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BioTechMed-Graz ... – Methods to study biopharmaceutical interactions of drug delivery systems with e.g., alcohol, food . – Development of innovative science driven platform knowledge

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  • Biomedical Basics-Technological Developments-Medical Implementation

    Research for Health

    BioTechMed-Graz

  • • MUG: – Assoz.-Prof. Dr. Ruth Prassl

    – Apl. Prof. Dipl.Biochem. Dr.med. Eleonore Fröhlich

    – Univ.-Prof. Dr.med.univ. Harald Mangge

    • TUG: – Univ.-Prof. Dr. Johannes Khinast

    – Ass.-Prof. Dr. Heidi Gruber-Wölfler

    – Ass.-Prof. Dr. Stefan Radl

    • KFU: – Univ.-Prof. Dr. Andreas Zimmer

    – Assoz.-Prof. Dr. Eva Roblegg

    – Dipl.-Ing. Dr. Oliver Werzer

    Representatives: Pharmaceutical and Medical Technology

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  • Pharmaceutical and Medical Technology

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    • Research: – Drug Delivery Systems and Drug Targeting

    • Multiparticulate Drug Delivery Systems (Extrusion)

    – Pharmaceutical Nanotechnology

    • In vitro nanoparticle evaluation

    • Particle characterisation and structure assessment

    – Nanotoxicology, 3Rs

    – Pharmaceutical Proteins / Peptides

    – Oral & Inhalative Dosage Forms (Aerosols)

    – Personalized Drugs and simplification of ODFs

    – Biopharmaceutics & Preformulations

    – Biological Barriers (Oral / Intestine / Placenta / Lung)

    – Process Development & Scale up

    – Continuous Processing Development and Implementation

    – Material Science & Characterization

    – Pharmaceutical Process Modeling & Simulation

  • • Trends: – Personalized Drugs and Drug Formulations

    • P4 Medicine: P4 = personalized – precise – predictive - preventive

    – Safety awareness / Nanotoxicology

    – Third generation nanomedicines / Novel Drug Delivery Routes & Formulations

    – Pharmacogenomics & Adoption of Genomic Medicine

    – Patient Centricity

    – Advanced Manufacturing

    Pharmaceutical and Medical Technology

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  • • Future ? – Drug Targeting of Nanocarriers

    – Drug Delivery carriers for alternative administration routes (e.g., oral, pulmonary etc.)

    – Fundamental basis for a predictive understanding of biological barriers and cellular processes (uptake mechanisms)

    – Methods to study biopharmaceutical interactions of drug delivery systems with e.g., alcohol, food ….

    – Development of innovative science driven platform knowledge for process and product design & development

    – Increasing the sustainability profile reducing costs and time in pharmaceutical development

    – Development of methods for designing, optimizing, scaling and controlling the manufacturing of next-generation products

    Pharmaceutical and Medical Technology

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  • • Request: – In vivo evaluations

    – Data Modeling and Analysis

    – Molecular/Cell Biology

    – Omics

    – Materials Science

    – Visualization tools

    – Strategy Development

    – Information Management

    – Clinical entry

    Pharmaceutical and Medical Technology

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  • Projects

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    Nanomedicine for target-specific imaging and treatment of atherosclerosis: development and initial clinical feasibility

    • Development of targeted nanoparticles

    • Preclinical evaluation of targeted nanoparticles

  • Projects

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    CONQUER - Contrast by Nuclear Quadrupole Enhanced Relaxation

    • Development of new 209Bi-based imaging agents

    • Labelling efficacy and safety studies

    http://www.google.at/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http://www.cetaf.org/news/fet-open-calls-novel-ideas-radically-new-technologies&ei=m25IVbHsN4r2UpSzgMgD&bvm=bv.92291466,d.d2s&psig=AFQjCNH99TdsMILNeR-50-dwTyeYovNTMw&ust=1430896591187294 https://www.google.at/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=https://ec.europa.eu/programmes/horizon2020/en/h2020-section/fet-open&ei=hm5IVc_GLcHpUoiggdgP&bvm=bv.92291466,d.d2s&psig=AFQjCNH99TdsMILNeR-50-dwTyeYovNTMw&ust=1430896591187294

  • Industry

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    – Modeling and Prediction

    – Material Science

    – Continuous Process and Quality Control

    – Continuous Manufacturing

    – Formulation Engineering

    – Platform Technologies: Hot-Melt Extrusion & Injection Molding

    – Drug and Drug Product Profiling

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