Professor Douglas BorchmanUniversity of Louisville School of Medicine

CURRICULUM VITAE

Name: Douglas Borchman, PhD

Address Birth date: September 12, 1953201 Beckley Woods Drive Birth Place: Detroit, MI U.S.A. Louisville KY 40245 U.S.A. Citizenship: United States

Phones Marital Status: MarriedWork: (502) 852-7435 Number of Children: One FAX: (502) 852-7450 Home: (502) 244-6743Cell: (502) 435-6200

E-mail: borchman@louisville.edu

A) Education Wayne State University, Detroit, Michigan, B.S. Chemistry 1977

Wayne State University, Detroit, Michigan, Ph.D. Chemistry (Biochemistry) 1986 (with minor in Biology)

Mt Sinai Hospital, New York, New York, Post Doctoral Fellowship, Physiology and Biophysics 1984.

B) Academic and Professional Experience7/2000-present, Professor, Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY

4/2001-6/30/2014, Professor (secondary appointment), Physiology and Biophysics, University of Louisville, Louisville, KY 1/1988-present, Professor (secondary appointment), Department of Chemistry, University of Louisville, Louisville, KY

1/2012-present, Associate in Biochemistry and Molecular Biology

7/2007-present, Founding Faculty, Institute for Advanced Education and Renewable Energy Research Institute, University of Louisville, Louisville, KY.

1998-present, Founding Faculty, Institute for Molecular Diversity and Drug Design, University of Louisville, Louisville, KY.

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10/9/2015

7/l987-2012, Professor (secondary appointment), Department of Biochemistry, University of Louisville, Louisville, KY

6/2008 (June, Oct), Ad hoc reviewer, National Eye Institute, NIH

1/1994-6/2000 Associate Professor, Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY

1/1988-12/1993 Assistant Professor, Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY

1/1987-1/1988 Research Associate, Department of Ophthalmology, University of Louisville, Louisville, KY

4/1984-7/1986 Postdoctoral Research Fellow, Department of Physiology and Biophysics, Mount Sinai Hospital, New York, New York.

1/1982-2/1984 Research Assistant, Wayne State University, Detroit, Michigan.

6/1979-9/1979 Biochemistry Research Technician, Veteran's Hospital, Allen Park, Michigan

8/1986-12/1986 Instructor, Lawrence Institute of Technology, Southfield, MI

9/1980-6/1982 Medical School Biochemistry Tutor, Wayne State University Medical School, Detroit, Ml

9/1979-1/1982 Teaching Assistant, Wayne State University, Detroit, MI

C) Military ServiceNone.

D) Board Certification and LicensureNone

E) Professional SocietiesAssociation of Research and Ophthalmology and Visual Sciences, International Association of

Biomedical Gerontology, International Congress of Eye Research, International Society for Free Radical Research, Japanese-USA Cooperative Cataract

Kentucky Academy of Sciences, Research Group, European Association for Vision and Eye Research, Tear Film and Ocular Surface Society.

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F) Awards and Named Lectureships

5/2015 Association of Research in Vision and Ophthalmology, ‘Hot Topics’ presentation.

1/2011 Association of Research in Vision and Ophthalmology, Silver Fellow Award.

12/2005 A Celebration of Teaching and Learning: The 2005 Faculty Favorite Award. University of Louisville.

4/2000 University of Louisville Community Service Award.

9/1992 Travel Fellowship to the 10th Congress of Eye Research, Stresa, Italy.

10/1991 Travel Fellowship to The European Community Concerted Action on Aging and Diseases, Ghent, Belgium.

1/1990 President's Young Investigators Award for Excellence in Research and Scholarship, University of Louisville

1/1987 Travel Fellowship to the 4th Congress US-Japan Cooperative Research Group, Honolulu, Hawaii

G. Committee Assignments and Administrative Services

2007-present, Internal Research Incentive Grants Advisory Committee, Primary reader, Study Section Member. October and April. University of Louisville, Louisville KY.

2015 Chaiman, Tenure Committee for Shlomit Schaal.

2015 Chairman, Promotion and tenure Committee for Dean and Barr.

2015 SIBUP Form Development

2014 Chairman, Promotion and tenure Committee for William Nunery.

2013 Chairman, Promotion and tenure Committee for Shigeo Tamiya and Shlomit Schaal.

2012 Chairman, Promotion and tenure Committee for T. Tezel.

2011, 2012 Poster Judge, Research Louisville, Undergraduate and faculty presentations. October, University of Louisville, Louisville KY.

2011 Chairman, Promotion and tenure Committee for Qiutang Li, Qingxian Lu and Nigel F. Cooper, Gulgun Tezel.

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2011-present. Chairman, Poster Judging Committee, The Institute for Molecular Diversity and Drug Design Symposium, Jewish Hospital.

2003-2011, Activity Director, Ophthalmology and Visual Sciences Journal Club, Continuing Health Sciences Education Program.

2010 Chairman, Promotion and tenure Committee for Gary Foulks and Hui Shao.

2002-2008 Department Performance-Based Salary Increase Committee

1998-present, Institute for Molecular Diversity and Drug Design, Fellowship/travel award Committee

2003-2006, University of Louisville School of Medicine Academic Technology Committee

2006 Scientific and awards committee chairman for the International Society for Oxygen Tissue Transport meeting, August, University of Louisville.

2003 Chairman, Promotion and tenure Committee for Gulgun Tezel and Deming Sun.

1999-2002, Graduate School Student Grievance Committee.

1999-2000 Department Committee on Y2K concerns, chairman

1999-2000 Department liaisons for the University of Louisville's Undergraduate Summer Research Opportunity Program.

1994-1999 Department Seminar Director.

1997 New Resident Evaluation Committee.

1997 Analytical Instrumentation, Core Grant Committee.

1990 Computer Facility Chairperson, Core Grant Planning Committee.

1991-1993 Department Strategic Planning Research Subcommittee.

1994 Organizer of Biochemistry/Ophthalmology Retreat.

H. Journal Editorial Boards and Advisory Councils

Recently Reviewed manuscripts for: Biophysical Journal; European Journal of Biophysics; Annals of Anatomy; Current Eye Research; Engineering in Life Sciences; Experimental Eye Research; Ocular Immunology and Inflammation; The Ocular Surface; Free Radicals in Biology and Medicine; Investigative Ophthalmology and

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Visual Sciences; Ophthalmic Research; Neurochemistry; Cell Calcium; Cornea; Biochem. Biophys. Acta; Journal of the American Aging Association; Toxicology; Biochemical Systematics and Ecology.

2015-0resent, Consultant, Sanofi Inc., Bridgewater, NJ

2014-present, Editorial Board of the Clinical Journal of Ophthalmology

2014-present, Editorial Board of Journal of Ophthalmic Diseases

2014-present, Editorial Board of Austin Journal of Clinical Ophthalmology

2013-present, Editorial Board of Ocular Surface.

2013-present, Senior Editor, Medjaden Bioscience Limited. Hong Kong.

2013-present, Consultant, Coleman Research Group Inc. Coleman Research Group, Raleigh, NC.

2013-present, Consultant, Global Pharmacovigilance and Epidemiology Dept. of Genzyme. Cambridge, MA.

2013-present, Consultant, Allergan Inc., Irvine, CA.

2015 Ad Hoc member of the Integrative Nutrition and Metabolic Processing Study Section, NIH.

2014 Ad Hoc member of the Special Emphasis Panel/Scientific Review Group 2015/01 Diseases and Pathophysiology of the Visual System Study Section, NIH.

2013 Grant reviewer for ‘The Center for the Advancement of Science in Space’ (selected by NASA).

2011. Grant reviewer, Foundation for Polish Science, Warszawa Poland

2010. Grant reviewer, Biomedical Research Council/Science and Engineering Research Council Agency for Science, Technology & Research Singapore

2008. Ad Hoc member of the Scientific Review Committee of the Anterior Eye disease Study Section, National Institute of Health

2008 Science Foundation of Ireland, Grant Reviewer

04/2002 Review of Biochemistry Department, Kuwait University, Kuwait

6/2000 National Health and Medical Research Council of Australia Grant Reviewer

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I. Teaching

Didactic Teaching at the University of Louisville, excluding seminars

1988-2011 Yearly lecture to the Residents entitled "Current Concepts of Lens and Cataracts"

2003-2010, Course Director, Chemistry 390 and Biology 490, Research Electives/directed study.

2000 Instructor in "Mini Med. School" class entitled "Health and Medicine in Today's World." Hosted by the University of Louisville School of Medicine.

1995-1999 Course Director, Student Seminars, University of Louisville

1992-1998, Principles in Visual Science Integration 601, Lecturer, University of Louisville.

9/1992-12/1992 Physical Biochemistry 681, (33% effort) University of Louisville, KY

1993-1994 Principles in Visual Science Integration 602, Course Director, University of Louisville, KY.

b. Mentoring of Laboratory Projects and Degrees

Principal Mentor Rajesh P. Ahuja, M.S., Biochemistry 1996Yernan Marrero, M.S., Biochemistry 2003. Moazez Marian, Ph.D., Biochemistry 2004. Li Huang Ph.D., Ophthalmology and Visual Sciences 2005.Sung-Hye Kim, B.S., Biology 2010.Shelly Kakar, M.S., Physiology 2011Samiyyah Sledge M.S., Physiology 2015Dylan Gerlach M.S., Physiology 2015

Post Doctoral/Research Associate MentorOm P Lamba Ph.D., S. Sinha Ph.D., Hidetoshi Sato, Ph.D., Daxin Tang Ph.D., Yusuke Oshima Ph. D., Ahmed Zaghloul M.D.,

Reader –Thesis Committee Indirect role Direct Role – Guided Laboratory Projects

Ophthalmology and Visual Sciences Graduate Thesis Committee: Jason Vittitow Ph.D., 1997 (reader). Lixia Liu, 2000 (direct role), Jin Xue, 2001 Ph.D. (reader).

Chemistry Graduate Thesis Committee:

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Roberto Rabini, M.S. (direct role) 1990; Sundeep Lal, (direct role) Ph.D. 1991; Q. Jiang, Ph.D., (direct role) 1992; Craig Brydwell, (direct role) Ph.D., 1993; (reader) Michael Sampson, 1997, Stacey Ferguson, Ph.D., (direct role) 1999; C. M. Talbot, Ph.D., (direct role) 1999, Li Li, M.S. (reader). Xiaoling Jin, 2000, M.S. (reader), Yali Wang. 2001 M.S. (reader). Mehjabin Kathiwala M.S. (reader) 2003. M.S. Elena Mikhaylova Oborina, Ph.D., (reader) 2003, M. Rujoi M, Ph.D. (reader) 2003 Rosendo Estrada Rojas (reader) MS, Andrès J. Puppato, Ph.D. (reader) 2008, Lucius Eugene Johnson II, Ph.D. (reader) 2009, Pawel Lorkiewicz, Ph.D. (reader) 2009, Prakash Doiphode (reader) 2011, Kristen A. Magness Ph.D. (reader) 2012, Marina Vladimirovna Malovichko Ph.D. (reader) 2013, Sarah E. Milliner (direct role) 2013, Abigail Schnepf (direct role) 2013, Brian Wessel (reader) 2014.

Chemistry, University of Wollongong, Australia. Jane M. Deeley Ph.D. (reader) 2010.

Chemistry, University of Western Sydney, Australia. C.K. Palaniappan, Ph.D. (reader) 2013.

Chemical Technology Ph.D. Thesis Adjudication Committee. Chandasri Bandhu, University of Calcutta, (reader) 2007.

Pharmacology and Toxicology Thesis Committee: Jain Cai, Ph.D., (reader) 1999., Christelle Komguem-Kamga, Ph.D. (reader) 2010.

Physics Ph.D. Thesis Committee: Hans Duindam, Ph.D., (reader) 1998, University of Twente, The Netherlands.

Medical School Student Research Advisor (Direct role in laboratory projects): Libby McCauley, 1989; Kean Arney, 1990; Paul Herell, 1990; Scott Nichol, 1992; Bart Brown, 1993, Sharmeen Ali, 1994; Rondo Giavonne, 1994, James Nuss, 1994, Chandhiran Rangaswamy 1995, Kassi Marshal 2000, Mark Esterly 2001, Ankar Data, 2005, Jim Bell, 2005, Dounghai Ho, 2005, Jim Bell, 2007, Nathan Podoll 2008, John W. McCay 2009, Edwin J. Apenbrinck 2009, 2011, Shantanu Nervetla, 2010, Samad Faheem 2010, Mariam Hanna 2011. Ryan Smith 2012, Hussain Khimji, (Ireland) 2015.

