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MD Part 1 Physiology MCQs 27
February 2011
40 MCQs
Multiple true false type MCQs
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1. Oedema in the following situations is correctly matchedwith the relevant derangements in Starling forces of thecapillary bed.
A. Nephrotic syndrome - decreased interstitial colloid osmoticpressure
B. Congestive cardiac failure - increased capillary hydrostatic
pressureC. Angio- oedema - increased capillary filtration
coefficent
D. Chronic lymphatic filariasis - decreased interstitial hydrostaticpressure
E. Kwashiokor - decreased capillary colloid osmoticpressure
F T T F T
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Starling forces
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A. Pernicious anaemia - defective DNA synthesisB. Sideroblastic anaemia - defective haem synthesisC. Sickle cell anaemia - defective cytoskeleton of the
red cellD. Beta Thallasaemia major - defective globin chain synthesisE. Hereditary spherocytosis - defective red cell metabolism
2. The following haematological disorders are correctlymatched with their pathophysiology
T T F T T
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Life story of the red cell
circulation
Tissuemacrophage
systemBone
marrow
Release/ quality Life span
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A. increased activity of tissue plasminogen activator (t-PA)
B. increased activity of tissue thromboplastin (TPL)C. inhibition of cyclo-oxygenaseD. decreased synthesis of factor VIIE. inhibition of formation of platelet IIbIIIa complex
3. A 70 year old man, who is on long term aspirin andclopidogrel for secondary prevention of IHD presents withsevere melaena and haematochezia. UGIE revealsoesophageal varices. Ultra sound scan findings support
cirrhosis of the liver. He is transfused 14 packs of red cellconcentrate, several packs of platelets and FFP to restorethe circulating volume. The transfusion takes place over 36hours. Malaena stops on banding oesophageal varices buton the third day he starts to bleed from the IV puncture sites.In this patient, factors that are likely to contribute tobleeding from IV puncture sites include
T T T T T
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A. Atrial systole - P waveB. Isovolumetric ventricular contraction - R waveC. Ventricular ejection - ST segmentD. Isovolumetric ventricular relaxation - T wave
E. Ventricular filling - PR interval
4. The following phases of the cardiac cycle is/are correctlypaired with the waves/intervals/segments of the ECG
T T T F F
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A. EpinephrineB. DigoxinC. HypoxiaD. Hypercarbia
E. Acidaemia
5. Which of the following increases the force of contraction ofa cardiac muscle fibre for a given length?
T T T F F
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Contractility, causes of change in-
Strokevolume
0
Ventricular End-diastolic volume
Changes in contractility
Decrease in contractility
Increase in contractility
INCREASE :Sympathetic nervesCatecholaminesDigitalisInotropic agents
Dopamine
Force-frequency relation
DECREASE :Parasympathetic nervesHypoxia, Hypercapnia,
AcidosisPharmacologicaldepressantsLoss of myocardiumIntrinsic depression
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A. NOB. PGI2C. EndothelinD. Angiotensin II
E. Endothelial derived hyper-polarizing factor
6. Compounds that relax vascular smooth muscle include
T T F F T
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A. Hypercapnoea cerebral vasodilatationB. Hypoxaemia - pulmonary vasoconstrictionC. NO - pulmonary vasodilatationD. Epinephrine - cutaneous vasoconstriction
E. Hyperkalemia - skeletal muscle vasoconstriction
7. The following stimuli are correctly matched with the vascularresponse evoked
T T T T F
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PO2
PCO2In alveoli
PO2
PCO2In alveoli
Reduced alveolar ventilation;excessive perfusion
Enhanced alveolar ventilation;inadequate perfusion
Pulmonary arteriolesServing these alveoliconstrict
Pulmonary arteriolesServing these alveolidilate
Reduced alveolar ventilation;
reduced perfusion
Enhanced alveolar ventilation;enhanced perfusion
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A. Increased discharge of aortic baroreceptorsB. Excitation of the vagal innervations of the heart
C. Decrease in the sympathetic discharge to the heartD. Arteriolar dilatationE. Decreased firing of atrial stretch receptors
8. A healthy normovolaemic young adult is given anintravenous infusion of 2L of isotonic saline over 30minutes. The cardiovascular regulatory mechanisms that willbe initiated to maintain his blood pressure within normal
limits include
T T T T F
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A. Ankle oedema - activation of RAAMB. Tachycardia - increased stretch in the
arterial baroreceptorsC. Decreased systolic blood pressure - decreased afterloadD. Elevated JVP - increased right atrial
contractionE. Third heart sound - increased ventricular filling
9. A 65 year old man complains of orthopnoea and paroxysmalnocturnal dyspnoea. On examination he has bilateral pittingankle oedema, a pulse rate of 110 beats per minute, a bloodpressure of 80/60 mmHg and an elevated jugular venous
pressure. His apex beat is felt in the 6th intercostal space inthe anterior axillary line. A third heart sound is heard at theapex.
