Cac Loai Bom Tren Mang Te Bao

7/21/2019 Cac Loai Bom Tren Mang Te Bao

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I HC THI NGUYNTRNG I HC KHOA HC

KHOA KHOA HC S SNG

CC LOI BM C TRN MNGSINH HC T BO

Ging vin: GS! TS L"#ng T$% H&ng '(n

N$)* +$,- $i.n: Ng/01n H23ng Lin$ Ng/01n B4-$ L25n '6n T$% M5i

Ng/01n T$% Min$


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N7i 8/ng 92 -2 g&*

Bm ion Na+-K+ ATPase

Bm Ca2+ ATPase

Bm proton ATP synthase


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I. Bm ion Na+ -K+ATPase

Bm Na + / K +-ATPasec pht hin bi nh

kha h!c"ens #h$istian%k& ' n(m )*, ti %%inh . h!c0 1i h!c

Aa$h&s0 1an 2ch3 N(m )**,0 4n5 c nh6n5i7i Nbe. 89a h!c3

;! L%-$ 5 ?@i A


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2. :; t$c c?a bm

2.1 V tr T6p t$&n5 cc thnh ph@n mn5 nh mn5 t b th@n

kinh0 mn5 cc m40 cc c C&an nh 5an0 th6n0 c0 m4nD0 m4 cc t&En0333F

G3G #=& t$>c H mIt .i p$tein 5Jm n '; c=& thnh tet$ame$F .iLn

kt kiM& G-GO0 c9 khi .n5 phQn tR G,S Ka.

1n '; .Un * Ka.F c9 chVa mIt ph@n c9 chVc n(n5 c;nh ' th?E phQn ATP0 .iLn kt 'Ui in Na+0 mIt ph@n .iLnkt 'Ui K+ ' cc ch=t ste$i cWn5 tim

1n '; bX OS KaF . mIt 5.Ecp$tein0 bY t$ ht In5

c?a tiM& ph@n


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24 hZnh bm Na+0K+ATPase


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.(mBUc )[ :Ui s\ c9 m]t c?a in 25G+ bm tiM& ph@n D

5^n 'Ui ATPF s_ .iLn kt 'Ui ` in Na+ nm t$n5 t b ch=t3

BUc G[ ATPase c k


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8t In5 c?a bm c id& khiMn bi mIt h thn5 phVc tp cccn Wn5 t$&Edn t


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2.) Ch*! nn& !'a (m

8t In5 c?a bm Nat$i-Ka.i 5i>p 7m b7 s\ cQn bn5 5iaC& t$Znh fE ' h>t cc ch=t C&a mn50 5i ch p s&=t thfmth=& t$n5 t b Yn ;nh0 t b kh4n5 b; t$n5 ' cht3

1in th mn5 c t $a bi bm Na+-K+ATPase . c sch s\ gn t$&Edn th@n kinh ' ht In5 c3

%\ .i b Na+ $a khi t b bi bm Na+-K+ATPase cn5

c&n5 c=p .\c k


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II. Bm Ca2+ ATPase )3 :; t$c c?a bm

)3) :; t$< Bm nE thWn5 5]p .Ui %l c?a t b c ' t$Ln mn5 c?a t

b hJn5 c@&3

Bm cani mn5 sinh ch=t n5 ) P2#A)F[ phQn b t$n5 cc m4' cc t b

Bm cani mn5 sinh ch=t n5 G P2#AGF[ .i nE c tZm th=Ech? E& h th@n kinh t$&n5 n50 cc m4 c C&an c9 chVc n(n5]c hi&3

Bm cani mn5 sinh ch=t n5 ` P2#A`F[ .i nE c tZm th=E'Ui mVc I ca nh=t t$n5 ' nD ' tiM& nD3

Bm cani mn5 sinh ch=t n5 P2#AF[ chim S thnh ph@n

bm cani mn5 sinh ch=t c?a hJn5 c@&3


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G3G #=& t$>c c?a bm

-/ +>- -D5 9#* i2n -5nEi F"i -# +"#ng

Bm #aG+ ATPase .Ui c tn5 c9 hai ch&oi p.Epepti n'Ui khi .n5 ))S a0 5Jm hai tiM& n ';[

- TiM& n '; .Un t$!n5 .n5 5@n )SS3SSS a.tnF . tiM& n'; >c tc

- TiM& n '; nh kt hp 'Ui Wn5 5.EcsE.ateF 'gn cha $qchVc n(n53 TiM& n '; .Un . ch&oi po,ypeptit !h! !hn


