book of suicidemethods for a quick and secure departure from life

part 1-26, 1st version of

jak się zabić wie bringt man sichum come si suicida как

совершать с амоубийств́

zěnme zìshā(怎么自杀, howto commit s

uicide)

this pdf was first uploaded the 5th of november 2013, is free to read and free to redistribute as a non-commercial e-book or text file of some other sort, under the terms of

CC BY-NC-ND

written by Nada Alleen

version 1.03 (6th of november 2013) added part 011-013, changed the front page a bit, and made some small amendments to 006 + 009. version 1.07 (7th of november 2013) added part 014-017, and digitalis to 006 and 010. version 1.13 (8th of november 2013) added part 018-023, the average lethal dose of HCN to 003, and the Sophocles quote. version 1.14 (9th of march 2014) united 003 with 009, in place of the appleseeds method there's now the methanol intoxication on position 003. toxalbumins have been included into 011. and the Evan Harris Walker quote was put at the very beginning of the preface. a nap in the bath (015) has been inserted between 014 and the former 015. version 1.15 (31st of march 2014) included nux vomica into 018and added method 025. version 1.16 (3rd of april 2014) extended 025 via an appendix, added a case example to 002, the Schopenhauer quote between 018 and 019, and finally, part 26.

content overview

introduction

part 0 001 partial suspension hanging, preceded by drinking... 002

overcoming the fear of heights 002 drinking, preceded by drinking... 004

suicide by snake bite 004 kissing your dearest ones yourself goodbye 006

breaking (hemlock & wolf's bane) for a cup of tea 007 dieting on salads 010

mixing 10 capsules of tramadol with... 011

giving in to bitterness 012 fasting yourself to death 013

eating from the tree of knowledge 014 exchanging headache for a headache 016

combining over-hydration with hypervitaminosis A 017 a nap in the cold 020

a nap in the bath 021 il dolce vino 026

metal 027 les autres fleurs du mal 030

“i ain't givin you no golden shot" 034 protective parathion hand lotion 038 impromptu railway promenade 039

pizza ai funghi 040 antitussives that toss away your tussis. for good 041

letting things end this way. in tears 042 SSRI * MAOI = peace of mind² 043

pressants, pressants, et al. 054

conclusion

introduction

„think of the plans we make for our lives […] our plans feed our daydreams. we stare out windows imagining loves fulfilled, futures blessed with success, riches, fame, recognition, and respect. we hope and we build ever more elaborate plans to hide our disillusionment as each hope slips away. then one day we awaken to find ourselves buying lottery tickets to patch these ludicrous fantasies together as they turn to nothing“ -Evan Harris Walker, from 'the physics of consciousness', p. 2

i guess a mixture of some barbiturate + some antiemetic or other kind of substance that prevents vomiting, like it's being used in Switzerland and Belgium and the Netherlands for euthanizing people, is not up for debate, because it's not easily available. but there's other ways that look promising and are within many people's (?) reach.

here are 26 methods i would consider worth considering.

part 0

going to work on a sunday because, as the bible says, "you shall keep the Sabbath, because it is holy for you. Everyone who profanes it shall be put to death"-Exodus 31:14

"for six days shall work be done, but the seventh day is a Sabbath of solemn rest, holy to the Lord. whoever does any work on the Sabbath shall be put to death"-Exodus 31:15.

okay, now let's be serious.001

part 1

partial suspension hanging, preceded by drinking... yourself unconscious. based on the results from my last attempt, 1 bottle of vodka (or a bit more), flushed down as quickly as possible, within a timespan of a few mins (one doesn't need to empty the bottle in one take, but one should not linger too long either) will make you pass out. so, if one is sitting upright and has a cord or cable or whatever wrapped around one's neck, and the other end fixed onto some spot above, maybe on a hook one screwed into the ceiling a while ago, with a total length just about not long enough to let you bend forward anymore (or into any other direction), it means... you'd asphyxiate yourself the moment you drop off and your upper body (at least by a few centimeters) sinks down. according to Geo Stone's "suicide and attempted suicide" no more than 15 kg pulling on your ligature are needed to close your trachea and to cut you off from oxygen.

part 2

overcoming the fear of heights the average height of an apartement is 2.5m (hollow space) + a 16-30cm thick ceiling. assuming it's 2.7m in total, then, when you'd be standing on the

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18th floor you'd be 45.9m above ground level. based on Geo Stone's investigation. a 150 feet (= 46 meters) fall onto the ground, or a 250 feet (= 76 meters) fall onto water, will almost certainly lead to death.

if there aren't any buildings or bridges tall enough where you live, one can travel abroad. i was thinking of the Yangtze river bridge in Nanjing (China), a famous suicide spot. It does not provide a 76 meters fall, but, it's proven itself to be safe investment. If the impact with the river won't kill you, you'll drown instead. China is a country one could potentially aquire some nice potentially lethal drugs from. also nembutal and cyanide. i thought about going to Nanjing, trying to get hold of sth like that, and if it fails, jumping off that bridge as a last resort.

as far as leaps of faith onto solid ground are concerned, you'll probably also die from a fall from a bit below the ideal of 46m. maybe take a lethal dose of some poison beforehand, as a security measure. South Korea, 2013...

"a 39-year-old man jumped to his death from the top of an 11 story building in the southeastern port city of Busan. In addition to killing himself, the suicide jumper landed on a little girl who was standing outside of the apartment building with her parents. the man died immediately from the fall. the little girl suffered broken bones and brain damage and died shortly after the incident at the hospital. the little girl's parents were not harmed in the fall."-kare11 news, http://www.youtube.com/watch?v=aSLket0pwQw

the top of a 11 story building, that's equivalent to the 12th floor, or to a height of around 29.7m. As the example above shows, you should be careful not to hit anyone, or else there will be 2 casualties.

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part 3

drinking, preceded by drinking... anything with methanol as a special ingredient in it. alcohol starts to work prior to methanol, assuming you'll consume both, you will first get drunk as expected, and then, a few hours later, lose consciousness due to the methanol intoxication, sounds like a pleasant way to go, and many have already taken this path, although often unintentionally. But there's a catch.„if as little as 10 mL of pure methanol is ingested, for example, it can break down into formic acid, which can cause permanent blindness by destruction of the optic nerve, and 30 mL is potentially fatal,[21] although the median lethal dose is typically 100 mL“-http://en.wikipedia.org/wiki/Methanol

„indeed, small amounts of ingested methanol are sufficient to produce acute destruction of parts of the central nervous system leading to permanent neurological dysfunction and irreversible blindness“-http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1771266/

this means, it's probably a good idea to learn the braille alphabet before your methanol suicide attempt. because if you survive, you might be blind afterwards.

part 4

suicide by snake bite getting hold of a snake should be easier than to aquire a gun is, in most countries. Cleopatra killed herself by inducing an asp (probably the Egyptian cobra in her case, there's some debate about this and in general about her death's circumstances) to bite her. let's use her as a rolemodel. "the venom [of the Egyptian cobra] affects the nervous system, stopping the nervesignals from being transmitted to the muscles and at later stages stopping

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those transmitted to the heart and lungs as well, causing death due to complete respiratory failure in just 10 minutes" -http://en.wikipedia.org/wiki/Egyptian_cobra

the European asp sadly doesn't seem to promise a quick and secure death. but 4 months ago, in France, someone (a German) actually managed to die (unintentionally) via cardiac arrest induced by his pet aspis viper-http://www.welt.de/vermischtes/kurioses/article117268527/Schlangen-Experte-stirbt-waehrend-Show-durch-Biss.htm.

he had the fortune of having been bitten several times. based on what i've gathered online, it appears as though several bites are indeed needed. one isn't toxic enough.

if you happen to live in the USA or Mexico, a mojave rattlesnakeenvenomation leads to respiratory failure aswell. since apparently the bite of this species "is usually not as painful as other rattlesnake bites." but "is considered ten times more toxic"-http://www.blueplanetbiomes.org/mojave_rattlesnake.htm

it might come relatively close to a peaceful death. of course i can give you no promise on that.

if you happen to live in India, the prestigious naja naja (Indian cobra) might not be your best bet with a fatality rate of below 20%-http://en.wikipedia.org/wiki/Indian_cobra

but you might be lucky enough to have one of those life-ending encounter

with the beaked sea snake, which is "notoriously aggressive and readily provoked, with 1 single bite containing enough venom to kill 50 people"- http://oceana.org/en/explore/marine-wildlife/beaked-sea-snake

if you happen to live in China or a country nearby, suppression of breathing + subsequent death also occurs at the mercy of the many-banded krait, that is, depending on the severity of the bite it may or may not end fatal, 29 hours later?-http://en.wikipedia.org/wiki/Joseph_Bruno_Slowinski

if you happen to live in Afrika, the black mamba will surely put you to death

apparently, “the most toxic venom, by far, of any snake in the world“-http://en.wikipedia.org/wiki/Inland_taipan

comes from the inland taipan, found in Australia. death follows within 30-005

45mins. so as far as velocity is concerned, the Egyptian cobra has a faster acting venom, but not the potential to kill 100 people.

part 5

kissing your dearest ones yourself goodbye some of you may have heard of "the frog prince", a story about a frog, who after having been kissed by a princess, is freed from a spell that was put on him, and turns back into a prince.

nth but a fairy tell... or maybe not. kissing a frog can have a spell-breaking effect, although not necessarily for the frog, but for yourself. it can free you from the burden of life.

Madagascar is the habitat of a genus of frogs called mantella most are toxic, but 2 especially so. the golden mantella and the black-eared mantella. just touching them may lead to "life-threatening consequences"-http://reptiles.wikia.com/wiki/Black-eared_Mantella

in some tropical rainforests, there live the so-called poison dart frogs, among which, the phyllobates terribilis, found mainly in Colombia, "is the most toxic frog known"-http://aalite.hubpages.com/hub/Poison-Dart-Frog-Facts

kiss it (or altearnatively, the phyllobates bicolor) and you'll kiss yourself goodbye. "this causes immediate severe pain, fever, and repeated electrical jolts in the fingers and toes. after forty-five seconds to one minute, seizures occur, quickly followed by paralysis and death"-http://reptiles.wikia.com/wiki/Golden_poison_dart_frog

the oophaga histrionica, also in Colombia, can also solve your problems for you. or the lovely poison dart frog, in Honduras, or the phyllobates

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aurotaenia, "the third-most toxic of the poison dart frogs"-http://reptiles.wikia.com/wiki/Kokoe_poison_dart_frog

(Colombia + Panama)

part 6

breaking (hemlock & wolf's bane) for a cup of tea after studying historical texts and consulting with toxicologist Dietrich Mebs, the German historian Christoph Schaefer concluded that Cleopatra "died from drinking a mixture of poisons. a mixture of hemlock, wolf's bane and opium“- http://edition.cnn.com/2010/WORLD/europe/06/30/cleopatra.suicide/index.html?_s=PM:WORLD

instead of a snake's venom. whether their theory is right is questionable, i personally doubt it because all other sources say otherwise and they seem to be misinformed about the effects of an Egyptian cobra bite, which does not take hours to induce death. but we're offered interesting information from a toxicologist about how to induce a pain-free (or at least not too painful) death. it appears to me, their idea was that mixing hemlock and wolf's bane, both by themselves already potentially lethal, both potentially leading in a similar manner to the same end result (cardiac arrest), will accelerate the process, and adding opiate to it will numb your body and lessen (or even eradicate) the pain. you can't buy the plants just like that, but you can buy their seeds and grow them yourself.

conium maculatum (hemlock): it apparently starts to blossom in the 2nd year after the seeds have been planted in some sunny place. every once in a while these seeds are being sold on ebay. all parts are toxic. because the main ingredient of the dúcānsh (ǔ 毒参属, conium/hemlock) plant is the alkaloid dúqínji n (ǎ 毒芹碱, coniine), which makes up around 90%-http://www.cysticus.de/klassische-homoeopathie/conium-maculatum.htm

yet, "within the unripe fruits it carries, its toxin coniin is especially strongly concentrated“

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-http://de.wikipedia.org/wiki/Conium_maculatum

the lethal dose of coniin is 1g (0.1 grams/"8 fresh leaves can suffice“)- http://www.inchem.org/documents/pims/plant/conium.htm#SectionTitle:2.5 Poisonous parts

wūtóush (ǔ 乌头属, aconitum/wolf's bane) : seeds can be ordered on amazon for little money. it grows in sunny or not so sunny places, out of moisturized earth. apparently already 1 year after the seeds have been planted-http://www.natur-lexikon.com/Texte/MZ/002/00183-Blauer-Eisenhut/MZ00183-Blauer-Eisenhut.html

all parts are toxic. wūtóuji n (ǎ 乌头碱, aconitine) is the alkaloid acting here, which is supposed to be "more toxic than“ -http://de.wikipedia.org/wiki/Aconitin

fānmùbiēji n (ǎ 番木鳖碱, strychnine). the lethal dose of the latter is 30-120mg-http://de.wikipedia.org/wiki/Strychnin

for an adult, 15mg if injected. and for the former, aconitine, (via oral intake) it could be as low as 3mg-http://pharmacology.georgetown.edu/urbanherbs/Aconite.htm

or even just 2mg-http://en.wikipedia.org/wiki/Aconitine

let's consider it to be 6mg, which doesn't even need to be swallowed, a "simple skin contact is sufficient and leads to a painful death“-http://www.gartendatenbank.de/wiki/aconitum-1_infos_eisenhut

within just a few hours. the root and its preflowering leafs and its seeds have the highest concentration. now, i sadly wasn't able to find out what the exact amount of aconitine is, as far as the seeds are concerned, but the root is supposed to contain 0.2%-http://botanical.com/botanical/mgmh/a/aconi007.html

this means 1g of root yields 2mg of aconitine. but don't expect your stomach to extract all of it.

