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Endocrine system and Hormones - · PDF fileเกี่ยวข้องกบันาฬิกาชีวิต (Biological clock)

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  • Biology by Peeranat Jatoorathaweechot 1

    Endocrine system and Hormones

    1. (Endocrine system and Hormones)

    1.1 (Direct cell communication)

    Gap junction

    1.2 (Neurotransmitter)

    Synaptic cleft

    1.3

    Endocrine gland (Target cell)

    1.4 (Neurohormone)

    (Target cell)

    2. 2

    2.1 (Exocrine gland) : (Duct)

    Ex. , , , ,

    2.2 (Endocrine gland) :

    Ex. , , ,

    http://th.wikipedia.org/wiki/%E0%B9%80%E0%B8%8B%E0%B8%A5%E0%B8%A5%E0%B9%8C

  • Biology by Peeranat Jatoorathaweechot 2

    3. 2

    3.1 (Essential Endocrine gland )

    -

    Ex. Parathyroid gland , Adrenal cortex , Pancreas

    3.2 (Non - essential Endocrine gland )

    -

    Ex. Adrenal medulla , Thyroid

    4. 3

    4.1

    Ex. Thyroid gland , Epinephrine , Nor epinephrine

    4.2 Peptide

    Ex. ADH , Oxytocin , Insulin , Glucagon

    4.3 Steroid

    Ex. Hormones Adrenal cortex , Sex hormones

    5. Hormones

    Peptide / Amine Steriod Thyroid - Cholesterol Thyroglobulin RER SER/Mitochondria SER/Mitochondria Golgi body/Exocytosis Simple diffusion Simple diffusion

    Cell membrane Nucleus Nucleus DNA

    DNA

  • Biology by Peeranat Jatoorathaweechot 3

    6.

    6.1 Hormones Hormones

    6.2 Hormones Transcription Translation

    6.3 Cell Free ribosome

    6.4 Hormones

    - Amine / Peptide : Cell membrane Secondary messeger

    - Steroid : Nucleus Cell

    Mechanism Steroid hormones

    Mechanism Protein / Amine Hormones

  • Biology by Peeranat Jatoorathaweechot 4

    7. 3

    7.1 (Hyposecretion)

    7.2 (Hypersecretion)

    7.3 Ex.

    Endocrine gland

    (Diabetes mellitus)

  • Biology by Peeranat Jatoorathaweechot 5

    8. 3 Glandular hormone

    Tissue hormone , Neurosecretory cell Neurohormone

    8.1 Hypothalamus

    Releasing hormone Inhibiting hormone

    Anterior pituitary gland Anterior pituitary gland

    Neurohormone

    Hypothalamus

    Glandular hormone Pituitary gland

    Posterior pituitary gland

    Anterior pituitary gland

    Parathyroid

    Thyroid

    Islets of Langerhans l Pineal gland l Thymus l

    Tissue hormone

    Gonad l

    Ovary

    Testis Placenta l Stomach l Small intestine l Kidney l

  • Biology by Peeranat Jatoorathaweechot 6

    8.2 Anterior pituitary gland

    Growth hormone or Somatotrophin

    Prolactin (PRL) (Lactation)

    Thyroid stimulating hormone (TSH) Thyroid gland Thyroid gland Thyroid gland

    Adrenocorticotropic hormone (ACTH) Adrenal gland Cortisol Adrenal cortex

    Gonadotropic hormone - FSH (Follicle stimulating hormone)

    - LH (Luteinizing hormone)

    : Seminiferous tubule : Ovary : Leydig cell : Ovary

    (Spermatogenesis) Follicle Estrogen Ovary Testosterone Ovulation Corpus luteum Estrogen , Progesterone

    Melanocyte stimulating hormone (MSH) Pineal gland

    An pituitary Post pituitary

  • Biology by Peeranat Jatoorathaweechot 7

    Anterior pituitary gland

    Growth hormone

    Dwarfism

    Simmons disease

    GH

    GH

    Metabolism

    Gigantism

    GH

    Acromegaly

    GH

  • Biology by Peeranat Jatoorathaweechot 8

    8.3 Posterior pituitary gland

    *Hypothalamus Posterior pituitary gland (Neurohomone) Neurosecretory cell

    Oxytocin (Uterus)

    ADH (Antidiuretic hormone) (Distal convoluted tubule) Osmotic pressure

    Neurosecretory cell

    Anterior pituitary gland

    Axon

    Posterior pituitary gland

    Posterior pituitary gland

    Hypothlamus Axon

    Neurosecretory cell Hypothlamus

  • Biology by Peeranat Jatoorathaweechot 9

    8.4 Thyroid

    Thyroid

    - Thyroxine T4

    - Triiodothyronine T3

    - Calcitonin

    ()