The physical signs are correctly matched with the
pathophysiology.
T F F F T
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A. measures the function of the respiratory pump.
B. is about 6000 ml in a healthy adult.C. is measured with a peak flow meterD. is greater in trained athletes than in sedentary adultsE. decreases when lying down from an erect position
10. Vital capacity
T T F T T
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A. measures the integrity of the alveolo-capillary membrane
B. is estimated using carbon dioxideC. needs to be corrected for the haemoglobin levelD. decreases in alveolar oedemaE. increases during isotonic exercise
11. Diffusing capacity of lungs
T F T T T
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A. is steep when PO2 is between 80- 100 mmHg
B. shows the relationship between haemoglobin content andoxygen content in bloodC. assumes its shape because of tense- relaxed
interconversion of haemoglobinD. shows that unloading of oxygen is facilitated when PO2 in
blood is 50 mmHgE. is shifted to the left when 2,3 biphosphoglycerate levels are
increased in blood
12. Oxygen- haemoglobin dissociation curve
F F T T F
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O2-Haemoglobin dissociation curve
P50
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Condition Response
Increased pH in body fluids - increasedrespiratory rate
Hyperinflation of lungs - bronchoconstriction Chronic hypoxia - increased
erythropoiesis
Isotonic exercise - pulmonary vasodilatation
Reduction of blood supply to a lung segment - bronchodilatation inthat segment
13. The following conditions are paired correctly with theresponses evoked by them
F T T T F
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A. quiet inspirationB. quiet expirationC. forced expirationD. PneumothoraxE. atelectasis
14. Intra-pleural pressure becomes positive relative to theatmospheric pressure in
F F T T F
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-2.5 mmHg
0
0
AT REST
Intrapleural
space
Elastic recoil forces of the lung
and chest wall are pulling in
opposite directions, resulting in
a negative pressure in the
intrapleural space.
IPP
These forces just
balance each other
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A. is the state of contraction of bronchial smooth muscle
B. has a circadian rhythmC. when increased leads to turbulent air flowD. remains unchanged during a normal respiratory cycleE. is decreased with cholinergic stimulation of bronchial smooth
muscle
15. Bronchial tone
T T T F F
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Calibre of airways and resistance
Diameter 1
Narrower the airway higher the
resistance
Airway resistance
Asthma
Increased smooth muscle tone
Oedema of the submucosal layer
Obstruction of the lumen by secretions
Smooth muscleSubmucosa
Mucosa
d
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A. is a determinant of arterial oxygenation
B. changes with postural differencesC. is independent of right ventricular outputD. is influenced by the concentration of inhaled oxygenE. when increased is referred to as alveolar dead space
16. V/Q ratio in the lungs
T T F T T
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A. Most of it is transported as carbamino compounds
B. Chloride shift occurs in the red cells in venous bloodC. A large partial pressure gradient is seen across the
alveolocapillary membraneD. Release of O2 at tissue level increases the affinity of
haemoglobin to CO2
E. Its solubility in biological membranes facilitates the process
17. Regarding elimination of CO2
F T F T T
Binds toInterstitial
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Tissue cell
CO2
CO2
CO2
O2
O2
O2 (dissolved in plasma)
Bloodplasma
CO2
CO2
CO2 CO2 (dissolved in plasma)
CO2 CO2 + H2O H2CO3 HCO3- + H+
Binds toplasma proteins
CO2 + H2O H2CO3 HCO3- + H+
Fast
Carbonicanhydrase
CO2 + Hb = HbCO2Carbamino-hemoglobin
HbO2 O2 + HbRed blood cell
HCO3-
Cl-
HHb
Cl-
Chlorideshift
fluid
Fused basal laminae
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CO2 CO2 (dissolved in plasma)
CO2 CO2 + H2O H2CO3 HCO3- + H+
CO2 + H2O H2CO3 H+ + HCO3
-Fast
Carbonicanhydrase
CO2 + Hb
HbCO2
Fused basal laminae
Slow
O2 + HHb HbO2 + H+
Carbamino-hemoglobin
HCO3-
Cl-
Reverse Chlorideshift
Cl-
Blood plasma
Red blood cell
O2 (dissolved in plasma)
CO2
CO2
O2
O2
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A. Increased uptake of glucose into skeletal muscle cells.B. Increased activity of the thoracic pump.C. Decrease in lymph flow.D. Accumulation of interstitial fluid in exercising muscles.E. Increased alveolar capillary oxygen gradient in lungs.