note, you can order both from http://www.weberseeds.eu if you plan to eat some aconitum napellus seeds, prepare yourself for "hours of violent vomiting and diarrhea“-http://circ.ahajournals.org/content/102/23/2907.full

before you'll pass out. ventricular arrhythmias would be the potential cause of death..

so the last ingredient needed would be opiate. which you can get from your drug dealer next door? i sadly don't maintain any contacts with people like that, and know of no easy way to get hold of opiate, but maybe an opioid will work aswell? "an opioid is any psychoactive chemical that resembles

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morphine or other opiates in its pharmacological effects."-http://en.wikipedia.org/wiki/Opioid

tramadol is such an exemplar, an "analgesic used to treat moderate to moderately severe pain“-http://en.wikipedia.org/wiki/Tramadol

you can get it prescribed, or you can order it from Spain "prescription free" (pharmacists there don't take bureaucracy too seriously, i managed to order all sorts of meds (including tramadol) from Spanish pharmacies that i wasn't able to obtain in other European countries. just contact the pharmacist directly via email, and maybe you'll be lucky and get what you want). i should mention, though, it takes 2-3 hours before tramadol starts to work for me. so take it first, and then drink your conium-aconitum tea once you begin to lose sensation in your body. if however you'd prefer a different flavor, oleander- http://www.annemergmed.com/article/S0196-0644(85)80103-7/abstract

tea might work aswell. or foxglove tea. Maurits Verzele, author of de milde dood claims oleander and foxglove are equally toxic. I'm not sure about that, but they are both suitable enough for a „good night“ tea.another analgesic, diclofenac "can be combined with opioids if needed“-http://en.wikipedia.org/wiki/Diclofenac

this, and tramadol, just to post some concrete links, can be obtained at http://pharmaonline.tv, or at http://generics24.com

and, to prevent vomiting, the antihistamine of my choice would be diphenhydramine, because, besides its antiemetic effect, it has been reported it "potentiates any opioid drug“-http://en.wikipedia.org/wiki/Diphenhydramine

aswell. so the 3 painkillers seem to be compatible with one another and enhance the overall effect towards a potentially painfree suicide experience.

stressfree it will be not, you will, unless you take a preventive step, asphyxiate consciously. I've tried this method myself in november 2013 and was rescued, with magnesium/water, apparently an effective antidote, that was injected into me.

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dramatic pause

"suicide is an important medical treatment for depression"-http://uncyclopedia.wikia.com/wiki/Suicide

part 7

dieting on salads recipe: first collect some datura leafs. that'll be the fundament. "in the Middle Ages, it was very popular among professional murderers who used to add parts of the plant with the victim’s food or wine and achieved an immediate poisoning effect, followed by death."-http://library.thinkquest.org/C007974/1_1hem.htm

alternatively, ingesting 200 datura seeds -http://www.erowid.org/plants/datura/datura_info5.shtml

should work aswell. either of those can be refined with some belladonna berries. from my internet research, it is unknown how many are required (english wiki says 5 can kill an adult. german wiki says 12 can kill an adult.thepoisongarden.co.uk says... a danish boy, 9 years young, survived the intake of 25) for a "good night" meal but by the time you've accumulated a bellyful of them, you've probably had enough. “coma and convulsions often precede death“-http://www.thepoisongarden.co.uk/atoz/atropa_belladonna.htm"

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instead of onions, use the bulb of a daffodil, where the alkaloid poison lycorine is mostly contained. apparently, people sometimes confuse these with onions and add them to their meals, cause they look similar. eating"large amounts can lead to death“ -http://de.wikipedia.org/wiki/Narzissen

to this, you might want to add some calabar beans, which look nice, like ordinary beans but have an interesting effect. eating them may lead to the "loss of control over the respiratory system, causing death by asphyxiation“-http://en.wikipedia.org/wiki/Calabar_bean

however, "if you vomit, you'll survive“-http://chestofbooks.com/reference/American-Cyclopaedia-2/Calabar-Bean.html#.UnJBXHAyJmM

4 to 8 castor beans are also worth a consideration. from a plant called ricinus communis, which is considered to be "the most poisonous in the world“-http://en.wikipedia.org/wiki/Castor_oil_plant

with some wine or vinegar the salad is complete... prepare your stomach (take meds against vomiting) and eat a spoon bowlful, and you'll be no more.

part 8

mixing 10 capsules of tramadol with... alcohol/antidepressants/sleeping pills/benzodia-zepines

"taken as prescribed, tramadol is a highly effective drug — the problems seem to arise where the dosage is exceeded or it is taken with alcohol and/or other drugs that have a sedative effect"-http://www.dailymail.co.uk/health/article-2305936/Tramadol-When-safe-option-painkiller-turns-lethal.html.

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10 capsules (500mg of tramadol) may be enough to kill even an obeseperson, as the link above shows (although her heart-disease may have added to the effect). you'd probably want to increase the chance for respiratorycessation, you can mix it with the 4 substances mentioned above, or with other non-opioid painkillers.

"John wants other people to know of the dangers of tramadol"excellent. thank you John.

part 9

giving in to bitterness this one i considered for a potential attempt at commiting zìshā (自杀, suicide). once the time was to come for me to sense that the time has come for me to go. 50-60g k xìng (ǔ 苦杏, bitter almonds) amount to around the lethal dose of cyanide. i got myself a pack of 200g. from India. and a brandnew coffee grinder, just for that.

unfortunately, the bitter taste is (under normal circumstances) un-over-come-able. bitter almonds are so bitter it burns your throat, palate and tongue when you want to swallow them. pouring some sweetened soy milk over the grinded seeds improved my meal, but only by a bit. Bel Cowie-https://www.google.de/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&ved=0CFAQFjAF&url=http%3A%2F%2Fnews.google.com%2Fnewspapers%3Fnid%3D2507%26dat%3D19830609%26id%3DesJAAAAAIBAJ%26sjid%3D_KUMAAAAIBAJ%26pg%3D2699%2C1797028&ei=v9t4UrSFFYPv4gSx9IDYCA&usg=AFQjCNEjyeFOsn2egKRLP9E_AWzVBAb1Cg&bvm=bv.55980276,d.bGE

managed to eat enough, but if you have a strong gustatory sense like it is the case with me, you can grind them into powder and fill them into empty capsules. people who drink lots of alcohol with ease, or who don't taste anything (due to ageusia, or xerostomia. the latter (also known as the dry mouth syndrom) can be the result of sjögren's syndrome, if you happen to

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suffer from this, you're lucky? or it can be induced artificially via meds that dry out your mouth) maybe won't even need capsules. it should also be mentioned that it's a good idea to eat more than just 50-60g. our bodies vary and maybe you'll need more. if you underdose, you'll risk a brain-damaged survival.

alternatively you can collect applesseeds, one needs lots of them. a fully filled cup (or 2) of seeds, from hundreds of apples. obviously it's impossible to test the exact amount of cyanide that's stored in every single seed (there's approx. 0.6mg HCN in 1g of seeds) and add it together to obtain the lethal dose (50 mg ). and even if you could, your stomach won't extract all of it. so eat lots of them to be on the safe side. and grind them properly just before ingestion.

part 10

fasting yourself to death it takes a while to starve. people who participated in the Irish hunger strike died after 46 to 73 days-http://en.wikipedia.org/wiki/1981_Irish_hunger_strike

however, 1 person there survived despite having ceased eating for 70 days. you can get yourself some painkillers or opiate to numb down your pain (that is the intense feeling of hunger), to make this process easier. amphetamine (especially dexamfetamine and methylphenidate are taken to lose weight. they lower your appetite). you might also find a good companion in the digitalis plants."a frequent side effect of digitalis is reduction of appetite, some individuals have used the drug as a weight-loss aid."-http://en.wikipedia.org/wiki/Digitalis

also, avoid sunlight, because you might end up in a state of inedia. "according to Ayurveda, sunlight is one of the main sources of prana“-http://en.wikipedia.org/wiki/Inedia

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prana is a vital force, according to Hinduism, that can suffice to maintain a body, without the need for food.

part 11

eating from the tree of knowledge and the Lord God commanded the man, saying, „you may surely eat of every tree of the garden, but of the tree of the knowledge of good and evil you shall not eat, for in the day that you eat of it you shall surely die“-Genesis 2:16

let's assume the tree in question is the taxus baccata, and from eating enoughof its seeds you shall surely die. my amount during my 2nd suicide attempt was sth around 100 (it was recommended to take a mouthful, which is what i did, not having had any better sources at that time), while a businessman from the link below, who succeeded, apparently took 400.-http://www.dailymail.co.uk/news/article-1088981/Businessman-committed-suicide-eating-graveyard-yew-seeds-losing-wife-company.html

if you plan to eat some of these (so-called) yew seeds, the english or japanese ones, make sure you eat enough of them. more than i did. the result of my failure, btw, was, i woke up the next day, vomited every couple of minutes, and had to crawl from room to room, because everytime i tried to rise, i blacked out. it completely messed up my blood circulation. yet, just for a while. my body functionality returned to normal after only 1 week.

the interval between ingestion and fainting was, as far as i remember, 30mins, and was painless. but if you'd experience a cardiac arrest before you pass out, it might not be painless after all.

"toxalbumins are protein phytotoxins [...] a type of ribosome-inactivating proteins (RIP, a most suitable acronym)", "poisoning proceeds as follows. First there is a latent period, in which nothing appears to be happening. in

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actuality, the toxin is hard at work, shutting down ribosomes. then things start to happen. time to get out your catastrophic health insurance card andhead to the hospital. A little nausea, some vomiting and diarrhea. Some victims develop ulcerative lesions throughout their GI tract. the gastric mucosa starts to hemorrhage. total disruption of intestinal function leads to massive fluid and electrolyte loss, and death soon follows."-http://www.drugsandpoisons.com/2008/01/lectins-peas-and-beans-gone-bad.html

toxalbumins are ricin (can be found in castor beans, which i already mentioned in my salad recipe), abrin (can be found in abrus precatorius seeds), viscumin and phoratoxin (both can be found in mistletoes), crepitin (can be found in hura creptians seeds), jatrophin/curcin (can be found in jatropha curcas seeds), momordin (can be found in momordica seeds, fruits, outer rind, but is probably not suitable for a suicide, its toxic effect appears to be limited, no matter how much you eat), robin and phasin (can be found in black locust leaves and the bark. and apparently also black locust seeds, but they seem harmless) "various reports suggest that the seeds and the young pods of the black locust are edible"-http://en.wikipedia.org/wiki/Robinia_pseudoacacia

"the fatal dose of abrin is approximately 75 times smaller than the fatal dose of ricin", "ingesting a single (abrus precatorius) seed can kill an adult human"-http://en.wikipedia.org/wiki/Abrus_precatorius

dying can take days, though.

eating jatropha curcas seeds leads to following simptoms, after 15-20mins: "difficulty in breathing, sorethroat, bloating, dizziness, vomiting, diarrhea, drowsiness, dysuria and leg cramps"-http://www.globinmed.com/index.php?option=com_content&view=article&id=104434:jatropha-integrimma&catid=135&Itemid=141

and can end in death if the meal was sumptuous enough. yet, neither an exact nor an approx fatal dose to aim for is known to me. the same pertains to the other toxalbumins. it appears dying usually takes longer than what you'd get from yew seeds poisoning, but toxalbumin-trees aren't necessarily 2nd choice trees of knowledge, RIPs should be lethal in much smaller amounts.

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part 12

exchanging headache for a headache no.1 of my attempts was at age 19, some years ago...with aspirin. 4 packages or so. approx 80 tablets.

it caused a horrible headache and i could barely take the pain. it felt as though my skull was about to crack any moment. eventually, after about half an hour, i lost consciousness and ended up in a hospital. no lasting damages, as far as i can tell, remained. and also no certainty of whether this would have been fatal or not. take some meds against vomiting, if you plan on trying it yourself. it's painful, but not as painful as conventional hanging, drowning, stabbing or burning yourself. i failed and survived without any apparent damage. Geo Stone, the author of suicide and attampted suicide also mentions having tried aspirin, and obviously survived, with a brain healthy enough to write a book.

.

so although there's a considerable uncertainty as to whether you'll succeed, if you fail, you can try again.

just before i passed out, i vomited. thoroughly. all that was in my stomach made it to the outside. the urge to throw up is immense, some call what occurs "projectile vomiting". even with suppressive meds you might still be urged to express yourself in such a way. and use this peculiarity about aspirin overdoses to your advantage. with a gasmask on your head, a hose attached to it, and one of those horizontal fold flat odour mask or the surgical masks Michael Jackson used to wear attached/duct-taped at the other end of the hose, you could breathe air up untill the point your halfway digested food runs down the hose and covers all the pores of the paper tissue. if you happen to lose consciousness just after throwing up, like i did,you'd asphyxiate yourself unconsciously. if you won't pass out and the lack of oxygen starts to bother you, you can always take off the mask. to prevent a traumatic experience.

in any case, aspirin overdoses, with or without mask, require you to be alone. or else you'd be rescued. the headache i felt was so painful i

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screamed, and alarmed my parents. they brought me to the hospital. i survived.

dramatic pause

“it is best not to have been born at all: but, if born, as quickly as possible to return whence one came.”

