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    MD Part 1 Physiology MCQs 27

    February 2011

    40 MCQs

    Multiple true false type MCQs

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    1. Oedema in the following situations is correctly matchedwith the relevant derangements in Starling forces of thecapillary bed.

    A. Nephrotic syndrome - decreased interstitial colloid osmoticpressure

    B. Congestive cardiac failure - increased capillary hydrostatic

    pressureC. Angio- oedema - increased capillary filtration

    coefficent

    D. Chronic lymphatic filariasis - decreased interstitial hydrostaticpressure

    E. Kwashiokor - decreased capillary colloid osmoticpressure

    F T T F T

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    Starling forces

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    A. Pernicious anaemia - defective DNA synthesisB. Sideroblastic anaemia - defective haem synthesisC. Sickle cell anaemia - defective cytoskeleton of the

    red cellD. Beta Thallasaemia major - defective globin chain synthesisE. Hereditary spherocytosis - defective red cell metabolism

    2. The following haematological disorders are correctlymatched with their pathophysiology

    T T F T T

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    Life story of the red cell

    circulation

    Tissuemacrophage

    systemBone

    marrow

    Release/ quality Life span

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    A. increased activity of tissue plasminogen activator (t-PA)

    B. increased activity of tissue thromboplastin (TPL)C. inhibition of cyclo-oxygenaseD. decreased synthesis of factor VIIE. inhibition of formation of platelet IIbIIIa complex

    3. A 70 year old man, who is on long term aspirin andclopidogrel for secondary prevention of IHD presents withsevere melaena and haematochezia. UGIE revealsoesophageal varices. Ultra sound scan findings support

    cirrhosis of the liver. He is transfused 14 packs of red cellconcentrate, several packs of platelets and FFP to restorethe circulating volume. The transfusion takes place over 36hours. Malaena stops on banding oesophageal varices buton the third day he starts to bleed from the IV puncture sites.In this patient, factors that are likely to contribute tobleeding from IV puncture sites include

    T T T T T

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    A. Atrial systole - P waveB. Isovolumetric ventricular contraction - R waveC. Ventricular ejection - ST segmentD. Isovolumetric ventricular relaxation - T wave

    E. Ventricular filling - PR interval

    4. The following phases of the cardiac cycle is/are correctlypaired with the waves/intervals/segments of the ECG

    T T T F F

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    A. EpinephrineB. DigoxinC. HypoxiaD. Hypercarbia

    E. Acidaemia

    5. Which of the following increases the force of contraction ofa cardiac muscle fibre for a given length?

    T T T F F

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    Contractility, causes of change in-

    Strokevolume

    0

    Ventricular End-diastolic volume

    Changes in contractility

    Decrease in contractility

    Increase in contractility

    INCREASE :Sympathetic nervesCatecholaminesDigitalisInotropic agents

    Dopamine

    Force-frequency relation

    DECREASE :Parasympathetic nervesHypoxia, Hypercapnia,

    AcidosisPharmacologicaldepressantsLoss of myocardiumIntrinsic depression

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    A. NOB. PGI2C. EndothelinD. Angiotensin II

    E. Endothelial derived hyper-polarizing factor

    6. Compounds that relax vascular smooth muscle include

    T T F F T

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    A. Hypercapnoea cerebral vasodilatationB. Hypoxaemia - pulmonary vasoconstrictionC. NO - pulmonary vasodilatationD. Epinephrine - cutaneous vasoconstriction

    E. Hyperkalemia - skeletal muscle vasoconstriction

    7. The following stimuli are correctly matched with the vascularresponse evoked

    T T T T F

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    PO2

    PCO2In alveoli

    PO2

    PCO2In alveoli

    Reduced alveolar ventilation;excessive perfusion

    Enhanced alveolar ventilation;inadequate perfusion

    Pulmonary arteriolesServing these alveoliconstrict

    Pulmonary arteriolesServing these alveolidilate

    Reduced alveolar ventilation;

    reduced perfusion

    Enhanced alveolar ventilation;enhanced perfusion

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    A. Increased discharge of aortic baroreceptorsB. Excitation of the vagal innervations of the heart

    C. Decrease in the sympathetic discharge to the heartD. Arteriolar dilatationE. Decreased firing of atrial stretch receptors