18. Following are known to occur during moderate isotonicexercise.
T T F T T
19 A 24 ld di l t d t i t d i f hi fi l
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A. Growth hormoneB. InsulinC. NorepinephrineD. ThyroxineE. Vasopressin
19. A 24- year old medical student is studying for his finalMBBS. He has had a clean record of health so far. He misseshis dinner on the day before the medicine paper and staysup the whole night. Which of the following hormones will be
present in excess amounts in his circulation, just beforebreakfast, the following morning?
T F T F T
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Endocrine regulation ofcarbohydrate metabolism
Starch
Gut
Glucose
Blood
Tissues
Glycogen
insulin
insulin
catecholamines
Thyroidhormones
Thyroid hormones
Glucocorticoids/glucagon
GH/Glucocorticoids
Protein catabolismLipid catabolism
Glucocorticoids/GH/ Glucagon
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A. Acromegaly - insulin hypoglycaemia testB. Hypopituitarism - glucose tolerance testC. Syndrome of inappropriate ADH secretion - water deprivation testD. Addisons disease - short synacthen testE. Cushings syndrome - dexamethasone suppression
test
20. The following disorders are paired correctly with the teststhat help in diagnosis
F F F T T
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A. secretion is stimulated by increased stretch of atrial baroreceptosB. primarily act on cytoplasmic receptorsC. increases the number of aquaporins in the collecting ductsD. facilitates reabsorption of water in the proximal convoluted tubuleE. when secreted in excess cause dilutional hyponatreamia
21. Antidiuretic hormone
F F T F T
22 A 25 year old woman complains of weight loss over the last
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A. weight loss is due to increased calorigenic action of thyroxineB. warmth in the hands is due to cutaneous vasodilatationC. increased heart rate is due to direct action of thyroxine on the SA
nodeD. sweating is best treated by parasympathetic blockers.E. a high LDL level is an expected finding
22. A 25 year old woman complains of weight loss over the last6 months. She feels unusually warm and sweaty all the timeand complains of rising from a squatting position. Onexamination her hands are warm and moist and have fine
tremors. Her pulse is irregularly irregular with a rate ofapproximately 120 beats per minute. She has proptosis anda palpable smooth goiter. Investigations show an increasedFT4 with suppressed TSH. In this woman
T T T F F
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A. decreased bone resorptionB. decreased renal tubular absorption of calciumC. decreased gut absorption of calciumD. reduced excretion of phosphate by kidneysE. poor dietary intake of calcium
23. A 54 year old man complains of severe anorexia, nausea,generalized swelling and parasthesia of hands and feet. Hehas a serum calcium of 3.3 meq/L (4.3-5.3 meq/L). His GFR is
25 ml/ minute. Ultrasonically his kidneys are small with poorcorticomedullary demarcation. He has not yet beenprescribed calcium replacement therapy. In this person, themechanisms leading to a low serum calcium level include
F T T T T
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A. Amino acidsB. GlucoseC. PotassiumD. CalciumE. Ketones