-Sophocles, in his play Oedipus at Colonus

.

part 13

combining over-hydration with hypervitaminosis A water intoxication "is a potentially fatal disturbance in brain functions that results when the normal balance of electrolytes in the body is pushed outside safe limits by over-hydration."-http://en.wikipedia.org/wiki/Water_intoxication

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well, how much water do you need (to drink to die)?.

in 1995, eighteen year old Leah Betts "drank approximately 1.85 gallons of water in less than an hour and half"-http://voices.yahoo.com/known-cases-water-intoxication-182666.html

she died. 1.85 gallons are approx. 7 liters.

the author of the top 20 suicide methods reports following..."i drank 7 liters of water in 2.5 hours. then i faced a terrible headache and a sensation of spinning head, nausea and vomited once. after vomiting, i forced down another liter of water. i went out to have a cup of tea, lighted a cigarette and that is all that i remember. i fainted, fell on the ground and had a severe cut at the back of my head. i was taken to hospital immediately by people standing around and there i had 5 stitches on my head. i was sent back to another hospital for a CT Scan and ended up with a report of signsof cerebral edema"-http://wantdeath.blogspot.de/2011/08/water-intoxication-it-actually-works.html

yet, nth will happen "even if you drink a lot of water, as long as you drink over time as opposed to intaking an enormous volume at one time"-http://chemistry.about.com/cs/5/f/blwaterintox.htm

that's because your kidneys can process 15 liters of water each day. if you drink slowly, you'd have to drink more than 7-8 liters.

so how can you force down 7-8 liters?firstly, you could stop eating for a day or 2, to accumulate hunger. and then try to alleviate it with water instead of food. from my own experience, i usually drink excessively when there's been nth to eat for a while.

secondly, maybe you won't need to drink this much after all. take a look at following occurence, which is listed as a potential suicide method in itself on some website. it's hypervitaminosis, it "refers to a condition of high storage levels of vitamins, which can lead to toxic symptoms. the medical names of the different conditions are derived from the vitamin involved: an excess of vitamin A, for example, is called hypervitaminosis A"-http://en.wikipedia.org/wiki/Vitamin_poisoning

hypervitaminosis A & hypervitaminosis D, that is, the overdose on these 2 fat-soluble vitamins, and especially on those 2, A and D (besides E and K, which are also fat-soluble) is most likely to occur-http://de.wikipedia.org/wiki/Hypervitaminose

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the kidney won't flush them out, they instead get stored in the liver & in fat.

people, polar researchers to be more precise, who weren't warned not to eat the liver of ice bears, (inuits, don't eat them) died-http://de.wikipedia.org/wiki/Hypervitaminose

apparently from an acute hypervitaminosis A. ingesting a hundredfold (or more) of the normally needed amount of vitamine A, is thought to end deadly..

during the Australasian Antarctic expedition of 1911–1914, Xavier Mertz died. apparently the first reported case of a hypervitamosis A fatality due to eating dog-liver.-http://healthadvisors.blogspot.de/2013/06/vitamin-overdose-or-hypervitaminosis-a.html

there's a problem. just like all the other reports about people dying in polar regions, these are anecdotes and there's room for specualtion as to what really caused their death.-https://www.mja.com.au/journal/2005/183/11/mawson-and-mertz-re-evaluation-their-ill-fated-mapping-journey-during-1911-1914

assuming hypervitaminosis A plays a role in these deaths, there were other contributory factors at play aswell. coldness, malnutrition, stress.

hypervitaminosis D looks no more promising: "it is instructive to note that as far back as 1939, some truly enormous doses of vitamin D were in fact found to be far less deadly than one might expect. in several countries, most infants, including preemies, survived 200,000 to as many as 600,000 units of vitamin D given in a single injected or oral dose"-http://www.doctoryourself.com/dvitamin.htm

despite the claims that hypervitaminosis (A or D) can have life-threatening consequences, i could find not one clear-cut case where this was the case. (that is, the case that it was the sole cause of death)

however!

"symptoms of acute (short-term) toxicity include nausea, headache, fatigue, loss of appetite, dizziness, dry skin, desquamation (loss of skin), and cerebral edema (swelling in the brain)"-http://www.mayoclinic.com/health/vitamin-a/NS_patient-vitamina/DSECTION=safety

cerebral œdema is the potentially fatal outcome of over-hydration, as well019

as of hypervitaminosis A. thus, combining lots of water with lots of vitamin A (supplements) might reduce your need for drinking all that much.

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part 14

a nap in the cold find yourself a nice place in a snowy, forsaken landscape, or on a mountain, or a cooled storage room, and wait for hypothermia to set in. "(from Greek ὑποθερμία) is a condition in which core temperature drops below the required temperature for normal metabolism and body functions which is defined as 35.0 °C (95.0 °F)."-http://en.wikipedia.org/wiki/Hypothermia

profound hypothermia is what one considers a body temperature at less than 20 °C (68 °F). that's what you should be aiming for. after a period of discomfort, you'll eventually fall asleep. your hearbeat rate will drop, your organs will get turned off, you'll die. unless you'll be found and rescued. then you might survive, with several amputated body parts that froze beyond repair. so make sure noone will find you.

to make the falling asleep procedure more pleasant, "alcohol consumption increases the risk of hypothermia via its action as a vasodilator. it increases blood flow to the body's skin and extremities, making a person feel warm, while increasing heat loss."-http://en.wikipedia.org/wiki/Hypothermia

but you might also take some sleeping pills, or if you're among those people for whom they don't work, like it's the case with me, chloroform might work instead. you can buy it from chemists, they sometimes put it on ebay, and then ebay deletes the offer, because they must not be sold to normal citizens.whenever you spot such an offer, note down the seller, and contact him/her privately. i managed to aquire a bottle of 100ml in this manner myself.

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or produce it via following recipe:500ml of sodium hypochlorite (as bleach with a concentration of 2.8%) +10ml of acetone = 3ml of chloroform

btw.... mixing these 2 ingredients in a salad bowl instead of a cylindrical vessel, gave me the best result = only 2 hours of waiting

based on my self test, 5ml (via oral intake) are enough to induce sleepyness.drinking 10ml instead made not much of a difference for me. tt should also be noted that, chloroform does not force unconsciousness onto the person who swallows/inhales it. this appears to be a misconception many people hold. making you feel like going to sleep, yes it does, but you, or i at least, still manage to keep myself awake.

part 15

a nap in the bath a bath-nap is "the action of napping whilst enjoying a relaxing bath"-http://urbandictionary.com/define.php?term=bath+nap

and if you do it right, you'll also enjoy a relaxing end-of-life experience. how do you do it to do it right?

there's 2 things that need to be paid attention to.making sure you'll have a thorough, deep nap that you can't be shaken out of by an otherwise drastic event like dying. making sure you'll find yourself submerged in water while asleep.as far as the first criteria is concerned, you could use chemical substances that induce sleep, or you could count on lowering the count of blood cells in your body.

"Sodium thiopental is an ultra-short-acting barbiturate and has been used021

commonly in the induction phase of general anesthesia [...] following intravenous injection, the drug rapidly reaches the brain and causes unconsciousness within 30–45 seconds."-http://en.wikipedia.org/wiki/Sodium_thiopental

but it can be used for more than just that."sodium thiopental is used intravenously for the purposes of euthanasia. in both Belgium and the Netherlands, where active euthanesia is allowed by law, the standard protocol recommends sodium thiopental as the ideal agent to induce coma, followed by pancuronium bromide."-http://en.wikipedia.org/wiki/Sodium_thiopental

"etomidate is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia", "the anaesthetic induction dose for adult humans is 0.3 mg/kg intravenously, with a typical dose ranging from 20–40 mg. etomidate causes loss of consciousness after one arm-brain circulation time."-http://en.wikipedia.org/wiki/Etomidate

an arm-brain circulation time is around 10-60sec, or "is simply the time taken for the drug to travel from the site of injection (usually the arm) to the brain"-http://www.frca.co.uk/Documents/107%20-%20IV%20induction%20agents.pdf

propofol, methohexital, thiopental, thiobarbital, pentobarbital or barbiturates in general would be some more substances usable for intravenous anaesthesia injections. but you'd have to be lucky to get hold of any of them.

sleep enforcing effects can also be expected from (non-)benzodiazepines (midazolam, diazepam, brotizolam, estazolam, flunitrazepam, flutopraze-pam, loprazolam, lormetazepam, nimetazepam, nitrazepam, quazepam, triazolam, zaleplon, zolpidem, zopiclone, ...) quinazolinones (methaqualone, methylmethaqualone, diproqualone, etaqualone, mebro-qualone, mecloqualone, nitromethaqualone, SL-164) antidepressants (mirtazapine, ketamine, trazodone, trimipramine, doxepin, mianserin) and especially potent sleeping pills (clomethiazole). whether they will be able to keep you unconscious even when you're in severe pain/dying is, for most of them, an open question. flunitrazepam has been used for surgeries and also midazolam has seen some professional use as an anaesthetic. these 2 seem the most reliable. and quite out of reach for most people. of the above lormetazepam plus clomethiazole

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can be obtained from Spain without prescription.

"clomethiazole is particularly toxic and dangerous in overdose and can be potentially fatal. Keith Moon (1946-1978), drummer of the renowned English rock band The Who, died after taking an overdose of clomethiazole on September 7, 1978"-http://en.wikipedia.org/wiki/Clomethiazole

as for hypnotic antidepressants, you might be able to persuade a psychiatrists to give you those, most of all if you've already been diagnosed with depression. which is not difficult to achieve, if you've already had a suicide attempt before.

the easiest and cheapest thing to do is to use alcohol instead (or in combination with one of the substances listed above). based on my self-test, approx. 900ml of vodka, which contained 37% alcohol, have been enough to make me pass out. now this already is the third time i recommend alcohol as an ingredient (method 001 and 003 were also based on drinking yourself unconscious) but what if you can't stand the agressive character of it that burns your throat and makes alcohol rather difficult to swallow?

instead of drinking it all, you could fill it into capsules. they are available in different sizes. 000 is the largest with a bit over 1mg or ml capacity. size 00, however, is all you can acquire if vegan (= gelatin free) capsules are required. they hold exactly 1mg or ml. be aware of this, though: they aren't meant for liquids but for powder or sth. non-liquid akin to it. alcohol will cause them to fall apart eventually. after around 15mins.

i was able to buy 70 percentaged ethanol/ethyl alcohol from a pharmacy next door, despite people on the internet (who happen to live in the same country i - sadly, still - live in) claiming that they had trouble doing so. if your pharmacist won't sell it to you, you can simply resort to the internet, where you'll even be able to find 96% versions.

around 476 capsules (or more, or less, depends on your bodily condition), sized 00 (each containing 1ml) filled with 70% ethanol (you can use a syringe for that procedure) is what you'd need to approximate 900ml vodka. the equivalent for 96% ethanol would be around 347 capsules.it is either way unlikely that anyone would manage to prepare and right

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away consume (you need to swallow each capsule within 15mins or so after it has been filled) such a large amount before the liver has metobolized enough of it to increase the need for an even larger dose in order to become unconscious.

"metabolism is the body's process of converting ingested substances to other compounds. metabolism results in some substances becoming more, and some less, toxic than those originally ingested"-http://pubs.niaaa.nih.gov/publications/aa35.htm

in the case of alcohol, metabolism leads to alcohol becoming less toxic, less effective in causing poisoning/enforced sleep.

"the liver can metabolize only a certain amount of alcohol per hour, regardless of the amount that has been consumed. the rate of alcohol metabolism depends, in part, on the amount of metabolizing enzymes in the liver, which varies among individuals""in general, after the consumption of one standard drink, the amount of alcohol in the drinker's blood (blood alcohol concentration, or BAC) peaks within 30 to 45 minutes."-http://pubs.niaaa.nih.gov/publications/aa35.htm

but with large doses, it can take a whole hour before you reach full drunkenness. then the blood alcohol concentration declines. you'd therefore want to get over with all the capsule preperation + ingestion within around 1 hour. if you use up more time, the potency of the capsules you swallowed at the beginning will become less and less and you logically will need more than just the 900ml vodka equivalent that i proposed here as a guideline.

there's capsule filling machines with recesses for 24 exemplars, and there's foam material, in which you can cut tiny holes for holding several capsules, for a varying amount of exemplars, depending on how many holes you can make fit into the foam. just holding a capsule in one hand, injecting ethanol with the other, putting the top back onto it... to complete 1 capsule at a time would take, for 347 or 476 iterations respectively, a very long time. just to give you an hypothetical example, if you managed to have prepared and swallowed 1 capsule within 10sec, for 347, it would take you 3470secs, that's 58mins. for 476, it would take 79mins.thus 347 96% ethanol capsules theoretically would be doable within 1 hour,but practically no. already half way through you'd be so drunk, you wouldn't

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be able to keep this pace up any longer.

you can speed up the filling process if you make enough holding places for capsules in foam materials, that hold all the capsules you need. then put all of them into their places. and then fill them up (25 or 50 or so in one take) without having to reach for a new empty capsules all the time during this process, because they will be closely lined up in rows, and you will only have to make miniscule movements (with the syringe) from one capsule to its neighbour.but even so, it'll still take too long. thus i'd recommend you aim for less, like only half of the capsules needed, the equivalent of 450ml vodka, and the rest you'd drink instead (drinking doesn't demand such precise motions and concentration that the filling of further capsules would demand), in the form of a low percentage wine or champagne or whatever, sth else that is not as hard to swallow as 37% vodka.

a typical wine has 13% alcohol. 1 liter would yield 130ml alcohol. 450ml vodka with 37% yields 167ml.so you would need even more wine than that. 1 liter and 300ml (= 169ml alcohol).that's 2 bottles of wine plus 173 96% capsules or 238 70% capsules prepared and ingested beforehand... in order to collapse.

another reliable method of losing (and keeping sufficient distance to) consciousness is blood loss. a person carries around 6 liters of blood in his/her/zir body. substract 1 liter and you're there. substract another and you die. it's been sugested to insert needles into one's veins and let the blood flow out. i tried this to see if/how it works. it doesn't work too well. one loses drop after drop with rather long intervals inbetween and it would take inconveniently long to discard enough blood for any sort of effect. i guess you'd rather eventually die of malnutrition if you stayed in your bath waiting to lose consciousness this way. But it's just a guess. You might aswell die of boredom.

arteries (those that carry blood away from the heart) are under significantly higher pressure than veins (those that carry blood back to the heart). the (or rather in this case... my) arteria femoralis (a large artery inside the thigh) has been tapped during one of my stays at a hospital, to have my blood levelsmonitored. when i was about to get released, a nurse pulled out the needle (it

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was a flexible one, not the ordinary solid made-of-steel one, around 5 or more cm in length) and mis-evaluated the amount of time that would have been needed for the injection spot to close itself, removed the medical cotton she held pressed there (to hinder any blood from flowing out) too soon, and i in the twinkling of an eye, or literally in a heartbeat, got all covered in red. and actually almost blacked out.this experience taught me, the blood pressure in the arteria femoralis is enormous, and just a small opening, like the one caused by a syringe's needle, is enough to allow for a rapid blood loss.

but whether you'd go for alcohol consumption, putting holes in arteries, or the intake/injection of some hypnotic/anaesthetic substance to initiate your nap attack, there's then the 2nd part that you'd need to take care of.

making sure you'll find yourself submerged in water while asleep.

i'd suggest you either bring yourself in a (kneeling) position within your filled-to-the-brim bathtube, to make sure that when you tip over, you tip over with your face facing the water. or you lay down on the bottom of your still empty bathtube, and when you're starting to feel seriously drunk and like you're approahing the threshold to unconsciousness, start to let the water be poured in. it will eventually reach a level above your head, and you'll start to drown yourself. maybe bind some weights onto your body (torso, hips, whatever) to make sure you stay pressed to the bottom of the bathtube.