Undergraduate Research Advisor (Direct role in laboratory projects): Tanuja Harding, 1998; Susan Stargel, 1992; Samera Salmasi, 1992; Kara Collins, 1999; Nere Onosode, 2000, Matuse Karwosski 2000, Elizabeth Dupre, 2001, Michael Dow, 2003 and 2004, John Kaoalozinski 2004, Lana Madorski 2004, Daniel M. Dierfeldt 2004, Emily M Rath 2005, Kathleen Clark 2006, Jonathan Matthews 2007/2008, Kim Leake 2007, Michael LeCompt 2007, Logan M Eberly 2008, Heider Rahman 2008, Sara Ratliff 2009, Sung-Hye Kim 2008/2009/2010, Nida Ahmed 2008-2010, Shelly Kakar 2008-2010, Eunin Y. Kim 2010, Soyoung L Chon 2010, Lauren Varble, 2010, Victoria Greenstone 2010-2012, Uzma Pasha 2009-2011, Rashmi K Shrestha 2010-2011, Matthew Ball 2011, Evelyn Rose Robuck 2011, Erin M Baumgartner 2011, Diana P Duran 2011/2012, Gregory Cox 2012, Sebyuk Kim 2012, Rimsha Chowhan 2013, , Alexandria L. Oliver, 2013, Morgan Hunter 2013, Eunjin Kim 2013, Kevin Cain 2014, Samiyyah Sledge 2014; Emily K. Dennis 2014, Heidi Michael 2014, Dylan Gerlach 2013/2014/2015, Kryshawna Beard 2015, Jessica Morgan Jones 2015, Hassan Haider 2015.

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G.E.M.S. Student Undergraduate Research Advisor (Direct role in laboratory projects): Sharmeen Ali, 1993-1994; Tanuja Ramaswamy, 1993-1994; Przemyslaw Kapalczynski, 1993-1994, Jonathan Nguyen, 2010/2011.

Highschool Student Research Mentor (Direct role in laboratory projects): Kartig Raju, 1998; Elizabeth Dupre 2001; Candice Quire, 2002; Hanna Cook, 2nd place Highschool, 3rd place Louisville regional science fair 2006, Uzma Pasha 2008/2009, Victoria Greenstone 2009, Zara Ashraf 2008-2011, Janeeta Akbar 2008-2011, Fareeda Pasha 2011, Sravya Vishnubhatla 2011-2012 1st place state science fair, Shanzeh Sayied 2015.

J. Abstracts and PresentationsPublished Conference Proceedings Abstracts

1. Borchman D. "Raman temperature studies of calcium binding to phosphatidic acid bilayers" and "Conformation dependence of the C=O stretch in Raman spectra of lipid bilayers". Presented at Division of Biological Chemistry Meeting, American Chemical Society, Minneapolis, Minnesota, 1981. 2. Borchman D. "Variation in the lipid composition of rabbit muscle sarcoplasmic reticulum with muscle type". Presented at Midwest Enzyme Conference, Chicago, Illinois, 1982. 3. Kirchberger M.A., Borchman, D., Kasinathan C. and Lanzara R.G. "Proteolytic activation of the calcium pump of canine cardiac sarcoplasmic reticulum". Biophys. J. 49, 236a, 1986. 4. Borchman D. "Selective inhibition of membrane ATPases by hydrogen peroxide in the lens of the eye". Presented at the 4th International Congress on Oxygen Radicals, La Jolla, California, June 1987. 5. Borchman D. "Spectroscopic studies on lens membrane". Presented at the 4th Congress US-Japan cooperative Cataract Research Group, Honolulu, Hawaii, December, 1987. 6. Borchman D. "Studies of human lens membranes using infrared and Raman spectroscopy". Presented at Studies on the Ocular Lens Symposium, Rochester, Michigan, September, 1988.7. Delamere NA, Paterson CA, Borchman D. Oxidative damage to electrolyte transport mechanisms in the mammalian lens. Ophthalmic Res. 20:80, 1988. 8. Borchman D. "Raman spectroscopic studies of normal and cataractous human lens lipids". Presented at the Fifth Congress of the US-Japan CCRG Kanazawa, Japan, November, 1989. 9. Kasinathan C., Borchman D. and Kirchberger M. A. "Phosphoinositide formation in cardiac sarcoplasmic reticulum (SR) and sarcolemal (SL) membranes and its sensitivity to calcium". Biophys. J. 51, (2, Pt. 2) la-592a, 1987. 10. Borchman D., Paterson C.A., Yappert M.C. and Delamere N.A. "Fourier transform infrared spectroscopy of human lens membrane components". Invest. Ophthalmol. Vis. Sci. (Suppl.) 22: 71, 1988. 11. Hensley S.K., Delamere N.A., Paterson C.A. and Borchman D. "The effects of transient oxidative insult upon lens membrane transport characteristics". Invest. Ophthalmol. Vis. Sci. (Suppl.): 29: 429, 1988. 12. Borchman D., Delemare N.A., Paterson C.A. and Yappert M.C. "The effect of oxidative damage on lens membrane ATPase activity and model lipid membrane structure" Invest. Ophthalmol. Vis. Sci. (Suppl.) 30: 483, 1989.

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13. Yappert M.C., Lal S., Rubini B., Borchman D. and Paterson C.A. "Novel approach for three- dimensional fluorometric characterization of the human lens using optical fiber probes" Invest. Ophthalmol. Vis. Sci (Suppl.) 30: 329, 1989. 14. Paterson C.A., Delamere N.A., Borchman D. and King K.L. "Calcium transport m a rabbit lens membrane vesicle preparation". Invest. Ophthalmol. Vis. Sci. (Suppl.) 30: 95, 1989. 15. Jumblatt M.M., Borchman, D., Manning Jr. R.E., Delamere N.A. and Paterson C.A. "Comparative membrane biochemistry in native and cultured rabbit lens epithelium." Invest. Ophthalmol. Vis. Sci (Suppl.) 30: 105, 1989. 16. Borchman D., Herrell P., Yappert M.C., Lamba O.P. and Paterson C.A. "Structure of lipid membranes from normal and cataractous human lenses by Fourier transform infrared spectroscopy" Invest. Ophthalmol. Vis. Sci. (Suppl.) 11: 346, 1990. 17. Paterson C.A., Delamere N.A., Borchman D: and Cawood S.A. "Further characterization of calcium transport in lens membrane vesicles" Invest. Ophthalmol. Vis. Sci. (Suppl.) 11: 346, 1990. 18. Lal S., Yappert M.C., Borchman D. and Paterson C.A. "Age dependence and distribution of green and blue fluorophores in human lens proteins" Invest. Ophthalmol. Vis. Sci. (Suppl.) 11: 346, 1990. 19. Lamba O.P. Borchman D. and Yappert M.C. "Comparative infrared studies of structural features in cataractous lens membrane and in model membrane deranged by oxidative damage" Invest. Ophthalmol. Vis. Sci (Suppl.) 31: 163, 1990. 20. Yappert M.C., Lal S., Borchman D. and Paterson C.A. "Localized changes in green fluorescence of human lenses due to regional exposure to UV radiation." Invest. Ophthalmol. Vis. Sci. (Suppl.) 11: 291, 1990. 21. Borchman D., Lamba O.P., Delamere N.A., Paterson C.A. and Herrell P. "The possible influence of lipid oxidation products on human lens calcium regulation." Proceedings of the International Society for Eye Research, 6, 180, 1990. (International Conference Finland). 22. Sung S., Mahmood T., Jean Y.C., Lou M.F. and Borchman D. Sensitivity of positronium annihilation on phase transition of phospholipids. Ed. Y.C. Jean, In "3rd International Conference in Positronium Chemistry," World Science Publishing, Milwaukee, WI (1990). 23. Delamere N.A., Paterson C.A., Borchman D. and Cawood S.A. "Active calcium transport in lens cortex membrane vesicles." Proceedings of the International Society for Eye Research 6, 180, 1990. (International Conference Finland). 24. Borchman D., Lamba O.P., Lou M.F. and Yappert M.C. "The distribution of lipid oxidation products and their effect on human lens membrane lipid structure." Free Rad. Biol. Med. 9, (Supp1.), 188, 1990. 25. Delamere N.A., Paterson C.A., Borchman D. and Manning Jr. R.E. "Studies on active sodium transport in rabbit lenses exposed to calcium ionophore A23187" Invest. Ophthalmol. Vis. Sci. (Suppl.) 12: 1158, 1991. 26. Yappert M.C., Jiang Q., Lal S., Borchman D. and Paterson C.A. "Secondary structure of bovine lens crystallins by infrared spectroscopy and computational methods of spectral resolution" Invest. Ophthalmol. Vis. Sci. (Suppl.).32: 973, 1991. 27. Lal S., Borchman D., Yappert M.C. and Paterson C.A. "Ordered and disordered components in the secondary structure of bovine lens crystallins by deuterium exchange and infrared spectroscopy" Invest. Ophthalmol. Vis. Sci (Suppl.) 32: 973, 1991.

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28. Lamba O.P., Borchman D., Yappert M.C. and Lou M.F. "Structural changes of human lens proteins and lipids with age using infrared spectroscopy" Invest. Ophthalmol. Vis. Sci. (Suppl.) 32: 849, 1991. 29. Husseini Z.M., Paterson C.A., Borchman D. and Delamere N.A. "Continued studies on lens calcium ATPase" Invest. Ophthalmol. Vis. Sci. (Suppl.) 32: 971, 1991. 30. Borchman D., Salmassi S., Yappert M.C. and Lamba O.P. " Structural changes in rabbit lens lipids induced by hydrogen peroxide and iron-catalyzed complexes using infrared spectroscopy." Invest. Ophthalmol. Vis. Sci. (Suppl.) 32: 973, 1991. 31. "Structural characterization of human lens membrane lipid by infrared spectroscopy." Presented at the European Conference of Molecular Spectroscopy, York, England, September, 1991.32. "Composition, structure and function of lipid membranes from clear and cataractous lenses." Invited key note speaker presented under the auspices of the European Community Concerted Action on Aging and Diseases, Ghent, Belgium, October, 1991. 33. "Infrared spectroscopy of cataractous lens membranes." Presented at the 6th U.S.-Japan CCRG Meeting, Hawaii, December, 1991. 34. Borchman D., Lamba O. and Delamere N.A. "Human lens lipid phase transitions using infrared spectroscopy" Bull. Amer. Physical Soc. 31: 653, 1992. 35. Lamba O.P., Borchman D., Garner W.H. and O'Brien P .J. "Fourier transform infrared study of disk lipids and membranes from rod outer segments of bovine retina" Invest. Ophthalmol. Vis. Sci. (Suppl.) 33: 1008, 1992. 36. Yappert C.M., Byrdwell W.C., Borchman D. and Paterson C.A. "Regional distribution of extrinsic fluorophores in normal and cataractous human lenses" Invest. Ophthalmol. Vis. Sci. (Suppl.) 33: 1170, 1992. 37. Borchman D., Lamba O.P. and Yappert M.C. "Relationship between lipid composition and membrane structure inhuman lenses" Invest. Ophthalmol. Vis. Sci. (Suppl.) 33: 865, 1992. 38. "Membrane lipid composition, structure relationship in lens and retinal ROS membranes." Presented at the 10th International Congress of Eye Research Meeting, Stresa, Italy, September, 1992. 39. "Lipid Oxidation and Cataractogenesis" Invited Speaker at International CCRG Congress, National Institute of Health Bethesda, Maryland, November 1993. 40. Borchman D., Ozaki Y., Lamba O.P., Brydwell C., Yappert C.M. and Cravnecki M. "Lens membrane protein and lipid structure by FT Raman." Invest. Ophthalmol. Vis. Sci. (Suppl.) 34: 1337, 1993. 41. Lamba O.P., Borchman D. and Garner W.H. "Structure and lipid composition of rabbit lens nucleus, cortex and epithelium as probed by FTIR spectroscopy." Invest. Ophthalmol. Vis. Sci. (Suppl.) 34: S1282, 1993. 42. Zeng J., Borchman D., Delamere N. and Paterson C. "Purification of the Ca-ATPase from bovine lens epithelia." Invest Ophthalmol. Vis. Sci. (Suppl.) 35: 82213, 1994. 43. Borchman D., Yappert M.C., Brydwell W.C. and Lamba O.P. "Age and regional lipid composition-structure relationships in human lenses." Invest. Ophthalmol. Vis. Sci. (Suppl.) 35:S2211, 1994. 44. Lamba O.P., Borchman D. and Garner W.H. "Comparative efficacy of lipophilic antioxidants in lipid membranes. "Invest. Ophthalmol. Vis. Sci (Suppl.) 35:S1391, 1994. 45. Hightower K., McCready J. and Borchman D. "Membrane damage in UVB Cataract.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 35: S1989, 1994.