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2. #c n5 bm cani

Bm #aG+ ATPase mn5 sinh ch=t P2#AF fEcani $a khi t b3

Bm #aG+ ATPase .Ui nIi ch=t ' .Ui c tn5 c9chVc n(n5 c4 .6p cani t$n5 an5 c?a cc b C&annIi b3

Bm cani c?a cn Wn5 k


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. o ng - 5 #*canx ctn! 8ai in cani tr ;ch b c?a t b c .iLn kt 'Ui cc '; t$< i

.\c ca c?a bm Jn5 thWi th?E phQn ATP M .=E n(n5 .n5

ch bm

BUc tip the . bm cani ' t$n5 an5

%a& 9 .iLn kt P- ATPase s_ c th& phQn ' bm C&aE 'dn5 ban @&

:anaat kZm ch s\ '6n ch&EMn in #a ' ht In5 c?aenEm ATPase

3 %\ kiMm st c?a ch& t$Znh ph7n Vn5 c 7m b7 bi s\ kt

c]p 5ia cc '; t$< .iLn kt cani 'Ui '; t$< phsph$E. h3


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M7 J 8 9. $ F ) Fi ? 9 i


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Bnh tiM& Wn5 .iLn C&an n %Al#A - un #aG+ . mIt E& t C&Et ;nh chVc n(n5 c?a t

b O 7 t&v3

- NJn5 I b=t thWn5 c?a in cani nIi b . mItthi& hwt ch&n5 t$n5 c7 hai tp bnh tiM& Wn53

- %\ t$a Yi in cani khc nha& cn5 D cn5hiLn cV& . 7nh hn5 tUi chVc n(n5 t b O

7 t&v0 C&a 9 7nh hn5 tUi c7 s\ tYn5 hp ins&.in3

! M7+


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B.n$ H5iF0P H5iF0 v3 9.n$ Q5>i> Bnh 8ai.eE- 8ai.eE

- H mIt kiM& bnh It bin t$Ii thM nhixm s^c3- BnhnE 5QE $a bi s\ It bin t$Ln 5en ATPG#) . 5enmD h ch mIt bm in cani khc thWn53


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Bnh /arier

- Bnh nE 5QE $a s\ kt


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III. Bm p$tn ATP sEnthaseBm nE &i0i th!h c ch enEm c?a C& t$Znh tYn5 hp ATP

c hai nh bc h!c tZm $a

Pa&. 3 BEe$ "hn 3 za.ke$


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1. V tr

1QE . enEme mn5 TZm th=E [

- 2n5 p.asma t b 'i kh&fn - 2n5 thE.aci c?a .wc .p

- 2n5 bLn t$n5 tE thM c?a t

b nhQn th6t


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2. C=& t

yJm c9 hai ph@n {S ' {)| Ph@n @& {) . ph@n a nUc nh4 $a tr mn5 nm t$n5 c

ch=t0 chVa \n5 cc phQn tR >c tc0 th\c hin s\ tYn5 hp' th& phQn ATP3 Ba 5Jm ` ch&oi en k_ nha& ' cc

tiM& ph@n }3

| Ph@n 7i .m nhim 'w .iLn kt {) ' {3

| {S . mIt kLnh p$tn0 kX i ht I E c?a mn50 .thnh ph@n kv nUc nm t$Ln mn53 Th\c hin s\ '6nch&EMn p$tn3


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M hnh lp ghp cc n v ca ATPsynthase


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. C ch ht In5 c?a bm

1@& tiLn . c95$aien in 8E$| un 8E$

P$tns F

c '6nch&EMn 'd mItph


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ATP sEnthase . bm p$tn .m 'icthe kiM& hai chid&

2 c=& t$>c[ 2 c=& t$>c


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2 c=& t$>c[ATP c 5i7i

ph9n50 ch& t$Znhb^t @&

#=& t$>c

9n5[AP0 Pi .iLnkt ch]t0t

ATP

2 c=& t$>c

#=& t$>c

m0AP0 Pi.iLn ktE&


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). ChVc n(n5 c?a bm

T $a ATP tr AP ' phtphat '4 c P iF

Q i n6ng F"ng + -$ vi.- 8/0 +>Z XH -D5 +i/ +$W 9[ng --$ 9#*i2n H v32 +i/ +$W

\ *3ng +$0F5]2i+ -D5 F- FKX 9#* +K2 *7+ g>58in+ ?i.n$)5 gi^5 $5i X$45 -D5 *3ng +$0F5]2i+


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Cac Loai Bom Tren Mang Te Bao