科目名 Course Title [Modern Trends in Chemical …...Assignment on a specified subject regarding to "Digital Microfluidics and Microfluidic Devises" (60%). In addition, we also

科目名 Course Title 先端総合化学特論Ⅰ [Modern Trends in Chemical Sciences and Engineering I]

講義題目 Subtitle 総合化学特論Ⅰ [Modern Trends in Physical and Material Chemistry]

責任教員 Instructor 村上洋太 [Yota MURAKAMI] (Faculty of Science)

担当教員 Other Instructors

開講年度 Year 2018 時間割番号Course Number 095111

期間 Semester Spring 単位数 Number of Credits 1

授業形態 Type of Class Lecture 対象年次 Year of Eligible Students ～

ナンバリングコード Numbering Code CHEM_REQEL 7111

キーワード Key Words

Advanced Physical Chemistry, Catalytic Transformation, Photochemistry, Theoretical Chemistry, Chemical Energy Conversion, Separation

Process Engineering, Process Engineering, Catalyst Design, Analysis of Physical Properties of Materials, Nano-Photonics Materials, Inorganic

Solid State Chemistry, Mesoscopic Material Chemistry, Interfacial Electrochemistry, Physical Chemistry of Electronic Materials, Solid State

Chemistry of Functional Materials, Applied Inorganic Materials Chemistry

授業の目標 Course Objectives

Lectures on scientific research in physical chemistry and materials chemistry will be given in English. In this course, the basic concepts and an

overview necessary for understanding the advanced research are introduced, followed by explanations of cutting-edge researches in various

fields of chemistry.

到達目標 Course Goals

Through a series of lectures in various fields of chemistry in English, students will learn a broad perspective and an international sense in

chemical researches.

授業計画 Course Schedule

Lectures will be provided by young assistant and associate professors in the Graduate School of Chemical Sciences and Engineering. A

schedule of lecturers and titles will be informed in the first lecture of the course.

準備学習（予習・復習）等の内容と分量 Homework

Assignment is required for every lecture.

成績評価の基準と方法 Grading System

It is required to attend at least 70% of the lectures. Evaluation as pass/fail will be based on the level of attendance (20%) and submitted reports

(each time, 80% in total).

テキスト・教科書 Textbooks

なし。適宜資料を配布する。

講義指定図書 Reading List

参照ホームページ Websites

研究室のホームページ Website of Laboratory

備考 Additional Information

科目名 Course Title 先端総合化学特論Ⅰ [Modern Trends in Chemical Sciences and Engineering I]

講義題目 Subtitle 総合化学特論Ⅱ [Modern Trends in Organic Chemistry and Biological Chemistry]




期間 Semester Summer 単位数 Number of Credits 1




Structural and Physical Organic Chemistry, Macromolecular Science, Organometallic Chemistry, Physical Chemistry of Organic Materials,

Genetic Regulation, Disease Regulation, Synthetic Organic Chemistry, Biophisycal Chemistry, Biosynthetic and Metabolic Engineering,

Biosystem Engineering, Analytical Biochemistry, Functional Polymer, Cell Processing Engineering


Lectures on scientific research in Organic Chemistry and Biological Chemistry will be given in English. In this course, the basic concepts and

an overview necessary for understanding the advanced research are introduced, followed by explanations of cutting-edge researches in various

fields of chemistry.


Through a series of lectures in various fields of chemistry in English, students will learn a broad perspective and an international sense in

chemical researches.


Lectures will be provided by young assistant and associate professors in the Graduate School of Chemical Sciences and Engineering. A schedule

of lecturers and titles will be informed in the first lecture of the course.




It is required to attend at least 70% of the lectures. Evaluation as pass/fail will be based on the level of attendance (20%) and submitted reports

(each time, 80% in total).






科目名 Course Title 先端総合化学特論Ⅱ [Modern Trends in Chemical Sciences and Engineering II]

講義題目 Subtitle Leading and Advanced Molecular Chemistry and Engineering I - 2018

責任教員 Instructor 伊藤肇 [Hajime ITOH] (Faculty of Engineering)

担当教員 Other Instructors Yoko YAMAKOSHI（ETH Zurich）


期間 Semester Intensive 単位数 Number of Credits 1




supramolecular chemistry, molecular recognition, non-covalent interaction


The objectives of this course are (i) developing a profound understanding of noncovalent bonding interactions and (ii) becoming prolific in the

most important synthetic methods applied to receptor syntheses.


