
Department of Medicine, Liaquat University Hospital
Hyderabad/Jamshoro,* Muhammad Medical College Mirpurkhas,
**Department
of Biochemistry, Ghulam Muhammad Medical College,
Sukkur,Department of Physiology, Muhammad Medical College,
Mirpurkhas
Background: Malaria is usually associated with reduced blood
cell counts & mild to moderate
thrombocytopenia is a common association of malaria. The cause
of thrombocytopenia is poorlyunderstood, but the immune-mediated
lysis, sequestration in the spleen and dyspoietic processes inthe
marrow with diminished platelet production have all been
postulated. This study wasconducted to evaluate thrombocytopenia in
the patients suffering from acute Plasmodiumfalciparum malaria.
Methods: This descriptive case series study was conducted at a
tertiary carehospital, Liaquat University of Medical & Health
Sciences Jamshoro, over a one-year period. Atotal of 370 Plasmodium
falciparum positive on peripheral blood film were studied. Full
bloodcounts were determined by using automated Coulter analyzer.
Thick & thin smears were stainedwith Giemsa stains and studied
by haematologist. Data was analyzed using the SPSS version
10.0.Results: Out of 370 patients, 260 were male & 110 were
female, with M:F ratio of 2.36:1. Meanage was 341.7 years (range
16-53 years). Haemoglobin values were 12.71.4g% and white
bloodcells counts were found 12600450/L. Out of 370, 114 (30.81%)
had normal platelet counts, and256 (69.18%) had thrombocytopenia
(p
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RESULTS
A total of 370 patients with Plasmodium falciparummalaria were
studied during one year period fromApril 2007 to May 2008. Out of
370 patients, 260were male & 110 were female, with M:F ratio
of2.36:1. Mean age was 341.7 years (range 1653
years). Haemoglobin values were 12.71.4g% andwhite blood cells
counts were found 12600450/L.
Out of 370, 114 (30.81%) had normal platelet countsand 256
(69.18%) had thrombocytopenia (p
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Address for Correspondence:Dr. Haji Khan Khoharo, Bungalow No.
C-17/II, Phase I Anwer Villas, Behind Government Technical College,
NewWahdat Colony, Qasimabad, Hyderabad, Pakistan. Tel:
+92-321-3010577.Email: [email protected]|
