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Leukemia
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What Is Leukemia?• Cancer of the white blood cells• Acute or
Chronic•
Affects ability to produce normal bloodcells• Bone marrow makes
abnormally large
number of immature white blood cellscalled blasts
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Symptoms• When there are excessi e white blood
cells !!" Infections•
When there are few red blood cells#$aleness !!" Anemia• When
there are few platelets !!"
%xcessi e bleeding
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$ictures &f Blood
'ormal human blood
White Cell (ed Cell
$latelet
Blood with leukemia
Blasts(ed Cell
$latelet
White Cell
Sources from Arginine.umdnj.eduSources from beyond2000.com
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Classification•
Classified based on cell type in ol edand the clinical course•
)* Acute #•
ALL• A+L
,* Chronic #• CLL• C+L
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Subclassification•
ALL – Common
type- pre!B. –
B!cell – /!cell – 0ndifferentiated
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A+LFrench-American-British (FAB) Classification
+1# +inimally differentiated leukemia+)# +yeloblastic leukemia
without maturation+,# +yeloblastic leukemia with maturation+2 #
3ypergranular promyelocytic leukemia+4%o# 5ariant# Increase in
abnormal marrow
eosinophils+4# +yelomonocytic leukemia+6 # +onocytic leukemia+7#
%rythroleukemia -8i9uglielmo:s disease.+;# +egakaryoblastic
leukemia
(ef!3arrison
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• CLL – B!cell# common – /!cell# rare
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• C+L
http://images.google.com.my/imgres?imgurl=http://home.kku.ac.th/acamed/kanchana/p69.jpg&imgrefurl=http://home.kku.ac.th/acamed/kanchana/bsi.html&h=444&w=580&sz=66&hl=en&start=5&tbnid=iMbXDiMglWvqgM:&tbnh=103&tbnw=134&prev=/images?q=chronic+myeloid+leukemia&svnum=10&hl=en
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AML
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C+L
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%chinocytes -=burr cells>.
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Iron 8eficiency Anemia
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olate 8eficiency
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/halassemia
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Sickle Cell Anemia
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Spherocytosis
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//$ @ 30S microangiopathic hemolysiswith schistocytes
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+alaria
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hematopoiesis
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%ritropoiesis
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+ielopoiesis
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Case
