7/24/2019 El Sokkary 2001
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Neuro Endocrinol Lett.2001 Apr;22(2):93-9.
Quantitative study on the effects of chronic
ethanoladministration on the testis of adult male rat.
El-Sokkary !.Author informationAbstract
OBJECTIVES
"on#iderin$ t%e po##i&ility t%at alco%oli#' induce# $onadal
dy#unction t%e pre#ent *ork *a#
de#i$ned to in+e#ti$ate t%e 'orp%op%y#iolo$y o rat te#te#
#u&'itted to e,peri'ental alco%oli#'.
!ET"O#S
ale Spra$ue-a*ley rat# *ei$%in$ 1/0-/ $' *ere c%ronically $i+en
$%& ethanol solution at a
dose of ' ()*( body +ei(ht for '% days. ,'-!-t%y'idine
autoradio$rap%ic in+e#ti$ation# and
%i#tolo$ical #tudie# *ere carried out to deter'ine t%e
prolierati+e acti+ity andor dierent #ta$e# o
#per'ato$ene#i# in t%e #e'inierou# tu&ule cycle and Leydi$
cell#.
ES/0TS%e 3!-t%y'idine autoradi$rap%ic in+e#ti$ation re+ealed
t%at t%ere *a# a #i$niicant in%i&ition in t%e
prolierati+e acti+ity o t%e #per'ato$onia in all #ta$e# o t%e
#e'inierou# tu&ule cycle in t%e alco%ol-
treated rat# +er#u# control# a# indicated &y t%e +alue# o
(3)!-la&ellin$ indice#. %e %i#tolo$ical and
nu'erical in+e#ti$ation# indicated t%at t%e alco%ol-treated rat#
pre#ented te#ticular lesions includin(
a si(nificant decrease in the diameter of the seminiferous
tubules1 the number of different
(erm cells in all sta(es of the seminiferous tubule cycle and
the 2resence of de(enerative
(erm cells. In addition1 there +as a si(nificant decrease in the
number of 0eydi( cells.
CO3C0/SIO3
%e pre#ent *ork #u$$e#t# t%e deleteriou# eect# o alco%ol on t%e
te#te#. %e#e eect# 'ay &e due
to t%e eect o alco%ol on t%e $onadotrop%ic cell# o t%e pituitary
$land andor directly on t%e
#e'inierou# tu&ule# and Leydi$ cell
http://www.ncbi.nlm.nih.gov/pubmed/11335885http://www.ncbi.nlm.nih.gov/pubmed/11335885http://www.ncbi.nlm.nih.gov/pubmed?term=El-Sokkary%20GH%5BAuthor%5D&cauthor=true&cauthor_uid=11335885http://www.ncbi.nlm.nih.gov/pubmed/11335885http://www.ncbi.nlm.nih.gov/pubmed?term=El-Sokkary%20GH%5BAuthor%5D&cauthor=true&cauthor_uid=11335885http://www.ncbi.nlm.nih.gov/pubmed/11335885http://www.ncbi.nlm.nih.gov/pubmed/11335885