Able to understand (1) the principle of molecular recognition principles, (2) synthetic strategy of artificial receptors and molecular machines,

and (3) supramolecular nanoscience / technological application.

Able to write synthetic strategy of supramolecular materials.


1. general principle of molecular recognition

2. cation and anion complex

3. complexation of neutral molecule, aromatic interaction

4. H-bonding, halogen-bonding, dipolar interaction

5. self-assembly and nanostructure, molecular machines


None


Students should provide a report.


No textbook required. Handouts will be distributed.




http://www.yamakoshi.ethz.ch/

http://labs.eng.hokudai.ac.jp/labo/organoelement/



講義題目 Subtitle Leading and Advanced Molecular Chemistry and Engineering II - 2018

責任教員 Instructor 渡慶次学 [Manabu TOKESHI] (Faculty of Engineering)

担当教員 Other Instructors Shih-Kang FAN（National Taiwan University）






digital microfluidics, microfluidic device, nanofluidic device, immunoassay, cell-based assay, MEMS


The course objective is to learn the basics and applications of DMF. It covers the principles of surface tension driven and electrically driven

microfluidics. The fabrication and design of the device and system will be introduced. Furthermore, the biomedical applications will be described.


The Couse goal is to illustrate the advances of electrically driven digital microfluidics (DMF). Class attendees would learn the principle, design,

and application of DMF.


Course title: Digital and Electric Microfluidics

1st lecture: Surface Tension and Microfluidics

Comparing to inertia and pressure, surface tension provides a more dominant force for liquid manipulations on a micro scale. The lecture focuses

on the basics of the surface tension and the means to alter surface tension including electrowetting. The lecture will cover the discovery of

electrocapillary, electrowetting, continuous electrowetting, and electrowetting-on-dielectric.

2nd lecture: Droplet-based Microfluidics and Digital Microfluidics (DMF)

Digital microfluidics (DMF) handles liquids in droplet forms. Different from emulsion-based droplet microfluidics, the droplets in DMF are

individually addressable. The lecture will introduce the droplet-based microfluidics including emulsion, DMF, and other mechanisms. The divide

fabrication, principle and design will also be described.

3rd lecture: Electrically-driven Microfluidics

The electrical forces are widely applied to alter surface tension and to realize DMF. Various electrically driven microfluidics will be addressed,

including electrophoresis, electro-osmosis, and dielectrophoresis. By combining electrowetting and dielectrophoresis, the lecture describes a

general electromicrofluidic platform manipulating (1) liquids with distinct electric conductivities, e.g., oil and water, (2) objects on variable scales

and phases, including solid particles, crosslinked microgels, liquid droplets, gas bubbles, and gaseous plasma, and (3) liquids in adjustable

geometries and formats, such as discrete droplets and continuous liquid columns.

4th lecture: Applications

In this lecture, several applications and varied configurations of DMF and electromicrofluidics will be covered. The commercial products of

DMF and electrowetting will also be introduced.

Seminar: 3D Heterogeneous Hydrogels Formation and Assembly on an Electromicrofluidic Platform

In this seminar, I will address the manipulations of prepolymer hydrogel droplets and cells on an electromicrofluidic platform to construct a

complex and heterogeneous microenvironment for cell culture. 3D hydrogel building blocks with reorganized cells or particles are formed and

assembled on the electromicrofluidic platform adopting electrowetting and dielectrophoresis.


None


Assignment on a specified subject regarding to "Digital Microfluidics and Microfluidic Devises" (60%).

In addition, we also consider it as the important factor for assessment how actively students participate in each class (40%).


Lecture notes will be provided.



http://fan-tasy.org/nanotascategory/news/

http://labs.eng.hokudai.ac.jp/labo/tokeshi_lab/



講義題目 Subtitle Leading and Advanced Molecular Chemistry and Engineering III - 2018

責任教員 Instructor 谷野圭持 [Keiji TANINO] (Faculty of Science)

担当教員 Other Instructors Akinori TAKAOKA(Institute for Genetic Medicine), Akira NAKAYAMA(Institute for Catalysis),

Takahiro SUZUKI(Faculty of Science), Atsushi MINAMI(Faculty of Science), Shinya TAKAHATA(Faculty

of Science), Tomohide SAIO(Faculty of Science), Hirokazu KOBAYASHI(Institute for Catalysis)






Biochemistry, Organic chemistry, Biosynthesis, Computational chemistry.