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part 16

il dolce vino aka. the sweet wine. sweetened with diethylene glycol. in 1990, out of 339 children who were delivered to a Bengali hospital, with an initially unexplained renal failure, 70% (in-hospital fatality rate) died.

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after further investigation it became evident that "a history of ingestion of a brand of paracetamol that contained diethylene glycol was found only in children with unexplained renal failure."-http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2550149/pdf/bmj00600-0022.pdf

they died of a syrup fortified with diethylene glycol.

in 2006, out of 174 people who ingested a cough linctus called Heparin, that instead of diphenhydramine contained diethylene glycol, 115 died.-http://www.tagesspiegel.de/weltspiegel/heparin-skandal-gift-aus-china-fuer-die-ganze-welt/1190092.html

but let's go back to 1985, to the wine scandal of Austria & Germany. whathappened there was, diethylene glycol was used instead of sugar to sweeten wine. sugar can't be added to wine because it would initate another fermentation process. although these adulterated wine bottles haven't caused any fatalities (the top rate was 46g per liter, while 60-100g diethylene glycol are required to end up dead) they could have.

if you're into drinking wine, and into suicide, add some 100g or more of diethylene glycol to your bottle(s). and you'll have un dolce vino per finirsi la dolce vita. it can be bought on ebay or from your favorite or any chemist. it's not on the USPS Pub 52 (list of hazardous, restricted, and perishable mail) and also not on ebay's prohibited material list.

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part 17

metal there's a few metals that cause people to cease existing, not all are recommendable.thallium, which is not found free in natura, usually comes into being as abyproduct during the refinement of heavy metal sulfide ores. 800mg arethought to be lethal-http://de.wikipedia.org/wiki/Thallium

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it takes a very long time until it breaks down your body (10 days or more)

lead monoxide exists in 2 color variations, yellow and red. in Germany the former is called Massicot, the latter (the red) Litharge. so red lead monoxide/Litharge is what Maurits Verzele recommends. but personally i'm not sure whether there's a toxicity difference between them. via inhalation or ingestion or skin absorption, the "estimated lethal dose is 0.5 g" but "to the best of our knowledge, the chemical, physical, and toxicity of this substance has not been fully investigated."-http://www.anachemia.com/msds/english/5398.pdf

it's unclear how long it takes to die.

lead carbonate aka. white lead ore aka. cerussite is thought to taste like sugar. and in its natural form looks like a sugar/salt crystal. in review of forensic medicine and toxicology, Gautam Biswas claims 40g are fatal, causing death within 1-2 days-http://books.google.de/books?id=_JdZN69AecoC&pg=RA7-PA48&lpg=RA7-PA48&dq=lead+carbonate+fatal+dose&source=bl&ots=CkMPzj63Qa&sig=danrJfrvvU6q6DkH_dbCz_BJM4w&hl=de&sa=X&ei=IYZ7Uo6kE4bJtQaT4IGYDQ&ved=0CEwQ6AEwAw#v=onepage&q=lead%20carbonate%20fatal%20dose&f=false

the celebrity among all toxic metals is arsenic, 120-170mg of it suffice.-http://de.wikipedia.org/wiki/Arsen

but it takes hours to days, and if you survive, you'll have a broken body with its skin diseased, damaged blood vessels, tumors. most of all your feet + upper legs will look (and probably) feel like shit. Take a look at pictures showing victims of the black foot disease.

the rather rare antimony acts in line with what arsenic does to destroy organisms. and needs a larger dose. if you do plan on using one of those 2 metals, i'd recommend you prepare a follow up suicide attempt, because if you survive, you'll have even more reasons to die. as quickly as possible.

acute beryllium poisoning is called berylliosis, is akin to sarcoidosis (which may lead to respiratory failure and death). nuclear physicist Herbert L. Anderson died of berylliosis in 1988-http://www.atomicarchive.com/Photos/CP1/image5.shtml

although here's a fatality case report, no fatal dose is available for our guidance, at least as far as i know.cadium, which can be found in rechargeable nickel-cadmium batteries, and foods like lseaweed, cacao powder, flux seeds, can be fatal, but usually is

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not and leads to horrible health problems. if you need to give it a try, inhalation seems the most secure way to secure a deadly outcome."inhaling cadmium-laden dust quickly leads to respiratory tract and kidney problems which can be fatal (often from renal failure)."-http://en.wikipedia.org/wiki/Cadmium_poisoning

now let's take a look at magnesium "the most common side effects of magnesium toxicity are stomach upset and diarrhea"-http://en.wikipedia.org/wiki/Magnesium.

not much can go wrong if you fail, but you'll probably also never succeed unless you're in the possession of a renal failure-http://www.easy-immune-health.com/magnesium-overdose.html

normally, magnesium overdoses get flushed away from your body via urine.you could destroy your kidneys (eg. con il colce vino) first and then overdose with magnesium, that's quite a hassle, though.

so far, nth is truly useful. unless you're looking for a complicated conclusion to your life.

my best bet would be this, zinc, which is notorious for causing accidental infant deaths every once in a while like in this a-thousandfold-overdose case-https://www.ismp.org/newsletters/acutecare/articles/20070906.asp

10-30g are thought to be fatal for adults. yet, as far as adults are concerned, there's no fatality case that i'd know of, and why would an adult accidentally overdose this excessively? there also usually are more convenient ways of killing oneself other than to throw in 60+ tablets (1 contains 50mg) of zinc supplements... if however you do happen to have no better options, this might be an option. time until death occurs: unknown.

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part 18

les autres fleurs du mal i've already mentioned some deadly flowers before, here's more.to finish off this line of ways to finish up in... either in hospital or preferably someplace beyond this world, l'autre monde, l'aldilà.

bloodroots, carry a liquid that is red and poisonous, they also carry a toxin called sanguinarine. "à dose élevée, cette substance cause des vomissements, des brûlures au niveau des muqueuses exposées, une sensation de faiblesse, des troubles cardiaques et visuels, et même la mort."-http://fr.wikipedia.org/wiki/Sanguinaire_du_Canada

vomitting, burns in the region that was touched, feeling weak, heart and eye problems, and death may be the result of high doses. that's it. it's thought to be fatal, but no fatal dose is offered anywhere. it certainly weakens your body, and maybe can be mixed with other plants in an suicide attempt.

duranta erecta is connected to a concrete fatality case... to that of a boy, 2 years young, who ate of its berries, in Qeensland. more than a decade ago, and it's just an anecdote, with no clear-cut source (at least as far as i have researched). the leafs, beside these berries, are also supposed to be toxic. yet, there's not much info. not even a fatal dose one could use for orientation. if you're willing to run selftests, to document how and in what doses it works, risking to eventually die. that would be nice.

the henbane is also noteworthy for standing on this world (or maybe not so much for that) + standing for a high toxicity, mostly within her root and her seeds. cessation of breath would be cause of the end of your partaking in this world, if you eat enough of her.hyoscyamine, a (potentially toxic) tropane alkaloid drug, together with scopolamine, a (potentially toxic) tropane alkaloid drug, make up around 0.035% of the root and around 0,02-0,13 % of the seeds. the deadly dose of scopolamine alone is 50mg-http://de.wikipedia.org/wiki/Schwarzes_Bilsenkraut

a guess for the lethal dose of hyoscyamine has arrived at 300mg-http://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+3552

but 100mg could suffice-http://books.google.de/books?id=Q3NYoVG1QJgC&pg=PA62&lpg=PA62&dq=Hyoscyamin+dosis+t%C3%B6dlich&source=bl&ots=rDfNdVGK97&sig=B8uzO8S3hsNODmck7dWODD3y2rY&hl=de&sa=X&ei=N7l7UqOiFIS0tAaUlYCICQ&ved=0CGgQ6AEwCA#v=onepage&q=Hyoscyamin%20dosis%20t%C3%B6dlich&f=false

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1g of seeds would yield at least 20mg scopolamine/hyoscyamine10g consequently would lead to 200mg of scopolamine/hyoscyamine (that is, at least 200mg. could be even morethan that)

assuming the ratio were 1:100 (1% scopolamine, 99% hyoscyamine)10g would amount to 2mg scopolamine & 198g of hyoscyamine (potentially fatal)

assuming the ratio were 100:1 (99% scopolamine, 1% hyoscyamine)10g would amount to 198mg scopolamine (potentially fatal) & 2g of hyoscyamine

assuming the ratio were 50:50... 100mg scopolamine & 100mg hyoscyamine would be the result, potentially fatal, too

but keep in mind, your stomach won't extract all the alkaloids contained in these seeds. you'll need more than 10mg. and you need to grind them properly, to break apart the shell. or to chew them properly. btw, the brugmansia is also replete with the same toxic alkaloids.

let's move on. of all the parts of the convallaria majalis, all parts are poisonous. except for the rhizome-http://it.wikipedia.org/wiki/Convallaria_majalis

the berries are particularly attractive. the nice effect comes from various "cardiac glycosides, which will cause symptoms similar to digitalis (foxglove) ingestion"-http://www.hikepups.com/blog/index.php?published-min=2013-03-01T00:00:00-00:00&published-max=2013-04-01T00:00:00-00:00

which is excellent, because the digitalis is quite suitable for suicide. sadly we know of no concrete convallaria majalis fatal dose for humans. you'd either have to do a leap of faith. and eat as many as possible. more than you'd need from the digitalis, because, unlike the digitalis, it has a "poor absorption and fast half life."-http://restorativemedicine.org/journal/the-use-of-convallaria-and-crataegus-in-the-treatment-of-cardiac-dysfunction/

and unlike the digitalis, the convallaria majalis has not been attributed to any reported human deaths. or, if you plan on offing yourself with digitalis anyway, but maybe can't get hold of enough of it, you can use convallaria majalis (berries or whatever of it) as an enhancer.

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lachryma papaveris is the dried latex obtained from the papaver somniferum, it contains 12% morphine-http://en.wikipedia.org/wiki/Opium

100-300mg is assumed to be the average lethal dose, but people survived with more inside their bodies. like for example 400mg-http://healthquestions.medhelp.org/morphine-lethal-dose

assuming you'd like to die for real, take 800mg or so. for this you'd need 6.7g of lachryma papaveris (out of 100% you get 8,3 times 12%, that is 100/12 = 8.3) (800g x 8.3 = 6666.6g) that's just a couple of plants to plant. they grow within 1 year. there's a bit of patience demanded of you. but just a bit. or ask one of those seeds sellers if they'd give you completed/grown up plants (i managed to obtain a conium maculatum this way). they surely have them in their gradens.

phytolacca, "if prepared incorrectly or carelessly it can make you quite ill, or worse, put a ‘k’ in front of ill as in kill you"-http://www.eattheweeds.com/can-be-deadly-but-oh-so-delicious-pokeweed-2/

all parts are dangerous "with the highest quantities of toxin present in the root and seeds"-http://www.northfloridaequine.com/horse%20health/poisonous_plants.html

in general, it "has no known good effect", (depends on how one sees it) and "it acts as an emetic and cathartic because it is extremely toxic."-http://www.holisticbird.org/pages/mdangerousherbs.htm

means, you'll throw up. maybe you should take some meds against vomiting prior to eating this. phytolaccatoxin & phytolaccigenin are the toxins acting here. the lethal dose for humans in unknown.

this plant is attractive, still, because "basically you are giving yourself a near death experience or if you get it wrong an actual death experience."-http://www.allaboutheaven.org/overload/183/109/pokeweed

if you underdose and survive, you'll at least have an interesting out-of-body experience. or that's what phytolacca/pokeweed is known for, to loosen your mind-body connection so that you can have a glimpse at the spiritual world. the author clarifies it's not a hallucinogen, the NDE is supposed to be genuine. now obviously i don't know whether this is true or not. try it yourself if you like.

colchicine, as can be found in the colchicum autumnale (Germany's poisonous plant of the year 2010), resembles the effect of arsenic. the seeds

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contain 0.5%, the root 0.2%, the blossoms up to 1.8%, the leafs 0.03%-http://de.wikipedia.org/wiki/Herbst-Zeitlose

65mg is the lethal dose-http://www.holisticbird.org/pages/mdangerousherbs.htm

or maybe even just 50mg-http://de.wikipedia.org/wiki/Herbst-Zeitlose

you become ill 2-6 hours after ingestion. then eventually you'll reach your last breath via respiratory paralysis or circulatory collapse. 1g of seeds yields 5mg colchicine, 10g of seeds...50mg. in theory, that's enough, but remember, you can't expect your stomach to get all the toxin out of those seeds. take more, 30g or 40g. and chew them properly. or grind them to powder. Alsoremeber how horrible a survived arsenic overdose is.

nux vomica. its "seeds contain approximately 1.5% strychnine, and the dried blossoms contain 1.0%"-http://en.wikipedia.org/wiki/Strychnine_tree

"there are no uses in modern medicine [...] strychnine is a deadly poison with a lethal dose to humans of about 30 to 120 mg. survival of substantially higher doses has been reported."-http://en.wikipedia.org/wiki/Strychnine_tree

8g of nux vomica seeds already contain 120mg, but, you should eat more that that.