    8. A healthy normovolaemic young adult is given anintravenous infusion of 2L of isotonic saline over 30minutes. The cardiovascular regulatory mechanisms that willbe initiated to maintain his blood pressure within normal

    limits include

    T T T T F

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    A. Ankle oedema - activation of RAAMB. Tachycardia - increased stretch in the

    arterial baroreceptorsC. Decreased systolic blood pressure - decreased afterloadD. Elevated JVP - increased right atrial

    contractionE. Third heart sound - increased ventricular filling

    9. A 65 year old man complains of orthopnoea and paroxysmalnocturnal dyspnoea. On examination he has bilateral pittingankle oedema, a pulse rate of 110 beats per minute, a bloodpressure of 80/60 mmHg and an elevated jugular venous

    pressure. His apex beat is felt in the 6th intercostal space inthe anterior axillary line. A third heart sound is heard at theapex.

    The physical signs are correctly matched with the

    pathophysiology.

    T F F F T

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    A. measures the function of the respiratory pump.

    B. is about 6000 ml in a healthy adult.C. is measured with a peak flow meterD. is greater in trained athletes than in sedentary adultsE. decreases when lying down from an erect position

    10. Vital capacity

    T T F T T

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    A. measures the integrity of the alveolo-capillary membrane

    B. is estimated using carbon dioxideC. needs to be corrected for the haemoglobin levelD. decreases in alveolar oedemaE. increases during isotonic exercise

    11. Diffusing capacity of lungs

    T F T T T

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    A. is steep when PO2 is between 80- 100 mmHg

    B. shows the relationship between haemoglobin content andoxygen content in bloodC. assumes its shape because of tense- relaxed

    interconversion of haemoglobinD. shows that unloading of oxygen is facilitated when PO2 in

    blood is 50 mmHgE. is shifted to the left when 2,3 biphosphoglycerate levels are

    increased in blood

    12. Oxygen- haemoglobin dissociation curve

    F F T T F

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    O2-Haemoglobin dissociation curve

    P50

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    Condition Response

    Increased pH in body fluids - increasedrespiratory rate

    Hyperinflation of lungs - bronchoconstriction Chronic hypoxia - increased

    erythropoiesis

    Isotonic exercise - pulmonary vasodilatation

    Reduction of blood supply to a lung segment - bronchodilatation inthat segment

    13. The following conditions are paired correctly with theresponses evoked by them

    F T T T F

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    A. quiet inspirationB. quiet expirationC. forced expirationD. PneumothoraxE. atelectasis

    14. Intra-pleural pressure becomes positive relative to theatmospheric pressure in

    F F T T F

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    -2.5 mmHg

    0

    0

    AT REST

    Intrapleural

    space

    Elastic recoil forces of the lung

    and chest wall are pulling in

    opposite directions, resulting in

    a negative pressure in the

    intrapleural space.

    IPP

    These forces just

    balance each other

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    A. is the state of contraction of bronchial smooth muscle

    B. has a circadian rhythmC. when increased leads to turbulent air flowD. remains unchanged during a normal respiratory cycleE. is decreased with cholinergic stimulation of bronchial smooth

    muscle

    15. Bronchial tone

    T T T F F

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    Calibre of airways and resistance

    Diameter 1

    Narrower the airway higher the

    resistance

    Airway resistance

    Asthma

    Increased smooth muscle tone

    Oedema of the submucosal layer

    Obstruction of the lumen by secretions

    Smooth muscleSubmucosa

    Mucosa

    d

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    A. is a determinant of arterial oxygenation

    B. changes with postural differencesC. is independent of right ventricular outputD. is influenced by the concentration of inhaled oxygenE. when increased is referred to as alveolar dead space

    16. V/Q ratio in the lungs

    T T F T T

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    A. Most of it is transported as carbamino compounds

    B. Chloride shift occurs in the red cells in venous bloodC. A large partial pressure gradient is seen across the

    alveolocapillary membraneD. Release of O2 at tissue level increases the affinity of

    haemoglobin to CO2

    E. Its solubility in biological membranes facilitates the process

    17. Regarding elimination of CO2

    F T F T T

    Binds toInterstitial

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    Tissue cell

    CO2

    CO2

    CO2

    O2

    O2

    O2 (dissolved in plasma)

    Bloodplasma

    CO2

    CO2

    CO2 CO2 (dissolved in plasma)

    CO2 CO2 + H2O H2CO3 HCO3- + H+

    Binds toplasma proteins

    CO2 + H2O H2CO3 HCO3- + H+

    Fast

    Carbonicanhydrase

    CO2 + Hb = HbCO2Carbamino-hemoglobin

    HbO2 O2 + HbRed blood cell

    HCO3-

    Cl-

    HHb

    Cl-

    Chlorideshift

    fluid

    Fused basal laminae

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    CO2 CO2 (dissolved in plasma)