1) know mechanisms for the activation of cellular responses against microbial infection.

2) know computational chemistry with special emphasis on the first principles simulation.

3) know usefulness of heterogeneous catalyst for conversion of biomass.

4) know function of enzymes in biosynthesis of secondary metabolites.

5) know molecular mechanism of chromatin regulation in cell cycle.

6) know methodologies in synthetic organic chemistry for natural product synthesis.

7) know how proteins get their role through folding into native 3D structure.


By the end of this course you will be able to

1. understand importance of chemistry for searching principle of life in nature.

2. understand molecular mechanisms of various reactions in living cells.

3. understand progress of computional chemistry for predicting chemical reactions.

4. understand how to use chemical transformations for obtaining useful compounds.


June 11 a) Molecular mechanisms underlying host defense reponses

b) Recent advances in computational chemistry: first-principles simulation

June 12 a) Conversion of biomass by heterogeneous catalysts

b) Structural diversification of biologically active secondary metabolites

June 14 a) Promoter chromatin activation mechanism and gene expression

b) Natural product synthesis based on Diels-Alder reaction

June 15 a) Exploring the Chaperone Network in the Cell

b) discussion


None


You will be asked to write a page (A4) of essay on several lectures of your choice (60%).



No textbook required.






講義題目 Subtitle Leading and Advanced Materials Chemistry and Engineering I - 2018

責任教員 Instructor 佐田和己 [Kazuki SADA] (Faculty of Science)

担当教員 Other Instructors Akira KAKUGO(Faculty of Science), Mir Wais HOSSEINI（Universite de Strasbourg）






Molecular Machine, Molecular Assembly, Biomolecular Motors, Self-organization, Molecular Networks, Supramolecular Chemistry, Molecular

Tectonics, Gel, Nanoporous Materials, Crystals, Kinesin, Myosin, Dynein


Self-organization and complex system are key concepts for designing molecules and molecular assemblies toward emerged functions. This

course will provide fundamentals of chemistry of self-organization with respect to two different viewpoints; molecular machines and

supramolecular materials with molecular networks.

(I) Molecular Machines

The Nobel prize in chemistry 2016 was awarded to three chemists, Jean-Pierre Sauvage, Sir J. Fraser Stoddart and Bernard L. Feringa, for the

design and synthesis of molecular machines". The half of this course covers the fundamentals of molecular machines and bio-molecular motors.

The students will get a chance to come to know about: (1) basic information, (2) their working principle including mechanism of molecular

motions in highly integrated supramolecular structures, and biomolecualr motors, and (3) correlation between the molecular structure and

dynamic property. Furthermore, this course will focus on further applications of these molecular machines in relation to nanotechnology.

(II) Supramolecular Materials with Molecular Networks

The latter half part will focus on construction and properties of molecular-level network structures as supramolecular materials; lattice inclusion

compounds, porous coordination polymers, polymer gels, organo- or hydrogels from low-molecular-weight gelators. It will include (1) basic

information, (2) their designing principle, and (3) further integration for emerged functional materials. Some applications of all these materials

such as separation, catalysis, storage will be given.


This course reviews fundamentals of molecular machines including biomolecular motors and supramolecular materials with molecular network

structures. Students will be able to acquire basic knowledge both on preparation and molecular design and finally understand their construction

and working principle, and learn advanced their applications as material science.


(Topic I) Molecular machines

1. Introduction to molecular machines & macrocyclic compounds as hosts

2. Working principle and applications of molecular machines

3. Self-organization of bio-molecular motors

4. Working principle and applications of bio-molecular motors

(Topic II) Supramolecular materials with molecular networks

1. Introductory for molecules, information, and self-organization

2. Organic Self-assembled Systems with Pores; Molecular Tectonics

3. Chemically-crosslinked functional gels

4. Physical gels from small molecules


Students will read reviews and the primary literature on each topic, and submit questions for instructor after every classes and some written

reports on the topics.


Attendance more than 70% classes is requisite for evaluation of the credit.