24. Insulin facilitates the entry of following compounds toskeletal muscle cells.
T T T F T
25 Pathophysiology of hyperglycaemia in insulin deficiency
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A. increased intestinal absorption of glucose
B. increased renal tubular absorption of glucoseC. decreased number of GLUT transporters in adipose tissueD. decreased number of GLUT transporters in skeletal muscle cellsE. decreased activity of glucokinase in the hepatocytes
25. Pathophysiology of hyperglycaemia in insulin deficiencyinvolves
F F T T T
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Pool of GLUT 4
26 The follo ing meas rements belong to an 18 ear old
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A. Renal plasma flow is calculated by above informationB. GFR is calculated by above informationC. He has diminished renal functionsD. The investigations are consistent with volume depletionE. He is likely to have eaten a high protein meal soon before the
investigations
26. The following measurements belong to an 18 year oldindividual.
urine creatinine - 35 mg/dL
Urine volume 3300 ml/ 24 hoursPlasma creatinine-0.7 mg/dLBlood urea- highHaematocrit - normal
Which of the following are true/false about this person?
F T F F T
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GFR= UV/P
U=35
V=3300/24X60=2.29
P=0.7
35X 2.29/0.7=114.5
27 Kid f f ll i h
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A. Erythropoietin
B. 1 25 DHCCC. AldosteroneD. Atrial natriuretic peptideE. Parathyroid hormone
27. Kidneys are target organs of following hormones
F T T T T
28 A 54 ld l i d i d h di l l i h
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A. Decreased Na reabsorption in the proximal convoluted tubuleB. Decreased renal threshold for glucoseC. increased secretion of angiotensin IID. Increased secretion of vasopressinE. Increased HCO3 in the extracellular fluid
28. A 54 year old male is admitted to the medical casualty with
dyspnoea and drowsiness. He has a history of diabetes mellitusand has suffered from polyuria and polydipsia in the recent fewweeks. On examination his pulse is thread with a rate of 110 beats
per minute. His blood pressure is 90/60 mmHg.
Investigation results are as follows.
RBS- 568 mg/dL
Urinalysis - reducing substances +++ketone bodies positive
Which of the following findings are consistent with this patient?
T F T T F
29 A 25 ld h lth f l i d i d f t f 8
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29. A 25 year old healthy female is deprived of water for 8hours. Her hydration status was satisfactory prior towater deprivation. Her plasma and urine osmolalitybefore and after water deprivation are shown below
At the end of 8 hoursA. Her ADH levels will be higher than normalB. Increased urine osmolality is due to increased aldosterone
secretionC. Osmoreceptors in the hypothalamus are inhibitedD. Urine output will be decreasedE. Specific gravity of urine will be high.
Normal
range(mosm/kg H2O)Before
deprivationAfter
deprivation
Plasma
osmololality280-295 285 289
Urine osmolality 50- 1400 400 750
T F F T T
30 A 60 year old man suffered a massive bout of
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30. A 60 year old man suffered a massive bout ofhaematemesis. On admission to the hospital he is pale,restless, and has cold peripheries. The blood pressure is90/60mmHg with a pulse rate of 120 per minute. An in-
dwelling urinary catheter is inserted and 30 ml dark urineis collected. In this man,
A. GFR is reduced due to decreased renal plasma flowB. Urinary Na excretion is increasedC. There is maximal vasopressin secretionD. ANP secretion is increasedE. Thirst is stimulated via baro- receptors in blood vessels
T F T F T
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Peripheralvasoconstriction
Sympathetic activation
BP
Increased HR &contractility
Adrenal medullaryCatecholaminesecretion
Baro
VMC
Baro
activation of RAAM
Renal Na & H2Oretention
Vasopressinsecretion
- +
Thirst
hypothalamusVagal stimulation
-
+
-
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Normal values for questions 31 and 32.
PaO2- 85-100 mmHgPaCO2- 35-45 mmHg
H+ concentration- 37-42 nanomol/LHCO3 concentration- 24-28 mmol/L
31 A 54 year old male is suffering from cardiac failure
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31. A 54 year old male is suffering from cardiac failurefollowing a myocardial infarction. He is breathless andmildly cyanotic on examination. His arterial blood gasanalysis reveals a pH of 7.2, HCO3 concentration of 14
mmol/L, PCO2 of 32 mmHg and PO2 of 65 mmHg. In thispatient
A. the actual H+ concentration is likely to be 20 nanomol/LB. the primary acid base disorder is in the respiratory systemC. urine is likely to have a decreased HCO3/H+ ratioD. renal acid excretion is facilitated by the current PCO2 level.E. arterial oxygen saturation is likely to be 95%.