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46. Borchman D., Yappert M.C., Byrdwell W.C. and Lamba O.P. "Relationships between lipid composition and membrane structure in ocular and other tissues." Exp. Eye Res. (Suppl.) 59: S16 (1994). (International I.C.E.R., New Delhi, India). 47. Borchman D., Yappert M.C., Brydwell W.C., Lamba O.P., Ozaki Y. and Sato, H. "Spectroscopic studies of lens lipid composition and structure. "Exp. Eye Res. (Suppl.) 59: S105 (1994). (International I.C.E.R, New Delhi, India). . 48. Lamba O.P., Borchman D., Kandpal H.C. and Garner W.H. "Antioxidant efficacy in a drugs liposome system." Exp. Eye Res. (Suppl) 59: 8105 (1994). (International I.C.E.R., New Delhi, India). 49. Ozaki Y., Sato H., Borchman D. and Mizuno, A. "Potential of near-infrared Raman spectroscopy in medical science. XIVth International Conference on Raman Spectroscopy Proceedings. John Wiley & Sons, NY, NY,(1994). 50. "Potential of Near-infrared Raman Spectroscopy in Medical Science" XIV th International Conference on Raman Spectroscopy" Hong Kong, China, August, 1994. 51. "2-glycoprotein 1 binding to cardiolipin results in conformational changes in both molecules by Fourier transform infrared spectroscopy." Harris E.N., Borchman, D., and Pierangeli S. Leuveu, Belgium. September, 1994. 52. "Molecular structure and interactions of cardiolipin and 2- glycoprotein 1 by Fourier transform infrared spectroscopy." Harris E.N., Borchman, D., and Pierangeli S. Leuveu, Belgium. September, 1994. 53. "Studies of oxidative stress on calcium homeostasis in the bovine lens." Zeng J., Borchman, D., Paterson C. and Delamere N. Beijing, China, July, 1994. 54. "Relationship between lipid composition and membrane structure in ocular and other tissues." Borchman, D., Yappert M.C., Byrdwell W.C., Lamba O.P. Beijing, China, July, 1994. 55. "Spectroscopic studies reveal an unusual lipid in the human, lens." Eu-Concerted Action Conference, Naples, Italy. March, 1995. 56. "Infrared transmission and reflection-absorption study on structure of Langmuir-Blodgett films of phospholipids" H. Matsura, H. Sato, Y. Ozaki, M. Suzuki, D. Borchman. Japanese Chemical Society. Osaka, Japan, July, 1995. 57. Borchman D. "Age related lipid oxidation in human lens membranes by infrared Spectroscopy." Vision Research (Suppl.) 35:S141, 1995. 58. Borchman D., Cenedella R.I. and Lamba O.P. "Role of cholesterol in the structural order of lens membrane lipids" Invest. Ophthalmol. Vis. Sci. (Suppl.) 36:S199, 1995. 59. Zeng J., Borchman D. and Paterson C.A. "Effect of ethanol on calcium permeability in bovine lens liposomes." Invest. Ophthalmol. Vis. Sci. (Suppl.): 36:S261, 1995. 60. Lamba O.P, Borchman D., Sinha S.K. and Organisciak D. T. "Membrane structure of normal and dystrophic RCS rat retinal rod outer segments as probed by FTIR spectroscopy."Invest. Ophthalmol. Vis. Sci. (Suppl.). 36:S914, 1995. 61. Yappert M.C., Coen D.A. and Borchman D. "Headgroup interactions in lens sphingolipids." Invest. Ophthalmol. Vis. Sci. (Suppl) 36:S265, 1995. 62. Borchman D. "Age related lipid oxidation in human lens membranes by infrared spectroscopy Cooperative Cataract Research Group. Kona, Hawaii. November Vis. Res. 35: Supplement, 3341, 1995. 63. Borchman D. "The membrane composition structure and function relationships of human lens sphingolipids." XVIth Washington International Spring Symposium, Frontiers in Bioactive Lipids ’96. May, 1996.

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64. Yappert M.C., Ferguson S., Talbot, C.M. and Borchman D. "Effects of cholesterol in sphingolipids interactions." Invest. Ophthalmol. Vis. Sci. (Suppl.) 37:8879, 1996. 65. Zeng J., Borchman D. and Paterson C. "The role of lipid environment on the activity of Ca2+- ATPase reconstituted in vesicles." Invest. Ophthalmol. Vis. Sci. (Suppl.) 37:S1115, 1996. 66. Lamba O.P., Sinha S.K. and Borchman D. "Fourier transform infrared study of phospholipid composition and structure of RCS rat retinal rod outer segment membranes." Invest. Ophthalmol. Vis. Sci. (Suppl.) 37:S504, 1996. 67. Matsuura H., Sato H, Ozaki Y., Borchman D., Masao S., and Keiji I. "An infrared study on the temperature dependence of structure of Langmuir-Blodgett films of phospholipids." Japan Chem. Soc. 30326, 1996. 68. Zeng J., Borchman D. and Paterson C. "Lens membrane polarity and Ca2+ -ATPase activity. Exp. Eye Res. (Suppl.) 63: 854, 1996 69. Borchman D. Human lens lipid composition - structure relationships with age and cataract. Exp. Eye Res. (Suppl) 63: 859, 1996. 70. Byrdwell W.C. and Borchman D. "Characterization of sphingomyelin and dihydrosphingomyelin of human lens membranes by liquid chromatography/mass spectrometry". Invest. Ophthalmol. Vis. Sci. (Suppl.) 38: 81033, 1997. 71. Ahuja RP., Borchman D., Dean W.L. and Paterson C.A "Ca2+ -ATPase kinetics and membrane oxidation relationships in lens epithelial microsomes." Invest. Ophthalmol. Vis. Sci. (Suppl.) 38: 8703, 1997. 72. Borchman D., Yappert M.C., Lamba O.P., Zeng J., Paterson C.A. "Human lens lipid composition - structure relationships with age and cataract." Invest. Ophthalmol. Vis. Sci. (Suppl.) 38: S1033, 1997. 73. Zeng J., Borchman D. and Paterson C.A. "Ethanol and lens calcium homeostasis," Invest. Ophthalmol. Vis. Sci. (Suppl.) 38:S1035, 1997. 74. Lamba O.P., Sinha S.K. and Borchman D. "Light-induced structural changes in bovine rod outer segment photoreceptor membranes." Invest. Ophthalmol. Vis. Sci. (Suppl) 38: S328, 1997. 75. Liu L., Zeng J., Borchman D. and Paterson C.A. "Distribution of Ca-ATPases in the bovine lens." Invest. Ophthalmol. Vis. Sci. (Suppl.) 38: 81035, 1997. 76. Bian L., Zeng J., Borchman D. and Paterson C.A. "Plasma membrane Ca-ATPase gene expression in bovine lens epithelium." Invest. Ophthalmol. Vis. Sci. (Suppl.) 38: S580, 1997. 77. Ferguson- Yankey S., Yappert M.C. and Borchman D. "Impact of hydration on the structure of dihydrosphingomyelin." Invest. Ophthalmol. Vis. Sci. (Suppl.) 38: 81034, 1997. 78. Sinha S.K., Lamba O.P. and Borchman D. "Phospholipid composition of bovine ROS disk and plasma membranes and their oxidative products measured by 2D. Invest. Ophthalmol. Vis. Sci. (Suppl.) 38: S328, 1997. 79. Yappert M.C., Thompson B. and Borchman D. "Nature and strength of interactions between sphingomyelin Invest Ophthalmol. Vis. Sci. (Suppl.) 38: 81033, 1997. 80. Tang D., Borchman D., Yappert M.C. and Cenedella R.J. "Lens -crystalline-lipid interactions." Invest. Ophthalmol. Vis. Sci. (Suppl.) 38: S302, 1997. 81. Talbot CM, Yappert MC, Borchman D. "Structural studies of hydration and cholesterol on sphingomyelin interactions" Invest. Ophthalmol. Vis. Sci. (Suppl.) 38: S1034, 1997. 82. Matsuura H., Sato H., Borchman D. Suzuki M. and Ozaki Y. "An FTIR study on one- monolayer Langmuir-Blodgett films of dipalmitoylphosphatidylcholine." FTIR conference on Biospectroscopy, Atlanta, GA. August 1997.

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83. Yappert M.C., Borchman D. "Sphingolipids in plasma membranes of human lenses: Unique composition and structural features." Sphingolipids as mediators of molecular events. American Soc. for Biochem. and Mol. BioI., Nappa Valley, CA. August, 1997. 84. Tang D., Borchman, D., Harris E.N. and Pierangeli S. "The structure of cardiolipin- phosphatidylcholine membrane and the effect of calcium and glycoprotein-1 binding as explored by fluorescent probe NBD-PE." American College of Rheumatology, National Scientific Meeting. Washington D.C., November, Arth. Rheum. 39: Supplement, 402, 1996. 85. Borchman D. "Human lens lipid oxidation-structure-membrane function relationships with age and cataract." Biological oxidants and antioxidants: molecular mechanisms and health effects workshop, Penang, Malaysia, September, 1997. 86. Borchman D. "Cataract and the function of lipids in the human lens" Molecular Mechanisms Symposium, Virginia Tech., Blackburn VA, October, 1997. 87. Zeng S., Ferguson-Yankey S., Yappert M.C. and Borchman D. “Membrane lipid composition, oxidation and lens calcium homeostasis.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 39: S659, 1998. 88. Byrdwell W.C. and Borchman, D., "Liquid Chromatography/Mass Spectrometric Characterization of Sphingomyelin and Dihydrosphingomyelin of Human Lens Extracts", 88th AOCS Annual Meeting Abstracts, p. 47. 1997.89. Pierangeli S., Tang D., Borchman D., Harris N .E. "The structure of cardiolipin- phosphatidylcholine membranes and the effect of calcium and 2-glycoprotein-1 binding as explored by fluorescent probe NBD-PE. American College of Rheumatology, National Scientific Meeting, Washington D.C., November, Arthritis Rheum. 40:Supplement: S, 433, 1997. 90. Ferguson-Yankey S., Talbot C.M., Li L., Borchman D. and Yappert M.C. “Sphingo- and glycerolipids: structural roles in mammalian lens membranes.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 39: 8788, 1998. 91. Schwarz A.K., Tang, D., Yappert M.C., Paterson C.A. and Borchman, D. “Light scattering of lens lipid vesicles.” Invest. Ophthalmol. Vis. Sci (Suppl.) 39: S789, 1998. 92. Zhang Z., Tang D., Zeng J., Borchman D. and Paterson C.A. “Binding of alpha crystallin to lens lipids.” Invest Ophthalmol Vis. Sci. (Suppl.) 39: S659, 1998. 93. Paterson C.A., Bian, L., Zeng, J. and Borchman, D. “Plasma membrane calcium-ATPase isoform expression in human lens epithelial cell lines.” Invest Ophthalmol Vis. Sci. (Suppl.) 39: 8790, 1998. 94. Liu L., Zeng J., Borchman D. and Paterson C.A. “Sarcoplasmic Ca2+-ATPase isoform 3 is expressed in cultured human lens epithelial cells.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 39: S791, 1998. 95. Borchman D., Zeng J., Zhang Z. and Paterson C.A. “Oxidation lipid structure and Ca-ATPase in ocular tissue.” Exp. Eye Res. (Suppl.) 67:S73, 1998. 96. Zeng J., Zhang Z., Borchman D. and Paterson C.A. “Lipid composition and calcium permeability of lens liposomes.” Exp. Eye Res. (Suppl.) 67:S139, 1998. 97. Li, L, Tang, XP, Taylor, KG, Borchman D., Yappert MC. Conformational features that distinguish ceramide from its analogs. Abstracts of the American Chemical Society. 218: U929. Abstract: 54-MEDI, 1999. 98. Yappert M.C., Ferguson-Yankey S, Talbot M., Jin X. and Borchman D. “Interactions between the two major lipids of human lens membranes.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 40: 8790, 1999.

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99. Borchman D., Giblin F.J., Leverenz V.R., Reddy V.N., Lin L.R., Yappert M.C., Li L. and Tang D. “Impact of aging and hyperbaric oxygen in vivo on guinea pig lens lipids and nuclear light scatter.” Invest Ophthalmol. Vis. Sci. (Suppl.) 41: S212, abst. # 1115., 2000. 100. Tang D., Borchman D., Zhang Y., Li L.S., Li T.J., Yappert M.C. and Vrensen G.F.J.M. “Mechanisms of calcium and pH induced lens lipid light scattering.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 41: S862, abst. # 4582, 2000. 101. Yappert M.C., Jin X., Li L., DuPre D.B., Tang D. and Borchman D. “Isolation of sphingolipid-cholesterol rafts from human and lens membranes.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 41: 8862, abst. # 4583, 2000. 102. Rujoi M., Yappert M.C., DuPre D.B., Tang D. and Borchman D. “Structural impact of calcium ions on lenticular sphingolipids.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 41: S862, abst. # 4584, 2000. 103. Borchman D., Tang D. and Yappert MC. “Lens lipid composition, structure, function, scattering relationships.” Ophthalmic Res. (Suppl.) 32:120 abst # 3123, 2000. 104. Garner W.H., Borchman D., Scheib S., Graff G. “Evidence for lipid peroxidation in the rabbit vitreous following ocular surgery.” Exp. Eye Res. (Suppl.) 71:S116, abst. #387, 2000. 105. Kulkarni P.S., Borchman D., Paterson C.A. and Luer C. “Lipid composition of gray snapper ocular tissues.” Invest Ophthalmol. Vis. Sci. (Suppl.) 43: 8662, abst. #3562, 2001. 106. Tang D., Borchman D., Lui G., Yappert M.C. “Light-scattering and calcium binding to human lens lipids in vitro as a function of age and cortical cataract.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 43: 8539, abst. # 2893, 2001. 107. Borchman D. “Lens membrane lipid composition, structure, function and light scattering relationships.” Invest. Ophthalmol. Vis. Sci (Suppl.) 43:S526, abst. # 2826, 2001. 108. Yappert MC., Borchman D., Vorobyov I., Rujoi M. and DuPre D.B. “Sphingolipid changes in cataractous lenses.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 43:S539, abst. # 2889, 2001. 109. Borchman D., Tang D., Yappert M.C., Paterson C.A. “Age related lens lipid composition, structure, function, light scattering relationships.” Aging Society, Vancouver B.O, Canada, June, 2001. 110. Borchman D., Tang D., Yappert M.C., Paterson C.A. "Lens lipids and calcium homeostasis." U.S. Japan Cooperative Cataract Research Group. Kona, Hawaii, November, 2001. 111. Jacob RF., Tang, D., Cenedella RJ., Borchman D. “Direct perturbation of lens membrane structure by U18666A, hypocholesterolemic drug.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 44, abst. # 4633, 2002. 112. Marrero Y.G., Tang D., Yappert M.C., Borchman D. “Influence of age and cataract on alpha-crystallin interactions with human lens lipids.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 44, abst. # 3557, 2002. 113. Borchman D., Huang L., John G., Tang D. “The composition, structure and protein interactions of human tear film lipid.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 44, abst. # 81, 2002. 114. Yappert M.C., Estrada R., Vorobyov I., Rujoi M., Rudolph J., Borchman D. “Phospholipid segregation in mammalian lens membranes and control of fiber growth.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 44, abst. # 4636, 2002. 115. Paterson C.A., Borchman D. “Regulation of sarco/endoplasmic Ca-ATPase expression by calcium in human lens cells.” Opthalmic Res. 34(81), abst. #2163, p 126,2002.