The grade is evaluated in the following two items;(1) reports on each class with learning attitude (40%), (3) term examination or paper (60%).

Understanding for each class is evaluated by report or question and answer during the classes, and the basic knowledge for the subject is by

term examination or paper.






http://complex-matter.unistra.fr/

http://wwwchem.sci.hokudai.ac.jp/~matchemS/index.html



講義題目 Subtitle Leading and Advanced Materials Chemistry and Engineering IIA - 2018

責任教員 Instructor 村越敬 [Kei MURAKOSHI] (Faculty of Science)

担当教員 Other Instructors Shuo HUANG（Nanjing University）






Single Molecule Methods, Bioanalytical Chemistry, Optics, Biosensors, Biophysics, Sequencing, Bio-imaging


The aim of the course will focus on how these technologies facilitates our understanding the mechamisms of biological activities in molecular

level and also how we can detect biological events of bio-analytical value (such as precision diagnoisis and disease curing). Besides that, this

course also helps the students to learn how to design innovative instruments for bio-analytical chemistry research at single molecule level.


By the end of this course you will be able to ;

1. understand the basic principle of biochemistry and genetics for the study of single molecule bio-analytical chemistry.

2. understand basic principle and state-of-art techniques in single molecule biosensing.

3. understand basic principles of optical microscopy, fluorescnece, instrumentation & programming.

4. design a novel single molecule biosensing instruments for specific scientific problems.


Lecture I: Fundamentals of Biochemistry & Genetics

Lecture II: Patch Clamp Technologies & Nanopore Biosensing

Lecture III: Single Molecule Imaging Techniques

Lecture IV: Single Molecule Force Spectroscopy

Seminar: Nanopore biophysics: from $1000 sequencing to single molecule biosensing


to be announced.


Your grade will be determined by how well you demonstrate your achievement of the course goals through

1. Daily course quizzes. 10%

2. Course discussions on specific topics. 40%

3. Short course proposal & presentation. 50%


Handouts will be distributed. (Single-molecule techniques : a laboratory manual, Paul R. Selvin, Taekjip Ha, ISBN: 087969775X)




http://wwwchem.sci.hokudai.ac.jp/pc/index.html

http://hysz.nju.edu.cn/bionano/index.html



講義題目 Subtitle Leading and Advanced Materials Chemistry and Engineering IIB - 2018

責任教員 Instructor 島田敏宏 [Toshihiro SHIMADA] (Faculty of Engineering)

担当教員 Other Instructors Taro NAGAHAMA(Faculty of Engineering), Rong TU（Wuhan University of Technology）






thin films, gradient materials, electronics, spintronics, ceramic, semiconductors, thermoelectricity, laser, vacuum


The modern life is impossible without using materials and chemical technology. In this course, we will shed light on the thin film and composite

materials, by inviting a leading researcher Prof. Rong TU from China. Now the thin film technology has reached to the level of controlling the

thickness of atomic layers. The emergence of nanomaterials which are synthesized by chemistry and various processing is now changing the

concept of composite materials. Your cellular phone is full of these technologies. We will explain the basic ideas behind the modern processes

and the fundamentals of the functions, including transparent conductors, solid state lasers, thermal insulation, ultrahard materials, various

sensing devices such as magnetic head of hard disk.

Prof. Rong TU had studied in Japan and has become a famous professor in China. He will explain how he studied and worked in the younger

days.



1. explain the basic concepts in electronics, spintronics, mechanical and thermal applications of thin films and composite materials.

2. explain the basic chemistry and physics behind the modern thin film technology and materials processing.

3. know how to study and work in overseas.


This course is focused on two subjects: materials processing and functions. In the materials processing part, we will provide three lectures and

one lab tour including

short demonstration experiments. The materials function part, we will provide four lectures. The course is organized as follows:

1. Introduction: How thin films and composite materials are used in the modern life.

2. Basic concepts behind the fabrication technology in atomic scales - interplay between the thermodynamics and kinetics, with the aid from

chemistry.

3. High energy processes:

4. Electronics and optical properties focusing on semiconductor circuits

5. Mechanical and thermal properties

6. Spintronics

7. Lab tour, showing plasma CVD, high pressure synthesis and various characterization techniques

8. Seminar by Prof. Rong TU.


It will be provided after each classes, if any.