"strychnine, when inhaled, swallowed or absorbed through eyes or mouth, causes a poisoning which results in muscular convulsions and eventually death through asphyxia"-http://en.wikipedia.org/wiki/Strychnine

asphyxia is not a pleasant way to go. but if you're planning to jump out of the window or to crash your car into someone else's (e.g. your psychiatrist's), or to make use of other physical means to end your life in an instant, you can aswell throw in some grinded-nux-vomica-seeds beforehand (maybe filled into capsules), that'll give you the rest if your primary method fails. you'd be in extreme pain anyway.

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dramatic pause

“life presents itself by no means as a gift for enjoyment, but as a task, a drudgery to be performed; and in accordance with this we see, in great and small, universal need, ceaseless cares, constant pressure, endless strife, compulsory activity, with extreme exertion of all the powers of body and mind [...] all push and drive [...] the tumult is indescribable. but the ultimate aim of it all, what is it? to sustain ephemeral and tormented individuals through a short span of time in the most fortunate case with endurable want and comparable freedom from pain, which however, is at once attended with ennui [...] in this evident disproportion between the trouble and the reward, the will to live appears to us from this point of view, if taken objectively, as a fool, or subjectively, as a delusion, seized by which everything living works with the utmost exertion of its strength for some thing that is of no value”

-Arthur Schopenhauer, „the world as will and representation“

part 19

“i ain't givin you no golden shot" the definition of a golden shot is "an intentional, lethal dose of heroin, can

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refer to other downers but most likely heroin"

guy 1: hey man can i get some heroin? guy 2: hell no yo wrist is all cut up guy 1: so? guy 2: i ain't givin you no golden shot"-http://www.urbandictionary.com/define.php?term=golden%20shot

heroin is illegal, in most countries. you'd need some contacts to drug dealers who might supply you with stuff of this kind. okay, one contact is enough. 75-375mg is the dose for a fatal injection for a first-timeer. if you've taken heroin before, you'll need more. how much more? that's what you should know better than me.besides this hard to get opioid, there's others that circulate within the world of medicine.sufentanil "is a powerful synthetic opioid analgesic drug, approximately 5 to 10 times more potent than its (already very potent) analog, fentanyl, and 400 to 1000 times as potent as morphine“-http://en.wikipedia.org/wiki/Sufentanil

injecting this plus midazolam has been shown to end fatal-http://www.ncbi.nlm.nih.gov/pubmed/2521891

but what is the lethal dose? the minimum of morphine you'd need is 200mg (of pure stuff), which is to say, you might need more. sufentanil is supposed to be at least 400 times as potent, which is to say, it could be more potent. it would follow (200mg/400 = 1mg/2) you'd need 0.5mg, but you might aswell need more, or you might even die with less.

so how much liquid do you need to inject? there's ampullae with 2ml or 5ml or 10ml or 20ml total content, of which 5ug (0.005mg) or 10ug (0.01mg) or 50ug (0.05mg) is the amount of sufentanil per ml. meaning, a 2ml ampullawith 50ug/ml has a total of 100ug (0.1mg) sufentanil. that's not enough. you'd need the 10ml ampulla, in the 50ug/ml version, and inject it all, 'cause that's just about 0.5mg sufentanil, and you'd possibly want to inject even more (the midazolam). that's a lot of injecting that's to be done.a conventional syringe has room for 5ml (it's really 6ml, but you're not supposed to fill it up completely) liquid. you'd have to use 2 syringes. eg. one for the left arm (or leg) and the other for the right.

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it appears there's fentanyl ampullae with 0.5mg fentanyl. that's five times the concentration of sufentanil in sufentanil ampullae. fentanyl is supposed to be 5-10 times weaker, so... they might be less effective after all. but 10ml can still be lethal. if possible, mix fantanyl also with midazolam. or drink alcohol, it's supposed to enhance the deadliness of opioids.

these 2 are among the most powerful painkillers legally available. getting a prescription will be difficult, because there's plenty of alternatives that when prescibed will not arrive at the opportune moment to aid people in suicidal moods in getting some definite rest from life... and therefore preferred by doctors. however, maybe you'll find one who's empathetic to your situation. in Belgium the doctors even perform euthanasia via injection for people who claim they don't feel comfortable with their body and can't stand living in their physical shell anymore.

-https://www.google.de/url?sa=t&rct=j&q=&esrc=s&source=web&cd=9&cad=rja&ved=0CHAQFjAI&url=http%3A%2F%2Fwww.telegraph.co.uk%2Fnews%2Fworldnews%2Feurope%2Fbelgium%2F10346616%2FBelgian-killed-by-euthanasia-after-a-botched-sex-change-operation.html&ei=CCB8UsnNC8LetAbdk4DABw&usg=AFQjCNGNWFPh5P3psoD4KyLinSwRlKb_jw&bvm=bv.56146854,d.Yms

or maybe you suffer from chronic pain, and already are on painkillers. you can then ask for sth stronger. or maybe you are on holiday in Mexico/China/Southeast Asia, you could possibly get them prescriptionfree there. but then you could also get heroin there,

if heroin/sufentanil/fentanyl is out of reach, there's one more option.

people who suffer from diabetes take insulin injections. they are prescription free in Canada, you can import it from a pharmacy there. -http://www.northwestpharmacy.com/Insulin/Cheap-Insulin.html

or just go to any pharmacy in your country, and lie. say you're a freshly arrived expat, or a world traveller, who's run out of reserves, you need a newsupply urgently. unlike where opioids are asked for, where you're not really in a position to demand a specific one, in a case of diabetes there's only insulin that prevents you from collapsing. the pharmacist can't persuade you to take sth less dangerous instead. and you probably won't be told to just go away, because without new supply, if you really were diabetic, you'd soon do collapse.

what you're looking for are ampullae/vials with an IU (international unit) of036

100, as opposed to 40. these stand for the concentrations. IU100 is the maximum/stringest that's being sold, IU40 is the minimum/weakest.

needles from insulin pens are apparently so thin that you (in the best case scenario) don't feel anything. in any case, they offer less painful injections than the conventional syringe-needle combo does. but they only store 3ml. and are much more expensive. You also don't inject into your veins (intravenously), but into your skin (subcutaneously). the lethal dose of insulin is IU400-900-http://curriculum.toxicology.wikispaces.net/2.1.7.1.1+Insulin

IU360 can suffice, if you're old/weak & diabetic-http://www.bbc.co.uk/news/uk-wales-south-east-wales-13625168

that would be 4-9ml out of the 10ml IU100 ampulla.you'd be required to recharge the insulin pen 2 times al minimo. or to buy 3 of them. i've seen some claims that, suicide via insulin overdose isn't such a good choice for non-diabetics. it might not work as well. there's some truthin this. but it did work this 17 year young Charlotte Wasey, who certainly managed to die by injecting her mother's medication.-http://yourlocalguardian.co.uk/news/9494698.Student_died_after_taking_overdose_of_mum___s_insulin/.

a non-diabetic man, however, comatose on IU16000, was brought into a hospital and rescued. "the presented patient who injected himself with the total dose 16,000 units of insulin is considered to be the first patient in the world who survived with such a massive dose of insulin."-http://www.thaiscience.info/journals/Article/Attempted%20suicide%20by%20massive%20insulin%20injection%20a%20case%20report%20and%20review%20of%20the%20literature.pdf

death doesn't occur immediately. you first will fall into a coma, from which you can be brought back if medics interfere. that's true for diabetics as well as for non-diabetics. the report above, about someone surving even such a large dose must be considered within the complete context. he didn't absorbthe insulin just like that all by himself, meds helpt to clean up his body.

similar to freezing yourself, which makes you fall asleep first, but the dying process itself takes days, and can be disrupted from outside, you'll face the same risk factor here. if you opt for the insulin method, make sure you'll do it in a place where there won't be anyone else... for the next couple of days.

most fatalities occur with doses between IU1000 and IU3000, or so is the estimation circulating on the web. if you'd inject 1 pen into your left arm (e.g. 1.5ml into your forearm, the remaining 1.5ml into your upper arm) and

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the next pen into your right arm. the 3rd pen into the left thigh, then the rightthigh. another one into your hips/butt, on one side, then pen nr.6 on the the other side, you'd arrive at 6x3ml … or IU1800. you'd be in the range that's most promising. you'd also have distributed the needle pricks all over your body, which appears to me to be least painful.

"the period from injection of an overdose of insulin to irreversible brain damage is frequently about 7 hours"-http://curriculum.toxicology.wikispaces.net/2.1.7.1.1+Insulin

just like it is the case with opioid overdoses, it's seems a wise idea to mix insulin with something else/e.g. a supplementary potentially fatal overdose of some sorts. or carbon monoxide. no, i ain't givin you no golden shot, you'd need to add sth extra to it yourself.

part 20

protective parathion hand lotion parathion, a byword for E 605, is an insecticide. its usaage is prohibited in Europe-http://de.wikipedia.org/wiki/Parathion

but not its storage. theoretically, you could buy it even there-http://hp-compounds.de/shop/ReferenceMaterials/Pesticides/Parathionethyl.php5?suche_on=1&suche=SR

it "is rapidly absorbed through the gastro-intestinal tract and the skin"-http://www.forensicscience.pl/pfs/43_marques2.pdf

"fatal human overdose occurred by ingestion, inhalation, eye, and dermal route."-http://www.acutetox.eu/pdf_human_short/38-Parathion%20revised.pdf

dermal route means... skin contact

the data on the lethal dose is obscure. via ingestion, it may be as low as 10mg or as high as 40g or even go beyond that

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"in most cases, the immediate cause of death is asphyxia (inability to breath and suffocation) following paralysis of respiratory centre in the brain"-http://www.acutetox.eu/pdf_human_short/38-Parathion%20revised.pdf

in his book, Maurits Verzele mentions a case where a peasant, after he dropped a coin into a bucket of parathon, took off his glove, reached for the coin with his bare hand. and died.

protective parathion hand lotion will protect you from having to endure life any longer.

part 21

impromptu railway promenade oxford dictionary's definition of impromptu is the following: „done without preparation or planning“. which is only from a certain poit of view what i have in mind. the point in time to step onto the railway is mostly determined by the train, and not you. although you can randomly pick a train that suits you. and the day to do it.speed, a byword for amphetamine, is a potent central nervous system stimulant. you can buy it as a medication or as a drug. for medical use, for athletic use, for la fête, la boum, pour attenter à ses jours. there's ways toproduce it in your private lab, but i won't descend into details here.

"the estimated minimum lethal dose in non-addicted adults is 200 mg"-http://www.emcdda.europa.eu/publications/drug-profiles/amphetamine

if you're used to it, even "doses of 400 to 500 mg are not uniformly fatal"-http://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+3287

you might need more.

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some doctors prescribe it for weight-loss. if you're obese, give it a try.

amphetamine give you an urge to move. for example, to move onto the railway in the right moment, when the train is approaching. without it, you might be overrun by a change of heart, and decide not to get hit and overrun by a train. also, there is a slight risk of survival. with a deadly dose of amphetamine, this risk is almost diminished. if the impact won't kill you, the chemical will.

.

part 22

pizza ai funghi on the pizza base, put whatever sauce you like, and then distribute some sliced mushrooms all over the place. here's some suggestions which to use.

amanita phalloides, apparently tastes not bad. "the principal toxic constituent is α-amanitin, which damages the liver and kidneys, often fatally."-http://en.wikipedia.org/wiki/Amanita_phalloides

"a keen gardener died after she accidentally picked some of the world’sdeadliest mushrooms from outside her home and made them into soup" "four days after eating the mushrooms, having suffered major organ failure."-http://www.telegraph.co.uk/gardening/10047149/Gardener-dies-after-making-soup-with-deadly-mushrooms.html

35g is the minimum fatal dose-http://de.wikipedia.org/wiki/Amanita_phalloides

1 fully matured amanita phalloides mushroom weighs 50g. that's about enough to die. amanita virosa, acts just this way. both are distributed across Europe. pantherina, from Europe and western Asia is also worth a mention. eating of & exceeding 100g of this mushroom, is fatal-http://de.wikipedia.org/wiki/Pantherpilz

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clitocybe rivulosa, from Europe & north America. in large amounts... fatal.bake your pizza, eat it. afterwards you'll never have to eat anything again.

part 23

antitussives that toss away your tussis. for good there's 2 cough syrups that can be easily obtained, in some countries they might be bound to prescriptions, but then, if you happen to live in such a country, you can import it from Spain. tosidrin, 30ml bottle, a dihydrocodeine concentration of 0.01g/ml-http://pharmaonline.tv/product_info.php?info=p1349_tosidrin-30-ml.html

1 bottle contains 0,3g of dihydrocodeine (which is twice as strong as tramadol, both are opioids, both are analgesics, but dihydrocodeine also works as an antitussive)

the slightly more expensive... paracodina, that comes in a 125ml bottle, witha concentration of "12mg/5ml" that's 2.4mg/ml, that's 0.0024g/ml-http://pharmaonline.tv/product_info.php?info=p1409_paracodina---dihydrocodein.html

the whole bottle yields 0.3g of of dihydrocodeine.

the lethal dose of codeine, from which dihydrocodeine is derived, is 1g. but dihydrocodeine is supposed to be twice as effective. 2 bottles (= 0,6g dihydrocodeine) of either product (tosidrin or paracodina) could be fatal. 3 bottles will almost certainly be so.