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116. Rujoi, M; Yappert, MC; Borchman, D. Composition and localization of cholesterol-rich domains in human lens membranes. Biophys. J. 82:520A. Abstract: 2543, 2002.117. Borchman D., Tang D., Yappert MC. “Sphingolipid composition-structure-function relationships and human lens aging, growth and cataractogenesis.” Abraham Spector International Symposium. Montauk, Long Island, New York, October, 2003. 118. Yappert M.C., Rujoil M., Borchman D. and DuPre D.B. “Dihydrosphingomyelin in Primate Lens Membranes: Correlations with Lens Growth.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 45, abst. #4480, 2003. 119. Tang D., Borchman D., Yappert M.C. “Does binding to lens lipid Slow -crystallin oxidation?” Invest. Ophthalmol. Vis. Sci. (Suppl.) 45, abst. #2365, 2003. 120. Huang L., John G., Yappert, M.C., Borchman D. “Tear film lipid composition of Schirmer strips from patients with and without dry eyes.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 45, abst. # 2497, 2003. 121. Marian M.J., Li H., Paterson C.A., Borchman D. “Plasma membrane Ca2+-ATPase expression in the human lens.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 45, abst. #4476, 2003. 122. Li H, Marian M.J., Paterson C.A., Borchman D. “Expression of plasma membrane calcium- ATPase in the in the cultured human lens epithelial B-3 cells.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 45, abst. #4475, 2003.123. Perry RH., Borchman D., Byrdwell W.C. “Changes in the phospholipid composition of the human lens with age and cataract formation.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 45, abst. #4481, 2003.124. Borchman D. “Sphingolipids and lens membrane lipid composition, structure function relationships.” 8th International Conference on Eicosinoids and other bioactive lipids in cancer, inflammation and Related Diseases. Chicago, IL, September, 2003.125. Borchman D. “Major changes in lens lipids with age and cataract.” ICER satelite meeting, Routoura, New Zealand, August, 2004.126. Steele P., Borchman D., and Tang D. “Tear lipid composition, structure function relationships” Tear Film and Ocular Surface Meeting, Puerto Rico, November, 2004.127. Borchman D. “Lens lipids and Maximum Lifespan” Invited Speaker of Dr. Abraham Spector International Symposium, Montauk, NY. 2004128. Madorski L., Borchman D. “Spectroscopic evaluation of lenses from guinea pigs treated in vivo with both UVA and hyperbaric oxygen.” Midwest medical Research Symposium. Omaha Nebraska, 2004.129. A.L. Hitt, B.S. Phinney, J.R. Reddan, K.F. Delaney, R.Estrada, L.W. Schovan, D.C. Dziedzic, D.Borchman, M.C. Yappert. Lipid Raft Proteins from Human Lens Epithelial Cells (HLECs). Annual Meeting of the American-Society-for-Cell-Biology. Washington, DC. December. Mol. Biol. Cell 15: S; 318A. Abstract: 1757, 2004.130. Huang L., Estrada R., Yappert M.C., Miller J.J., Borchman D. “Phospholipid compositional changes of human lens epithelial cells treated with thyroxin and their resistance to oxidative stress.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 46, abst. #390, 2004.131. Borchman D., Yappert M.C., Afzal M., Tang D. “Lens lipids and maximum lifespan.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 46, abst. #1030, 2004.132. Grami V., Marrero Y.G., Tang D., Yappert M.C., Borchman D. “The influence of age and diabetes on the binding capacity of α-Crystallin to human lens lipids.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 46, abst. #3963, 2004.

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133. Yappert M.C., Hahn B., Estrada R., Huang L., Borchman D. “Regional Phospholipid Analysis of bovine lens epithelia by in situ MALDI-TOF MS” Invest. Ophthalmol. Vis. Sci. (Suppl.) 46, abst. #3987, 2004.134. Hitt A., Phinney B.S., Reddan J.R., Estrada R., Schovan L.W., Dziedzic1 D.C., Borchman D., Yappert M.C. “Identification of Lipid Raft Associated Proteins from Human Lens Epithelial Cells.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 46, abst. #4599, 2004.135. D. Borchman, F.J. Giblin, M. Dow, V.R. Leverenz, D. Tang, V. Grami. “Spectroscopic evaluation of lenses from guinea pigs treated in vivo with both UVA and hyperbaric oxygen.” Exp Eye Res. (Suppl.) 2004.136. Hitt A., Phinney B.S., Reddan J.R., Estrada R., Schovan L.W., Dziedzic1 D.C., Borchman D., Yappert M.C. “Proteomic analysis of Mitochondrial Proteins associated with a lipid raft fraction in cultured human lens epithelial cells.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 47, abst. #637, 2005.137. Yappert M.C., Estrada R., Huang L., Borchman D., Hitt A., Reddan J.R. “Choline-phospholipid biogenesis in human lens epithelial cells by MALDI-MS.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 47, abst. #632, 2005.138. Tang D., Dean W., Borchman D., Paterson C.A. “The influence of membrane lipid composition on plasma membrane Ca-ATPase function.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 47, abst. #630, 2005.139. Grami V., Reddy V., Giblin F.J. Leverenz Y.R., Tang D., Borchman D. “Profiles of hyperbaric oxygen/UVA treated guinea pig lenses, GPX-1 knock out rat lenses and clear human lenses.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 47, abst. #456, 2005. 140. Borchman D., Yappert M.C., Huang L., Grami V., Tang D., Rasi V., Marrero Y. “Substantial changes in the phospholipids content of human lenses with age and cataract.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 47, abst. #4639, 2005.141. Estrada, R; Borchman, D; Yappert, MC. “Tracking phospholipid biogenesis by MALDI-TOFMS.” 49th Annual Meeting of the Biopysical-Society, Long Beach, CA. February Biophys. J.: 88, 354A, 2005142. Douglas Borchman, “Oxidation induced changes in lens lipids and the mitochondria.” International Society on Oxygen Transport to Tissue. Louisville KY August 2006.143. Douglas Borchman, Gary N. Foulks, Marta C. Yappert, Donghai Ho. Temperature-induced Conformational Changes in Human Tear Lipids Hydrocarbon Chains. 5th International Conference on the Tear Film and Ocular Surface: Basic Science and Clinical Relevance. Taormina Sicily, Italy, September 2007.144. Douglas Borchman, Gary N. Foulks, Marta C. Yappert, Donghai Ho. Temperature-induced Conformational Changes in Human Tear Lipids Hydrocarbon Chains. Federation of Analytical Chemistry and Spectroscopy Societies. Memphis TN, October 2007.145. Borchman D., Foulks G.N., Yappert M.C. Ho D., Tang D. “Temperature-induced conformational changes in human tear lipids determined by Fourier transform infrared and fluorescence spectroscopies.” Invest. Ophthalmol. Vis. Sci. (Suppl.) 49, abst. #430, 2007.146. Borchman D., Foulks G.N., Yappert M.C. Ho D., Tang D., Bell J. M. Human Tear Lipid Compositional, Structural and Functional Relationships Using Spectroscopy. Invest. Ophthalmol. Vis. Sci. (Suppl.) 50, abst. #82, 2008.147. Douglas Borchman (Invited Speaker), Gary N Foulks, Marta C Yappert. Human Tear Lipid Compositional and Structural Relationships Using Spectroscochemical Analysis. 14th

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Symposium on the Material Science and Chemistry of Contact Lenses. New Orleans, Louisiana, November 2008.148. Foulks G.N., Borchman D., Yappert M.C. Modification of Meibomian gland lipids by topical azithromycin. Invest. Ophthalmol. Vis. Sci. (Suppl.) 51, abst. #82, 2009.149. Douglas Borchman, Gary N Foulks, Marta C Yappert Human Tear Lipid Compositional, Structural and Functional Relationships Using Spectroscopy. The Pittsburgh Conference. Chicago IL, March 2009.150. Douglas Borchman. Invited speaker “Mebomian Gland Disease and Mebum” Academic Industrial cooperative conference on biomedical optics and optical biopsy conference. Riken, Japan, December 2009.151. Douglas Borchman (Invited Speaker) “Tear lipid-protein Interactions” Meibomian Gland Dysfunction Workshop. Fort Lauderdale FL, May 2009.152. Douglas Borchman, Gary N. Foulks, Marta C. Yappert. “Age related changes in human tear lipid. 39th Annual Meeting of the American Aging Association. Portland OR, June 2010.153. Douglas Borchman, Gary N. Foulks, Marta C. Yappert. “Dry eye and human tear lipid compositional, conformational and functional relationships using spectroscopy.” 6th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance, Florence, Italy, September 2010.154. Foulks G.N., Borchman D., Yappert M.C. Changes in Human Meibum with Age and Meibomian Gland Dysfunction. Invest. Ophthalmol. Vis. Sci. (Suppl.) 52, abst. #3383, 2010.155. Borchman D., Foulks G.N., Yappert M.C. Dry eye and human tear lipid compositional conformational and functional relationships using spectroscopy. Acta Ophthalmologica 88 (Suppl. 246), 2010.156. Borchman D, Tear film lipids, and lipid-protein interactions, in health and disease. (Invited Talk). Acta Ophthalmologica 88 (Suppl. 246), 2010. 157. Douglas Borchman, Gary N. Foulks, Marta C. Yappert. “Dry Eye and Human Tear Lipid Compositional and Structural Relationships Using Spectroscopy.” Federation of Applied Chemical Spectroscopy Society. Raleigh, North Carolina, October, 2010.158. Douglas Borchman, Gary Foulks, Marta C Yappert. The cure for dry eye and spectroscopy. Federation of Analytical Chemistry and Spectroscopy Societies Meeting. Reno NV. Oct 2011.159. Borchman D., Foulks G.N., Yappert M.C. Comparative Effectiveness of Azithromycin and Doxycycline In Therapy Of Meibomian Gland Dysfunction. Invest. Ophthalmol. Vis. Sci. (Suppl.) 53, abst. #3816, 2011.160. Borchman D., Foulks G.N., Yappert M.C. Differences in human meibum composition with age, meibomian gland dysfunction and after treatment with azithromycin and doxycycline using 1H NMR spectroscopy. Invest. Ophthalmol. Vis. Sci. (Suppl.) 54, abst. #607, 2012. 161. Douglas Borchman, Gary N. Foulks, Marta C. Yappert. Spectroscopic approaches to explore how human meibum composition conformation and lipid-protein interactions are affected by age, meibomian gland dysfunction and dry eye treatment. International Congress of Eye Research. Berlin, Germany. August 2012.162. Douglas Borchman, Gary N. Foulks, Marta C. Yappert. “Raman, infrared and NMR spectroscopies on the same samples and the etiology and cure for dry eyes” Federation of Applied Chemistry and Spectroscopy Society. Kansas City, MO, October 2012.