Grading will be based on the final reports submitted some period after the lectures






http://sklwut.whut.edu.cn/english/

http://www.eng.hokudai.ac.jp/labo/kotai/



講義題目 Subtitle Leading and Advanced Materials Chemistry and Engineering IIC - 2018

責任教員 Instructor 島田敏宏 [Toshihiro SHIMADA] (Faculty of Engineering)

担当教員 Other Instructors Yu-Lun CHUEH（National Tsing Hua University）






low dimensional materials, solar energy conversion, memory devices, sensors, semiconductors, nanotubes


Study on low dimensional nanomaterials is an emerging interdisciplinary field between chemistry and materials physics. The synthesis,

characterization, functionalization and device fabrication have become possible by recent development of nanotechnology. In this lecture, we

invite Prof. Yu-lun Chueh from National Tsinghua University, Taiwan, who is a leading young figure of atomic layer materials such as graphene,

MoS2, and applications on solar energy harvesting and memory devices. Nanomaterials have very unique electronic structures and full of

surfaces which can be chemically modified and functionalized. Various new concepts have been proposed and confirmed, and some have come

into practical applications. We provide basic view of this exciting research field.



1. explain the basic concepts in nanomaterials synthesis and functionalization, and device fabrication.

2. explain the basic chemistry and physics behind the application of nanomaterials.

3. know how to make international collaboration.


This course is focused on two subjects: synthesis of low dimensional nanomaterials and their functions. In the synthesis part, we will provide

three lectures and one lab tour including short demonstration experiments. The materials function part, we will provide four lectures. The

course is organized as follows:

1. Introduction: What are low dimensional nanomaterials?

2. Basic concepts of solid state chemistry and physics of low dimensional nanomaterials.

3. Synthesis techniques

4. Sensor and memory applications

5. Energy harvesting - basic concepts

6. Energy harvesting - application of low dimensional nanomaterials

7. Lab tour, showing equipment for nanomaterials synthesis and various characterization techniques

8. Seminar by Prof. Yu-lun Chueh


It will be provided after each classes, if any.


Grading will be based on the final reports requested to submit some period after the lecture.






http://nanoscienceandnanodevicelab.weebly.com/

http://www.eng.hokudai.ac.jp/labo/kotai/



講義題目 Subtitle Leading and Advanced Materials Chemistry and Engineering III - 2018

責任教員 Instructor 加藤昌子 [Masako KATO] (Faculty of Science)

担当教員 Other Instructors Hidenori NOGUCHI(NIMS), Akihiro OKAMOTO(NIMS)






Electrochemistry, Elecrtocatalisis, In situ surface probe, microbial extracellular electron transport (EET)


This course is designed to acquire basic knowledge in electrochemistry, such as electron transfer, electrocatalysist, microbial extracellular

electron transport (EET), and in situ surface probe techniques for the research in energy conversion.


Students will gain not only knowledge of electrochemistry, which form the basis of surface electrontrasfer which is important in energy conversion

materials. Also acquire problem-solving ability for exploring functionality of materials.


Course schedule is as follows:

(1) Basics of electrochemistry

(2) Electro transfer reaction, Electrocatalysis

(3) In situ surface characterization methods

(4) Protein electrochemical methods

(5) Microbial electrode catalysis

In FY2018, this course provides overviews of recent research on some topics from (1) to (5).


To read text books for electrochemistry at undergraduate level is highly recommended.


Assignment on a specified subject regarding to "Recent energy conversion systems at solid/liquid interface" (60%).







http://www.nims.go.jp/



講義題目 Subtitle Leading and Advanced Biological and Polymer Chemistry and Engineering I - 2018

責任教員 Instructor 坂口和靖 [Kazuyasu SAKAGUCHI] (Faculty of Science)

担当教員 Other Instructors Rui KAMADA(Faculty of Science), James G. OMICHINSKI（Universite de Montreal）






intrinsically disordered, protein-protein interactions, NMR, X-ray crystallography, post-translational modifications, acidic activation domains,

transcription, SUMO, SUMO-interacting motifs (SIM), PML-nuclear bodies, LC3, LC3-interacting region (LIR), autophagy; cancer, stress,

viral infections.


1) To establish the basics of the importance of intrinsically disordered protein regions in regulating dynamic biological processes.

2) To establish the correlation between an increase probability of post-translational modifications and intrinsically disordered protein regions.