041

part 24

letting things end this way. in tears "a biocide is a chemical substance or microorganism which can deter,render harmless, or exert a controlling effect on any harmful organism by chemical or biological means."-http://en.wikipedia.org/wiki/Biocide

also from wikipedia..."biocide can also refer to the destruction of life, a form of omnicide that affects every living thing, not just humans"

anyways, an interesting set of biocides (in the primary sense) are quats (short for quaternary ammonium cations). they are a kind of soaps, but unlike commonly used soaps, they have molecules that are positively charged. micro/macro-organisms tend to get destroyed by them.

swallowing a quat is like swallowing a soap. you'll feel unwell and want to throw up. but if you take meds against throwing up, it will clean your body away from the face of earth. not completely, but to a large enough extend tocause death. within less than 1 hour.

there's so many quats as part of so many products, it makes no sense to list them all. but just to meantion one: Siccaprotect® Augentropfen, containing these so-called artifial tears, is an eye cleanser/moisturizer, prescription free. 30 mg/ml is the benzalkonium chloride concentration, 1 bottle (10ml) provides us with 0.3g of benzalkonium chloride.

instead of squeezing it out onto your eyes, you can squeeze it out into your mouth. and do swallow.

"the fatal dose in humans ingesting cationic detergents has been estimated to be 1 to 3g"-http://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+567

this is more or less true for all quats. but especially in the case of our case, consider... "benzalkonium chloride (a quaternary ammonium compound)can produce rapid toxic effects (caustic burns and respiratory depression) following minimal ingestions; doses of about 100 mg/kg are thought to be potentially life-threatening"-same source as above

a 60kg person might need 6g then. that's 20 bottles (200ml) of artificial tearsfor a proper disinfection of his/her/zir body.

042

part 25

SSRI * MAOI = peace of mind² the often prescribed citalopram is among SSRI antidepressants the most potent one. normal blood concentrations are usually in the range of 50-400μg/L, in patients who don't survive their (over)dose, 3-30mg/L-http://en.wikipedia.org/wiki/Citalopram

for treating anxiety, doses of 10mg are administered al minimo, for depression suppression, it starts at 20mg, goes up to 40mg or even higher. assuming the 50μg/l pertains to the lowest dose of a 10mg tablet, you'd have to take 60 10mg tablets (50μg/l * 60 = 3000μg/l or 3mg/l) to reach a potentially fatal dose, and 600 10mg tablets (50μg/l * 600 = 30mg/l) to almost certainly die, at least if you won't be taken to a hospital. it is most common to sell citalopram in 20mg tablet forms, so you'd then need 300 of these.

4 documented suicide cases, that took place in Denmark, from 1989 to 1996show that, people who died via citalopram, who's blood concentrations were measured, carried 2mg to 6.2mg of it. per kg.-http://link.springer.com/article/10.1007/s004140050147#page-1

with 1 liter of blood having the weight of 1060mg. converting these results to mg/l gives us 1.9mg/l (2mg / 1060 *1000 ) and 5.8mg/l (6.2mg / 1060 * 1000). one of these people needed no more than 38 10mg tablets (50μg/l * 38 = 1900μg/l or 1.9mg/l).

"five non-fatal cases of citalopram overdose (up to 5200 mg) resulted in seizures developing in 4 cases and all (five cases) had QT prolongation, sinus tachycardia and inferolateral repolarization disturbances"-http://www.antidepressantsfacts.com/celexa.htm

one of these people would have needed even more than 520 10mg tablets.043

what a successful suicide case looks like is shown below:"she had been prescribed citalopram by her family doctor 3 weeks before her death for a depressive syndrome. police found in her house 3 empty blister packages of 28 citalopram tablets (20 mg) and 2 bottles of citalopram oral solution (4%, 15 mL each). "-http://journals.lww.com/amjforensicmedicine/pages/articleviewer.aspx?year=2005&issue=12000&article=00012&type=abstract

citalopram solution bottles usually contain 40mg per ml, and i guess this is what they meant. 2 bottles would then yield (30 * 40mg) 1200mg citalopram. the 84 tablets she swallowed, 1680mg. together 2880mg

citalopram isn't a secure way to go. you first have to consider that, although there are fatal case reports with doses that you could reach with just a handful of tablets, a massive dose like 5200mg has been shown to be not necessarily fatal. i'd go for 6000mg. then, consider that, you might get rescued, even 8 hours after your intoxication, as it was the case with a 2000mg overdosed 52-year old female-www.ggiz-erfurt.de/pdf/pub_2005_citalopram.pdf

who was detoxicated with charcoal and sodium sulphate. make sure nobody will find you, or make sure you take a long nap with some hypnotic substance/anaesthetic/alcohol, so nobody who will find you will notice you're dying, or mix citalopram with something else.

"three cases of fatal serotonin syndrome (tremor, hyperpyrexia, and seizures) occurred following overdoses involving citalopram and moclobemide. the three males died within 3 to 16 hours after overdose (Neuvonen et al, 1993).

(1) citalopram serum concentration was at a therapeutic level in one patient and 2 and 5 times therapeutic levels in the other cases.

(2) moclobemide serum concentrations were 5 times therapeutic levels in one patient and 20 to 50 times higher in the other two cases."-http://www.antidepressantsfacts.com/celexa.htm

"intoxications with moclobemide as single agent are usually mild; however, when combined with tricyclic or SSRI antidepressants the overdose much more toxic and potentially fatal"-http://en.wikipedia.org/wiki/Moclobemide

044

"moclobemide is a benzamide, derivative of morpholine, which acts pharmacologically as a selective, reversible inhibitor of monoamine oxidase A (RIMA), a type of monoamine oxidase inhibitor (MAOI)"-http://en.wikipedia.org/wiki/Moclobemide

it primarily inhibits monoamine oxidase A, but to a lesser extent also monoamine oxidase B. generally it is considered to be a MAOI (monoamineoxidase inhibitor) antidepressant of the type RIMA (reversible inhibitor of monoamine oxidase A)

there's more pharmaceutical drugs of this kind that you could use instead (if you can't get hold of moclobemide). these are: brofaromine, caroxazone, eprobemide, metralindole, minaprine, pirlindole and toloxatone.

additionally, RIMAs also exist in nature.

the alkaloid piperine can be found in white or black pepper, which is obtained from the pepper plant (piper nigrum)."the unripe, unpeeled, dried, wrinkly fruits of a size of 3 - 6 mm are known as black pepper, while white pepper is obtained from the fully ripe fruit by removing (peeling) the outer pericarp after 2 - 3 days' fermentation and drying the seeds to yield smooth, yellow to dirty yellow peppercorns of a size of 2 - 4 mm." "fresh peppercorns contain approx. 5 - 9% piperine"-http://www.tis-gdv.de/tis_e/ware/gewuerze/pfeffer/pfeffer.htm#selbsterhitzung

it's also part of tailed pepper and long pepper. extraction methods vary, here's a desription of one that uses ethanol + KOH + acteone/hexane:

"place 30g of finely ground black pepper in a porous thimble in the central chamber of a soxhlet extractor and 175ml of 95% ethanol in a RB flask. gently heat solvent under reflux for 6 hours. concentrate the solution to a volume of 20-30ml on a rotary evaporator and add 30ml of warm 2M ethanolic potassium hydroxide (this is ESSENTIAL to keep all the acidic components in solution). after shaking the warm mixture well, filter the solution and remove any insoluble materials (quite a bit). while keeping the solution warm over a water bath, and water until no more yellow solid forms. allow the resulting solution to stand overnight and then isolate yellow precipitate that has formed by filtration. recrystalise the crude product in hot 3:2 acteone/hexane, cooling in ice bath if necessary to promote recyrstallisation. the resulting product (piperine) is in the form of

045

spectacular yellow needles, a yield of around 2g (in my case) was obtained."-http://www.erowid.org/archive/rhodium/chemistry/3base/piperonal.pepper/piperine.pepper/recipe_piperine_piperic_acid.txt

that's a lot of work that sadly can't be avoided (and on top of that a rotary evaporator isn't exactly cheap). ready-to-swallow capsules are available prescriptionfree. they contain approx 10mg of piperine, per unit (capsule).that's 100 capsules just to reach an intake of 1g of piperine. more on that later. the half maximal inhibitory concentration (IC50) "indicates how much of a particular drug or other substance (inhibitor) is needed to inhibit a given biological process (or component of a process, i.e. an enzyme, cell, cell receptor or microorganism) by half. "-http://en.wikipedia.org/wiki/IC50

49.3 μM (M stands for molecular concentration) is the IC50 inhibitory value of piperine against MAO A. (and 91.3 μM against MAO B)-http://www.ncbi.nlm.nih.gov/pubmed/15120460

6μM is the IC50 inhibitory value of moclobemide against MAO A (and against MAO B it appears to be only slightly effective with an insignificantly high IC50 value of >1000 μM)-https://www.google.de/url?sa=t&rct=j&q=&esrc=s&source=web&cd=4&cad=rja&uact=8&ved=0CEoQFjAD&url=http%3A%2F%2Fonlinelibrary.wiley.com%2Fdoi%2F10.1111%2Fj.1527-3458.2002.tb00229.x%2Fpdf&ei=OwMmU6DWCIOHtQa3sIDADg&usg=AFQjCNF3iwkDNaQAjjInItaQKLawsFFQlQ&bvm=bv.62922401,d.Yms

this means moclobemide is a (49.3 / 6 =) 8.2 times more effective MAO A inhibitor than the naturally occuring piperine.

in the 3 fatal case reports that were previously mentioned, the moclobemide concentrations were 5, 20, 50 times the "normal therapeutic level"

a typical dose for most patients is 300mg per day, sometimes it is raised up to 600mg-http://de.wikipedia.org/wiki/Moclobemid

let's assume the worst case scenario where the "normal therapeutic level" stands for 600mg. then the fatal doses (in conjunction with citalopram) would have been as follows: (5 x 600mg =) 3g, (20 x 600mg =) 12g, (50 x 600mg =) 30g.

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if one simply ignores the higher potency of piperine as a MAO B inhibitor, and only takes the effects on MAO A into account (= makes piperine look weaker than it actually is compared to moclobemide), the equivalent fatal doses of piperine (when taken together with citalopram) would have been:(8.2 x 3g =) 24.6g, (8.2 x 12g =) 98.4g, (8.2 x 30g =) 246g.

if 30g black pepper yields 2g piperine, like it was the case in the extraction tutorial above, the concentration there then was (100% / (30 / 2) =) 6.7%.

this means, to aim for the lowest of these 3 known fatal doses, 24.6g of piperine, you'd need (if your pepper also has a concentration of 6.7%) an amount of (100% / 6.7 * 24.6g =) 367g of black pepper. for the other 2 doses you'd need (100% / 6.7 * 98.4g =) 1469g and (100% / 6.7 * 246g =) 3672g respectively.

in the light of these enormous amounts of source material that one needs to obtain useful amounts of piperine, it's unlikely you could poison yourself sufficiently by simply eating powdered black pepper. or by ingesting some of these readily available capsules with a piperine content that is no more than 10mg. (you'd need 2460 capsules to reach the lowest fatal dose)laboratory equipment is a must then.

another naturally occuring RIMA could be the flavonoid quercetin (at the time of writting this, it has not yet been confirmed whether quercetin is "selective" and "reversible" but it certainly inhibits MAO A)-http://www.ncbi.nlm.nih.gov/pubmed/19013512

"capers contain more quercetin per weight than any other plant"-http://en.wikipedia.org/wiki/Capers

234mg are contained in 100g of raw capers (that's a concentration of 0.234%)-http://www.ars.usda.gov/SP2UserFiles/Place/12354500/Data/Flav/Flav_R03.pdf

the IC50 against MAO A is 18μM-http://www.ncbi.nlm.nih.gov/pubmed/19013512

so moclobemide is 3 times as effective as quercetin, and the lowest of the known fatal doses of moclobemide is 3g (in conjunction with citalopram). you'd have to consume 9g of quercetin (in conjunction with citalopram) al

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minimo.

now, the amount of raw capers that would theoretically yield 9g of quercetin is (100% / 0.234 = 427; 9g x 427 =) 3.8kg.you can't possibly eat that much. it, however, is quite possible to extract quercetin via methanol. i'm not going to descend into details, though. because i've never tried it myself and the information on this procedure is sparse. let me just mention that there are ready-to-ingest capsules you can buy (prescription free) that contain 250mg quercetin per unit.

you'd gain a 9g quercetin augmentation in your body after only (9g / 0.25 =) 36 capsules. that's a quite realistically realizable meal. the other 2 known lethal doses of moclobemide were, as mentioned earlier, 12g and 30g. the equivalent of 36g and 90g of quercetin. 36g is what 144 capsules provide. (that's still swallowable) 90g is contained in 360 capsules. (that'll be a challenge, but is theoretically also swallowable).

