1

大阪大学大学院薬学研究科研究業績集 (2007)

高分子化学 (Biophysical Chemistry) Purification, crystallization and preliminary X-ray diffraction study of human ribosomal protein L10 core domain Nishimura M, Kaminishi T, Kawazoe M, Shirouzu M, Takemoto C, Yokoyama S, Tanaka A, Sugano S, Yoshida T, Ohkubo T, Kobayashi Y Acta Crystallograph. Sect. F, 63, 950-952 (2007) NMR solution structure of lipocalin-type prostaglandin D synthase: Evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity Shimamoto S, Yoshida T, Inui T, Gohda K, Kobayashi Y, Fujimori K, Tsurumura T, Aritake K, Urade Y, Ohkubo T J. Biol. Chem., 282, 31373-31379 (2007) Crystallization of human nicotinamide phosphoribosyltransferase Takahashi R, Nakamura S, Yoshida T, Kobayashi Y, Ohkubo T Acta Crystallograph. Sect. F, 63, 375-377 (2007) Tautomerism of histidine 64 associated with proton transfer in catalysis of carbonic anhydrase Shimahara H, Yoshida T, Shibata Y, Shimizu M, Kyogoku Y, Sakiyama F, Nakazawa T, Tate S, Ohki S, Kato T, Moriyama H, Kishida K, Tano Y, Ohkubo T, Kobayashi Y J. Biol. Chem., 282, 9646-9656 (2007) NMR structure of a human homologous methuselah gene receptor peptide Kikkou T, Matsumoto O, Ohkubo T, Kobayashi Y, Tsujimoto G Biochem. Biophys. Res. Commun., 352, 17-20 (2007) 機能素子化学 (Medecinal and Organic Chemistry) Bromoallenes as allyl dication equivalents in the presence or absence of palladium(0): Direct construction of bicyclic sulfamides containing five- to eight-membered rings by tandem cyclization of bromoallenes Hamaguchi H, Kosaka S, Ohno H, Fujii N, Tanaka T Chem. Eur. J., 13, 1692-1708 (2007)

A highly regio- and stereoselective formation of bicyclo[4.2.0]oct-5-ene derivatives through thermal intramolecular [2 + 2] cycloaddition of allenes

2

Ohno H, Mizutani T, Kadoh Y, Aso A, Miyamura K, Fujii N, Tanaka T J. Org. Chem., 72, 4378-4389 (2007) Synthesis of fluorescent solamin for visualization of cell distribution Maezaki N, Urabe D, Yano M, Tominaga H, Morioka T, Kojima N, Tanaka T Heterocycles, 73, 159-164 (2007) Zipper-mode double C-H activation: Palladium-catalyzed direct construction of highly-fused heterocyclic systems Ohno H, Iuchi M, Fujii N, Tanaka T Org. Lett., 9, 4813-4815 (2007) Heck-type cyclization of oxime ethers: Stereoselective carbon-carbon bond formation with aryl halides to produce heterocyclic oximes Ohno H, Aso A, Kadoh Y, Fujii N, Tanaka T Angew. Chem. Int. Ed., 46, 6325-6328 (2007) A stereocontrolled construction of rel -(7S, 8S, 7'R, 8'S)-7,7'-epoxylignan skeleton Kitamura M, Hayashi H, Yano M, Tanaka T, Maezaki N Heterocycles, 71, 2669-2680 (2007) Radical fixation of functionalized carbon resources: α-sp3C-H carbamoylation of tertiary amines with aryl isocyanates Yoshimitsu T, Matsuda K, Nagaoka H, Tsukamoto K, Tanaka T Org. Lett., 9, 5115-5118 (2007) フリーラジカルによる α-ヘテロ原子置換 sp3 炭素-水素結合の新変換法の発見と進展

(Review) 好光健彦

ファルマシア, 43, 219-223 (2007) 高反応性ラジカル種が誘起する炭素-炭素および炭素-水素結合変換と生物活性物質合成への

活用 (Review) 好光健彦, 長岡博人, 田中徹明

有機合成化学協会誌, 65, 665-676 (2007) 生体機能分子化学 (Bio-Functional Molecular Chemistry) Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction Ebihara C, Kondoh M, Harada M, Fujii M, Mizuguchi H, Tsunoda S, Horiguchi Y, Yagi K,

3

Watanabe Y Biochem. Pharmacol., 73, 824-830 (2007) Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin Harada M, Kondoh M, Ebihara C, Takahashi A, Komiya E, Fujii M, Mizuguchi H, Tsunoda S, Horiguchi Y, Yagi K, Watanabe Y Biochem. Phamacol., 73, 206-214 (2007) Effect of forskolin on the expression of claudin-5 in human trophoblast BeWo cells Harada M, Kondoh M, Masuyama A, Fujii M, Nakanishi T, Utoguchi N, Yagi K, Watanabe Y Pharmazie, 62, 291-294 (2007) Synergistic effect of D-glucose and epidermal growth factor display on dynamic behaviors of human epithelial cells Kim MH, Kino-oka M, Kawase M, Yagi K, Taya M J. Biosci. Bioeng., 104, 428-431 (2007) Response of human epithelial cells to culture surfaces with varied roughnesses prepared by immobilizing dendrimers with/without D-glucose display Kim MH, Kino-oka M, Kawase M, Yagi K, Taya M J. Biosci. Bioeng., 103, 192-199 (2007) Morphological regulation of rabbit chondrocytes on glucose-displayed surface Kino-oka M, Morinaga Y, Kim MH, Takezawa Y, Kawase M, Yagi K, Taya M Biomaterials, 28, 1680-1688 (2007) Effect of 2-methacryloyloxyethylphosphorylcholine butylmethacrylate copolymer on the skin penetration of 2-ethylhexyl methoxycinnamate Fujii M, Wakui M, Hanada M, Otani H, Ishikawa A, Kondoh M, Watanabe Y J. J. Cos. Sci. Soc., 31, 1-7 (2007) Total synthesis and cytotoxicity of (＋)-and (－)-goniodiol and 6-epi-goniodiol. Construction of α,β-unsaturated lactones by ring-closing metathesis Nakashima K, Kikuchi N, Shirayama D, Miki T, Ando K, Sono M, Suzuki S, Kawase M, Kondoh M, Sato M, Tori M Bull. Chem. Soc. Jpn., 80, 387-394 (2007) Effect of characteristics of compounds on maintenance of an amorphous state in solid dispersion with crospovidone Shibata Y, Fujii M, Kokudai M, Noda S, Okada H, Kondoh M, Watanabe Y J. Pharm. Sci., 96, 1537-1547 (2007)

