Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdullaziz University. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdullaziz University. NEOPLASIANEOPLASIA Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA NEOPLASIA What Why Where When How Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA An abnormal mass the growth of which exceeds and is uncoordinated with that of the normal tissue and persists in the same excessive manner after the cessation of stimuli which evoked the change. Definition : Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA DIFINITIONS TUMOR VS NEOPLASM ONCOLOGY= ONCOS + LOGOS BENIGN = RELATIVELY INNOCENT MALIGNANT = CANCER ( CRAB ) Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Nomenclature Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors: oma + cell type Papilloma : benign surface neoplasm Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors A Polyp : mass projecting above a mucosal surface Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors An Adenoma: benign epithelial neoplasm producing or arising from glands Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors connective tissue Leiomyoma : A benign neoplasm of smooth muscle Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Leiomyoma DR OSAMA I NASSIF FRCPC NEOPLASIA LEIOMYOMA HPF Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Nomenclature Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors Fibroadenoma : more than one cell type, from one germ layer Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors Mixed tumor of salivary glands (pleomorphic adenoma) Derived from one germ layer Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Nomenclature Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign neoplasms Mature teratoma :more than one neoplastic cell type derived from more than one germ layer. Mature teratoma :more than one neoplastic cell type derived from more than one germ layer. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Malignant tumors Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign Vs malignant Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Malignant neoplasms differentiation and anaplasia Adenocarcinoma Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Malignant neoplasms Squamous cell carcinoma: Well-differentiated. Differentiation and anaplasia Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign vs Malignant Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Anaplasia Pleomorphism Hyperchromasia High N/C ratio Polynuclearity High mitotic rate Bizarre shapes/sizes Atypical mitoses Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA HAVE A NICE DAY