1 package (120 capsules) mixed with as many citalopram as you can get (also small doses might suffice, though), is what i'd go for.

resveratrol, a phytoalexin, is a RIMA with a MAO A inhibitory potency of IC50 25µM-http://www.scbio.de/datasheet-205254-cis-resveratrol.html

moclobemide is (25 / 6 =) 4.2 times as effective as resveratrol. the latter can be found in all sorts of fruits, like for example grapes (an in those most of all in their skin). freshly pressed red grape juice has a concentration of 1.1mg per liter while red wine apparently has a concentration of 2mg to 12mg per liter. -http://de.wikipedia.org/wiki/Resveratrol

so can you achieve a deadly dose of resveratol by drinking wine? no. (3g x 4.2 =) 12,6g would be the minimum that, combined with an SSRI, could lead to death. 250mg are contained in one of those commercially available capsules, which are far more suitable for suicide. you can get them prescription free. you'd need a minimum of 51 capsules (+ citalopram).

harmine is another naturally occuring MAOI antidepressant, which reversibly and selectively inhibits MAO-A (monoamine oxidase A),

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peganum harmala seeds contain harmine, an amount of 0.44 of it in percentage terms-http://www.ncbi.nlm.nih.gov/pubmed/18980138

or even more according to other sources.and they contain at least 0.25% of harmaline (a reversible (non-selective) inhibitor of monoamine oxidase A)-http://www.ncbi.nlm.nih.gov/pubmed/17723604

the IC50 (against MAO-A) of harmine lies somewhere between 2µM and 5µM, so, it is more or less equivalent, possibly even more potent than moclobemide (with an IC50 ranging between 3.9µM and 6µM. the IC50 (against MAO-A) of harmaline seems to be around* 4.5µM -http://books.google.de/books?id=c8rg6rPsvUYC&pg=PA91&lpg=PA91&dq=harmaline+ic50+mao+nm&source=bl&ots=goIjYRYrnT&sig=halyCeFLfK-v5G0ccuuQgrMLpX4&hl=de&sa=X&ei=CF44U8P5D8PdtAae-oB4&ved=0CGUQ6AEwBQ#v=onepage&q=harmaline%20ic50%20mao%20nm&f=false

*i've seen values between 2.5µM and 8µM

also harmaline seems to be at least equivalent to (if not, even stronger than) moclobemide.

so, (0.25 + 0.44 =) 0.69% of potent MAOI alkaloids can be found in peganum harmala seeds. (100 / 0.69 = 145; 3g x 145 =) 435g of such seeds is what you'd need for a minimum lethal doseit's unlikely you'd be able to eat enough, unless if you grind and fill these seeds into 435 capsules, you'd have to go through following steps of Albert Most's recipe

"the crushed seeds are covered with three times their weight of water containing 30 g. of acetic acid per liter of water, the seeds swell as they absorb the liquid and form a thick dough which is pressed after 2 or 3 days. the pressed seeds are once more treated as above with twice their weight of dilute acetic acid and, after maceration, the liquid is again pressed out. to the combined liquors, sodium chloride (100 g., liter of liquid) is added to transform the acetates of harmine and harmaline into the hydrochlorides which are insoluble in cold sodium chloride solutions and are precipitated during cooling. the supernatant liquid is siphoned off, the crystaline residue filtered with suction and redissolved in hot water. addition of sodium chloride to the filtered solution results in the precipitation of the

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hydrochlorides as a crystalline mush and this process is repeated until the hydrochlorides have acquired a yellow color. the separation of harmaline from harmine is based on the fact that when a warm aqueous solution of the hydrochlorides is alkalinized with ammonia, harmaline is liberated onlyafter the decomposition of harmine hydrochloride is complete. the appearance of harmaline is readly detected under the microscope since it consists of plates while harmine forms long needles. the addition of ammonia, therefore, is stopped as soon as crystals of harmaline are detected, the harmine is filtered off and the harmaline recovered from the filtrate by the addition of ammonia, the bases are then further purified by recrystallization of their hydrochlorides."-isolation of harmine and harmaline, "Ann. chim (10) 7,15l" from 1927, by Albert Most

besides citalopram (which can induce death all by itself in high doses) there's other SSRIs (which are not very likely to become lethal all by themselves) that can bring about peace of mind² when combined with MAOIs. these are: dapoxetine, escitalopram, fluoxetine, fluvoxamine, indalpine, paroxetine, sertraline, zimelidine. since they are less effective compared to citalopram, you'd have to dose them higher. other than that, the preceding text in this chapter applies also to them.

serotonine syndrom the ultimate cause of convulsions, coma & disseminated intravascular coagulation. the latter, leading to the formation of small blood clots inside the blood vessels throughout the body, is also known as "death is coming" or DIC for short, and disrupts blood flow to all sorts of organs, and causes them to go on strike.

this is a potentially pleasant way to go, because you'd fall into a coma prior to dying unconsciously. but, if you don't dose high enough to reach a comatose state, you'll be stuck in process 1, convulsions.

"she took all of her anti-depressant medication, including mood stabilizers and who knows what else, but it was a total of 60 pills [...] she then changed her mind on taking her own life, so she sought help, but it was too late to pump her stomach. she is now in hospital in an induced coma, and on a ventilator. they have diagnosed her with extreme serotonin syndrome. they have attempted to bring her out of her coma 3 times in the last 3 days, without success. her convulsions were very bad, so they put her back into the coma. when you talk to her, her heart rate increases, which apparently

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means that she can hear us sub-consciously. the doctors aren't giving us anything, because they are very scared to give us false hope in case there is a backlash."- posted on a web forum, by djcandiflip, http://www.drugs.com/forum/featured-conditions/acute-serotonin-syndrome-fentanyl-prozac-effexor-xr-43361-2.html

part 25 appendix

about irreversible MAOIs & tyramine the book of suicide is meant to primarily provide methods that are accessible to (almost) everyone, including non-privileged people, and i generally try to put the focus away from substances that most people will never be able to hold in their hands.but, seeing as the last chapter introduced MAOI inhibitors of the RIMA type, it seems appropriate to conclude the topic with a brief discourse about the remaining MAOIs. presented to you as an appendix.

"MAOIs act by inhibiting the activity of MAO and preventing the breakdown of monoamine neurotransmitters (serotonin and NE) [in the case of MAO-A], thereby increasing their availability. Inhibition may be reversible or irreversible. When an MAOI covalently binds to the enzyme, it is irreversibly inhibited and the enzyme is permanently deactivated. enzyme activity cannot be restored until the body replaces the enzyme through new enzyme synthesis. restoration of full activity can take up to 2 weeks."-http://www.psychiatrictimes.com/major-depressive-disorder/irreversible-monoamine-oxidase-inhibitors-revisited

so, besides reversible inhibitors of monoamine oxidase A (RIMAs) there's also irreversible MAOIs: phenelzine, isocarboxazid, tranylcypromine, clorgyline, resagline (mainly for MAO-B inhibition), nialamide, selegiline (mainly for MAO-B inhibition). and a few more, which have been completely withdrawn from the market.

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"the older, non-selective, irreversible drugs have very severe and prolonged toxicity in overdose and potentially life-threatening interactions with tyramine"-http://curriculum.toxicology.wikispaces.net/Monoamine+oxidase+inhibitors+(Detail)

irreversible MAOIs are very toxic all by themselves, and they are also difficult to obtain. if you however did get hold of such an antidepressant, butonly in small amounts, and have no SSRIs at hand, you can instead mix it with tyramine. in order to cause a hypertensive crisis. reversible MAOIs most likely won't be strong enough to cause a fatal hypertension (high blood pressure) when combined with tyramine, but with irreversible ones things look different, and might build up to an "acute impairment of one or more organ systems (especially the central nervous system, cardiovascular system and/or the renal system)"-http://en.wikipedia.org/wiki/Hypertensive_emergency

aka hypertensive crisis. if this won't soon lead to organ failure, followed by death, it will do so later. the probability to die within the following year following a non-immediately-fatal hypertensive crisis lies at 80%-http://emedicine.medscape.com/article/1952052-overview

except if you get treated with medications, then you'll most likely be forced to go on living for some unknown number of years.

"when using a MAO inhibitor (MAOI), the intake of approximately 10 to 25 mg of tyramine is required for a severe reaction"-http://en.wikipedia.org/wiki/Tyramine

more than 25mg leads then to a hypertensive crisis. the following drink can be useful to achieve that: tap beer, a 355ml portion, may contain around 38mg tyramine-http://www.mc.vanderbilt.edu/documents/neurology/files/Tyramine%20Menu%20Book%2006227101.pdf

but it'll probably be less. it seems to depend on whether it was "produced by bottom fermentation (lagers) and brewed by a secondary fermentation process"-http://www.ncbi.nlm.nih.gov/pubmed/8151003

or not. if you get hold of tap beer, since it possibly won't be too potent after all, and contain less than 25mg of tyramine per liter, drink more than 1 liter. i'd recommend 2.

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note that ordinary (canned/bottled) beer, per 355ml bottle, only contains around 1.5mg, and therefore is not useful. soya products look promising, they are thought to be replete with tyramine, but there aren't any concrete concentration values to guide us.

"the enzyme monoamine oxidase exists as 2 subtypes, MAO-A and MAO-B. MAO-A metabolizes serotonin and norepinephrine (NE) [...] MAO-B preferentially metabolizes dopamine and trace amines, including phenethylamine. tyramine is metabolized by both MAO-A and MAO-B"-http://www.psychiatrictimes.com/major-depressive-disorder/irreversible-monoamine-oxidase-inhibitors-revisited

most MAOIs mainly inhibit MAO-A, and MAO-B only a little bit if at all. the effect on MAO-A of irreversibles is thorough enough, however, it does not really matter whether MAO-B gets neglected or not. but if you'd be trying to achieve a hypertensive crisis with the much more common reversibles, inhibiting MAO-B in addition to MAO-A, instead of just MAO-A alone, will lead to a more excessive build-up of tyramine, and increase your (otherwise rather slim) chances for success.

among the naturally occuring RIMAs, paeonol's Inhibition of MAO-B corresponds to an IC50 of 42.5µM, and it is also noteworthily effective against MAO-A (54.6µM)-http://www.ncbi.nlm.nih.gov/pubmed/15120460

paeonol (a phenolic compound), also known as paeonolum, contained (for example) in the paeonia suffruticosa, native to China, hasn't been mentioned in 025, mostly because it's not known (to me) how high the concentration is you'd encounter in any of the plants harboring it. this being so, i can't provide any information of how much plant you need to get what's needed out of it, and it's not being sold in pure form in most of the world (= except for China). but let's mention paeonol here, because, herbal extracts with a paenol concentration of 98%-99% can, after all, be ordered from China, (for example) from Shanghai, in 1kg bags, for a 3-digit sum per bag.

other sources of paeonol (btw) are paarisaema erubescens, dioscorea japonica, luculia intermedia, rosmarinus officinalis, exacum affine, primula auricula, cynanchum paniculatum and prosopis cineraria (see Sumitra Singh's, Vijay Naresh's and Surendra Kr Sharma's "isolation of novel phytoconstituents from the bark of wonder tree" for a tutorial of how to get

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paeonol out of the bark of the prosopsis cinaria tree). maybe you'll be able to get to the bottom of the mystery (of how much of the aforementioned plants you need to reach a lethal dose of paeonol in conjunction with tyramine) yourself.

MAO-A and MAO-B is almost equally suppressed, so, you won't need any extra MAOI that would take care of any remaining enzyme. more than paeonol (in large amounts) and tyramine (>25mg) is not needed.

besides MAOI irreversibles, tricyclic antidepressents are also highly toxic, usable as a sole means to kill yourself, and unfortunately also very difficult to obtain nowadays. therefore, let's skip them and let's move on to easier accessible "mood-enhancers".

part 25

pressants, pressants, et al. besides selective serotonin reuptake inhibitors (SSRI), there's 1 more class of antidepressants that is in vogue and readily prescribed, the serotonin–norepinephrine reuptake inhibitors (SNRI)

I'll go through that and also through norepinephrine-dopamine reuptake inhibitors (NDRI), serotonin–norepinephrine–dopamine reuptake inhibitors (SNDRI) and dopamine reuptake inhibitor (DRI).