4

Tight junction modulators: Promising candidates for drug delivery (Review) Kondoh M, Yagi K Curr. Med. Chem., 14, 2482-2488 (2007) Progress in absorption enhancers based on tight junction (Review) Kondoh M, Yagi K Expert Opin. Drug Deliv., 4, 275-286 (2007) Applications of whole-cell bacterial sensors in biotechnology and environmental science (Review) Yagi K Appl. Microbiol. Biotechnol., 73, 1251-1258 (2007) The claudin family as a new approach for drug delivery (Review) Kondoh M, Yagi K Drugs Fut., 32, 1053-1059 (2007) チオレドキシン(TRX) (Review) 八木清仁, 磯田勝広, 近藤昌夫 Surgery Frontier, 14, 197-199 (2007) Barriologyを基盤とした難吸収性薬物の透過促進戦略 (Review) 近藤昌夫, 藤井まき子, 八木清仁, 渡邊善照 薬学雑誌, 127, 601-609 (2007) 大学院薬学研究科生体機能分子化学分野

八木清仁 生産と技術, 59(2), 1-3 (2007) 分子生物学 (Biochemistry and Molecular Biology) Interaction of Mat-8 (FXYD-3) with Na+/K +-ATPase in colorectal cancer cells Arimochi J, Ohashi-Kobayashi A, Maeda M Biol. Pharm. Bull., 30, 648-654 (2007) Cisplatin upregulates Saccharomyces cerevisiae genes involved in iron homeostasis through activation of the iron insufficiency-responsive transcription factor Aft1 Kimura A, Ohashi K, Naganuma A J. Cell. Physiol., 210, 378-384 (2007) Hybrids in Crepidiastrum (Asteraceae) Ohashi H, Ohashi K

5

J. Jpn. Bot., 82, 337-347 (2007) ABC 輸送体 TAP-like と TAP ファミリー (Review) 前田正知, 大橋綾子 生化学, 79, 588-596 (2007) 分子合成化学 (Synthetic Organic Chemistry) Cerium ammonium nitrate (CAN) for mild and efficient reagent to remove hydroxyethyl units from 2-hydroxyethyl ethers and 2-hydroxyethyl amines Fujioka H, Hirose H, Ohba Y, Murai K, Nakahara K, Kita Y Tetrahedron, 63, 625-637 (2007) One-pot synthesis of imidazolines from aldehydes: Detailed study about solvents and substrates Fujioka H, Murai K, Kubo O, Ohba Y, Kita Y Tetrahedron, 63, 638-643 (2007) Direct cyanation of heteroaromatic compounds mediated by hypervalent iodine(III) reagents: In situ generation of PhI(III)-CN species and their cyano transfer Dohi T, Morimoto K, Takenaga N, Goto A, Maruyama A, Kiyono Y, Tohma H, Kita Y J. Org. Chem., 72, 109-116 (2007) Oleamide derivatives suppress the spontaneous metastasis by inhibiting connexin 26 Ohba Y, Kanao Y, Morita N, Fujii E, Hohrai M, Takatsuji M, Hirose H, Miura D, Watari A, Yutsudo M, Zhao H, Yabuta N, Ito A, Kita Y, Nojima H Int. J. Cancer, 121, 47-54 (2007) Facile and efficient synthesis of lactols by a domino reaction of 2,3-epoxy alcohols with a hypervalent iodine(III) reagent and its application to the synthesis of lactones and the asymmetric synthesis of (+)-tanikolide Fujioka H, Matsuda S, Horai M, Fujii E, Morishita M, Nishiguchi N, Hata K, Kita Y Chem. Eur. J., 13, 5238-5248 (2007) Reaction of tetrahydropyranyl ethers with triethylsilyl trifluoromethanesulfonate-2,4,6-collidine combination: Speculation on the intermediate, efficient deprotection, and application to efficient ring-closing metathesis as a tether Fujioka H, Okitsu T, Ohnaka T, Sawama Y, Kubo O, Okamoto K, Kita Y Adv. Synth. Catal., 349, 636-646 (2007) First hypervalent iodine(III)-catalyzed C-N bond forming reaction: Catalytic spirocyclization of amides to N-fused spirolactams

6

Dohi T, Maruyama A, Minamitsuji Y, Takenaga N, Kita Y Chem. Commun., 1224-1226 (2007) Alkyl- and arylation of oxacyclic ethers with triethylsilyl triflate－2,4,6-collidine－Gilman reagent combination: Remarkable discrimination of two ether oxygens Fujioka H, Ohnaka T, Okitsu T, Kubo O, Okamoto K, Sawama Y, Kita Y Heterocycles, 72, 529-540 (2007) Synthesis of N-functionalized oleamide derivatives Ohba Y, Kanao Y, Takatsuji M, Ito M, Yabuta N, Nojima H, Kita Y Tetrahedron, 63, 3754-3761 (2007) Nucleophilic attack of intramolecular hydroxyl groups on electron-rich aromatics using hypervalent iodine(III) oxidation Hata K, Hamamoto H, Shiozaki Y, Cämmerer SB, Kita Y Tetrahedron, 63, 4052-4060 (2007) New three-component reaction: Novel formation of a seven-membered ring by the unexpected reaction at the γ-position of the β-keto ester Fujioka H, Murai K, Kubo O, Ohba Y, Kita Y Org. Lett., 9, 1687-1690 (2007) Direct lactone formation by using hypervalent iodine(III) reagents with KBr via selective C-H abstraction protocol Dohi T, Takenaga N, Goto A, Maruyama A, Kita Y Org. Lett., 9, 3129-3132 (2007) Versatile direct dehydrative approach for diaryliodonium(III) salts in fluoroalcohol media Dohi T, Ito M, Morimoto K, Minamitsuji Y, Takenaga N, Kita Y Chem. Commun., 4152-4154 (2007) Total synthesis of (±)-γ-rubromycin on the basis of two aromatic pummerer-type reactions Akai S, Kakiguchi K, Nakamura Y, Kuriwaki I, Dohi T, Harada S, Kubo O, Morita N, Kita Y Angew. Chem. Int. Ed., 46, 7458-7461 (2007) Organic chemistry using weakly electrophilic salts: Efficient formation of O,O-mixed, O,S- and N,O-acetals Fujioka H, Okitsu T, Ohnaka T, Li R, Kubo O, Okamoto K, Sawama Y, Kita Y J. Org. Chem., 72, 7898-7902 (2007) Regioselective bipyrrole coupling of pyrroles and 3-substituted pyrroles using phenyliodine(III) bis(trifluoroacetate)

7

Dohi T, Morimoto K, Ito M, Kita Y Synthesis, 2913-2919 (2007) New perspective for natural products synthesis: Concise synthesis of (+)-Sch 642305 by chiral auxiliary multiuse methodology Fujioka H, Ohba Y, Nakahara K, Takatsuji M, Murai K, Ito M, Kita Y Org. Lett., 9, 5605-5608 (2007) Concise total synthesis of (－)-spongotine A Murai K, Morishita M, Nakatani R, Kubo O, Fujioka H, Kita Y J. Org. Chem., 72, 8947-8949 (2007) Concise asymmetric total synthesis of scyphostatin, a potent inhibitor of neutral sphingomyelinase Fujioka H, Sawama Y, Kotoku N, Ohnaka T, Okitsu T, Murata N, Kubo O, Li R, Kita Y Chem. Eur. J., 13, 10225-10238 (2007) Enantioselective constructions of quaternary carbons and their application to the asymmetric total syntheses of fredericamycin A and discorhabdin A (Review) Kita Y, Fujioka H Pure Appl. Chem., 79, 701-713 (2007) Oleamide derivatives are prototypical anti-metastasis drugs that act by inhibiting connexin 26 (Review) Nojima H, Ohba Y, Kita Y Current Drug Safety, 2, 204-211 (2007) リパーゼが触媒する不斉合成反応の新展開 （Review）