    CO2 CO2 + H2O H2CO3 HCO3- + H+

    CO2 + H2O H2CO3 H+ + HCO3

    -Fast

    Carbonicanhydrase

    CO2 + Hb

    HbCO2

    Fused basal laminae

    Slow

    O2 + HHb HbO2 + H+

    Carbamino-hemoglobin

    HCO3-

    Cl-

    Reverse Chlorideshift

    Cl-

    Blood plasma

    Red blood cell

    O2 (dissolved in plasma)

    CO2

    CO2

    O2

    O2

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    A. Increased uptake of glucose into skeletal muscle cells.B. Increased activity of the thoracic pump.C. Decrease in lymph flow.D. Accumulation of interstitial fluid in exercising muscles.E. Increased alveolar capillary oxygen gradient in lungs.

    18. Following are known to occur during moderate isotonicexercise.

    T T F T T

    19 A 24 ld di l t d t i t d i f hi fi l

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    A. Growth hormoneB. InsulinC. NorepinephrineD. ThyroxineE. Vasopressin

    19. A 24- year old medical student is studying for his finalMBBS. He has had a clean record of health so far. He misseshis dinner on the day before the medicine paper and staysup the whole night. Which of the following hormones will be

    present in excess amounts in his circulation, just beforebreakfast, the following morning?

    T F T F T

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    Endocrine regulation ofcarbohydrate metabolism

    Starch

    Gut

    Glucose

    Blood

    Tissues

    Glycogen

    insulin

    insulin

    catecholamines

    Thyroidhormones

    Thyroid hormones

    Glucocorticoids/glucagon

    GH/Glucocorticoids

    Protein catabolismLipid catabolism

    Glucocorticoids/GH/ Glucagon

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    A. Acromegaly - insulin hypoglycaemia testB. Hypopituitarism - glucose tolerance testC. Syndrome of inappropriate ADH secretion - water deprivation testD. Addisons disease - short synacthen testE. Cushings syndrome - dexamethasone suppression

    test

    20. The following disorders are paired correctly with the teststhat help in diagnosis

    F F F T T

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    A. secretion is stimulated by increased stretch of atrial baroreceptosB. primarily act on cytoplasmic receptorsC. increases the number of aquaporins in the collecting ductsD. facilitates reabsorption of water in the proximal convoluted tubuleE. when secreted in excess cause dilutional hyponatreamia

    21. Antidiuretic hormone

    F F T F T

    22 A 25 year old woman complains of weight loss over the last

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    A. weight loss is due to increased calorigenic action of thyroxineB. warmth in the hands is due to cutaneous vasodilatationC. increased heart rate is due to direct action of thyroxine on the SA

    nodeD. sweating is best treated by parasympathetic blockers.E. a high LDL level is an expected finding

    22. A 25 year old woman complains of weight loss over the last6 months. She feels unusually warm and sweaty all the timeand complains of rising from a squatting position. Onexamination her hands are warm and moist and have fine

    tremors. Her pulse is irregularly irregular with a rate ofapproximately 120 beats per minute. She has proptosis anda palpable smooth goiter. Investigations show an increasedFT4 with suppressed TSH. In this woman

    T T T F F

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    A. decreased bone resorptionB. decreased renal tubular absorption of calciumC. decreased gut absorption of calciumD. reduced excretion of phosphate by kidneysE. poor dietary intake of calcium

    23. A 54 year old man complains of severe anorexia, nausea,generalized swelling and parasthesia of hands and feet. Hehas a serum calcium of 3.3 meq/L (4.3-5.3 meq/L). His GFR is

    25 ml/ minute. Ultrasonically his kidneys are small with poorcorticomedullary demarcation. He has not yet beenprescribed calcium replacement therapy. In this person, themechanisms leading to a low serum calcium level include

    F T T T T

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    A. Amino acidsB. GlucoseC. PotassiumD. CalciumE. Ketones

    24. Insulin facilitates the entry of following compounds toskeletal muscle cells.

    T T T F T

    25 Pathophysiology of hyperglycaemia in insulin deficiency

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    A. increased intestinal absorption of glucose

    B. increased renal tubular absorption of glucoseC. decreased number of GLUT transporters in adipose tissueD. decreased number of GLUT transporters in skeletal muscle cellsE. decreased activity of glucokinase in the hepatocytes