    Metabolism Metabolism Carbohydrate Protein , Lipid Metabolism Ca2+ Ca2+ Ca2+ Ca2+

    8.5 Parathyroid gland

    Parathyroid hormone

    Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+

  • Biology by Peeranat Jatoorathaweechot 10

    Thyroid gland Parathyroid

    Thyroxine

    PTH (Parathormone)

    Cretinism

    Thyroxine

    Myxedema

    Thyroxine

    Toxic goiter

    Thyroid

    Hypothyroidism

    Parathyroid

    Hyperthyroidism

    Parathyroid

    Ca2+

  • Biology by Peeranat Jatoorathaweechot 11

    8.6 Islets of Langerhans

    Insulin ( cell)

    Glucagon ( cell)

    Glycogen Glycogen (Fatty acid) (Adipose tissue) Glycogen (Fat mobilization)

  • Biology by Peeranat Jatoorathaweechot 12

    Islets of Langerhans

    Insulin

    Diabetes mellitus

    Insulin

    Hypoglycemia

    Insulin

    Metabolism

  • Biology by Peeranat Jatoorathaweechot 13

    8.7 Adrenal gland

    Adrenal cortex

    - Mineralocorticoid (Zona Glomerulosa)

    - Glucocorticoid (Zona fasciculata)

    - Sex hormones Adrenal medulla

    - Epinephrine and Norepinephrine

    Na+ K+ Gluconeogenesis (Lipolysis) (Mobilize fat) Sympathetic (Fat mobilzation)

  • Biology by Peeranat Jatoorathaweechot 14

    Adrenal gland

    Cortisol

    8.8 Pineal gland

    Melatonin Hypothalamus

    (Biological clock)

    Addisons disease

    Cortisol

    Simmons disease

    Cortisol

  • Biology by Peeranat Jatoorathaweechot 15

    8.9 Thymus gland

    Thymosin T cell Lymphocyte Lymphocyte T cell Lymphocyte T cell Lymphocyte

    8.10 Gonad

    Ovary

    - Estrogen (estradiol)

    - Progesterone Testis

    - Testosterone

    Sex characteristic (Breast development) (female puberty) Sex characteristic (Spermatogenesis) (Male puberty)

    8.11 placenta

    Estrogen

    Human Chorionic Gonadotropin

    (Placenta)

    (Corpus luteum)

  • Biology by Peeranat Jatoorathaweechot 16

    8.12 Stomach

    Gastrin Stomach Gastric juice

    8.13 Small intestine

    Secretin Cholecystokinin Gastrin inhibitor peptide (GIP)

    NaHCO3 pH (Bile) (Pancreatic juice) (Bile)

    8.14 Kidney

    Erythropoietin Spinal cord

    O2

  • Biology by Peeranat Jatoorathaweechot 17

    9.

    Hormone

    Growth hormone (Anterior pituitary gland ) Dwarfism : Gigantism :

    Simmons disease : Acromegaly :

    Cortisol (Adrenal cortex) Addisons disease Cushings syndrome

    Thyroxine (Thyroid gland) Cretinism :

    Toxic goiter Myxedema :

    Insulin (Pancrease) Diabetes mellitus Hypoglycemia

    PTH : Parathormone (Parathyroid) Hypoparathyriod Hyperparathyriod

    ADH : Vasopressin (Posterior pituitary gland) Diabetes mellitus -

  • Biology by Peeranat Jatoorathaweechot 18

    10.

    ()

    Pituitary gland

    Pineal gland

    Adrenal medulla

    Ectoderm

    Neural crest

    4

    7

    5

    16

    11

    7

    Testis and Ovary

    Adrenal cortex Mesoderm

    6

    5

    8

    7

    Thyroid gland

    Parathyroid gland

    Islets of Langerhans

    Endoderm

    3.5

    7

    12

    12

    9

    14

    11. (Hormones and Homeostasis)

    (Negative feedback mechanism)

    10. Negative feedback mechanism Thyroxine hormone

  • Biology by Peeranat Jatoorathaweechot 19

    10.2 Ca2+ thyroid Parathyroid

    10.3

  • Biology by Peeranat Jatoorathaweechot 20

    12. (Positive feedback mechanism)

    Oxytocin hormone Posterior pituitary gland

    Posterior pituitary gland Oxytocin

    hormone

    13.

    Mollusk , Annelid , Arthropod Echinoderm

    3

    1. Ecdysone (Molting) Ecdysone

    Brian Hormone

    2. Juvenile hormone (Larval

    3. Brain hormone Ecdysone

    stage)

  • Biology by Peeranat Jatoorathaweechot 21

    14. Pheromone

    - Sex attractant : , ,

    - Alarm substance : ,

    - Primer Pheromone : , ,

    Pheromone

    Pheromone species

    Pheromone

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