赤井周司, 北泰行

有機合成化学協会誌, 65, 772-782 (2007) Recent advances in pummerer reactions Akai S, Kita Y Topics in Current Chemistry (Springer), 274, 35-76 (2007) 植物由来の天然有機化合物の合成

北泰行, 有澤光弘 天然物化学 植物編 (アイピーシー), 324-335 (2007)

分子反応解析学 (Analytical Chemistry)

8

Design of a practical fluorescent probe for superoxide based on protection-deprotection chemistry of fluoresceins with benzenesulfonyl protecting groups Maeda H, Yamamoto K, Kohno I, Hafsi L, Itoh N, Nakagawa S, Kanagawa N, Suzuki K, Uno T Chem. Eur. J., 13, 1946-1954 (2007) Synthetic control of interchromophoric interaction in cationic bis-porphyrins toward efficient DNA photocleavage and singlet oxygen production in aqueous solution Ishikawa Y, Yamakawa N, Uno T Bioorg. Med. Chem., 15, 5230-5238 (2007) The proton pumping pathway of bovine heart cytochrome c oxidase Shimokata K, Katayama Y, Murayama H, Suematsu M, Tsukihara T, Muramoto K, Aoyama H, Yoshikawa S, Shimada H Proc. Natl. Acad. Sci. USA, 104, 4200-4205 (2007) Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidase Shinzawa-Itoh K, Aoyama H, Muramoto K, Terada H, Kurauchi T, Tadehara Y, Yamasaki A, Sugimura T, Kurono S, Tsujimoto K, Mizushima T, Yamashita E, Tsukihara T, Yoshikawa S EMBO J., 26, 1713-1725 (2007) A histidine residue acting as a controlling site for dioxygen reduction and proton pumping by cytochrome c oxidase Muramoto K, Hirata K, Shinzawa-Itoh K, Yoko-o S, Yamashita E, Aoyama H, Tsukihara T, Yoshikawa S Proc. Natl. Acad. Sci. USA, 104, 7881-7886 (2007) 質量分析法

宇野公之 パートナー分析化学 II (南江堂), 120-138 (2007) 酸・塩基の電離平衡

前田初男 パートナー分析化学 I (南江堂), (2007) レーザーラマン分光 ～タンパク質の構造解析～

宇野公之 生命科学のための機器分析実験ハンドブック (羊土社), 65-68 (2007) 薬用資源解析学（三栄源エフ・エフ・アイ）寄附講座 (Medicinal Plant Resource Exploration) 植物資源の新規機能性の開拓 －大阪大学薬学部創立 50 周年記念事業・第 7回地域研究交流

9

フォーラム－ (Review) 村上啓寿 FFI ジャーナル, 212, 169-171 (2007) 新規生物活性を標的とする薬用植物由来の天然物 (Review) 村上啓寿 FFI ジャーナル, 212, 217-226 (2007) 細胞生物学 (Cell Biology) Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit Kawasaki-Nishi S, Yamaguchi A, Forgac M, Nishi T Biochem. Biophys. Res. Commun., 364, 1032-1036 (2007) Regulation of multidrug efflux systems involved in multidrug and metal resistance of Salmonella enterica serovar Typhimurium Nishino K, Nikaido E, Yamaguchi A J. Bacteriol., 189, 9066-9075 (2007)

多剤排出トランスポーターの結晶構造解析により明らかになった機能的回転メカニズム

(Review) 村上聡

生物物理, 47, 309-316 (2007) 多剤排出トランスポーターの構造と機能 (Review) 村上聡

表面科学, 28, 184-191 (2007) 異物排出タンパクのメカニズム (Review) 山口明人

感染・炎症・免疫, 37, 106-115 (2007) 大腸菌の異物排出トランスポーターAcrB の構造と異物認識機構 (Review) 村上聡, 山口明人

生化学, 79, 542-549 (2007) 多剤排出トランスポーターの構造と機能 ： 結晶構造から明らかになった機能的回転メカニ

ズム (Review) 村上聡

蛋白質 核酸 酵素, 52, 406-414 (2007)

10

薬剤耐性と病原性発現における異物排出トランスポーターの役割 (Review) 西野邦彦

日本臨牀, 65 増刊号 2, 407-414 (2007) タンパク質光結晶化技術 (Review) 安達宏昭, 森勇介, 佐々木孝友, 高野和文, 井上豪, 松村浩由, 村上聡

光学, 36, 10-14 (2007) 生物有機化学 (Bioorganic Chemistry) Double-stranded DNA-templated oligonucleotide digestion triggered by triplex formation Obika S, Tomizu M, Negoro Y, Orita A, Nakagawa O, Imanishi T ChemBioChem, 8, 1924-1928 (2007) Biologically stable 2-5A analogues containing 3'-O,4'-C-bridged adenosine as potent RNase L agonists Morita K, Kaneko M, Obika S, Imanishi T, Kitade Y, Koizumi M ChemMedChem, 2, 1703-1707 (2007) N-Methyl substituted 2',4'-BNANC: A highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization Miyashita K, Rahman SMA, Seki S, Obika S, Imanishi T Chem. Commun., 3765-3767 (2007) Development of a novel nucleoside analogue with S-type sugar conformation: 2'-deoxy-trans-3',4'-bridged nucleic acids Osaki T, Obika S, Harada Y, Mitsuoka Y, Sugaya K, Sekiguchi M, Roongjang S, Imanishi T Tetrahedron, 63, 8977-8986 (2007) Acid-mediated cleavage of oligonucleotide P3' N5' phosphoramidates triggered by sequence-specific triplex formation Obika S, Tomizu M, Negoro Y, Osaki T, Orita A, Ueyama Y, Nakagawa O, Imanishi T Nucleosides Nucleotides Nucleic Acids, 26, 893-896 (2007) Synthesis of novel 2'-deoxy type trans-3',4'-bridged nucleic acid Osaki T, Obika S, Harada Y, Mitsuoka Y, Sugaya K, Sekiguchi K, Roongjang S, Imanishi T Nucleosides Nucleotides Nucleic Acids, 26, 1079-1082 (2007) 2',4'-BNANC: A novel bridged nucleic acid analogue with excellent hybridizing and nuclease resistance profiles Rahman SMA, Seki S, Utsuki K, Obika S, Miyashita K, Imanishi T