    25. Pathophysiology of hyperglycaemia in insulin deficiencyinvolves

    F F T T T

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    Pool of GLUT 4

    26 The follo ing meas rements belong to an 18 ear old

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    A. Renal plasma flow is calculated by above informationB. GFR is calculated by above informationC. He has diminished renal functionsD. The investigations are consistent with volume depletionE. He is likely to have eaten a high protein meal soon before the

    investigations

    26. The following measurements belong to an 18 year oldindividual.

    urine creatinine - 35 mg/dL

    Urine volume 3300 ml/ 24 hoursPlasma creatinine-0.7 mg/dLBlood urea- highHaematocrit - normal

    Which of the following are true/false about this person?

    F T F F T

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    GFR= UV/P

    U=35

    V=3300/24X60=2.29

    P=0.7

    35X 2.29/0.7=114.5

    27 Kid f f ll i h

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    A. Erythropoietin

    B. 1 25 DHCCC. AldosteroneD. Atrial natriuretic peptideE. Parathyroid hormone

    27. Kidneys are target organs of following hormones

    F T T T T

    28 A 54 ld l i d i d h di l l i h

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    A. Decreased Na reabsorption in the proximal convoluted tubuleB. Decreased renal threshold for glucoseC. increased secretion of angiotensin IID. Increased secretion of vasopressinE. Increased HCO3 in the extracellular fluid

    28. A 54 year old male is admitted to the medical casualty with

    dyspnoea and drowsiness. He has a history of diabetes mellitusand has suffered from polyuria and polydipsia in the recent fewweeks. On examination his pulse is thread with a rate of 110 beats

    per minute. His blood pressure is 90/60 mmHg.

    Investigation results are as follows.

    RBS- 568 mg/dL

    Urinalysis - reducing substances +++ketone bodies positive

    Which of the following findings are consistent with this patient?

    T F T T F

    29 A 25 ld h lth f l i d i d f t f 8

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    29. A 25 year old healthy female is deprived of water for 8hours. Her hydration status was satisfactory prior towater deprivation. Her plasma and urine osmolalitybefore and after water deprivation are shown below

    At the end of 8 hoursA. Her ADH levels will be higher than normalB. Increased urine osmolality is due to increased aldosterone

    secretionC. Osmoreceptors in the hypothalamus are inhibitedD. Urine output will be decreasedE. Specific gravity of urine will be high.

    Normal

    range(mosm/kg H2O)Before

    deprivationAfter

    deprivation

    Plasma

    osmololality280-295 285 289

    Urine osmolality 50- 1400 400 750

    T F F T T

    30 A 60 year old man suffered a massive bout of

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    30. A 60 year old man suffered a massive bout ofhaematemesis. On admission to the hospital he is pale,restless, and has cold peripheries. The blood pressure is90/60mmHg with a pulse rate of 120 per minute. An in-

    dwelling urinary catheter is inserted and 30 ml dark urineis collected. In this man,

    A. GFR is reduced due to decreased renal plasma flowB. Urinary Na excretion is increasedC. There is maximal vasopressin secretionD. ANP secretion is increasedE. Thirst is stimulated via baro- receptors in blood vessels

    T F T F T

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    Peripheralvasoconstriction

    Sympathetic activation

    BP

    Increased HR &contractility

    Adrenal medullaryCatecholaminesecretion

    Baro

    VMC

    Baro

    activation of RAAM

    Renal Na & H2Oretention

    Vasopressinsecretion

    - +

    Thirst

    hypothalamusVagal stimulation

    -

    +

    -

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    Normal values for questions 31 and 32.

    PaO2- 85-100 mmHgPaCO2- 35-45 mmHg

    H+ concentration- 37-42 nanomol/LHCO3 concentration- 24-28 mmol/L

    31 A 54 year old male is suffering from cardiac failure

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    31. A 54 year old male is suffering from cardiac failurefollowing a myocardial infarction. He is breathless andmildly cyanotic on examination. His arterial blood gasanalysis reveals a pH of 7.2, HCO3 concentration of 14

    mmol/L, PCO2 of 32 mmHg and PO2 of 65 mmHg. In thispatient

    A. the actual H+ concentration is likely to be 20 nanomol/LB. the primary acid base disorder is in the respiratory systemC. urine is likely to have a decreased HCO3/H+ ratioD. renal acid excretion is facilitated by the current PCO2 level.E. arterial oxygen saturation is likely to be 95%.