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163. Douglas Borchman. “Raman, Infrared and NMR Spectroscopies on the Same Samples and the Etiology and Cure for Dry Eyes.” Paid Invited Speaker. Pittcon Conference, Philadelphia PA. March 2013.164. Douglas Borchman, Georgi Georgiev, Marta C. Yappert, Norihiko Yokoi. Confirmation of Squalene in Tears and Sebum and It’s Potential Function Invest. Ophthalmol. Vis. Sci. (Suppl.) 55, abst. #607, 2013.165. Rahul Bhola, Morgan Hunter, Marta C. Yappert, Douglas Borchman, Dylan Gerlach. “Influence of Eyeliner Cosmetics and Squalene on the Conformation of Human Meibum.” ARVO, Ft Lauderdale FL, May 2014.

b. Non-Conference Local Presentations and Invited Talks (Not Published)

1. "The ocular lens Ca-ATPase protein." University of New Jersey School of Medicine, Newark, New Jersey, November, 1990. 2. "Drug efficacies and lens lipid oxidation." Presented at Alcon laboratories Fort Worth, Texas, July, 1990. 3. "Membrane lipid composition, structure function relationship in lens and retina." Presented at Alcon laboratories, Fort Worth, Texas, August, 1992. 4. "Membrane lipid composition, structure function relationship in lens" Invited Speaker, Department of Chemistry, Kwansei Gakuin University, Nishinolniya, Japan, November 1992, 5. "Drug Efficacies and Lens Lipid Studies" Alcon Laboratories, Fort Worth, TX, August 1993 6. "Lipid Composition-structure relationships in human lens membranes", Oakland University, Rochester, Michigan December 1993. 7. "Light, Oxidation and the Lens" Invited Speaker at the 22nd Annual C. Dwight Townes Memorial Seminar, Louisville KY, March, 1994. 8. "Spectroscopic Techniques in Lipid Research" Invited Speaker at Department of Ophthalmology and Visual Sciences - Biochemistry Retreat. March, 1994. 9. "Age and regional lipid composition-structure relationships in human lenses." Invited Poster Presentation at University of Kentucky -University of Louisville, Departments of Biochemistry Retreat. June, 1994. 10. "Structure - composition relationships in human lens membranes" D. Borchman. Invited Seminar. Kirksville College of Osteopathic Medicine; Kirksville, MO. November 1995. 11. "Membrane lipid composition, structure, function relationships." D. Borchman. University of Louisville, Dept. of Ophthalmology and Visual Sciences, November, 1996. 12. "Membrane lipid composition, structure, function relationships." D. Borchman. University of Louisville, Dept. of Biochemistry, April, 1997. 13. "Membrane lipid composition, structure, function relationships." D. Borchman. Morehouse University, Atlanta, April, 1997. 14. Borchman D. "Cataract in human lens: Spectroscopic analysis of lipid composition and structure" Dept. of Biochemistry, Virginia Tech. Blackburn V A, October, 1997. 15. Borchman D and Paterson CA "Lipid composition, structure and Ca2+-ATPase kinetics in clear and cataractous lens microsomes, and oxidized reconstituted lipid systems. Cooperative Cataract Research Group, Kona Hawaii, November, 1997.

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16. Borchman D. "Lipid composition - structure - function relationships in human clear and cataractous lenses" Department of Morphology, The Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands, March 25, 1998. 17. Yankey F., Borchman D. and Yappert M.C. "Nature of lipid-lipid and lipid-water interactions in dihydrosphingomyelin assemblies." Institute for molecular diversity and drug design, inaugural symposium. Louisville KY, March, 1999. 18. Yappert M.C., Talbot C.M., Borchman, D., Ferguson-Yankey and Li L. "Sphingo- and glycerolipids: Structural roles in mammalian lens membranes." Institute for molecular diversity and drug design inaugural symposium. Louisville KY, March, 1999. 19. Li, L., Borchman D. and Yappert M.C. "Concerted impact of sphingolipids on membrane structure." Institute for molecular diversity and drug design, inaugural symposium. Louisville KY, March, 1999. 20. Li L., Taylor K.G., Borchman, D., DuPre D.B. and Yappert M.C. "Conformational features that distinguish ceramide from its analogs." Institute for molecular diversity and drug design, inaugural symposium. Louisville KY, March, 1999. 21. Borchman D. "Membranes and Cataracts" Institute for molecular diversity and drug design, inaugural symposium. Louisville KY, March, 1999. 22. Borchman D. "Anti oxidant Efficacy of Drugs used in Ocular Irrigation Solutions." Institute for molecular diversity and drug design, inaugural symposium. Louisville KY, March, 2000. 23. Borchman D. “An Overview of Cataract Research in the New Millennium.” Kentucky chapter of the Association for Education and Rehabilitation of the Blind and Visually Impaired. Barren River State Park, KY, March, 2000. 24. Borchman D. "An Overview of Cataract Research in the New Millennium." University of Louisville, Summer Research Opportunity Program. Louisville KY, June, 2000. 25. Borchman D. "An Overview of Cataract Research in the New Millennium." University of Louisville, Department of Chemistry, Louisville KY, June, 2000. 26. Borchman D. "Ocular lipid composition, structure, function relationships" University of Louisville, Department of Ophthalmology, Louisville, KY. September, 2000. 27. Tang D. and Borchman D. "Light Scattering and Lens Lipid" The Third Asian Cataract Research Conference, Kowloon, Hong Kong, China, November, 2000. 28. Borchman D. "Lipid Tear film and dry eye disease" Institute for molecular diversity and drug design, 2nd annual symposium. Louisville KY, March, 2001. 29. Borchman D. "An Overview of Cataract Research in the New Millennium." Louisville Lions Club, April 2001. 30. Borchman D. "Ocular lipid composition, structure, function relationships" University of Louisville, Department of Biochemistry, Louisville, KY., May, 2001. 31. Borchman D. "Ocular lipid composition, structure, function relationships" University of Louisville, Department of Ophthalmology, Louisville, KY. September, 2001. 32. Borchman D. "Ocular lipid composition, structure, function relationships" University of Louisville, SROP Student Seminar, Louisville, KY. September, 2001. 33. Esterle M. E., Tang D., Borchman D. "Calcium permeability in large unilamellar vesicles prepared from synthetic lipids and lipid from clear and cataractous human lenses. Research Louisville symposium, University of Louisville, KY., October, 2001.

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34. Borchman D., Tang D., John G.R., Huang L., Chen M. “The structure and protein interactions of human tear film lipid. Research Louisville symposium, University of Louisville, KY., October, 2001. 35. Borchman D., "Lens lipid composition and structure relationships" Department of Biological Sciences, University of Kuwait, Kuwait City Kuwait, April, 2001. 36. Borchman D., "Lens lipid oxidation and the aging human lens" Department of Biological Sciences, University of Kuwait, Kuwait City Kuwait, April, 2001. 37. Borchman D. "Ocular lipid composition, structure, function relationships" University of Louisville, American Association of University Women. Louisville, KY. January, 2002. 38. Rujoi M., Borchman D., Tang D., Yappert M.C. “Composition and localization of cholesterol-rich domains in human lens membranes.” Institute for molecular diversity and drug design, 4th annual symposium. Louisville KY, March, 2002. 39. Borchman D., Huang L., Tang D. “Lipids relationships in dry eye and cataract.” Institute for molecular diversity and drug design, Fall symposium. Simpsonville, KY, November, 2002. 40. Borchman D. “Calcium homeostasis in the lens.” University of Louisville, Department of Ophthalmology, November, 2002. 41. Borchman D. “Sphingolipids, cataract and long life.” University of Louisville, Department of Ophthalmology, September, 2003. 42. Borchman D. “Lipid Rafts.” Departmental Journal Club Presentation, University of Louisville, Department of Ophthalmology, April, 2003. 43. Borchman D. “Experimental Eye Research 2003,77:711-720.” Departmental Journal Club Presentation, University of Louisville, Department of Ophthalmology, Louisville KY, November. 200344. Huang L. and Borchman D. 2nd place prize. “Phospholipid compositional changes of human lens epithelial cells treated with thyroxin and their resistance to oxidative stress.” Institute for molecular diversity and drug design symposium, Louisville, KY, March, 2004. 45. Borchman D. “Lens Lipids, Cataracts, Aging and Maximum Lifespan” Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford England, March, 2003.46. Borchman D. “Drusen Article” Departmental Journal Club Presentation, University of Louisville, Department of Ophthalmology, Louisville KY, May. 200447. Borchman D. “From atoms to Adam” University of Louisville Intervarsity Group. University of Louisville September, 2004.48. Madorski L., Borchman D. 2nd place prize. “Spectroscopic evaluation of lenses from guinea pigs treated in vivo with both UVA and hyperbaric oxygen.” Research Louisville, University of Louisville, November, 2004.49. Borchman D. “J.Biol.Chem. 278, 38141–38148, 2003” Departmental Journal Club Presentation, University of Louisville, Department of Ophthalmology, Louisville KY, November. 2004.50. Borchman D. Substantial Changes in the Phospholipid Content of Human Lenses With Age and Cataract”, University of Louisville, Department of Ophthalmology and Visual Sciences, Louisville KY, September, 2004.51. Madorski L., Borchman D. “Spectroscopic evaluation of lenses from guinea pigs treated in vivo with both UVA and hyperbaric oxygen.” Research Louisville, Louisville KY, November, 2004.52. Huang L., Borchman D. Major changes in lens lipids with age and cataract.” Institute for molecular diversity and drug design symposium, Louisville, KY, March, 2005.

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53. Estrada R., Borchman D., and Yappert M.C. “Tracking phospholipid biogenesis by MALDI-TOFMS.” Institute for molecular diversity and drug design symposium, Louisville, KY, March, 2005.54. Ankur Datta, Mahendra K. Sunkara, Hari Chandrasekharan, Douglas Borchman “Structure-Light Scattering Relationships in Clear and Cataractous Human Lenses.” Research Louisville, Louisville KY, November, 2005.55. Joe M. Donaldson, D. Tang, D. Borchman, S. Xiox, “Liposome enhanced drug delivery through the cornea.” Research Louisville, Louisville KY, November, 2005.56. Donghai Ho, Gary Foulks, Douglas Borchman, “Tear film instability in meibomian and dry eye disease. Research Louisville, Louisville KY, November, 2005.57. Emily Rath, Douglas Borchman, “Does Fructose inhibit the Na, K-ATPase pump from porcine lenses?” Research Louisville, Louisville KY, November, 2005.58. Douglas Borchman, “Mammoths lipids and cataracts” Department of Ophthalmology and Visual Sciences, University of Louisville, September, 2005.59. Kathleen Cole, Douglas Borchman, “Inhibition of Lens Ca-ATPase with Caloxin” KRIN program, University of Louisville, July, 2006.60. Kathleen Cole, Douglas Borchman, “Inhibition of Lens Ca-ATPase with Caloxin” Kentucky Academy of Science, Morehead State University, Morehead KY, November, 2006.61. Douglas Borchman, “Tear Film Lipids and the Mystery of Louisville's Egyptian Mummy, Tchaenhotep.” Department of Ophthalmology and Visual Sciences, University of Louisville, November, 2006.62. Jim Bell, Douglas Borchman, Gary N Foulks “Conformational and Functional Relationships in Human Tear Lipids with Age and Meibomian Gland Dysfunction Symptoms” Dean's Special Commendation. Research Louisville, Louisville, KY, October 2007.63. Kim Leake, Douglas Borchman, Gary N, Foulks “Conformational and Functional Relationships in Human Tear Lipids with Age and Meibomian Gland Dysfunction Symptoms” Summer Undergraduate Research Opportunity Program, Louisville KY, August 2007.64. Logan M Eberly, Douglas Borchman, Gary N, Foulks “Conformational Relationships in Human Meibum Lipids with Age and Meibomian Gland Dysfunction Symptoms” Summer Undergraduate Research Opportunity Program, Louisville KY, August 2008.65. Nathan Podoll, Douglas Borchman, Gary N, Foulks “Conformational Relationships in Human Meibum Lipids with Age and Meibomian Gland Dysfunction Symptoms” Research Louisville, September 2008.66. Douglas Borchman “Tear Lipid Flow” Department of Ophthalmology and Visual Sciences, Journal Club. University of Louisville, May, 2009.67. Douglas Borchman “Chemistry of Eye Lid Secretions.” Department of Ophthalmology and Visual Sciences, University of Louisville, May, 2009.68. Douglas Borchman (Invited Speaker) “Tear Lipids and Dry Eye" Solving Dry Eye - An International Exchange, Sidney Australia. August 2009.69. James E. Bell, Douglas Borchman and Gary N..Foulks. "Meibomian Gland Dysfunction - The Etiology, Diagnosis, Treatment, and Potential Future Treatments." Grand Rounds at the Moran Eye Center, University of Utah in Salt Lake City on September 2009.70. John McKay, Douglas Borchman, Gary Foulks. Modification of Meibomian Gland Lipids by Topical Azithromycin. Research Louisville, University of Louisville, October 2009.