11

Nucleosides Nucleotides Nucleic Acids, 26, 1625-1628 (2007) Highly stable pyrimidine-motif triplex formation at physiological pH values by a bridged nucleic acid analogue Rahman SMA, Seki S, Obika S, Haitani S, Miyashita K, Imanishi T Angew. Chem. Int. Ed., 46, 4306-4309 (2007) Total synthesis of leustroducsin B via a convergent route Miyashita K, Tsunemi T, Hosokawa T, Ikejiri M, Imanishi T Tetrahedron Lett., 48, 3829-3833 (2007) Polymerisation of a DNA strand using oligo-DNA template with modified bases, sugars and phosphates Nagashima J, Minezaki S, Obika S, Imanishi T, Kuwahara M, Sawai H Nucleic Acids Symp. Ser., 51, 55-56 (2007) Inhibition of bcl-xL expression by antisense oligonucleotides containing various bridged nucleic acids (BNAs) Roongjang S, Takahashi K, Obika S, Imanishi T Nucleic Acids Symp. Ser., 51, 113-114 (2007) Synthesis and properties of a 2'-deoxy analogue of trans-3',4'-BNA with an S-type sugar conformation Sugaya K, Harada Y, Mitsuoka Y, Osaki T, Obika S, Kodama T, Imanishi T Nucleic Acids Symp. Ser., 51, 155-156 (2007) Synthesis and chemical properties of a novel 2',4'-bridged nucleic acid analogue with a seven-membered cyclic carbamate structure Nishida M, Kodama T, Obika S, Imanishi T Nucleic Acids Symp. Ser., 51, 157-158 (2007) Synthesis and evaluation of a novel 2',5'-bridged nucleic acid with sugar conformation fixed to S-type by N-O linkage Kodama T, Matsuo C, Ori H, Obika S, Miyashita K, Imanishi T Nucleic Acids Symp. Ser., 51, 159-160 (2007) フォストリエシンおよび類縁天然物の合成研究 (Review) 宮下和之, 池尻昌宏, 常深智之, 松本あゆみ, 今西武 有機合成化学協会誌, 65, 874-887 (2007) 細胞生理学 (Immunology)

12

Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice Tsujikawa K, Yayama K, Hayashi T, Matsushita H, Yamaguchi T, Shigeno T, Ogitani Y, Hirayama M, Kato T, Fukada S, Takatori S, Kawasaki H, Okamoto H, Ikawa M, Okabe M, Yamamoto H Proc. Natl. Acad. Sci. USA, 104, 16702-16707 (2007) Molecular signature of quiescent satellite cells in adult skeletal muscle Fukada S, Uezumi A, Ikemoto M, Masuda S, Segawa M, Tanimura N, Yamamoto H, Miyagoe-Suzuki Y, Takeda S Stem Cells, 25, 2448-2459 (2007) Expression and sub-cellular localization of human ABH family molecules Tsujikawa K, Koike K, Kitae K, Shinkawa A, Arima H, Suzuki T, Tsuchiya M, Makino Y, Furukawa T, Konishi N, Yamamoto H J. Cell. Mol. Med., 11, 1105-1116 (2007) NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS Suzuki N, Motohashi N, Uezumi A, Fukada S, Yoshimura T, Itoyama Y, Aoki M, Miyagoe-Suzuki Y, Takeda S J. Clin. Invest., 117, 2468-2476 (2007) Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer Owatari S, Akune S, Komatsu M, Ikeda R, Firth SD, Che XF, Yamamoto M, Tsujikawa K, Kitazono M, Ishizawa T, Takeuchi T, Aikou T, Mercer JFB, Akiyama S, Furukawa T Cancer Res., 67, 4860-4868 (2007) Expression of mdr1 is required for efficient long term regeneration of dystrophic muscle Israeli D, Ziaei S, Gjata B, Benchaouir R, Rameau P, Marais T, Fukada S, Segawa M, Yamamoto H, Gonin P, Danos O, Garcia L Exp. Cell Res., 313, 2438-2450 (2007) Autologous transplantation of SM/C-2.6+ satellite cells transduced with micro-dystrophin CS1 cDNA by lentiviral vector into mdx mice Ikemoto M, Fukada S, Uezumi A, Masuda S, Miyoshi H, Yamamoto H, Wada MR, Masubuchi N, Miyagoe-Suzuki Y, Takeda S Mol. Ther., 15, 2178-2185 (2007) Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids Aoki S, Watanabe Y, Tanabe D, Arai M, Suna H, Miyamoto K, Tsujibo H, Tsujikawa K, Yamamoto H,

13

Kobayashi M Bioorg. Med. Chem., 15, 6758-6762 (2007) γδ T cells: Firefighters or fire boosters in the front lines of inflammatory responses (Review) Nanno M, Shiohara T, Yamamoto H, Kawakami K, Ishikawa H Immunol. Rev., 215, 103-113 (2007) 神経ペプチド CGRP が有する抗炎症作用 (Review) 扇谷祐輔, 加藤鉄也, 辻川和丈, 山元弘

臨床免疫・アレルギー科, 47, 100-108 (2007)

ヒト ABH ファミリー分子の DNA・RNA 損傷修復とがん化 (Review) 辻川和丈

生産と技術, 59, 69-71 (2007) 毒性学 (Toxicology) Design of a practical fluorescent probe for superoxide based on protection-deprotection chemistry of fluoresceins with benzenesulfonyl protecting groups Maeda H, Yamamoto K, Kohno I, Hafsi L, Itoh N, Nakagawa S, Kanagawa N, Suzuki K, Uno T Chemistry Eur. J., 13, 1946-1954 (2007) Imposex induction is mediated through the Retinoid X Receptor signalling pathway in the neogastropod Nucella lapillus Castro LFC, Lima D, Machado A, Melo C, Hiromori Y, Nishikawa J, Nakanishi T, Reis-Henriques MA, Santos MM Aquat. Toxicol., 85, 57-66 (2007) Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes Wu X, Iguchi T, Hirano J, Fujita I, Ueda H, Itoh N, Tanaka K, Nakanishi T Biochem. Pharmacol., 74, 1020-1028 (2007) Potential toxicity of organotin compounds via nuclear receptor signaling in mammals (Review) Nakanishi T J. Health Sci., 53, 1-9 (2007)

サイトカインによるメタロチオネイン誘導とメタロチオネインによるサイトカイン発現の修

飾 (Review) 伊藤徳夫, 木村朋紀

14

薬学雑誌, 127, 685-694 (2007)

重金属汚染による生物撹乱作用の分子基盤 (Review) 中西剛, 西川淳一

細胞工学, 26, 1374-1379 (2007) 神経薬理学 (Molecular Neuropharmacology) Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia Hashimoto R, Hashimoto H, Shintani N, Chiba S, Hattori S, Okada T, Nakajima M, Tanaka K, Kawagishi N, Nemoto K, Mori T, Ohnishi T, Noguchi H, Hori H, Suzuki T, Iwata N, Ozaki N, Nakabayashi T, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Kunugi H, Baba A Mol. Psychiatry, 12, 1026-1032 (2007) A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: Implication in the modulation of DISC1-dependent neurite outgrowth Hattori T, Baba K, Matsuzaki S, Honda A, Miyoshi K, Inoue K, Taniguchi M, Hashimoto H, Shintani N, Baba A, Shimizu S, Yukioka F, Kumamoto N, Yamaguchi A, Tohyama M, Katayama T Mol. Psychiatry, 12, 398-407 (2007) Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist Koyama Y, Baba A, Matsuda T Neuroreport, 18, 1275-1279 (2007) Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression of tissue inhibitor of matrix metalloproteinase-1 and -3 in rat brain Koyama Y, Baba A, Matsuda T Neuroscience, 147, 620-630 (2007) Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test Ago Y, Takahashi K, Nakamura S, Hashimoto H, Baba A, Matsuda T J. Pharmacol. Sci., 104, 153-158 (2007) Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical sensitization in mice Ago Y, Nakamura S, Kajita N, Uda M, Hashimoto H, Baba A, Matsuda T Synapse, 61, 757-763 (2007) Nitric oxide-induced apoptosis in cultured rat astrocytes: Protection by edaravone, a radical

