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Collaborative possibilities with the Biomedical Research Foundation of the Academy of Athens in the context of IMI European Programmes Conference Week 6 December 2016 Nicosia, Cyprus Aristidis Charonis MD PhD Biomedical Research Foundation of the Academy of Athens

Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

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Page 1: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

Collaborative possibilities with the Biomedical Research Foundation of the

Academy of Athensin the context of IMI

European Programmes Conference Week

6 December 2016

Nicosia, CyprusAristidis Charonis MD PhD

Biomedical Research Foundation of the Academy of Athens

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About IMI

• Information about the Innovative Μedicines Ιnitiative can be found at www.imi.europa.eu

• It is the largest European initiative which is public-private and aims at speeding up the development of better and safer medicines for patients

• To achieve this goal it tries to built networks of industrial and academic partners in order to reach innovation in pharmaceutical products by supporting scientific excellence

Page 3: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

A glance at the current budget (ΙΜΙ2)

• The current IMI programme has a total budget of about 3.300 million euros for 2014-2024

• The EU will contribute via the Horizon programme 1.638 million euros

• The EFPIA (European Federation of Pharmaceutical Industries and Associations) will contribute 1.425 million euros

• Other Associated Partners will contribute 213 million euros

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The first period 2008-13 (IMI1)

• The budget for the first period was 2.000 million euros

• About 50 projects were funded

• Subjects varied, focusing on cancer, neurodegeneration, diabetes, osteoarthritis, bacterial resistance, vaccines, ect

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Actions supported by IMI2

• Activities aiming to establish new knowledge

• Activities aiming to explore the feasibility of a new or improved technology, product, process or service

So, both basic and applied research proposals are accepted

Page 6: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

How can Cyprus Institutes

collaborate with

the Biomedical Research Foundation

of the Academy of Athens

Page 7: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS(BRFAA) - www.bioacademy.gr

Page 8: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for
Page 9: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

MAIN MISSION OF BRFAA :

THE CATALYSIS OF TRANSLATIONAL RESEARCH

BIOMEDICAL APPLICATIONS

Page 10: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

RESEARCH DIRECTIONS

CARDIOVASCULAR NEUROBIOLOGY

Development

Physiology - Pathology

Cellular Death

REGULATION OF GENE EXPRESSION

INFLAMMATION-TISSUE REMODELING

GENETICS OF AGEING

CANCER BIOLOGY

Basic Molecular Mechanisms

Gene Expression Networks

Genetic re-programming

Severe Asthma

Chronic Obstructive Pulmonary Disease

Interstitial Lung Diseases

Renal Failure

Rheumatoid Arthritis

Ulcerative Colitis, Crohn’s Disease

Mechanisms of carcinogenesis

Novel Markers

Cutting edge methodologies for:

Treatment and diagnosis

Gene Therapy

New drugs

Development

Neurodegenerative Diseases

Memory and Learning

Metabolic Diseases

Diabetes Obesity

Systemic Responses

In C. elegans

Telomeres

Systemic analysis

BIOLOGY OF STRESS

Page 11: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

Animal Facility

Total Surface area: 1,600 sq.m.

Housing capacity: 20.000 transgenic mice, 1.000 conventional mice or

equal number of rats, 70 rabbits and 20 pigs.

ATLS COURSES, ENDOSCOPIC OTOLARYNGOLOGY. LIVER AND INTESTINE SURGERY,

ENDOSCOPIC SURGERY, ENDOSCOPIC ORTHOPEDICS, SPINAL CORD SURGERY,

PLASTIC SURGERY, ARTHROSCOPY, ROBOTIC SURGERY, LAPAROSCOPIC SURGERY

NUMBER OF COURSES: 119

NUMBER OF TRAINEES: 4.823

Surgery Rooms: Total surface area: 1,300 sq.m.

Four operating rooms, Two Intensive Care Units, Central Supply Area

Personnel involved:

A director, two Special Scientist, one head nurse, three technologists,

three animal specialists, two fully dedicated cleaning personnel

Page 12: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for
Page 13: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for
Page 14: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

RESEARCH ACTIVITY 2004 - 2015

• Number of surgical procedures: 12.129

• Publications: 107

• Presentations in Congresses: 272

• Obtained awards: 15

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BioImaging Unit (BIU)Two confocal microscopesOne is equipped for live cell imaging (with environment chamber, CO2 perfusion, very

fast live scanner). The other is on an upright fixed stage microscope, which makes it ideal for big samples such as whole animal embryo imaging

Fast Imaging system for quantitative intracellular measurements

Stereology and neuron tracing imaging workstation

Several automated microscopes with monochrome and colour high resolution digital cameras.

Image analysis suite with modern, wide screen computer workstations loaded with specialised Image Analysis software (Volocity, Imaris, LAS AF, Matlab, ImageJ etc).