F F T F F
32 A 30 ld h lth l t i li bi
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32. A 30 year old healthy male goes on a mountain climbingexpedition in the Himalayas. He reaches the first camp at3000 meters and spends two days there. On the secondday he is found to have a respiratory rate of 34 breaths/minute and complains of faintness. This person is likelyto have
A. a plasma pH of > 7.4B. a PCO2 of 45 mmHgC. bicarbonaturiaD. an increased anion gapE. cerebral vasodilatation
T F T F F
33 Stimulants of Gastric acid secretion include
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33. Stimulants of Gastric acid secretion include
A. stretching of the stomach wall
B. presence of a high protein content in the stomachC. Helicobacter pylori infection of the stomachD. presence of a high fat content in the duodenumE. hypoglycaemia
T T F F T
34 A 32 ld f d t h bili bi f
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34. A 32 year old man was found to have a serum bilirubin of5 mg/dL on a routine medical check. All the other liverbiochemistry and physical examination is normal. Hisreticulocyte count is within normal limits. Hishyperbilirubinaemia is likely to be due to
A. decreased UDP glucuronyl transferase activity.B. decreased uptake of bilirubin into liver cells.C. impaired secretion of bile in to the biliary canaliculi.D. increased breakdown of red cells.E. intrahepatic bile duct obstruction.
T T F F F
Matured red cellRed cell production and
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Life span 120 days
Globin ReutilizedDestruction inreticuloendothelial system
Fe
Haem
Iron Reutilized
C CBilirubin
Transport in plasma bound to albuminEnterohepatic Circulation of urobilinogen
Urinary urobilinogen
Gut
Stercobilinogen
Urobilinogen
Bilirubinglucuronide
pbreakdown
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Bile pigments
Heam Globin
Porphyrin Fe++
Biliverdin
Bilirubin
Bilirubin +albumin
Circulation
RES cell eg.Kupffer cellsof liver
Hepatocyte
Bilirubin + 2UDPGA
glucuronyltransferase
Bilirubin
diglucuronide
breakdown
RBC Hb Hb
Excreted in bile
35 Following GI hormones and their actions are correctly
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35. Following GI hormones and their actions are correctlypaired.
A. Gastrin - stimulation of mucosalgrowth of the stomachB. Secretin - stimulation of pancreatic
juice secretionC. Cholecystokinin-Pancreozymin - relaxation of the gall
bladder
D. Somatostatin - inhibition of gastric acidsecretionE. Vasoactive Intestinal Polypeptide - secretion of electrolytes
from the small intestine
T T F T T
36 The following structures are depolarized due to opening
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36. The following structures are depolarized due to openingof Voltage gated Na channels.
A. Visceral smooth muscleB. Motor nervesC. Skeletal muscleD. Cardiac muscleE. Cardiac pace maker tissue
F T T T F
37 A myelinated nerve
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37. A myelinated nerve
A. evokes a local response with a sub-threshold stimulus
B. has sodium channels distributed evenly along its lengthC. is refractory to stimulation during the spike potentialD. is susceptible to conduction block with hypoxiaE. does not regenerate after damage
T F T T F
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38 Regarding the stretch reflex
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38. Regarding the stretch reflex
A. Muscle spindle is the receptor.
B. The excitatory pathway is polysynaptic.C. The main efferents are motor neurons.D. Motor cortex has inhibitory inputs to the stretch reflex.E. Basal ganglia facilitate the stretch reflex.
F F T T T
Dorsal rootganglion
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g g
MotorNeuron of
Protagonistmuscle
Ventralroot
Antagonist muscle
Motor
neuron ofAntagonist
muscle
interneuronreleasingglycine
Protagonistmuscle
39 Withdrawal reflex
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39. Withdrawal reflex
A. is prepotent.
B. is monosynaptic.C. occurs as a result of contractions of ipsilateral extensormuscles.
D. removes the limbs from harmful stimuli.
E. is accompanied with a crossed extensor response.
T F F T T
40 Sensory receptors
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40. Sensory receptors
A. are sensory nerve endings
B. produce generator potentials proportionate to the strength ofthe stimulusC. are found more concentrated in the viscera than the somaD. can transform chemical energy in to action potentialsE. have a low threshold for their adequate stimuli
T T F T T
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Best response MCQS
Select the best answer.