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71. Eddie Apenbrink, Douglas Borchman, Gary Foulks. Quantification of Human Sebum on Skin and Quantification of Human Meibum on the Eye Lid. Research Louisville, University of Louisville, October 2009.72. Douglas Borchman. “A Biometric Gauge for the Age of an Individual.” University of Louisville, Department of Ophthalmology Journal Club Presentation. October 2009.73. Douglas Borchman. Invited speaker “Mebomian Gland Disease and Mebum” Department of Chemistry, Kwansei Gakuin University, Japan, December 2009.74. Douglas Borchman. Invited speaker “Mebomian Gland Disease and Mebum” Kyoto Univeristy, Medical School, Kyoto Japan, December 2009.75. Shelley Kakar, Douglas Borchman. “Infrared Spectroscopic Study of Human Meibum.” Undergraduate Research Symposium. University of Louisville, Kentucky, April 2010.76. Sung-Hye Kim, Douglas Borchman. “Lipid-Protein Interactions in Human Tear Film.” Undergraduate Research Symposium. University of Louisville, Kentucky, April 2010.77. Lauren Varble, Douglas Borchman, Gary N. Foulks. “Compositional changes in human tear lipids with Meibomian Gland Dysfunction.” Kentucky Academy of Science, Western Kentucky University, Bowling Green, Kentucky, November 2010.78. Douglas Borchman. Invited Speaker. “Dry Eye and Human Tear Lipid Compositional and Structural Relationships Using Spectroscopy.” Ohio State University, Department of Optometry, Columbus Ohio, November 2010.79. Douglas Borchman. “Molecular and Conformational Markers of Dry Eye.” University of Louisville, Department of Ophthalmology and Visual Sciences Seminar, May 2011.80. Diana Duran, Douglas Borchman. "Compositional Changes in Human Tear Lipids with Meibomian Gland Dysfunction" Physiology Cardiovascular Minority Program Summer Undergraduate Research Opportunity Program, Louisville KY, August 2011.81. Evelyn R. Robuck, Douglas Borchman. " Compositional Changes in Human Tear Lipids with Age." Undergraduate Research Opportunity Program, Louisville KY, August 2011.82. Douglas Borchman. "Current Concepts in Lens & Cataract." Lecture to Residence. Department of Ophthalmology and Visual Sciences, Louisville KY, August 2011.83. Mariam Hanna, Douglas Borchman. Resolution of Dry Eye Symptoms Followed by Mass Spectrometric Analysis of Changes in Human Tear Meibum Lipids with Age, Dry Eye and Treatment. Research Louisville. Louisville KY. Oct. 2011.84. Evelyn R. Robuck, Douglas Borchman. " Compositional Changes in Human Tear Lipids with Age." 3rd place. Kentucky Academy of Science, Murray KY, November 2011.85. Vishnubhatla Sravya, Douglas Borchman “Evaporation Through Contact Lenses and Contact Lens Tolerance” 1st place, American Chemical Society award for best poster, Yale Science and Engineering award for most outstanding 11th grade project, US Navy most outstanding poster award. Manual High School Science Fair. March 2012.86. Vishnubhatla Sravya, Douglas Borchman “Evaporation Through Contact Lenses and Contact Lens Tolerance” 1st place and Best of Fair. Kentucky Science and Engineering Fair. EKU campus, Richmond KY, April 2012.87. Vishnubhatla Sravya, Douglas Borchman “Evaporation Through Contact Lenses and Contact Lens Tolerance” Won scholarship to Florida Institute of Technology and an award from the Patent Office. International Science and Engineering Fair. Pittsburg PA, May 2012.88. Diana Duran, Douglas Borchman. “Meibum Composition Tear Film Stability and Rates of Evaporation” Physiology Cardiovascular Minority Program Summer Undergraduate Research Opportunity Program. Louisville KY. August 2012.

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89. Gregory W. Cox, Douglas Borchman.” Compositional Changes in Human Tear Lipids with Meibomian Gland Dysfunction.” The Kentucky Biomedical Research Infrastructure Network Symposium. Louisville KY. August 2012.90. Douglas Borchman. Spectroscopic Studies of Human Meibum. Department of Optometry, Ohio State University, Columbus Ohio, September 2012.91. Ryan Smith, Douglas Borchman, Rahul Bhola, Gary N. Foulks Marta C. Yappert. Spectroscopic approaches to explore how human meibum composition, conformation and lipid-protein interactions are affected by age, meibomian gland dysfunction and dry eye treatment. Research Louisville. Louisville KY, September, 2012.92. Gregory W. Cox, Douglas Borchman. “Compositional Changes in Human Tear Lipids with Meibomian Gland Dysfunction.” Gregory W.. Kentucky Academy of Science, Eastern Kentucky University, Richmond KY, October , 2012.93. Douglas Borchman. “Spectroscopy and the Cure for Dry Eye. Department of Physiology and Biophysics.” The University of Louisville. November 2012.94. Douglas Borchman. “Spectroscopy and the Cure for Ery Eye.” Department of Ophthalmology and Visual Sciences. University of Lousiville. December 2012.95. Douglas Borchman. “15 years of IMD3 and Session Chair.” Institute for Molecular Diversity and Drug Design. 15th Annual Symposium. Wagner Conference Center, Louisville KY. March 2013.96. Diana Duran, Douglas Borchman (paid invited talk) “Dry Eye, Tear film Stability and the Composition of Human Infant and Child Meibum.” 8th annual ACC Meeting of the Minds. Wake Forest University. Winston-Salem, NC, April, 2013.97. Alexandria Oliver, Douglas Borchman. “Inhibition of the Rate of Evaporation by n-Alcanols” Physiology Cardiovascular Minority Program Summer Undergraduate Research Opportunity Program. Louisville KY. August 2013.98. Dylan Gerlach, Douglas Borchman. “Influence of Squalene on Human Meibum Molecular Structure” The Kentucky Biomedical Research Infrastructure Network Symposium. Louisville KY. August 2013.99. Morgan Hunter, Marta C. Yappert, Douglas Borchman. “Influence of Eye Makeup on Human Meibum Molecular Structure” The Kentucky Biomedical Research Infrastructure Network Symposium. Louisville KY. August 2013.100. Samiyyah Sledge, Emily Dennis, Heidi Michael, Douglas Borchman. Evaporation, dry eye and lipid films. The Kentucky Biomedical Research Infrastructure Network Symposium. Louisville KY. August 2014.101. Emily Dennis, Heidi Michael, Samiyyah Sledge, Douglas Borchman. Raman Spectroscopy and the structure and function of tear film surface lipids. The Kentucky Biomedical Research Infrastructure Network Symposium. Louisville KY. August 2014.102. Borchman Douglas, “The cure for Dry Eye, from the Bench to the Bedside.” Invited Talk, UCLA, Department of Ophthalmology, Los Angeles, CA, July 2014.103. Borchman Douglas, “Mammoths, lipids and the lens” Genzyme/Sanofi consultation seminar. Cambridge, MA. December 2014.104. Borchman Douglas, “Mammoths, Lipids and Cataracts” Center Collage, Danvuille KY, March 2015.105. Jessica Morgan Jones, Douglas Borchman. “Vitreous Liquefaction and Lipids” The Kentucky Biomedical Research Infrastructure Network Symposium. Louisville KY. July 2015.

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106. Kryshawna Beard, Douglas Borchman. “Phospholipid Composition of Tears” The Kentucky Biomedical Research Infrastructure Network Symposium. Louisville KY. August 2015.

K. Research Funding

a. Funded Grants

11/01/15-10/31/16. PI Borchman “Camel milk as a possible anti cataract agent” Al Baha University, Saudi Arabia. $30,000 total.

11/01/15-10/31/16. PI Borchman “Lens Organ Culture Studies and Lens Clarity” Sanofi/Genzyme, Study Number: DIV1756; $70,984 total.

012/01/2015-12/1/2020 PI Borchman (50%), RO1 EYO26180 (2% score), “Tear film lipid compositional, structural functional relationships, and dry eye disease. $1,125,000 total.

06/2014-09/2014 PI Borchman, “Institute for Molecular Diversity & Drug Design Summer Research fellowship” for Heidi Michael. $1,500.

03/2014-10/2015. PI Borchman, “Standard Analysis of Human Meibum.” Allergan Sales, Inc. $65,302.70.

07/01/2013-06/31/2014, PI Borchman, “Lipid Saturation and Meibum Structure” $5,000, University of Louisville, Research Initiation Grant.

12/2011-12/2012, P.I. Borchman, “Lipid-protein interactions in human tear meibum” $3000. University of Louisville, Undergraduate Research Grant for Diana P Duran.

1/01/2011-6/30/2012 P.I. Borchman, (7% effort) “Lipids of the Human Tear Film Supplemental Studies” $40,800, Inspire Pharmaceuticals.

06/01/2011-09/01/2011. P.I. Borchman. “Lipids of the Human Tear Film” $1,500. Institute for Molecular Diversity and Drug Design, University of Louisville, Undergraduate Research for Erin Baumgartner.

12/2010-12/2011, P.I. Borchman, “Human meibum compositional changes with dry eye symptoms using NMR spectroscopy.” $3000. University of Louisville, Undergraduate Research Grant for Rashmi K Shresthu.

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12/2010-12/2011, P.I. Borchman, “Lipid-protein interactions in human tear meibum.” $3000. University of Louisville, Undergraduate Research Grant for Jonathan Nguyen.

12/2010-12/2011, P.I. M.C. Yappert, Co.I. Borchman “Biophysical Studies of Hyaluronan and Lipids in Ocular Vitreous Gels.” $5,000. University of Louisville, Research Initiation Grant.

4/2006-03/2011 (2011, P.I., 2006-2010, Co-Investigator, Borchman) 80% effort; G.N. Foulks (P.I.) "Tear Film Lipids and Dry Eye" $1,286,250, National Eye Institute, EY017094.

5/21/2009-5/20/2010, P.I. Borchman, “Tear lipid-protein interactions that contribute to dry eye disease.” $300. University of Louisville, Undergraduate Research Scholar Grant for Sung-Hye Kim.

12/2009-12/2010 P.I. Borchman “Lipid-Protein Interactions and Dry Eye Symptoms” $3,000. University of Louisville Undergraduate Research Grant, for Sung-Hye Kim.

6/2009-5/2010 PI, “Raman spectroscopic characterization of human meibum in donors with meibomian gland dysfunction.” $3,000. University of Louisville Undergraduate Research Grant, for Shelley Kakar.

4/2008-4/2009 Co-Investigator; G.N. Foulks (P.I.) “Prospective evaluation of topical azasite for blepharitis” $88,400. Inspire Pharmaceuticals Inc.

1/2005-12/2005 Co-Invesitigator, 10% effort, Daxin Tang, PI. “Liposome fusion and corneal drug delivery.” $160,000. Alcon Laboratories. Fort Worth TX.

5/2004-6/2005 Principal Investigator, “Tear film lipids.” Competitive Enhancement Grant, University of Louisville, $15,000 total.

7/2004-6/2005 Principal Investigator, “Enhancement of drug permeation through cornea via liposomes.” Intramural Research Incentive Grant, University of Louisville, $5,000 total.

4/2001-3/2005 Borchman D. (Co-I, 20%), Paterson C.A. (P.I.), "Regulation of lens cation balance and distribution." RO1 EYO 6916, $1,250,456- Total.

1/2000-06/2004 Principal Investigator, "Spectroscopic and related studies on lens membrane lipid," National Eye Institute, RO1 EYO7975, $1,182,550-Total.

1/2000-12/2001 Principal Investigator, "Dry eye, topical drugs and lipid tear film relationships" Jewish Hospital Foundation of Louisville, KY, $50,000- Total.

5/2000-4/2001 Principal Investigator, "Drug efficacy of naproxin-vitamin E ester" Alcon Research Inc., Fort Worth Texas, $36,000 total.

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9/1999-8/2000 Principal Investigator, "Antiphospholipid Antibodies and Thrombosis," The School of Medicine Research Committee, Cecil E. and Mamie M. Bales Fund, University of Louisville School of Medicine, $15,000 total.

1/1/97-12/31/2000 Co-Investigator (5%), M.C. Yappert PI "Structural role of Sphingolipids in Human Lens Membranes", National Eye Institute, (RO1 EYO 11657) $752,879 Total costs.

12/1999-12/2000 Intramural, Competitive Enhancement Grant, University of Louisville. $15,000.

5/1993-5/1999 Co-Investigator (10%), C.A. Paterson PI "Regulation of lens cation balance and distribution", National Eye Institute, RO1 EYO 6916, $692,361 Total costs

1/1993-12/1998 Principal Investigator, "Spectroscopic and related studies on lens membrane lipid," National Eye Institute, RO1 EYO7975-01, $1,413,168-Total

5/1988-5/1993 Co-Investigator (80%), C.A. Paterson PI "Regulation of lens cation balance and distribution", National Eye Institute, RO1 EYO 6916.

10/1992-10/1994 Principal Investigator, "Drug efficacy in oxidized lipid model systems." Alcon Laboratories, $40,000/year.

6/1994 Center for International Studies, University of Louisville, International Relationships Grant, $500.

1/1992-12/1992 Principal Investigator, "Structure of Retinal Rod Outer Segment Lipids by Infrared Spectroscopy". Adolph O. Pfingst Fund for Medical Research, $8,000.

6/1992-5/1993 Principal Investigator, "Age and Cataract Changes in Lens Protein Structure." Life Span Gerontology Research Grant, $5,000.

4/1989-5/1990 Principal Investigator, "Infrared Spectroscopy of Normal and Cataractous Human Lens Membrane Lipid". University of Louisville Research Committee, $4,488.

1/1988-12/1992 Principal Investigator, "Spectroscopic and related studies on lens membrane lipid," National Eye Institute, RO1 EYO7975-01.

b. Grants Pending

L. Bibliography

a. Publications

26

Peer Reviewed Publications. Contributing author underlined

1. Borchman D, Simon R, Bicknell-Brown E. Variation in the lipid composition of rabbit muscle sarcoplasmic reticulum membrane with muscle type. J. Biol. Chem. 257: 14136-14139, 1982.

2. Navarro S, Borchman D, Bicknell-Brown E. Lipid-protein ratios by infrared spectroscopy. Analytical Biochemistry 136:382-389, 1984.

3. Bicknell-Brown E , Borchman D, Brown K. Atomic and Raman spectroscopy of the phosphatidic acid-calcium complex and bilayer phase. Biochem. Biophys. Acta 862:134-140, 1986.