    F F T F F

    32 A 30 ld h lth l t i li bi

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    32. A 30 year old healthy male goes on a mountain climbingexpedition in the Himalayas. He reaches the first camp at3000 meters and spends two days there. On the secondday he is found to have a respiratory rate of 34 breaths/minute and complains of faintness. This person is likelyto have

    A. a plasma pH of > 7.4B. a PCO2 of 45 mmHgC. bicarbonaturiaD. an increased anion gapE. cerebral vasodilatation

    T F T F F

    33 Stimulants of Gastric acid secretion include

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    33. Stimulants of Gastric acid secretion include

    A. stretching of the stomach wall

    B. presence of a high protein content in the stomachC. Helicobacter pylori infection of the stomachD. presence of a high fat content in the duodenumE. hypoglycaemia

    T T F F T

    34 A 32 ld f d t h bili bi f

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    34. A 32 year old man was found to have a serum bilirubin of5 mg/dL on a routine medical check. All the other liverbiochemistry and physical examination is normal. Hisreticulocyte count is within normal limits. Hishyperbilirubinaemia is likely to be due to

    A. decreased UDP glucuronyl transferase activity.B. decreased uptake of bilirubin into liver cells.C. impaired secretion of bile in to the biliary canaliculi.D. increased breakdown of red cells.E. intrahepatic bile duct obstruction.

    T T F F F

    Matured red cellRed cell production and

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    Life span 120 days

    Globin ReutilizedDestruction inreticuloendothelial system

    Fe

    Haem

    Iron Reutilized

    C CBilirubin

    Transport in plasma bound to albuminEnterohepatic Circulation of urobilinogen

    Urinary urobilinogen

    Gut

    Stercobilinogen

    Urobilinogen

    Bilirubinglucuronide

    pbreakdown

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    Bile pigments

    Heam Globin

    Porphyrin Fe++

    Biliverdin

    Bilirubin

    Bilirubin +albumin

    Circulation

    RES cell eg.Kupffer cellsof liver

    Hepatocyte

    Bilirubin + 2UDPGA

    glucuronyltransferase

    Bilirubin

    diglucuronide

    breakdown

    RBC Hb Hb

    Excreted in bile

    35 Following GI hormones and their actions are correctly

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    35. Following GI hormones and their actions are correctlypaired.

    A. Gastrin - stimulation of mucosalgrowth of the stomachB. Secretin - stimulation of pancreatic

    juice secretionC. Cholecystokinin-Pancreozymin - relaxation of the gall

    bladder

    D. Somatostatin - inhibition of gastric acidsecretionE. Vasoactive Intestinal Polypeptide - secretion of electrolytes

    from the small intestine

    T T F T T

    36 The following structures are depolarized due to opening

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    36. The following structures are depolarized due to openingof Voltage gated Na channels.

    A. Visceral smooth muscleB. Motor nervesC. Skeletal muscleD. Cardiac muscleE. Cardiac pace maker tissue

    F T T T F

    37 A myelinated nerve

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    37. A myelinated nerve

    A. evokes a local response with a sub-threshold stimulus

    B. has sodium channels distributed evenly along its lengthC. is refractory to stimulation during the spike potentialD. is susceptible to conduction block with hypoxiaE. does not regenerate after damage

    T F T T F

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    38 Regarding the stretch reflex

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    38. Regarding the stretch reflex

    A. Muscle spindle is the receptor.

    B. The excitatory pathway is polysynaptic.C. The main efferents are motor neurons.D. Motor cortex has inhibitory inputs to the stretch reflex.E. Basal ganglia facilitate the stretch reflex.

    F F T T T

    Dorsal rootganglion

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    g g

    MotorNeuron of

    Protagonistmuscle

    Ventralroot

    Antagonist muscle

    Motor

    neuron ofAntagonist

    muscle

    interneuronreleasingglycine

    Protagonistmuscle

    39 Withdrawal reflex

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    39. Withdrawal reflex

    A. is prepotent.

    B. is monosynaptic.C. occurs as a result of contractions of ipsilateral extensormuscles.

    D. removes the limbs from harmful stimuli.

    E. is accompanied with a crossed extensor response.

    T F F T T

    40 Sensory receptors

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    40. Sensory receptors

    A. are sensory nerve endings

    B. produce generator potentials proportionate to the strength ofthe stimulusC. are found more concentrated in the viscera than the somaD. can transform chemical energy in to action potentialsE. have a low threshold for their adequate stimuli

    T T F T T

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    Best response MCQS

    Select the best answer.