1 A 22 year old previously healthy young woman was
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1. A 22 year old previously healthy young woman wasfound to be hyperventilating on admission to thehospital. She complained of dizziness and pins andneedles in her hands and feet. On examination she hadcarpal spasms. Rest of the system examination wasunremarkable. Which of the following biochemical profilematches her clinical profile?
A. Both serum ionized calcium and free hydrogen levels will beincreasedB. Both serum ionized calcium and free hydrogen levels will be
decreasedC. Both serum ionized calcium and free hydrogen levels will be
normal
D. Serum ionized calcium will be increased and free Hydrogen ionswill be decreasedE. Serum ionized calcium will be decreased and free Hydrogen ions
will be increased
B
2. A 35 year old female tea estate worker from Talawakelle is admitted tothe rural hospital with fever, productive cough with rusty sputum and
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the rural hospital with fever, productive cough with rusty sputum anddifficulty in breathing. She has left sided pleuritic pain. Onexamination she has a respiratory rate of 30 breaths/ minute, reducedchest expansion on the left side, dull percussion note and crepitationsin the left lower zone. She is mildly pale but not cyanotic. Theinvestigations reveal a haemoglobin content of 10 g/dL, a white cellcount of 17000/mm3 with a differential neutrophil leucocytosis and anESR of 78 mm in the first hour. On the second day followingadmission her respiratory symptoms worsen and she becomesrestless. The attending medical officer suspects severe tissue hypoxia
and plans to transfer her to a provincial hospital for specializedmanagement.
The most likely reason for suspected tissue hypoxia here is
A. severe ventilation perfusion imbalance
B. respiratory muscle fatigueC. a combination of ventilation perfusion imbalance and respiratory musclefatigue
D. decreased concentration of inhaled oxygenE. decreased cellular cytochrome oxidase level activity
C
3. A 30 year old woman presents with drooping of eyelids
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and diplopia for 3 months. She notes that symptomsworsen towards the end of the day. EMG showsdecremental potentials during repetitive stimulation and
is otherwise normal. Mediastinal magnetic resonanceimaging confirms thymic hyperplasia.
The most probable reason for the symptoms in thiswoman is
A. post- synaptic inhibition of ligand gated Na+- K+ channelsB. decreased quantal release of acetylcholine from the pre
synaptic end
C. pre- synaptic inhibition of voltage gated Ca channelsD. a raised level of acetylcholine esterase in the synaptic cleftE. decreased conduction velocity of motor nerves
A
EVENTS AT NERVE ENDING
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EVENTS AT NERVE ENDING
Ca
Ach
Ach
Ach
Ach
Ach
- - - - - - - - - - -
- - - - - - - - - - -
+ + + + + + + +
+ + + + + + + ++
+
+
- - +
-
- -+
Ach --vesicles containing Acetylcholine
Ca -- Calcium ionsSynaptic
cleft
Axon Ca
Ca
CaCa
Events at motor end plate
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Events at motor end plate
Na+
K+
- - - - -
+ + +
-- Acetylcholine molecule
-- Acetylcholine receptor
Motor end plate
Na+
sarcolemma
+ + + + + + + +
+ + +
- - -
Ligand- gated
channel
4. A 40 year old man presents with changing faciali ht i d diffi lt i tti f
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appearance, weight gain, and difficulty in getting up froma squat, polyuria and polydipsia. He has a history ofunsupervised treatment for severe chronic asthma.
Examination and investigations reveal abdominalobesity, proximal muscle weakness, a raised bloodpressure and hyperglycaemia. In this patient, which ofthe following is nota component of the pathophysiologyof raised blood pressure?
A. Permissive action of glucocorticoids on catecholaminesB. Increased sodium and water retentionC. Direct action of glucocorticoids on blood vessels
D. Direct action of angiotensin II on blood vesselsE. Compromised renal blood supply
E
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Further reading:
Review of Medical Physiology WF Ganong 22nd editionTextbook of Medical Physiology Guyton & HallKumar and Clarks Clinical Medicine 7th edition
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Acknowledgements
Dr. Suresh Dissanayake
Dr. Dilshani Dissanayake
Mrs. Nadeesha Keragala
All of department of Physiology, Colombo