15

scavenger Kawasaki T, Kitao T, Nakagawa K, Fujisaki H, Takegawa Y, Koda K, Ago Y, Baba A, Matsuda T Glia, 55, 1325-1333 (2007) Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice Fujii H, Ishihama T, Ago Y, Shintani N, Kakuda M, Hashimoto H, Baba A, Matsuda T Peptides, 28, 1674-1679 (2007) Role of postsynaptic serotonin1A receptors in risperidone-induced increase in acetylcholine release in rat prefrontal cortex Sato M, Ago Y, Koda K, Nakamura S, Kawasaki T, Baba A, Matsuda T Eur. J. Pharmacol., 559, 155-160 (2007) Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain Takayasu Y, Nakaki J, Kawasaki T, Koda K, Ago Y, Baba A, Matsuda T J. Pharmacol. Sci., 103, 434-437 (2007) Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum Kawasaki T, Ishihara K, Ago Y, Baba A, Matsuda T J. Pharmacol. Exp. Ther., 322, 274-281 (2007) AMPA-mediated excitotoxicity in oligodendrocytes: Role for Na+-K+-Cl- co-transport and reversal of Na+/Ca2+ exchanger Chen H, Kintner DB, Jones M, Matsuda T, Baba A, Kiedrowski L, Sun D J. Neurochem., 102, 1783-1795 (2007) Ca2+ extrusion in aged smooth muscle cells Gomez-Pinilla PJ, Pozo MJ, Baba A, Matsuda T, Camello PJ Biochem. Pharmacol., 74, 860-869 (2007) 遺伝子改変マウスの表現型解析法：SHIRPA一次スクリーニング法 (Review) 笠井淳司, 新谷紀人 日本薬理学雑誌, 130, 281-285 (2007) 新しい GPCR リガンド研究の現状と展望～神経ペプチド PACAP の生理機能 (Review) 新谷紀人, 橋本均, 馬場明道 ホルモンと臨床, 55, 131-139 (2007) ニューロペプチド PACAP と精神神経機能：変異マウスからの予想外の知見 (Review) 橋本均, 新谷紀人, 馬場明道

16

生化学, 79, 375-379 (2007) 中枢神経系におけるトリメチルスズの作用 (Review) 新谷紀人, 荻田喜代一, 橋本均, 馬場明道 薬学雑誌, 127, 451-461 (2007) 分子薬理学的アプローチによる新規創薬標的分子の機能解析 (Review) 馬場明道 薬学雑誌, 127, 1643-1654 (2007) 動物個体を用いた概日リズム解析法 (Review) 川口ちひろ, 礒島康史, 馬場明道 日本薬理学雑誌, 130, 193-199 (2007) 統合失調症とセロトニン 1A受容体 (Review) 吾郷由希夫, 角田享也, 橋本均, 馬場明道, 松田敏夫 脳 21, 10, 256-260 (2007) PACAP 欠損マウス (Review) 新谷紀人, 橋本均, 馬場明道 Keyword精神第４版, 214-215 (2007) 神経ペプチド PACAP-新しい創薬標的分子探索へ (Review) 馬場明道, 橋本均, 新谷紀人 遺伝子医学 MOOK⑧, 168-172 (2007) 薬剤学 (Biotechnology and Therapeutics) Improved cytosolic translocation and tumor-killing activity of Tat-shepherdin conjugates mediated by co-treatment with Tat-fused endosome-disruptive HA2 peptide Sugita T, Yoshikawa T, Mukai Y, Yamanada N, Imai S, Nagano K, Yoshida Y, Shibata H, Yoshioka Y, Nakagawa S, Kamada H, Tsunoda S, Tsutsumi Y Biochem. Biophys. Res. Commun., 363, 1027-1032 (2007) CC-chemokine ligand 17 gene therapy induces tumor regression through augmentation of tumor-infiltrating immune cells in a murine model of preexisting CT26 colon carcinoma Kanagawa N, Niwa M, Hatanaka Y, Tani Y, Nakagawa S, Fujita T, Yamamoto A, Okada N Int. J. Cancer., 121, 2013-2022 (2007) Interaction of penton base Arg-Gly-Asp motifs with integrins is crucial for adenovirus serotype 35 vector transduction in human hematopoietic cells

17

Murakami S, Sakurai F, Kawabata K, Okada N, Fujita T, Yamamoto A, Hayakawa T, Mizuguchi H Gene Ther., 14, 1525-1533 (2007) Creation of a novel cell penetrating peptide, using a random 18mer peptides library Nomura T, Kawamura M, Shibata H, Abe Y, Ohkawa A, Mukai Y, Sugita T, Imai S, Nagano K, Okamoto T, Tsutsumi Y, Kamada H, Nakagawa S, Tsunoda S Pharmazie, 62, 569-573 (2007) Efficient generation of antigen-specific cellular immunity by vaccination with poly (γ-glutamic acid) nanoparticles entrapping endoplasmic reticulum-targeted peptides Matsuo K, Yoshikawa T, Oda A, Akagi T, Akashi M, Mukai Y, Yoshioka Y, Okada N, Nakagawa S Biochem. Biophys. Res. Commun., 362, 1069-1072 (2007) TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection Yao X, Yoshioka Y, Eto Y, Morishige T, Okada Y, Mizuguchi H, Mukai Y, Okada N, Nakagawa S Biochem. Biophys. Res. Commun., 362, 419-424 (2007) Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration Gao JQ, Eto Y, Yoshioka Y, Sekiguchi F, Kurachi S, Morishige T, Yao X, Watanabe H, Asavatanabodee R, Sakurai F, Mizuguchi H, Okada Y, Mukai Y, Tsutsumi Y, Mayumi T, Okada N, Nakagawa S J. Control. Release, 122, 102-110 (2007) Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors Yamaguchi T, Kawabata K, Koizumi N, Sakurai F, Nakashima K, Sakurai H, Sasaki T, Okada N, Yamanishi K, Mizuguchi H Hum. Gene Ther., 18, 753-762 (2007) Fiber-modified adenovirus vectors containing the TAT peptide derived from HIV-1 in the fiber knob have efficient gene transfer activity Kurachi S, Tashiro K, Sakurai F, Sakurai H, Kawabata K, Yayama K, Okamoto H, Nakagawa S, Mizuguchi H Gene Ther., 14, 1160-1165 (2007) Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants Shibata H, Kamada H, Kobayashi-Nishibata K, Yoshioka Y, Nishibata T, Abe Y, Nomura T, Nabeshi H, Minowa K, Mukai Y, Nakagawa S, Mayumi T, Tsunoda S, Tsutsumi Y Biochim. Biophys. Acta, 1774, 1029-1035 (2007)