All computers are linked via a fast (Gbit) network to two data servers (RAID5 - NAS servers) for more than 12TB safe, unified storage

Full time personnel involved

HEAD OF FACILITY: STAMATIS N. PAGAKIS, MS, PhD

MICROSCOPY SCIENTIST: ELENI RIGANA, MS, PhD

Page 16: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for
Page 17: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

Clinical Imaging

• Imaging of live animals with high resolution ultrasound and positron emission tomography (PET/CT)

• Ultrasound and PET/CT technologies are also used for outpatient services

Page 18: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

Dr. Dimitris Thanos ([email protected])

Dr. Alexandros Polyzos ([email protected])

Page 19: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

FACS Analyzer Isolation of Cell

Subpopulations

Fluidigm C1Single Cell

Sequencing

Analysis

BD FACSAria™ III

Cell population sequencing

analysis

NextSeq 500

HiSeq 4000

MiSeq

NGS ExpressLibrary Preparation Robotic

System

Sequencing Platforms

single cell genomics

High Power

Computing Cluster

Mac Cluster

CyTOF2Single cell

proteomics analysis

PolarisSingle Cell

Functional Analysis

IrysStructural Variation

Detection

Analysis of Biological

Samples

NextSeq500

Study the transcriptome of 12 patients in 11 hours

Perform WGS for 1 patient in 29 hours (30x coverage)

Perform WES for 12 patients in 29 hours (100x coverage)

MAC cluster

CPU - 120 cores (threads)RAM - 0.5 TB

HARD DRIVES - 120 TB

Align > 400GB of data (WGS 30x) in less than 22 hours

Or Analyze the transcriptome of 24

patients in less than 24 hours

LINUX HPC

500 cores>2TB RAM

160TB HARD DRIVE for NGS analysis

>300TB HARD DRIVE for BACK-UP and STORAGE

Analyze (align) 16 Whole Genomes (30x) or > 6 TB of data

in less than a day

Page 20: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

GGC techniques

4C-seqHiC

WGSWES

Page 21: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

GGC projects

Germany

Freiburg – MAX PLANCK

Heidelberg - EMBL

Chania - MAICh Heraklion - IMBB

Ioannina - IMBB

Thessaloniki-AUTH

BRFAA Fleming NTUA UOA

New York - COLUMBIA

Seattle - UW

USA

• 50 Different Lab-projects

• 700 Sequenced Samples

• 70 Runs

• 2 publications in 1 year

Page 22: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

PHARMACOLOGY UNIT WITH BIOANALYTICAL CAPABILITIES

Page 23: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

DIVISION OF PHARMACOLOGY - PHARMACOTECHNOLOGY

The laboratory operates according to

the Good Laboratory Practice (GLP)

standards and has been awarded an

ISO/IEC 17025:2005 certificate.

The lab is equipped with Hybrid system of Liquid

Chromatography – Mass Spectroscopy of triple

quadrupole – Ion trap (LC-MS/MS), and all the

other equipment that are required to perform

bioanalysis and validation of drugs.

• Qualitative/ Quantitative analysis of drugs in biological fluids/tissues

• Pharmacokinetics (PK) of drugs in pre-clinical/clinical stages

• Drug metabolism

• Bioavailability and bioequivalence studies

• Quantitative determination of biomarkers (e.g. peptides, proteins) in various

matrices (e.g. plasma)

Page 24: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

PROTEOMICS GENOMICS CYTOGENETICS

SUPPORT FACILITIES AT BRFAA

TransgenicsLaser Micro-dissection FACS-SORTING Lung Function

Measurements

Page 25: Collaborative possibilities with the Biomedical Research ... · Biomedical Research Foundation of the Academy of Athens. ... •Ultrasound and PET/CT technologies are also used for

Pan-Hellenic Research Infrastructure Networksthat will support Translational Research in Greece

(PIs: Drs Efsratiadis, Sideras, Thanos, Charonis, Kollias)

INFRAFRONTIER-GR

ΦΛΕΜΙΝΓΚIIBEAA

European Infrastructure for phenotyping and archiving of model mammalian genomes

BBMRI-GR

IIBEAAΦΛΕΜΙΝΓΚ, ΠΑΣΤΕΡ, EIE, ΕΚΠΑ, ΔΗΜΟΚΡΙΤΟΣ

ΠΙ

ΑΠΘΔΠΘ

ΠΘ

ΠΠ

ΠΚ, ΙΤΕΠΡ

Biobanking and Biomolecular Resources Research Infrastructure

EATRIS-GR

IIBEAAΦΛΕΜΙΝΓΚ, ΠΑΣΤΕΡ, EIE, ΕΚΠΑ

ΠΙ

ΑΠΘΔΠΘ

ΠΘ

ΠΠ

ΠΚ, ΙΤΕ

European Advanced Translational Research Infrastructure

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Eager to collaborate…