4. Borchman D . Infrared Raman and composition studies of skeletal muscle sarcoplasmic reticulum. Doctoral Dissertation. Wayne State University, Detroit Michigan (1986).

5. Kirchberger M , Borchman D, Kasinathan C. Proteolytic activation of the calcium pump of canine cardiac sarcoplasmic reticulum. Biochemistry 25:5484-5492, 1987.

6. Borchman D , Delamere NA, Paterson CA. Selective inhibition of membrane ATPases by hydrogen peroxide in the lens of the eye. Basic Life Sci. 49:1029-1033, 1988.

7. Borchman D , Delamere NA, Paterson CA. Ca-ATPase activity in the rabbit and bovine lens, Invest. Ophthalmol. Vis. Sci. 29:148-153, 1988.

8. Delamere NA , Paterson CA, Borchman D, Hensley SK. Alteration of lens electrolyte transport parameters following transient oxidative perturbation. Curr. Eye Res. 7:969-979, 1988.

9. Borchman D , Paterson CA, Delamere NA. Oxidative inhibition of Ca2+-ATPase in the rabbit lens. Invest. Ophthalmol. Vis. Sci. 30:1633-1637, 1989.

10. Borchman D , Yappert MC, Rubini RQ, Paterson CA. Distribution of phospholipid-malondialdehyde-adduct in the human lens. Curr. Eye Res. 8:939-946, 1989.

11. Borchman D , Paterson CA, Delamere NA. Ca-ATPase activity in the human lens. Curr. Eye Res. 8:1049-1054, 1989.

12. Borchman D , Delamere NA, McCauley LA, Paterson CA. Studies on the distribution of cholesterol, phospholipid, and protein in the human bovine lens. Lens Eye Tox. Res. 6:703-724, 1989.

13. Lamba OP, Lal S, Yappert MC, Borchman D. Spectroscopic detection of lipid peroxidation products and structural changes in a sphingomyelin model system. Biochem. Biophys. Acta 1081:181-187, 1991.

14. Delamere NA , Paterson CA, Borchman D, King KL, Cawood SC. Calcium transport, Ca-ATPase and lipid order in rabbit ocular lens membranes. Am. J. Physiol. 260:C731-C737, 1991.

15. Borchman D , Herrell P, Yappert MC. Structural characterization of human lens membrane lipid by infrared spectroscopy. Invest. Ophthalmol. Vis. Sci. 32:236-248, 1991

16. Lamba OP, Borchman D, Sinha SK, Lal S, Yappert MC, Lou M. Structure and molecular conformation of anhydrous and of aqueous sphingomyelin bilayers determined by infrared and Raman spectroscopy. J. Mol. Structure 248:1-24, 1991.

17. Borchman D , Salmassi S, Lamba OP, Lou M, Yappert MC. The dual effect of oxidation on bilayer structure. Lipids 27:261-265, 1992.

18. Yappert MC, Lal S, Borchman D. Age dependence and distribution of green and blue fluorophores in human lens homogenates. Invest. Ophthalmol. Vis. Sci. 33:3555-3560 1992.

27

19. Delamere NA , Borchman D, Paterson CA, Manning RE. The influence of calcium upon the rabbit lens sodium pump. Invest. Ophthalmol. Vis. Sci. 34:405-412, 1993.

20. Borchman D , Lamba OP. Raman structural characterization of clear human lens lipid membranes. Curr. Eye Res. 12:279-284, 1993.

21. Yappert MC , Byrdwe11 C, Borchman D. Comparison of blue and green fluorescence in cataractous vs. normal human lens fractions. Invest. Ophthalmol. Vis Sci. 34:630-636, 1993.

22. Lamba OP, Borchman D, Sinha SK, Yappert MC, Shah J., RenugopaIakrishnan V. Estimation of the secondary structure and conformation of bovine lens crystallins by infrared spectroscopy: quantitative analysis and resolution by Fourier self-deconvolution and curve fit. Biochim. Biophys. Acta 1163:113-123, 1993.

23. Lamba OP, Borchman D, Garner WH. Infrared study of the structure and composition of rabbit lens membranes: A comparative analysis of the lipids of nucleus, cortex and epithelium. Exp. Eye Res. 57:1-12, 1993.

24. Borchman D , Lamba OP, Yappert MC. Structural Characterization of Human Lens Membrane Clear and Cataractous Lipid. Exp. Eye Res. 57:199-208, 1993.

25. Lamba OP, Borchman D, Garner WH. Spectral characterization of lipid peroxidation in rabbit lens membranes induced by hydrogen peroxide in the presence of Fe2+/Fe3+: A site-specific catalyzed oxidation. Free Rad. Biol. Med. 16:591-601, 1994.

26. Lamba OP , Borchman D, O'Brien PJ. Fourier transform infrared study of the rod outer segment disk and plasma membranes of vertebrate retina. Biochemistry 33: 1704- 1712, 1994.

27. Hightower KR , McCready J, Borchman D. Membrane damage in UV-irradiated lenses. Photo Chem. Photo Biol. 59:485-590, 1994.

28. Borchman D, Byrdwell WC, Yappert MC. Regional and age-dependent differences in the phospholipid composition of human lens membranes. Invest. Ophthalmol. Vis. Sci. 35: 3938-3942, 1994. 29. Byrdwell WC, Borchman D, Porter RA, Taylor KG, Yappert MC. Separation and characterization of the unknown phospholipid in human lens membranes. Invest. Ophthalmol. Vis. Sci. 35:4333-4343, 1994. PMID: 8002253.

30. Zeng J, Borchman D, Paterson CP. ATPase activities of rabbit and bovine lens epithelial microsomes: a continuous fluorimetric assay study. Curr. Eye Res. 14:87-93, 1995.

31. Borchman D , Ozaki Y, Lamba OP, Byrdwell C, Czarnecki M, Yappert MC. Structural characterization of clear human lens lipid membranes by near-infrared Fourier transform Raman spectroscopy. Curr. Eye Res. 14:511-514, 1995.

32. Borchman D , Harris EH, Pierangeli SS. and Lamba, O.P. Interactions and molecular structure of cardiolipin and β-GP1. Clinical and Experimental Immunology 102:373-378, 1995.

33. Sato H, Borchman D, Ozaki Y, Byrdwell WC, Yappert MC Paterson CA. Lipid-protein interactions in human and bovine lens membranes by Fourier transform Raman and infrared spectroscopy. Exp. Eye Res. 62:47-53, 1996.

34. Borchman D , Cenedella RI, Lamba OP. Role of cholesterol in the structural order of lens lipids. Exp. Eye Res. 62:191-197, 1996.

35. Borchman D , Byrdwell WC, Yappert MC. Thermodynamic phase transition parameters of human lens dihydrosphingomyelin. Ophthalmic Res. 28: 81-85, 1996.

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36. Dean WL, Delamere NA, Borchman D, Moseley AE. Studies on lipids and the activity of Na, K-ATPase in lens fiber cells. Biochem. J. 314:961-967, 1996.

37. Borchman D , Ozaki Y, Lamba OP, Byrdwell WC, Yappert MC. Age and regional structural characterization of clear human lens lipid membranes by infrared and near-infrared Raman spectroscopes. Biospectroscopy 2:113-123, 1996.

38. Ferguson SR, Borchman D, Yappert MC. Confirmation of the identity of the major phospholipid in human lens membranes. Invest. Ophthalmol. Vis. Sci 37: 1703 -1706, 1996.

39. Borchman D , Tang D. Binding capacity of -crystallin to bovine lens lipids. Exp. Eye Res. 63:407-410, 1996.

40. Paterson CA, Zeng J, Husseini Z, Borchman D, Delamere NA, Garland D, Jimenez-Asenio J. Calcium ATPase activity and membrane structure in clear and cataractous human lenses. Curr. Eye Res. 16:333-338, 1997. PMID: 9134322.

41. Zeng J , Borchman D, Paterson CA. Calcium permeability in large unilamellar vesicles prepared from bovine lens cortical lipids. Exp. Eye Res. 64:115-120, 1997.

42. Byrdwell CW , Borchman D. Liquid chromatography/mass spectrometric characterization of the unknown phospholipid of human lens membranes. Ophthalmic Res. 29:191-206, 1997.

43. Tang D, Borchman D, Cenedella RJ, Yappert MC. Influence of cholesterol on the interaction of -cystallin with phospholipid. Exp. Eye Res. 66:559-567, 1998.

44. Zeng J , Borchman D, Paterson CA. Ethanol and lens cation homeostasis. Alcohol 16:189-193, 1998.

45. Borchman D , Yappert MC. Age related lipid oxidation in human lenses. Invest. Ophthalmol. Vis. Sci. 39: 1053-1058, 1998.

46. Tang D, Borchman D, Harris N, Pierangeli S. Lipid interactions with human antiphospholipid antibody 2-glycoprotein and normal human IgG using the fluorescent probes NBD-PE and DPH. Biochim. Biophys. Acta 1372:45-54, 1998.

47. Tang D, Borchman D . Temperature induced structural changes of a crystallin and sphigomyelin binding. Exp. Eye Res. 67:113-118, 1998.

48. Zhang Z, Zeng J, Tang D, Borchman D, and Paterson, C.A. Membrane lipid - crystallin interaction and Ca2+-ATPase activity. Curr. Eye Res. 18:56-61, 1999.

49. Tang D, Borchman D, Yappert MC. - Crystallin -lens lipid interactions using resonance energy transfer. Ophthalmic Res. 31:452-462, 1999.

50. Borchman D , Tang D, Yappert MC. Lipid composition, membrane structure relationships in lens and muscle sarcoplasmic reticulum. Biospectroscopy 5:151-167, 1999.

51. Ahuja RP, Borchman D, Dean WL, Paterson CA, Zeng J, Zhang S, Ferguson-Yankey S, Yappert MC. Effect of oxidation on Ca2+-ATPase activity and membrane lipids in lens epithelial microsomes. Free Rad. BioI. Med. 27:177-185, 1999.

52. Zeng J, Zhang Z, Paterson CA, Ferguson-Yankey S, Yappert MC, Borchman D . Ca2+ -ATPase activity and lens lipid composition in reconstituted systems. Exp. Eye Res. 69:323-330, 1999.

53. Liu L, Bian L, Borchman D, Paterson CA. Expression of sarco/endoplasmic reticular Ca2+ -ATPase in human lens epithelial cells and cultured human lens epithelial β-3 cells. Curr. Eye Res. 19:389-394, 1999.

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54. Bian L, Zeng J, Borchman D, Paterson CA. Plasma membrane calcium ATPase gene expression pattern in bovine lens epithelium. Ophthalmic Res. 32:100-105, 2000.

55. Borchman D , Gibblin FJ, Yappert MC, Leverenz VR, Reddy VN, Lin L, Tang D. Impact of aging and hyperbaric oxygen in vivo on guinea pig lens lipid and nuclear light scatter. Invest. Ophthalmol. Vis Sci. 41:3061-73, 2000.

56. Ferguson-Yankey S, Borchman D, Taylor KG, DuPre DB, Yappert MC. Conformational Studies of sphingolipids by NMR spectroscopy. I. Dihydrosphingomyelin. Biochim. Biophys. Acta 1467:307-325, 2000. PMID: 11030590

57. Talbot CM, Vorobyov I, Borchman D, Taylor KG, DuPre DB, Yappert MC. Conformational Studies of sphingolipids by NMR spectroscopy. II. Sphingomyelin. Biochim. Biophys. Acta 1467:326-337, 2000.

58. Borchman D , Sinha S. Determination of products of lipid oxidation by infrared spectroscopy. Methods Mol. Biol. 186:21-28, 2002.

59. Rujoi M, Borchman D, DuPre DB, Yappert MC. Interactions of Ca2+ with sphingomyelin and dihydrosphingomyelin. Biophysical J. 82:3096-3104, 2002.

60. Giblin FJ , Leverenz VR Padgoankar VA, Unakar NJ, Dang L, Lin L-R, Lou MF, Reddy VN, Borchman D, Dillon JP. UVA Light in vivo reaches the nucleus of the guinea pig lens and produces deleterious, oxidative effects. Exp. Eye Res., 75:445-58, 2002.

61. Liu L, Paterson CP, Borchman D. Regulation of sarco/endoplasmic Ca2+-ATPase expression by calcium in human lens cells. Exp. Eye Res., 75:583-590, 2002.

62. Byrdwell WC, Sato H, Schwarz A, Borchman D, Yappert MC, Tang, D. 31P-NMR Quantification and monophasic solvent purification of human and bovine lens phospholipids. Lipids 37:1087-1092, 2002.

63. Rujoi M, Borchman D, Vorobyov I, Estrada R, Yappert MC. Isolation and lipid characterization of cholesterol-enriched fractions in cortical and nuclear human lens fibers. Invest. Opthalmol. Vis. Sci., 44:1634-1642, 2003.

64. Tang D, Borchman D, Schwarz A, Yappert MC, Vrenson GFJM, van Marle J, DuPre D. Light scattering of human lens vesicles in vitro. Exp. Eye Res.76:605-612, 2003.

