Combined Measurement of Synovial Fluid α-Defensin and C-Reactive Protein Levels: Highly Accurate for Diagnosing

Periprosthetic Joint Infection

by Carl Deirmengian, Keith Kardos, Patrick Kilmartin, Alexander Cameron, Kevin Schiller, and Javad Parvizi

J Bone Joint Surg AmVolume 96(17):1439-1445

September 3, 2014

©2014 by The Journal of Bone and Joint Surgery, Inc.

Synovial fluid α-defensin values (logarithmic scale) for the patients in the study.

Carl Deirmengian et al. J Bone Joint Surg Am 2014;96:1439-1445

©2014 by The Journal of Bone and Joint Surgery, Inc.

Synovial fluid α-defensin levels in the total cohort of 149 patients, revealing a bimodal distribution with few values near the diagnostic cutoff.

Carl Deirmengian et al. J Bone Joint Surg Am 2014;96:1439-1445

©2014 by The Journal of Bone and Joint Surgery, Inc.

Synovial fluid CRP values (logarithmic scale) for the patients in the study.

Carl Deirmengian et al. J Bone Joint Surg Am 2014;96:1439-1445

©2014 by The Journal of Bone and Joint Surgery, Inc.

α-defensin and CRP results are assessed in a combined algorithm.

Carl Deirmengian et al. J Bone Joint Surg Am 2014;96:1439-1445

©2014 by The Journal of Bone and Joint Surgery, Inc.