3) To explain the special considerations that must be taken when preparing intrinsically disordered protein regions for structural

characterization.

4) To explain the limits of various structural biology techniques in characterizing intrinsically disordered protein regions.

5) To examine how intrinsically disordered protein regions can regulate the formation of dynamic complexes during transcriptional activation.

6) Highlight the flexibility of acidic activation domains in binding to transcriptional regulatory factors to regulate transcriptional activation and/or

repression.

7) To examine how intrinsically disordered protein regions regulate the transit of proteins in and out of PML-nuclear bodies function through

SUMO-SIM interactions.

8) Highlight how post-translational modifications regulate SUMO-SIM interactions in PML-nuclear bodies.

9) To examine how intrinsically disordered protein regions regulate autophagy through their role in regulate interactions with the LC3 family of

proteins.

10) Highlight how post-translational modifications regulate LC3-LIR interactions during autophagy.


1) To achieve an appreciation of what intrinsically disordered protein regions are and their role importance in regulating a wide range of cellular

processes through

their participation in dynamic protein-protein interactions.

2) To appreciate the tools and methods for structurally characterizing protein-protein complexes containing intrinsically disordered protein

regions.

3) To learn in detail about important processes where intrinsically disordered protein regions play key roles and why viral proteins often target

cellular functions regulated by intrinsically disordered protein regions.


Day 1: The role of intrinsically disordered protein regions in biological systems.

• Introduction and definition of intrinsically disordered protein regions.

• Relative occurrence in proteins as it relates to cellular functions.

• Functions and advantages for regulating biological systems.

• Relationship between intrinsically disordered regions and posttranslational modifications.

Day 2: Experimental methods for structurally characterizing interactions involving intrinsically disordered protein region.

• Special considerations for purifying intrinsically disordered protein regions.

• Advantages and disadvantage of various structural techniques.

• Characterizing intrinsically disordered protein regions using heteronuclear NMR spectroscopy.

Day 3: The role of intrinsically disorder protein regions in regulating transcription.

• Review the occurrence of intrinsically disordered protein regions in transcriptional regulatory factors.

• Discuss the role of transactivation domains (TADs) in regulating transcription and their connection to intrinsically disordered proteins regions.

• Present overview of how acidic TADs present in key transcriptional regulatory factors (such as p53, NF-kB, VP16) function through their

ability to form promiscuous protein-protein interactions.

• Discuss how many viral proteins that play a role in regulating host cell transcription contain intrinsically disordered protein regions.

Day 4: The key role of intrinsically disordered proteins regions in regulating cellular response to stress, cancer and viral infections.

• Review the factors that regulate the SUMOylation machinery.

• Discuss the role of SUMO-family proteins and SUMO-SIM interactions in regulating protein transit in and out of PML-nuclear body.

• Discuss how acetylation of SUMO proteins and phosphorylation of SIMs regulate SUMO-SIM interactions.

• Discuss the role of the of LC3-family protein and LC3-LIR interactions in regulating autophagy.

• Discuss how acetylation of LC3-family proteins and phosphorylation of LIRs regulate LC3-LIR interactions.


Scan through a few of the articles in the reading list


Assignment on a specified topic regarding "Structure determination of intrinsically disordered protein domains" or “Functional roles of

intrinsically disordered protein domains” (60%).




・Sigler PB. (1988) Nature 333:210-2. ・Wright PE, Dyson HJ. (2015) Nat Rev Mol Cell Biol. 16:18-29. ・Dyson HJ, Wright PE. (2016) J Biol

Chem. 291:6714-22. ・Babu MM. (2016) Biochem Soc Trans. 44:1185-1200. ・Staby L, O'Shea C, Willemoes M, Theisen F, Kragelund BB,

Skriver K. (2017) Biochem J. 474:2509-2532. ・Ahrens JB, Nunez-Castilla J, Siltberg-Liberles (2017) J. Cell Mol Life Sci. 74:3163-3174. ・

Birgisdottir AB, Lamark T, Johansen T. (2013) J Cell Sci. 126:3237-47. ・Lecoq L, Raiola L, Chabot PR, Cyr N, Arseneault G, Legault P,

Omichinski JG. (2017) Nucleic Acids Res. 45:5564-5576. ・Cyr N, de la Fuente C, Lecoq L, Guendel I, Chabot PR, Kehn-Hall K, Omichinski