    1 A 22 year old previously healthy young woman was

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    1. A 22 year old previously healthy young woman wasfound to be hyperventilating on admission to thehospital. She complained of dizziness and pins andneedles in her hands and feet. On examination she hadcarpal spasms. Rest of the system examination wasunremarkable. Which of the following biochemical profilematches her clinical profile?

    A. Both serum ionized calcium and free hydrogen levels will beincreasedB. Both serum ionized calcium and free hydrogen levels will be

    decreasedC. Both serum ionized calcium and free hydrogen levels will be

    normal

    D. Serum ionized calcium will be increased and free Hydrogen ionswill be decreasedE. Serum ionized calcium will be decreased and free Hydrogen ions

    will be increased

    B

    2. A 35 year old female tea estate worker from Talawakelle is admitted tothe rural hospital with fever, productive cough with rusty sputum and

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    the rural hospital with fever, productive cough with rusty sputum anddifficulty in breathing. She has left sided pleuritic pain. Onexamination she has a respiratory rate of 30 breaths/ minute, reducedchest expansion on the left side, dull percussion note and crepitationsin the left lower zone. She is mildly pale but not cyanotic. Theinvestigations reveal a haemoglobin content of 10 g/dL, a white cellcount of 17000/mm3 with a differential neutrophil leucocytosis and anESR of 78 mm in the first hour. On the second day followingadmission her respiratory symptoms worsen and she becomesrestless. The attending medical officer suspects severe tissue hypoxia

    and plans to transfer her to a provincial hospital for specializedmanagement.

    The most likely reason for suspected tissue hypoxia here is

    A. severe ventilation perfusion imbalance

    B. respiratory muscle fatigueC. a combination of ventilation perfusion imbalance and respiratory musclefatigue

    D. decreased concentration of inhaled oxygenE. decreased cellular cytochrome oxidase level activity

    C

    3. A 30 year old woman presents with drooping of eyelids

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    and diplopia for 3 months. She notes that symptomsworsen towards the end of the day. EMG showsdecremental potentials during repetitive stimulation and

    is otherwise normal. Mediastinal magnetic resonanceimaging confirms thymic hyperplasia.

    The most probable reason for the symptoms in thiswoman is

    A. post- synaptic inhibition of ligand gated Na+- K+ channelsB. decreased quantal release of acetylcholine from the pre

    synaptic end

    C. pre- synaptic inhibition of voltage gated Ca channelsD. a raised level of acetylcholine esterase in the synaptic cleftE. decreased conduction velocity of motor nerves

    A

    EVENTS AT NERVE ENDING

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    EVENTS AT NERVE ENDING

    Ca

    Ach

    Ach

    Ach

    Ach

    Ach

    - - - - - - - - - - -

    - - - - - - - - - - -

    + + + + + + + +

    + + + + + + + ++

    +

    +

    - - +

    -

    - -+

    Ach --vesicles containing Acetylcholine

    Ca -- Calcium ionsSynaptic

    cleft

    Axon Ca

    Ca

    CaCa

    Events at motor end plate

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    Events at motor end plate

    Na+

    K+

    - - - - -

    + + +

    -- Acetylcholine molecule

    -- Acetylcholine receptor

    Motor end plate

    Na+

    sarcolemma

    + + + + + + + +

    + + +

    - - -

    Ligand- gated

    channel

    4. A 40 year old man presents with changing faciali ht i d diffi lt i tti f

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    appearance, weight gain, and difficulty in getting up froma squat, polyuria and polydipsia. He has a history ofunsupervised treatment for severe chronic asthma.

    Examination and investigations reveal abdominalobesity, proximal muscle weakness, a raised bloodpressure and hyperglycaemia. In this patient, which ofthe following is nota component of the pathophysiologyof raised blood pressure?

    A. Permissive action of glucocorticoids on catecholaminesB. Increased sodium and water retentionC. Direct action of glucocorticoids on blood vessels

    D. Direct action of angiotensin II on blood vesselsE. Compromised renal blood supply

    E

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    Further reading:

    Review of Medical Physiology WF Ganong 22nd editionTextbook of Medical Physiology Guyton & HallKumar and Clarks Clinical Medicine 7th edition

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    Acknowledgements

    Dr. Suresh Dissanayake

    Dr. Dilshani Dissanayake

    Mrs. Nadeesha Keragala

    All of department of Physiology, Colombo