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1,4‐ジクロロ‐2‐ニトロベンゼンのラットを用いた 経口投与による 13 週間毒性試験 ( 混餌試験 ) 報告書 試験番号:0301 APPENDIX

APPENDIX - mhlw · methods for hematology, biochemistry and urinalisys in the 13-week feed study of 1,4-dichloro-2-nitrobenzene . appendix n 1 units and decimal place for hematology

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Page 1: APPENDIX - mhlw · methods for hematology, biochemistry and urinalisys in the 13-week feed study of 1,4-dichloro-2-nitrobenzene . appendix n 1 units and decimal place for hematology

1,4‐ジクロロ‐2‐ニトロベンゼンのラットを用いた 経口投与による 13 週間毒性試験(混餌試験)報告書

試験番号:0301

APPENDIX

Page 2: APPENDIX - mhlw · methods for hematology, biochemistry and urinalisys in the 13-week feed study of 1,4-dichloro-2-nitrobenzene . appendix n 1 units and decimal place for hematology
Page 3: APPENDIX - mhlw · methods for hematology, biochemistry and urinalisys in the 13-week feed study of 1,4-dichloro-2-nitrobenzene . appendix n 1 units and decimal place for hematology
Page 4: APPENDIX - mhlw · methods for hematology, biochemistry and urinalisys in the 13-week feed study of 1,4-dichloro-2-nitrobenzene . appendix n 1 units and decimal place for hematology

APPENDIX A 1

CLINICAL OBSERVATION : SUMMARY, RAT : MALE

(13-WEEK STUDY)

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APPENDIX A 2

CLINICAL OBSERVATION : SUMMARY, RAT : FEMALE

(13-WEEK STUDY)

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APPENDIX B 1

BODY WEIGHT CHANGES :SUMMARY, RAT : MALE

(13-WEEK STUDY)

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APPENDIX B 2

BODY WEIGHT CHANGES : SUMMARY, RAT : FEMALE

(13-WEEK STUDY)

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APPENDIX C 1

FOOD CONSUMPTION CHANGES : SUMMARY, RAT : MALE

(13-WEEK STUDY)

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APPENDIX C 2

FOOD CONSUMPTION CHANGES : SUMMARY, RAT : FEMALE

(13-WEEK STUDY)

Page 18: APPENDIX - mhlw · methods for hematology, biochemistry and urinalisys in the 13-week feed study of 1,4-dichloro-2-nitrobenzene . appendix n 1 units and decimal place for hematology
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APPENDIX D 1

CHEMICAL INTAKE CHANGES : SUMMARY, RAT : MALE

(13-WEEK STUDY)

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APPENDIX D 2

CHEMICAL INTAKE CHANGES : SUMMARY, RAT : FEMALE

(13-WEEK STUDY)

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APPENDIX E 1

HEMATOLOGY : SUMMARY, RAT : MALE

(13-WEEK STUDY)

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APPENDIX E 2

HEMATOLOGY : SUMMARY, RAT : FEMALE

(13-WEEK STUDY)

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APPENDIX F 1

BIOCHEMISTRY : SUMMARY, RAT : MALE

(13-WEEK STUDY)

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APPENDIX F 2

BIOCHEMISTRY : SUMMARY, RAT : FEMALE

(13-WEEK STUDY)

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APPENDIX G 1

URINALYSIS : SUMMARY, RAT : MALE

(13-WEEK STUDY)

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APPENDIX G 2

URINALYSIS : SUMMARY, RAT : FEMALE

(13-WEEK STUDY)

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APPENDIX H 1

GROSS FINDINGS : SUMMARY, RAT : MALE ALL ANIMALS

(13-WEEK STUDY)

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APPENDIX H 2

GROSS FINDINGS : SUMMARY, RAT : FEMALE ALL ANIMALS

(13-WEEK STUDY)

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APPENDIX I 1

ORGAN WEIGHT, ABSOLUTE : SUMMARY, RAT : MALE

(13-WEEK STUDY)

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APPENDIX I 2

ORGAN WEIGHT, ABSOLUTE : SUMMARY, RAT : FEMALE

(13-WEEK STUDY)

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APPENDIX J 1

ORGAN WEIGHT, RELATIVE : SUMMARY, RAT : MALE

(13-WEEK STUDY)

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APPENDIX J 2

ORGAN WEIGHT, RELATIVE : SUMMARY, RAT : FEMALE

(13-WEEK STUDY)

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APPENDIX K 1

HISTOLOGICAL FINDINGS : NON-NEOPLASTIC LESIONS : SUMMARY

RAT : MALE : ALL ANIMALS

(13-WEEK STUDY)

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APPENDIX K 2

HISTOLOGICAL FINDINGS : NON-NEOPLASTIC LESIONS : SUMMARY

RAT : FEMALE: ALL ANIMALS

(13-WEEK STUDY)

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APPENDIX L 1

IDENTITY OF 1,4-DICHLORO-2-NITROBENZENE

IN THE 13-WEEK FEED STUDY

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APPENDIX L 2

STABILITY OF 1,4-DICHLORO-2-NITROBENZENE

IN THE 13-WEEK FEED STUDY

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APPENDIX L 3

CONCENTRATION OF 1,4-DICHLORO-2-NITROBENZENE

IN FORMULATED DIETS IN THE 13-WEEK FEED STUDY

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APPENDIX L 4

STABILITY OF 1,4-DICHLORO-2-NITROBENZENE

IN FORMULATED DIETSIN THE 13-WEEK FEED STUDY

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APPENDIX M 1

METHODS FOR HEMATOLOGY, BIOCHEMISTRY AND URINALISYS IN

THE 13-WEEK FEED STUDY OF 1,4-DICHLORO-2-NITROBENZENE

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APPENDIX N 1

UNITS AND DECIMAL PLACE FOR HEMATOLOGY AND BIOCHEMISTRY IN THE

13-WEEK FEED STUDY OF 1,4-DICHLORO-2-NITROBENZENE

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