JG. (2015) Proc Natl Acad Sci U S A. 112:6021-6. ・Cappadocia L, Mascle XH, Bourdeau V, Tremblay-Belzile S, Chaker-Margot M, Lussier-

Price M, Wada J, Sakaguchi K, Aubry M, Ferbeyre G, Omichinski JG. (2015) Structure 23:126-38. ・Krois AS, Ferreon JC, Martinez-Yamout

MA, Dyson HJ, Wright PE. (2016) Proc Natl Acad Sci U S A. 113:E1853-62. ・Iakoucheva LM, Radivojac P, Brown CJ, O'Connor TR, Sikes

JG, Obradovic Z, Dunker AK. (2004) Nucleic Acids Res. 32:1037-49. ・Huang R, Xu Y, Wan W, Shou X, Qian J, You Z, Liu B, Chang C,

Zhou T, Lippincott-Schwartz J, Liu W. (2015) Mol Cell. 57:456-66.



https://biochimie.umontreal.ca/en/department/professors/james-g-omichinski/

http://wwwchem.sci.hokudai.ac.jp/~biochem/index.html



講義題目 Subtitle Leading and Advanced Biological and Polymer Chemistry and Engineering II - 2018 [Leading and

Advanced Biological and Polymer Chemistry and Engineering II - 2018]

責任教員 Instructor 佐藤敏文 [Toshifumi SATOH] (Faculty of Engineering)

担当教員 Other Instructors Takuya YAMAMOTO(Faculty of Engineering),

Moonhor REE（Pohang University of Science and Technology）






polymer chemical structure; polymer chain structure; polymer morphology; chain structure/morphology characterization methods; scatterings;

microscopies


This course provides the understanding on (i) polymer chain structure and its relations to chemical structure and synthesis history, (ii) polymer

morphology and its relations to chain structure and process history, and characterization skills of polymer chain and morphological structures.


Get knowledge on

(1) Polymer chain structure and its correlation to chemical structure and polymerization condition and pathway;

(2) A variety of polymer morphologies and their formation forces and their correlations to chain and chemical structures and process pathway;

(3) Characterization skills on polymer chain and morphological structures;

(4) The relationships of chain and morphology to polymer properties and applications.

Overall, build up background stronger in polymer physical chemistry (i.e., polymer physics).


1st lecture: Introduction to the correlations between chemical structure, chain structure, morphology, and properties of polymer

- Chemical composition; monomeric sequence; molecular weight; polydispersity index

- Chain structure characteristics

- Morphological structures

- Properties

2nd lecture: Polymer chain structure

- Monomeric unit sequence

- Stereoregularity; regioregularity

- Conformation

- Rigidity/flexibility

- Three-dimensional structure

- Characterization methods

3rd lecture: Polymer morphology in solid and in solution (I)

- Hierarchical structure in morphology

- Morphology representatives

- Driving forces of morphological structure formation

- Characterization methods

4th lecture: Polymer morphology in solid and in solution (II)

Seminar: Morphological Structures and Their Impacts on Properties of Functional Polymers in Various Topologies


None


Assignment on a specified subject regarding to "Structures and Their Correlations to Properties in Polymer Science".

We consider it as the important factor for assessment of three short tests (90%) and final report (10%).


Lecture notes in PDF files will be provided.


M. Ree, “Probing the Self-Assembled Nanostructures of Functional Polymers with Synchrotron Grazing Incidence X-Ray Scattering”,

Macromol. Rapid Commun. 2014, 35, 930-959



http://mree.postech.ac.kr/

http://poly-bm.eng.hokudai.ac.jp/mol/index.html


References suitable for this course:

(1) P.J. Flory, "Statistical Mechanics of Chain Molecules"

(2) R. J. Young,"Introduction to Polymers"

(3) G. Strobl, "The Physics of Polymers"

(4) H.-G. Elias, "An Introduction to Polymer Science"

(5) A. Tager, "Physical Chemistry of Polymers"

(6) L. F. Alexander, "X-Ray Diffraction Methods in Polymer Science"

(7) R.-J. Roe, "Methods of X-ray and Neutron Scattering in Polymer Science"

(8) G.H. Michler, "Electron Microscopy of Polymers"