65. Tang D, Borchman D, Yappert MC, Vrenson GFJM. Influence of age, diabetes, and cataract on lipid-calcium and protein-calcium relationships in human lenses. Invest. Ophthalmol. Vis. Sci. 44:2059-2066, 2003. PMID: 12714644.

66. Yappert MC , Rujoi M, Borchman D, Vorobyov I, Estrada R. Glycero- versus sphingo-phospholipids in the control of mammalian lens growth Exp. Eye Res. 76:725-734, 2003.

67. Cenedella RJ , Jacob R, Borchman D, Tang D, Neely AR, Samadi A, Mason RP, Sexton P. Cataracts caused by the oxidosqualene cyclase inhibitor U18666A may result from activation of membrane-mediated stress response pathways, independent of restricting cholesterol availability. Lipids. 45:1232-41, 2004.

68. Yappert MC , Borchman D. Sphingolipids in human lens membranes: an update on their composition and possible biological implications. Chem. Phys. Lipids. 129:1-20, 2004.

69. Borchman D , Yappert MC, Afzal M. Lens lipids and maximum lifespan. Exp. Eye Res., 79:761-768, 2004. PMID: 15642313.

70. Grami V, Marrero Y, Huang L, Tang D, Yappert MC, Borchman D. α-Crystallin Binding In Vitro to Lipids from Clear Human Lenses. Exp. Eye Res., 81, 138-146, 2005.

71. Marian MJ, Li H, Borchman D, Paterson CA. Plasma Membrane Ca2+-ATPase Expression in the Human Lens. Exp. Eye Res., 81, 57-64, 2005.

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72. Huang L, Grami V, Marrero Y, Tang D, Yappert MC, Rasi V, Borchman D . Human Lens Phospholipid Changes with Age and Cataract. Invest. Ophthalmol. Vis. Sci., 46:1682-9, 2005. PMID: 15851569.

73. Tang D, Dean WL, Borchman D, Paterson CA. The Influence of Membrane Lipid Structure on Plasma Membrane Ca2+-ATPase Activity. Cell Calcium, 39:209-216, 2006. PMID: 16412504.

74. Estrada R, Borchman D, Reddan J, Hitt A, Yappert MC. In-Vitro and in-Situ Tracking of Choline-Phospholipid Biogenesis by MALDI TOF-MS. Analytical Chemsitry, 78:1174-80, 2006.

75. Huang L, Tang D, Yappert MC, Borchman D. Oxidation Induced Changes in Human Lens Epithelial Cells. 2. Mitochondria and the Generation of Reactive Oxygen Species. Free Rad. Biol. Med. 41:926-936, 2006.

76. Huang L, Estrada R, Yappert MC, Borchman D. Oxidation Induced Changes in Human Lens Epithelial Cells. 1. Phospholipids. Free Rad. Biol. Med. 41:1425-32, 2006.

77. Marian MJ, Liu L, Mukhopadhyay P, Paterson CA, Borchman D, Tang D . Regulation of Sarco/Endoplasmic and Plasma Membrane Calcium ATPase Gene Expression by Calcium in Cultured Human Lens Epithelial Cells. Cell Calcium, 41:87-95, 2007.

78. Borchman D , Foulks GN, Yappert MC, Tang D, Ho DV. Spectroscopic Evaluation of Human Tear Lipids. Chem. Phys. Lipids, 147:87-102, 2007.

79. Borchman D , Foulks GN, Yappert MC, Ho DV. Temperature-Induced Conformational Changes in Human Tear Lipids Hydrocarbon Chains. Biopolymers/Biospectroscopy 87:124-133, 2007.

80. Huang L, Yappert MC, Miller JJ, Borchman D . Thyroxine Ameliorates Oxidative Stress by Inducing Lipid Compositional Changes in Human Lens Epithelial Cells. Invest. Ophthalmol. Vis. Sci. 48:3698-704, 2007

81. Marian M, Mukhopadhyay P, Paterson CA, Borchman D. Membrane Calcium ATPase Gene Expression with Age and Cataract in Human Lenses. Ophthalmic Res. 40:86-93, 2008.

82. Huang L, Yappert MC, Jumblatt M, Borchman D. Hyperoxia and Thyroxine-Treatment and the Relationships Between Reactive Oxygen Species Generation, Mitochodrial Membrane Potential and Cardiolipin in Human Lens Epithelial Cell Cultures. Curr. Eye Res. 33:575-586, 2008.

83. Marian MJ, Mukhopadhyay P, Borchman D, Tang D, Paterson CA. The effect of hydrogen peroxide on sarco/endoplasmic and plasma membrane calcium ATPase gene expression in cultured human lens epithelial cells. Open Ophthtalmol. J. 2:123-129, 2008. PMID: 19517033

84. Borchman D , Foulks GN, Yappert MC, Mathews J, Leake K, Bell J. Factors Affecting Evaporation Rates of Tear Film Components Measured In Vitro. Eye and Contact Lens, 35:32-37, 2009. PMID: 19125046.

85. Oshima Y, Sato H, Zaghloul A, Foulks GN, Yappert MC, Borchman D . Characterization of Human Meibum Lipid using Raman Spectroscopy. Curr. Eye Res. 34:824–835, 2009. PMID: 19895310.

86. Borchman D, Foulks GN, Yappert MC, Kakar S, Podoll N, Rychwalski P, Schwietz E. Physical Changes in Human Meibum with Age as Measured by Infrared Spectroscopy. Ophthalmic Res. 44:34-42, 2010. PMID: 20160464.

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87. Estrada R, Puppato A, Borchman D, Yappert MC. Re-evaluation of the phospholipid composition in membranes of adult human lenses by 31-P NMR and MALDI-MS. Biochim. Biophys. Acta-Biomembranes. 1798:303–311, 2010. PMID: 19925778.

88. Foulks GN , Borchman D, Yappert MC, Sung-Hye K, McKay JW. Topical Azithromycin Therapy of Meibomian Gland Dysfunction: Clinical response and lipid alterations. Cornea, 29:781-788, 2010. PMID: 20489573.

89. Foulks GN , Borchman D. Meibomian gland dysfunction:the past, the present, the future. Eye Contact Lens. 36:249-53, 2010. PMID: 20724853.

90. Borchman D. and Yappert M.C. Lipids and the Ocular Lens. J. Lipid Res. 51:2473-88, 2010. PMID: 20407021.

91. Borchman D, Foulks GN, Yappert MC. Confirmation of changes in human meibum lipid infrared spectra with age using principal component analysis. Curr. Eye Res. 35:778-86, 2010. PMID: 20795859.

92. Borchman D, Foulks GN, Yappert MC. Changes in human meibum lipid with meibomian gland dysfunction using principal component analysis. Exp Eye Res. 91:246-56, 2010. PMID: 20546726.

93. Green-Church KB , Butovich I, Willcox M, Borchman D, Paulsen F, Barabino S, Glasgow B. Meibomian Gland Contribution to the Tear Film. In: The Report of the International Workshop on Meibomian Gland Dysfunction. Invest. Ophthalmol. Vis. Sci. 52:1979-1993, 2011. PMID: 21398284.

94. Borchman D, Foulks GN, Yappert MC, Bell J, Wells E, Neravetla S, Greenstone V. Human meibum lipid conformation and thermodynamic changes with meibomian-gland dysfunction. Invest. Ophthalmol. Vis. Sci. 52:3805-17, 2011. PMID: 21398284.

95. Ashraf Z, Pasha U, Greenstone V, Akbar J, Apenbrinck E, Foulks GN, Borchman D. Quantification of Human Sebum on Skin and Human Meibum on the Eye Lid margin using Sebum Tape, Spectroscopy and Chemical Analysis. Curr Eye Res. 36:553-62, 2011. PMID: 21591865.

96. Shresthu RK, Borchman D, Foulks GN, Yappert MC. Analysis of the Composition of Lipid in Human Meibum from Normal Infants, Children, Adolescents, Adults and Adults with Meibomian Gland Dysfunction using 1H-NMR Spectroscopy. Invest Ophthalmol Vis Sci. 52:7350-7358, 2011. PMID: 2184942.

97. Borchman D , Foulks GN., Yappert MC, Milliner SE. Differences in Human Meibum Lipid Composition with Meibomian Gland Dysfunction using NMR and Principal Component Analysis. Invest Ophthalmol Vis Sci. 53:337-47, 2012. PMID: 22131391.

98. Borchman D , Foulks GN., Yappert MC, Milliner SE. Changes in Human Meibum Lipid Composition with Age Using NMR Spectroscopy. Invest Ophthalmol Vis Sci. 53:475-482, 2012. PMID: 22169100.

99. Faheem S, Kim S, Nguyen J, Neravetla S, Ball M, Foulks GN, Yappert MC, Borchman D. Wax-Tear and Meibum Protein, Wax-β-carotene Interactions in Vitro Using Infrared Spectroscopy. Exp Eye Res 100:32-9, 2012. PMID: 22564968.

100. Vishnubhatla S, Foulks GN, Borchman D. Contact Lenses and the Rate of Evaporation Measured in Vitro; the Influence of Wear, Squalene and Wax. Contact Lens Anterior Eye, 35:277– 281, 2012. PMID: 22906863.

101. Foulks GN , Borchman D, Yappert MC, Kakar S. Topical Azithromycin and Oral Doxycycline Therapy of Meibomian Gland Dysfunction: A Comparative Clinical and Spectroscopic Pilot Study. Cornea. 32:44-53, 2013. PMID: 2266858.

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102. Borchman D , Yappert MC, Milliner S, Duran D, Cox GW, Smith RJ, Bhola R. 13C and 1H NMR Ester Region Resonance Assignments and the Composition of Human Infant and Child Meibum. Exp Eye Res, 112:151-159, 2013. PMID: 2364409.

103. Borchman D , Yappert MC, Milliner S, Bhola R. Confirmation of squalene in human eye lid lipid by heteronuclear single quantum correlation spectroscopy. Lipids. 48:1269-1277, 2013. PMID: 24081494.

104. Mudgil P, Borchman D, Yappert MC, Duran D, Cox GW, Smith RJ, Bhola R, Dennis GR, Whitehall JS. Human Meibum Saturation and Lipid Order. Exp Eye Res 116C:79-85, 2013. PMID: 23973715.

105. Borchman D . From the Bench to the Bedside. Infrared Spectroscopy and the Diagnosis and Treatment of Dry Eye and Cataracts. Spectroscopy. 29: 38-52, 2014.

106. Hunter M, Bhola,R, Yappert MC, Borchman D, Gerlach D. Pilot Study of the Influence of Eyeliner Cosmetics on the Molecular Structure of Human Meibum. Ophthalmic Res. Ophthalmic Res. 53:131-5, 2015.

107. Ivanova S, Borchman D, Yappert MC, Tonchev V, Yokoi N, Georgiev G. Surface properties of squalene/meibum films and NMR confirmation of squalene in tears. International J Mol Sci. In press 2015.

b. Book chapters, monographs and textbooks

1. Delamere NA, Borchman D, Paterson CA, Manning RE, Mito T.: Studies on lens calcium and the active sodium-potassium pump. In: Eye Lens Membranes and Aging, Vrensen G.F.J.M. and Clauwaert (Eds.), Eurage, Leiden, pp. 11-20, 1991.

2. Lamba OP, Borchman D.: Influence of hydrogen peroxide and lipid composition on regional rabbit lens membrane structure. In: Eye Lens Membranes and Aging; Vrensen G.F.J.M. and Clauwaert (Eds.), Eurage, Leiden, pp. 15:113-122, 1991.

3. Borchman D, Sinha S. Determination of products of lipid oxidation by infrared spectroscopy. In: Oxidative Stress Biomarkers and Antioxidant Protocols, Armstrong D. (Ed.), Humana Press Inc., Totowa, NJ, pp. 21-28, 2002.

4. Borchman D, Yin Hulian. Introduction of the lens physiology, biochemistry and mechanisms of cataract formation. In: Lens Disorders and Surgical Management, Zhenping Zhang (Ed.), Guang Dong Science and Technology, Guang Zhou, Guang Dong, China, pp. 9-16, 2006.

5. Foulks GN, Borchman D. Lipid abnormalities of the Eye. In: Ocular disease: Mechanisms and management, Ben G. Davie (Ed.) Elsevier, Ltd., Oxford, 2010.

c. Editorials, special non-peer reviewed articles and book review

Borchman, D., Ozaki, Y., Sato, H., Yappert, M.C., Byrdwell, W.C. and Lamba, O.P.: "FT- Raman study of age and regional trends in lipid composition and structure of human lenses." Reports on Topical Meeting of the Laser Society of Japan, Biological and Medical Applications of Lasers. RTM-94-14~21:5-8, 1994.

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Sight Saver News, 1998 update from the Lions Eye Bank. "Cataracts and Fat. Advancement in our World through Research" by Douglas Borchman, page 3, 1998.

Borchman D and Foulks GN. Are gasoline and wax natural in our tears? Eye to Eye 2, page 4, 2008.

Manuscripts Submitted

1. 2. Sarah Milliner, Douglas Borchman, Marta C. Yappert, Gray N. Foulks, Ryan J Smith, Rahul

Bhola. 13C and 1H NMR Assignments for Human Infant Meibum Using Inverse Heteronuclear 2D Experiments. In Preparation. 2013.

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