18

Design of a practical fluorescent probe for superoxide based on protection-deprotection chemistry of fluoresceins with benzenesulfonyl protecting groups Maeda H, Yamamoto K, Kohno I, Hafsi L, Itoh N, Nakagawa S, Kanagawa N, Suzuki K, Uno T Chemistry Eur. J., 13, 1946-1954 (2007) Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer Gao JQ, Kanagawa N, Motomura Y, Yanagawa T, Sugita T, Hatanaka Y, Tani Y, Mizuguchi H, Tsutsumi Y, Mayumi T, Okada N, Nakagawa S Gene Ther., 14, 491-502 (2007) Comparison of gene expression efficiency and innate immune response induced by Ad vector and lipoplex Sakurai H, Sakurai F, Kawabata K, Sasaki T, Koizumi N, Huang H, Tashiro K, Kurachi S, Nakagawa S, Mizuguchi H J. Control. Release, 117, 430-437 (2007) Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon Kurachi S, Koizumi N, Sakurai F, Kawabata K, Sakurai H, Nakagawa S, Hayakawa T, Mizuguchi H Gene Ther., 14, 266-274 (2007) Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from Tat transduction domain Kamada H, Okamoto T, Kawamura M, Shibata H, Abe Y, Ohkawa A, Nomura T, Sato M, Mukai Y, Sugita T, Imai S, Nagano K, Tsutsumi Y, Nakagawa S, Mayumi T, Tsunoda S Biol. Pharm. Bull., 30, 218-223 (2007) A strategy for efficient cross-presentation of CTL-epitope peptides leading to enhanced induction of in vivo tumor immunity Hayashi A, Wakita H, Yoshikawa T, Nakanishi T, Tsutsumi Y, Mayumi T, Mukai Y, Yoshioka Y, Okada N, Nakagawa S J. Control. Release, 117, 11-19 (2007) Studies on heterobifunctional cross-linking reagents, 6-maleimidohexanoic acid active esters Kida S, Maeda M, Hojo K, Eto Y, Nakagawa S, Kawasaki K Chem. Pharm. Bull., 55, 685-687 (2007) Improvement of adenovirus vectors for cancer gene therapy Eto Y, Yoshioka Y, Mukai Y, Okada N, Nakagawa S Recent Development in Gene Therapy, 18, 341-367 (2007)

19

ファージ抗体ライブラリを用いた抗体の迅速創製法の開発

向洋平 Drug Delivery System, 22, 600-601 (2007) 細胞内薬物導入キャリアとしての細胞内移行ペプチドの応用技術

向洋平, 堤康央, 中川晋作 遺伝子医学 MOOK 別冊「絵で見てわかるナノ DDS」, 184-190 (2007) 金磁性ナノ粒子が遺伝子解析を変える？！－ポストゲノム研究に貢献する新しい磁気ビーズ

の開発 (Review) 清野智史, 山本孝夫, 中川晋作, 土井健史 化学, 62(6), 24-28 (2007) 膜融合リポソームによる細胞内薬物動態制御法の確立とその応用 (Review) 吉川友章, 岡田直貴, 中川晋作 薬学雑誌, 127, 789-796 (2007) 免疫細胞の体内動態制御に基づいた癌免疫療法の最適化 (Review) 岡田直貴, 中川晋作 薬学雑誌, 127, 327-339 (2007) 薬物キャリアーの最前線

中川晋作 薬学雑誌, 127, 779 (2007) 天然物化学 (Natural Product Chemistry) The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line Matsui T, Sowa Y, Murata H, Takagi K, Nakanishi R, Aoki S, Yoshikawa M, Kobayashi M, Sakabe T, Kubo T, Sakai T Int. J. Oncology, 31, 915-922 (2007) Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived fungus Aspergillus candidus IF10 Wei H, Inada H, Hayashi A, Higashimoto K, Pruksakorn P, Kamada S, Arai M, Ishida S, Kobayashi M J. Antibiotics, 60, 586-590 (2007) Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids Aoki S, Watanabe Y, Tanabe D, Arai M, Suna H, Miyamoto K, Tsujibo H, Tsujikawa K, Yamamoto H,

20

Kobayashi M Bioorg. Med. Chem., 15, 6758-6762 (2007) Stereoselective total synthesis of arenastatin A, a spongean cytotoxic depsipeptide Kotoku N, Narumi F, Kato T, Yamaguchi M, Kobayashi M Tetrahedron Lett., 48, 7147-7150 (2007) Crambescidin 800, a pentacyclic guanidine alkaloid, protects a mouse hippocampal cell line against glutamate-induced oxidative stress Suna H, Aoki S, Setiawan A, Kobayashi M J. Nat. Med., 61, 288-295 (2007) Novel isomarabarican triterpenes, exhibiting selective anti-proliferative activity against vascular endothelial cells, from marine sponge Rhabdastrella globostellata Aoki S, Sanagawa M, Watanabe Y, Setiawan A, Arai M, Kobayashi M Bioorg. Med. Chem., 15, 4818-4828 (2007) Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex Aoki S, Watanabe Y, Tanabe D, Setiawan A, Arai M, Kobayashi M Tetrahedron Lett., 48, 4485-4488 (2007) Cortistatins E, F, G, and H, four novel steroidal alkaloids from marine sponge Corticium simplex Watanabe Y, Aoki S, Tanabe D, Setiawan A, Kobayashi M Tetrahedron, 63, 4074-4079 (2007) Concise asymmetric total synthesis of scyphostatin, a potent inhibitor of neutral sphingomyelinase Fujioka H, Sawama Y, Kotoku N, Ohnaka T, Okitsu T, Murata N, Kubo O, Li R, Kita Y Chem. Eur. J., 13, 10225-10238 (2007) Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli Zimhony O, Vilchèze C, Arai M, Welch JT, Jacobs WR, Jr. Antimicrobial Agents and Chemotherapy, 51, 752-754 (2007) 複合薬物動態学 (Medicinal Pharmacology) Role of postsynaptic serotonin1A receptors in risperidone-induced increase in acetylcholine release in rat prefrontal cortex Sato M, Ago Y, Koda K, Nakamura S, Kawasaki T, Baba A, Matsuda T