(9) D.B. Williams and C.B. Carter, "Transmission Electron Microscopy"


講義題目 Subtitle Leading and Advanced Biological and Polymer Chemistry and Engineering III - 2018

責任教員 Instructor 大利徹 [Toru DAIRI] (Faculty of Engineering)

担当教員 Other Instructors Hirofumi TANI(Faculty of Engineering), Kenichiro MATSUMOTO(Faculty of Engineering),

Shinichiro SATOH(Faculty of Engineering), Kenji TAJIMA(Faculty of Engineering),

Tomoki ERATA(Faculty of Engineering)






Biochemistry, Bioluminescence, Chemiluminescence, Computational chemistry, Polymer chemistry, Biopolymer, Bacteria, NMR, Metabolic

pathway, Biopolymer.


1) understand biosynthesis of natural products.

2) understand how to use the spectroscopy on biological system.

3) understand bio- and chemiluminescence in analytical applications.

4) introduction of computational chemistry and its application to biochemistry and polymer chemistry.

5) understand biosynthesis and application of bacterial cellulose.

6) know basic of pathway and protein engineering and analytical methods.



1. simulate the biological engineering for production of useful compounds.

2. analyze the biopolymer such as bacterial cellulose with NMR spectroscopy.

3. design bio- and chemiluminescence reaction for chemical and biochemical analysis.

4. understand how to use computational chemistry in designing useful compounds.

5. design biopolymer-based materials.

6. understand the strategy to produce unnatural products.


June 25 a) natural product biosynthesis.

b) NMR spectroscopy for analysis on the structure and the metabolic pathway of bacterial cellulose.

June 26 a) production of nano-fibrillated cellulose using a cellulose-producing bacterium.

b) introduction of computational chemistry.

June 27 a) bio- and chemiluminescence in analytical chemistry.

b) basic of pathway and protein engineering and analytical methods.

June 28 discussion


None


Assignment on a specified subject regarding to "Biological Engineering Directed Production of Useful Chemicals" (60%).



No textbook required.





科目名 Course Title 総合化学特別研究第二 [Research in Chemical Sciences and Engineering II]

講義題目 Subtitle



科目種別 Course Type


期間 Semester Irregular 単位数 Number of Credits 1




Advanced Chemistry, Special Topics in Chemistry, Various Fields of Chemistry


In this course, foreign researchers from abroad give a lecture in chemistry. This course will provide students with an overview of advanced

researches in chemistry.


Students should acquire an international sense in chemical researches, as well as the ability for discussion in English which should be required

at the international conference.


This course is given by a lot of guest researchers who visit laboratories in the Graduate School of Chemical Sciences and Engineering in

Hokkaido University. The schedule will be informed every time when the lecture is open.




Class participation (more than 7 lectures) and report.






科目名 Course Title 総合化学研究・指導法 [Research in Chemical Sciences and Engineering III]

講義題目 Subtitle

責任教員 Instructor 武次徹也 [Tetsuya TAKETSUGU] (Faculty of Science)

担当教員 Other Instructors Provided by supervisor

開講年度 Year 2018 時間割番号Course Number

期間 Semester Full-year 単位数 Number of Credits 2

授業形態 Type of Class Seminar 対象年次 Year of Eligible Students 1～3



Development and improvement of experimental techniques: teaching and research skills: presentation skills: Chemical English


Graduate course students are requested to play leaderships in both teaching and research. This course examines how to manage research

experiments and to present student's achievements in Japanese and English. Also, the course examines how to gain teaching skills and abilities.


Through the course, students will be able to

- get abilities on development and/or improvement of experimental techniques and equipments

- get high teaching and research skills

- get high presentation skills in both Japanese and English

- play leadership in each reseach field and teaching


On the basis of evaluating the teaching and research achievements of each student, the course offers on-the-job-training to

- get abilities in development and/or improvement of experimental skills and/or experimental equipments

- get high oral and poster presentation skills

- get speaking, hearing, and writing abilities in English

- get high teaching and research skills

- play leaderships in both research and teaching


Preparatory works for laboratory experiments


Evaluate based on total attitudes in teaching (50%), experimental and scientific achievements (50%).






Documents

科目名 Course Title [Modern Trends in Chemical …...Assignment on a specified subject regarding to "Digital Microfluidics and Microfluidic Devises" (60%). In addition, we also