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Diabetes Metab. 2015 Jun 30. pii: S1262-3636(15)00087-7. doi: 10.1016/j.diabet.2015.06.001. [Epub ahead of print] Pregnancy adverse outcomes related to pregravid body mass index and gestational weight gain, according to the presence or not of gestational diabetes mellitus: A retrospective observational study. Cosson E 1 , Cussac-Pillegand C 2 , Benbara A 3 , Pharisien I 3 , Nguyen MT 2 , Chiheb S 2 , Valensi P 2 , Carbillon L 3 . Author information Abstract AIM: This study retrospectively evaluated the complications associated with prepregnancy overweight (OW) or obesity (OB) and gestational weightgain (GWG) in women with or without universally screened and treated gestational diabetes mellitus (GDM). METHODS: A total of 15,551 non-Asian women without pregravid diabetes or hypertension who delivered singleton babies (2002-2010) were classified according to GDM (13.5%), pregestational body mass index (BMI; normal range: 18.5-24.9kg/m 2 ), OW (26.2%), OB (13.9%; BMI≥30kg/m 2 ) and GWG (<7kg: 32%; 7-11.5kg: 37%; 11.6-16kg: 23%;>16kg: 8%). Main outcome measures were large/small for gestational age (LGA/SGA), caesarean section, preeclampsia, preterm delivery and shoulder dystocia. RESULTS: GDM was associated with more LGA babies [Odds Ratio (OR): 2.12, 95% confidence interval (CI): 1.85-2.43], caesarean section (OR: 1.49, 95% CI: 1.34-1.65) and preeclampsia (OR: 1.59, 95% CI: 1.21-2.09). OW/OB and GWG were associated with LGA infants whatever the GDM status, and with SGA babies only in women without GDM. LGA status was independently associated with GWG in women with GDM (11.6-16kg: OR: 1.74, 95% CI: 1.49-2.03 and>16kg OR: 3.42, 95% CI: 2.83-4.13 vs 7- 11.5kg) and in women without GDM (OR: 2.14, 95% CI: 1.54-2.97 or OR: 2.65, 95% CI: 1.68-4.17, respectively), and with BMI only in women without GDM (OR: 1.12, 95% CI: 1.00-1.24, per 10kg/m 2 ). SGA status was independently associated with OW (OR: 0.86, 95% CI: 0.77-0.98), OB (OR: 0.84, 95% CI: 0.72-0.98) and GWG<7kg (1.14, 95% CI: 1.01-1.29) only in women without GDM. CONCLUSION: In our European cohort and considering the triumvirate of GDM, BMI and GWG, GDM was the main contributor to caesarean section and preeclampsia. OW/OB and GWG contributed to LGA and SGA infants mainly in women without GDM. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

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Diabetes Metab.2015 Jun 30. pii: S1262-3636(15)00087-7. doi: 10.1016/j.diabet.2015.06.001. [Epub ahead of print]Pregnancy adverse outcomes related to pregravid body mass index and gestationalweightgain, according to the presence or not of gestational diabetes mellitus: A retrospective observational study.Cosson E1,Cussac-Pillegand C2,Benbara A3,Pharisien I3,Nguyen MT2,Chiheb S2,Valensi P2,Carbillon L3.Author informationAbstractAIM:This study retrospectively evaluated the complications associated with prepregnancyoverweight(OW) or obesity (OB) and gestationalweightgain (GWG) in women with or without universally screened and treated gestational diabetes mellitus (GDM).METHODS:A total of 15,551non-Asian women without pregravid diabetes or hypertension who delivered singleton babies (2002-2010) were classified according to GDM (13.5%), pregestational body mass index (BMI; normal range: 18.5-24.9kg/m2), OW (26.2%), OB (13.9%; BMI30kg/m2) and GWG (16kg: 8%). Main outcome measures were large/small for gestational age (LGA/SGA), caesarean section,preeclampsia, preterm delivery and shoulder dystocia.RESULTS:GDM was associated with more LGA babies [Odds Ratio (OR): 2.12, 95% confidence interval (CI): 1.85-2.43], caesarean section (OR: 1.49, 95% CI: 1.34-1.65) andpreeclampsia(OR: 1.59, 95% CI: 1.21-2.09). OW/OB and GWG were associated with LGA infants whatever the GDM status, and with SGA babies only in women without GDM. LGA status was independently associated with GWG in women with GDM (11.6-16kg: OR: 1.74, 95% CI: 1.49-2.03 and>16kg OR: 3.42, 95% CI: 2.83-4.13 vs 7-11.5kg) and in women without GDM (OR: 2.14, 95% CI: 1.54-2.97 or OR: 2.65, 95% CI: 1.68-4.17, respectively), and with BMI only in women without GDM (OR: 1.12, 95% CI: 1.00-1.24, per 10kg/m2). SGA status was independently associated with OW (OR: 0.86, 95% CI: 0.77-0.98), OB (OR: 0.84, 95% CI: 0.72-0.98) and GWG 16 kg o 2,83 a 4,13 vs 7-11.5kg) y en las mujeres sin GDM (OR: 2,14; IC del 95%: 1,54 a 2,97 u OR: 2,65; IC del 95%: 1,68 a 4,17, respectivamente), y con el IMC slo en las mujeres sin GDM (OR: 1,12 IC del 95%: 1,00 a 1,24 , por 10 kg / m2).Estado SGA se asoci independientemente con OW (OR: 0,86; IC 95%: 0,77-0,98), OB (OR: 0,84 IC 95%: 0,72 a 0,98) y GWG 20 semanas, en Ontario, Canad (abril 2007 a marzo 2010).Nuestros resultados primarios fueron una combinacin de complicaciones maternas (por ejemplo, la hipertensin gestacional,preeclampsia, ruptura prematura de membranas, etc.), y una combinacin de complicaciones en el parto (por ejemplo, parto por cesrea, distocia de hombro, la hemorragia posparto, etc.).RESULTADOS:La poblacin de estudio consisti de 70 605 mujeres, de los cuales 50.3% fueroncon sobrepeso/ obesidad.La depresin se inform en el 5,0% de normalesde pesolas mujeres y el 6,2% desobrepeso/ obesidad mujeres.La proporcin de mujeres con complicaciones maternas fue la ms alta entre loscon sobrepeso/ obesidad las mujeres embarazadas con depresin (16% de lo normalde pesono deprimidos, 22% de lo normalde pesodeprimido, el 22% desobrepeso/ obesidad no deprimidos, y el 29% delexceso de peso/ obesidad deprimido, P