21

Eur. J. Pharmacol., 559, 155-160 (2007) Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain Takayasu Y, Nakaki J, Kawasaki T, Koda K, Ago Y, Baba A, Matsuda T J. Pharmacol. Sci., 103, 434-437 (2007) Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical sensitization in mice Ago Y, Nakamura S, Kajita N, Uda M, Hashimoto H, Baba A, Matsuda T Synapse, 61, 757-763 (2007) Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test Ago Y, Takahashi K, Nakamura S, Hashimoto H, Baba A, Matsuda T J. Pharmacol. Sci., 104, 153-158 (2007) Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum Kawasaki T, Ishihara K, Ago Y, Baba A, Matsuda T J. Pharmacol. Exp. Ther., 322, 274-281 (2007) Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice Fujii H, Ishihama T, Ago Y, Shintani N, Kakuda M, Hashimoto H, Baba A, Matsuda T Peptides, 28, 1674-1679 (2007) Nitric oxide-induced apoptosis in cultured rat astrocytes: Protection by edaravone, a radical scavenger Kawasaki T, Kitao T, Nakagawa K, Fujisaki H, Takegawa Y, Koda K, Ago Y, Baba A, Matsuda T Glia, 55, 1325-1333 (2007) Ca2+ extrusion in aged smooth muscle cells Gomez-Pinilla PJ, Pozo MJ, Baba A, Matsuda T, Camello PJ Biochem. Pharmacol., 74, 860-869 (2007) AMPA-mediated excitotoxicity in oligodendrocytes: Role for Na+-K+-Cl- co-transport and reversal of Na+/Ca2+ exchanger Chen H, Kintner DB, Jones M, Matsuda T, Baba A, Kiedrowski L, Sun D J. Neurochem., 102, 1783-1795 (2007) Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist

22

Koyama Y, Baba A, Matsuda T Neuroreport, 18, 1275-1279 (2007) Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression of tissue inhibitor of matrix metalloproteinase-1 and -3 in rat brain Koyama Y, Baba A, Matsuda T Neuroscience, 147, 620–630 (2007) 統合失調症とセロトニン 1A受容体 (Review) 吾郷由希夫, 角田享也, 橋本均, 馬場明道, 松田敏夫 脳 21, 10, 256-260 (2007) 臨床薬効解析学 (Clinical Pharmacology and Pharmacogenomics) Nonlinear mixed effects model analysis of the pharmacokinetics of aripiprazole in healthy Japanese males Koue T, Kubo M, Funaki T, Fukuda T, Azuma J, Takaai M, Kayano Y, Hashimoto Y Biol. Pharm. Bull., 30, 2154-2158 (2007)

Pharmacokinetics of aripiprazole, a new antipsychotic, following oral dosing in healthy adult Japanese volunteers: Influence of CYP2D6 polymorphism Kubo M, Koue T, Maune H, Fukuda T, Azuma J Drug Metab. Pharmacokinet., 22, 358-366 (2007)

Dose-escalation study of isoniazid in healthy volunteers with the rapid acetylator genotype of arylamine N-acetyltransferase 2 Kubota R, Ohno M, Hasunuma T, Iijima H, Azuma J Eur. J. Clin. Pharmacol., 63, 927-933 (2007)

Delirium associated with paroxetine in an elderly depressive patient: A case report Wakeno M, Okugawa G, Takekita Y, Kato M, Fukuda T, Yamashita M, Hosoi Y, Azuma J, Kinoshita T Pharmacopsychiatry, 40, 199-200 (2007)

Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes Ito T, Asakura K, Tougou K, Fukuda T, Kubota R, Nonen S, Fujio Y, Azuma J Mol. Pharmacol., 72, 173-181 (2007)

Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in 1α,25 dihydroxyvitamin D3 treated Caco-2 cells Hou XL, Takahashi K, Kinoshita N, Qiu F, Tanaka K, Komatsu K, Takahashi K, Azuma J

23

Int. J. Pharm., 337, 169-177 (2007)

Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine Kimura R, Maeda M, Arita A, Oshima Y, Obana M, Ito T, Yamamoto Y, Mohri T, Kishimoto T, Kawase I, Fujio Y, Azuma J Cytokine, 38, 107-115 (2007) Genetic polymorphism of bile acid CoA: Amino acid N-acyltransferase in Japanese individuals Tougou K, Fukuda T, Ito T, Yamazaki H, Fujio Y, Azuma J Drug Metab. Pharmacokinet., 22, 125-128 (2007)

Determination of single nucleotide polymorphisms in N-acetyltransferase2 gene using an electrochemical DNA chip and an automated DNA detection system Nakamura N, Ito K, Hongo S, Hashimoto K, Furutsuka M, Kubota R, Fukuda T, Ohno M, Azuma J, Gemma N Rinsho Byori, 55, 216-223 (2007)

Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress Yamane M, Matsuda T, Ito T, Fujio Y, Takahashi K, Azuma J Biochem. Biophys. Res. Commun., 353, 1023-1027 (2007)

Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes Ito T, Fujio Y, Takahashi K, Azuma J J. Biol. Chem., 282, 1152-1160 (2007) 大規模臨床調査の意義 (Review) 東純一

大阪府内科医会会誌, 16, 199-203 (2007)

KRN1493（シナカルセト塩酸塩）の健康成人男子を対象とした第 I 相臨床試験 ―単回経口

投与時の薬物動態，薬力学および安全性の検討― (Review) 東純一, 古屋良宏, 内田英二

薬理と治療, 35, 941-951 (2007)

KRN1493（シナカルセト塩酸塩）の健康成人男子を対象とした第 I 相臨床試験 ―反復経口

投与時の薬物動態，薬力学および安全性の検討― (Review) 東純一, 古屋良宏, 内田英二

薬理と治療, 35, 953-962 (2007)

ファーマコゲノミクスの薬物治療への応用に関する市民の意識調査 (Review) 藤尾慈, 津谷喜一郎, 渡邉裕司, 玉起美恵子, 東純一

24

臨床薬理, 38, 225-230 (2007)

薬効ゲノム情報に基づく薬物治療法の確立を目指した臨床薬理学的研究－2003年度 臨床薬

理研究振興財団賞学術奨励賞研究成果報告－ (Review) 福田剛史

臨床薬理, 38, 279-284 (2007)

遺伝子検査 (Review) 東純一, 南畝晋平

日本臨牀, 65(増刊 4), 455-459 (2007) 分子生理病態学 (Molecular Pathophysiology) Efficient capture of cardiogenesis-associated genes expressed in ES cells Terami H, Hidaka K, Shirai M, Narumiya H, Kuroyanagi T, Arai Y, Aburatani H, Morisaki T Biochem. Biophys. Res. Commun., 355, 47-53 (2007) Remote reperfusion lung injury is associated with AMP deaminase 3 activation and attenuated by inosine monophosphate Li P, Ogino K, Hoshikawa Y, Morisaki H, Cheng J, Toyama K, Morisaki T, Hashimoto K, Ninomiya H, Tomikura-Shimoyama Y, Igawa O, Shigemasa C, Hisatome I Circ. J., 71, 591-596 (2007) Endocardiogenesis in embryoid bodies: Novel markers identified by gene expression profiling Narumiya H, Hidaka K, Shirai M, Terami H, Aburatani H, Morisaki T Biochem. Biophys. Res. Commun., 357, 896-902 (2007) Phenotypic heterogeneity of Marfan-like connective tissue disorders associated with mutations in the transforming growth factor-β receptor genes Akutsu K, Morisaki H, Takeshita S, Sakamoto S, Tamori Y, Yoshimuta T, Yokoyama N, Nonogi H, Ogino H, Morisaki T Circ. J., 71, 1305-1309 (2007) Activation of MEK-ERK by heregulin-β1 promotes the development of cardiomyocytes derived from ES cells Kim HS, Cho JW, Hidaka K, Morisaki T Biochem. Biophys. Res. Commun., 361, 732-738 (2007) Inhibition of β-adrenergic signaling by intracellular AMP is independent of cell-surface adenosine receptors in rat cardiac cells Ogura K, Miake J, Sasaki N, Iwai C, Bahrudin U, Li P, Kato M, Iitsuka K, Hirota Y, Koshida T,