SNRIs are: milnacipran, duloxetine, levomilnacipran, bicifadine, desvenlafaxine, sibutramine and, the most potent of them is venlafaxine, which i'll be focusing on now.

the IMS Health rating from 2009 lists venlafaxine at no.9 among the most frequently prescribed psychiatric medications within the US.-http://psychcentral.com/lib/top-25-psychiatric-prescriptions-for-2009/0003170

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if you happen to get a prescription for an SNRI, it'll probably be for this one, which, conveniently enough, "seems to be more dangerous in overdose than the SSRIs, except perhaps citalopram which is more dangerous than the other SSRIs in overdose."-http://en.wikipedia.org/wiki/Venlafaxine

based on a fatality report reported to us from the medical University of South Carolina, from 2003, "a 39-year-old woman with a history of depression and suicidal ideations came to the emergency department after intentionally ingesting approximately 30 g of extended-release venlafaxine capsules. family members postulated that she had ingested the capsules 12-24 hours before coming to the emergency department [...] the patient was transferred to the medical intensive care unit, where vasopressor therapy with dopamine was started [...] she required multiple courses of treatment with broad-spectrum antibiotics for persistent fever [...] her clinical condition continued to deteriorate, and she died on day 43"-http://www.medscape.com/viewarticle/465884_2

it follows, you'd need to take 400 of the 75mg venlafaxine capsules, or 200 of the 125mg capsules (both adding up to 30g) to reach a fatal overdose. it might take a long time to die, which, won't matter so much to yourself, though, because a potentially severe overdose leads to severe CNS depression. you'd be in a coma. of course, you'll be keeping the hospital staff (provided that you'll be delivered to a hospital) busy and your family/friends in suspense. but of course, that's not necessarily a bad thing.

but, if you happen to have diabetes mellitius, a smaller dose might suffice

"a 40-year-old male with a history of non–insulin-dependent diabetes mellitus [...] after itentionally ingesting ninety 150-mg venlafaxine [...] and seventy-five 75-mg venlafaxine […] the total amount ingested was 19g [...] [was, ] on initial presentation [...] asymptomatic except for nausea ...] the patient arrived at the tertiary ED 3.5 hours post-ingestion. he became progressively more lethargic, and approximately 9 hours post-ingestion developed refractory ventricular fibrillation (VF) and subsequently expired"-http://jmt.pennpress.org/strands/jmt/pdfHandler.pdf;jsessionid=9C6EFBA5F6C0EC58B4CB82581089A6A2?issue=20080401&file=20080401_018_020.pdf

it isn't quite clear whether diabetes mellitius played a role. maybe a non-055

diabetic person would also die with no more than 19g

just for your information, "venlafaxine [...] appears less dangerous than bupropion"-http://en.wikipedia.org/wiki/Venlafaxine

let's take a look at bupropion then. according to the IMS Health rating from 2009, it's the no.14 of the most frequently prescribed psychiatric medications within the US-http://psychcentral.com/lib/top-25-psychiatric-prescriptions-for-2009/0003170

if taken in large quantities, it leads to cardiac arrest/respiratory failure-www.rxlist.com/wellbutrin-drug/overdosage-contraindications.htm

less than 10g are sufficient to bring your life to an end, as a few success stories tell us-http://jat.oxfordjournals.org/content/17/7/436.short

if not fatal, it should at least lead to loss of consciousness, so you can mix it with some other method that would be too painful by itself.

in 2008 "a 35-year-old male was found lying in his bed about 72 h after he died. An empty box of [...] 30 slow-release tablets of 150 mg of BUP was near the body [...] no other known medication was involved."-http://jat.oxfordjournals.org/content/32/2/192.full.pdf

that's a dose of 4.5g. to play it safe, take 67 150mg tablets instead (which more or less sum up to 10g) similar to the situation with SSRIs, bupropion can be mixed with MAOIs to lessen the risk of survival. and it also can be mixed with citalopram (introduced in 025) to increase the toxicity of citalopram.

bupropion belongs to (and is the most potent of) the NDRIs, of which there's a lot. of the ones currently used for medical treatments, there's, besides the one in question here, dexmethylphenidate, fencamfamine, methylphenidate, prolintane, pyrovalerone. of the one's currently in use as designer drugs, there's diphenylprolinol and methylenedioxypyrovalerone.

also worth a mention is the research chemical amfonelic acid, which is "not a controlled substance in the United States, and thus is legal to possess. it is

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available from many biotechnology supply companies"-http://en.wikipedia.org/wiki/Amfonelic_Acid

and is price-wise ok. $88.88 per gram.

there's not much information on this still new substance, and how much you'd need to die, but let's investigate and speculate.

dog_on_acid's self-test says that a dose of "20mg [...] produced nothing [...] well almost nothing. i felt a slight rise in energy and euphoria but close to maybe one cup of coffee or 40mg speed [...] the next day I pushed it to 30. there was definite action here [...] it was subtle but I was very aware of the smaller details of life. i was processing information faster, i was happier, euphoric you could say and to a substantial degree [...] after an hour or so I jumped another barrier and insufflated 10mg [...] it only seemed to extend the action, possibly elevating it only slightly [...] a perfect dose [...] is between 30 and 40mg"-http://www.reddit.com/r/Nootropics/comments/1f4z0j/amfonelic_acid/

by comparison, a "perfect" (= typical) dose of cocaine lies between 50 and 150mg.

in Izenwasser's, Werling's and Cox'es comparison of dopamine inhibitors, amfonelic acid "biphasically inhibited uptake (of dopamine) in the striatum, nucleus accumbens and olfactory tubercle with [...] amfonelic acid being approximately 50-fold more potent than cocaine or methylphenidate"-https://www.ncbi.nlm.nih.gov/pubmed/2145054

as far as the medial prefrontal cortex is concerned, there seems to be no inhibitory difference between GBR 12909 (aka vanoxerine, a DRI) and cocaine. vanoxerine and amfonelic acid seem to be generally equivalent, though, as dopomine ihibitors. this lets us assume that in some areas of the brain amfonelic acid inhibits dopamine much more thoroughly than cocaine, while in others there's probably no difference. "45mg [...] really is the upper end of the scale, which is what I wanted to experience but not quite to this extent", says dog_on_acid, while 150mg is the upper end of the scale for cocaine.

does this mean, amfonelic acid is around 3 times as potent as cocaine? possibly.

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and if it were so, just a few grams of amfonelic acid would suffice to kill a person.

DRIs:

they are primarily used by researchers and don't generally find medical applications, but

difluoropine "is not explicitly illegal anywhere in the world as of 2008, but might be considered to be a controlled substance analogue of cocaine on the grounds of its related chemical structure, in some jurisdictions such as the USA, Canada, Australia and New Zealand."-http://en.wikipedia.org/wiki/Difluoropine

also RTI-229 "is legal throughout the world as of 2010. Some jurisdictions such as the USA, Australia and New Zealand might however consider RTI-229 to be a controlled substance analogue of cocaine on the grounds of its related chemical structure."-http://en.wikipedia.org/wiki/RTI-229

you could possibly get hold of the 2 substances above.labeled as designer drugs are methoxetamine and methoxydine, also potentially obtainable, from your drug dealer of trust.

vanoxerine aka GBR-12909, which, has already been compared to amfonelic acid a few moments earlier, is (at the time of writing this = 2014) being investigated for its potential benefits in treating cardiac arrhythmias. it might or might not see some medical use someday. if it does, you could induce some arrhytmia via conium or aconitum seeds, then go to see your doctor, and demand a medication (the brand new vanoxerine!) that'll stabilize your heart rhythm.

SNDRIs:

there's only one on the medical market, nefopam (for use as a non-opiod analgesic agent). and there's 3 naturally occuring SNDRIs, which will be covered soon.

"nefopam is approximately 10 times more potent than aspirin and 2 to 3

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times less potent than morphine."-Puchnarewicz's, Button's, D Lee's and Holt's case report @ http://www.the-ltg.org/data/uploads/posters/puchnarwicz.pdf

and it can be mixed with SSRIs or MAOIs to enhance the toxic effect. ("there is the potential for serotonin syndrome or hypertensive crises to result")-http://en.wikipedia.org/wiki/Nefopam

"a 37-year-old caucasian female, who had worked as a nurse in a medical erhabilitation unit, was found lying on the floor dead at home. the body was markedly putrefied (estimated time since death: 7-10 days [...]) and covered with numerous fly larvae. no signs of violence were observed. fifteen broken ampules of acupan (equivalent to 300mg nefopam) were found near the body, together with a used syringe equipped with an i.v. needle."- Traqui's, Berthelon's and Lude's case report @ http://www.deepdyve.com/lp/oxford-university-press/fatal-overdosage-with-nefopam-acupan-Si0U0iuBtv

one needs to consider, that, an intrevenous intake usually needs less drug to kill than an oral intake. a tablet has 30mg.

"dosage may range from 1 to 3 tablets three times daily depending on response. the recommended starting dosage is 2 tablets three times daily. "-http://www.medsafe.govt.nz/profs/datasheet/a/acupantabinj.pdf

as far as injections are concerned, "20 mg (1 ml) intramuscularly repeated if necessary every six hours (see instructions for administration). onset of effect after intramuscular injection is within 15 to 20 minutes and peak effect is reached one to one-and-a-half hours after administration."-same source as above

one ampule has 20mg (x 15 = 300mg = fatal dose) while 3 tablets amount to 90mg (x 15 = 1350mg = fatal dose). you'd need 45 tablets.

hypericum perforatum "is widely known as an herbal treatment for depression",-http://en.wikipedia.org/wiki/Hypericum_perforatum

probably because of the phytochemicals hyperforin and adhyperforin that it carries within itself.

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(ad)hyperforin is, among other effects that is produces, a natural SNDRI.

"over-the-counter (OTC) drugs are medicines sold directly to a consumer without a prescription"-http://en.wikipedia.org/wiki/Over-the-counter_drug

and so are hypericum perforatum herbal extracts. but they might not be as potent as they claim to be. Laif900 is a product of this type that has a hyperforin content of 5,75mg to 8,64mg (although it says on the package there's 18mg in a tablet), based on a study-report from 2002, conducted by some researcher in the Universität Frankfurt.-http://www.pharmazeutische-zeitung.de/index.php?id=23988

hyperforin acts as a reuptake inhibitor of (e.g.) dopamine, to some extent. it does have a slight effect on the reuptake of serotonin, too, and in high doses can bring about a mild serotonine syndrome. mixed with other antidepressants (of the SSRI class) it might lead to a deadly serotonine syndrome. mixed with yet others (of the DRI, NDRI or SNDRI class) it can possibly enhance the effect of these.

2% is the (ad)hyperforin content in the blossoms, 4% in the fruits.-http://de.wikipedia.org/wiki/Echtes_Johanniskraut

a selfmade, 1g teabag of hypericum perforatum blossoms would contain 20mg hyperforin. that's so little, you'd be better off buying those tablets.

"in the early hours of the morning a 20-year-old girl was taken to the ED of th elocal hospital where, shortly thereafter, was pronounced dead. as told by her boyfriend, the evening before, they bought a dose of about 5 grams of cocaine; at around 8.30pm they were stopped by the police agents for control. the girl, in fear of a drug arrest, ingested the polyethylene wrapper containing the drug. Once back home, the girl made several attempts to expel the wrapper by vomiting. although the boy-friend tried to bring her to the hospital, she asserted to feel good, so they went to sleep. at around 2.40 a.m. the boy-friend was woken up because the girl was “strongly shaken” by convulsions. promptly carried to hospital, the girl arrived around 3.00 a.m. at ED with severe agitation [...] and unconsciousness [...] at 3.10 a.m. she died"-http://www.droganews.com/pubdownload.php?id=2458

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the preceding was a case that occured in 2010, as published by Barbera, Romano and Spadaro in their "lethal cocaine intoxication due to “body-stuffer syndrome”

it is known that some people can survive the ingestion of several grams. but also that people died after a meal of less than 5g. what to aim for? 10g is my recommendation.

the alkaloid content of coca leaves is low, between 0.25% and 1.5%.-http://en.wikipedia.org/wiki/Coca

if you were to extract cocaine yourself, you'd need (assuming the concentration is only 0.25%) 4kg of source material (= leaves from grown up trees). that's a lot of work (plucking such an amount of leaves and then subjecting them to chemical reactions), and, on top of that, if you happen to live outside of Colombia, Peru or Bolivia, it's unlikely you'll ever bump into a coca tree anyway. so your best point of reference would be a drug dealer who has ready-to-consume stuff of this sort ready for you.

conclusion

death is not necessarily the end, though. read...

irreducible mind by, Edward & Emily Kelly, Adam Crabtree, Alan Gauld, Michael Grosso and Bruce Greyson (6 non-mainstream psychiatrists/ psychologists) which competently explains why human personalty is not generated by physical processes in the brain but that the brain is just an organ which, like a radio, tunes in to the thoughts of the soul. there are no memory traces to be found anywhere in the brain. multiple personalities can't be accounted for by measurable bio-chemical activity. the authors offer several documented OBEs (out-of-body experiences) + NDEs (near-death experiences) that yielded veridical sights of happenings taking

place some place away from the experiencers' bodies. and another point they mention is that during the process of exocytosis, when neurotransmitter molecules are being released into the synaptic cleft. they are being released out of their vesicles once calcium ions enter the areas where those transmitters are being stored, the vesicles. however, once the calcium ions have arrived, they stop. of all the measurable (material) processes going on in the brain that neurologists could possibly observe, nothing determines where & on what trajectory line these neurotransmitter molecules move within people's synapses. and there's trillions of active synapses with neurotransmitter molecules moving around (as if by magic) at every moment of one's functional brain. making it highly dependent on quantum coordination. (to update Descartes' dualism: it's not the pineal gland where the soul acts upon the brain, it's within the synapses). at one point, on page 613 they digress to von Neumann and his formulation of quantum theory. which says that the original finding of there being an inextricable link between a small observed physical system (which is described mathematically) and the observer (which is described empirically/phenomenally) can be shifted so that the observed part (the mathematically describable, neurologically scannable) includes the whole brain... which is being observed by the mind. without the mind excerting its influence upon the brain via quantum mechanics the brain would be stuck in a state of potentiality, not knowing where to send the neurotransmitters to.

and... much more. it's a comprehensive book with 700+ pages. and is intended to be an updated version of...

human personality and its survival of bodily death by Frederic Myers. it's from 1903, and now free. download links are below...-http://archive.org/details/humanpersonality010089mbp volume 1 (72mb)-http://archive.org/details/humanpersonality005815mbp

volume 2 (42mb)

"how strange and how unfortunate it is that this amazingly rich, profound, and stimulating book should have been neglected in favor of descriptions of human nature less complete and of explanations less adequate to the given facts"-Aldous Huxley, a foreword by. from the compact 1 volume edition