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8/8/2019 BM, Anemia, Leukemia
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I. Anemias of Blood Loss
Acute trauma
Chronic
lesions of GI tract, gynecologic
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II. Hemolytic Anemias
Intrinsic / Intracorpuscular
Hereditary Membrane disorders - HS
Enzyme deficiencies - G-6PD
Disorders of Hb synthesis
Deficient Hb synthesis - thalassemia
Structurally abnormal globin synthesis sickle cells
Acquired
Membrane defect - PNH
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II. Hemolytic Anemias
Extrinsic / Extracorpuscular
Antibody mediated Isohemagglutinis (HTR, EF), Autoabs (SLE,
Mycoplasma), AIHA (warm, cold, PCH)
Mechanical trauma to RBC - DIC
Infections - malaria Chemical injury Pb poisoning
Sequestration in mononuclear phagocytesystem (hypersplenism)
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III. Anemias of Diminished
Erythropoiesis/Impaired RC Production
Disturbance of proliferation &differentiation of stem cells
Aplastic Anemia
Acquired, idiopathic, Fanconi (familial)
Pure red cell aplasia
Congenital erythroid hypoplasia -Diamond Blackfan
Acquired acute / chronic
Anemia of renal failure
Anemia of endocrine disorder
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III. Anemias of Diminished
Erythropoiesis/Impaired RC Production
Disturbance of proliferation & maturationof stem cells
Defective DNA synthesis
Megaloblastic anemia B12(pernicious), folate
Defective Hb synthesis
Deficient heme synthesis
Fe deficiency
Deficient globin synthesis - thalassemias
Unknown or multiple mechanisms
Sideroblastic, anemia of chronic infections
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WBC Disorders
Leukopenia
Reactive (inflammatory) proliferations ofWBC & nodes
Leukocytosis
Non specific lymphadenitis (acute, chronic) Neoplastic proliferation
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Neoplastic proliferation
Lymphoid
Precursor B and T cell neoplasms
ALL
Precursor B cell neoplasms
CLL, Burkitt, plasma cell neoplasms, multiplemyleoma, hairy cell leukemia
Peripheral T cell and NK neoplasms
Mycosis fungoides
Hodgkin Disease
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Neoplastic proliferation
Myeloid
AML Myelodysplastic syndromes
Chronic myeloproliferative disorders
CML
Polycythemia vera
Essential thrombocytosis
Myelofibrosis with myeloid metaplasia
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