25

Yamamoto Y, Inoue Y, Yano A, Adachi M, Igawa O, Kurata Y, Morisaki T, Shiota G, Shirayoshi Y, Ninomiya H, Hisatome I J. Mol. Cell. Cardiol., 43, 648-652 (2007) Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet Mehta JL, Sanada N, Hu CP, Chen J, Dandapat A, Sugawara F, Satoh H, Inoue K, Kawase Y, Jishage K, Suzuki H, Takeya M, Schnackenberg L, Beger R, Hermonat PL, Thomas M, Sawamura T Circ. Res., 100, 1634-1642 (2007) Possible involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system in pathogenesis and progression of human osteoarthritis Akagi M, Kanata S, Mori S, Itabe H, Sawamura T, Hamanishi C Osteoarthritis Cartilage, 15, 281-290 (2007) Lectin-like oxidized LDL receptor-1 as extracellular chaperone receptor: Its versatile functions and human diseases Inoue N, Sawamura T Methods, 43, 218-222 (2007) LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion Hu C, Dandapat A, Chen J, Fujita Y, Inoue N, Kawase Y, Jishage K, Suzuki H, Sawamura T, Mehta JL Cardiovasc. Res., 76, 292-302 (2007) Modulation of ADP-induced platelet activation by aspirin and pravastatin: Role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling Marwali MR, Hu CP, Mohandas B, Dandapat A, Deonikar P, Chen J, Cawich I, Sawamura T, Kavdia M, Mehta JL J. Pharmacol. Exp. Ther., 322, 1324-1332 (2007)

生体諸臓器におけるアデニンヌクレオチドの役割と AMPD (Review) 森崎隆幸

高尿酸血症と痛風, 15, 70-74 (2007)

ES 細胞による心臓再生の可能性と課題 (Review) 森崎隆幸, 日高京子

呼吸と循環, 55, 715-720 (2007)

ES 細胞の臨床応用：心血管系の再生医療実現に向けて (Review) 森崎隆幸, 日高京子

循環器病研究の進歩, 28, 2-9 (2007)

26

ES 細胞から心筋をつくる (Review) 森崎隆幸, 日高京子

Heart View, 11, 1375-1381 (2007)

「生命倫理と人権に関する世界宣言」成立の経緯と今後の課題

森崎隆幸

普遍性と多様性 (上智大学出版 ), 26-34 (2007)

臨床薬物学 (Clinical Pharmaceuticals) A retrospective chart review of the antiemetic effectiveness of risperidone in refractory opioid-induced nausea and vomiting in advanced cancer patients Okamoto Y, Tsuneto S, Matsuda Y, Inoue T, Tanimukai H, Tazumi K, Ono Y, Kurokawa N, Uejima E Journal of Pain and Symptom Management, 34, 217-222 (2007) 整形外科領域における大量癌化学療法に対する 5-HT3 受容体拮抗剤の効果比較

竹中美樹, 岡本禎晃, 池田賢二, 橋本陵, 上田孝文, 黒川信夫, 高木達也, 上島悦子

癌と化学療法, 34, 403-407 (2007) 細胞構造学 (Cellular Physiology) In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation Yasuda G, Nishi R, Watanabe E, Mori T, Iwai S, Orioli D, Stefanini M, Hanaoka F, Sugasawa K Mol. Cell. Biol., 27, 6606-6614 (2007) A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation Furumoto T, Tanaka A, Ito M, Malik S, Hirose Y, Hanaoka F, Ohkuma Y Genes Cells, 12, 119-132 (2007) 遺伝子機能解析学 (Experimental Genome Research) Lats2 is an essential mitotic regulator required for the coordination of cell division Yabuta N, Okada N, Ito A, Hosomi T, Nishihara S, Sasayama Y, Fujimori A, Okuzaki D, Zhao H, Ikawa M, Okabe M, Nojima H J. Biol. Chem., 282, 19259-19271 (2007) PGAP1 knock-out mice show otocephaly and male infertility

27

Ueda Y, Yamaguchi R, Ikawa M, Okabe M, Morii E, Maeda Y, Kinoshita T J. Biol. Chem., 282, 30373-30380 (2007) cHS4 insulator-mediated alleviation of promoter interference during cell-based expression of tandemly associated transgenes Yahata K, Maeshima K, Sone T, Ando T, Okabe M, Imamoto N, Imamoto F J. Mol. Biol., 374, 580-590 (2007) Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer Okada Y, Ueshin Y, Isotani A, Saito-Fujita T, Nakashima H, Kimura K, Mizoguchi A, Oh-hora M, Mori Y, Ogata M, Oshima RG, Okabe M, Ikawa M Nat. Biotechnol., 25, 233-237 (2007) PGC7/Stella protects against DNA demethylation in early embryogenesis Nakamura T, Arai Y, Umehara H, Masuhara M, Kimura T, Taniguchi H, Sekimoto T, Ikawa M, Yoneda Y, Okabe M, Tanaka S, Shiota K, Nakano T Nat. Cell Biol., 9, 64-71 (2007) Innate versus learned odour processing in the mouse olfactory bulb Kobayakawa K, Kobayakawa R, Matsumoto H, Oka Y, Imai T, Ikawa M, Okabe M, Ikeda T, Itohara S, Kikusui T, Mori K, Sakano H Nature, 450, 503-508 (2007) Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors Murayama K, Kimura T, Tarutani M, Tomooka M, Hayashi R, Okabe M, Nishida K, Itami S, Katayama I, Nakano T Oncogene, 26, 4882-4888 (2007) Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells Akazawa T, Ebihara T, Okuno M, Okuda Y, Shingai M, Tsujimura K, Takahashi T, Ikawa M, Okabe M, Inoue N, Okamoto-Tanaka M, Ishizaki H, Miyoshi J, Matsumoto M, Seya T Proc. Natl. Acad. Sci. USA, 104, 252-257 (2007) Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice Tsujikawa K, Yayama K, Hayashi T, Matsushita H, Yamaguchi T, Shigeno T, Ogitani Y, Hirayama M, Kato T, Fukada S, Takatori S, Kawasaki H, Okamoto H, Ikawa M, Okabe M, Yamamoto H Proc. Natl. Acad. Sci. USA, 104, 16702-16707 (2007) Efficient derivation of embryonic stem cells by inhibition of glycogen synthase kinase-3

28

Umehara H, Kimura T, Ohtsuka S, Nakamura T, Kitajima K, Ikawa M, Okabe M, Niwa H, Nakano T Stem Cells, 25, 2705-2711 (2007) Mechanisms of sperm-egg interactions emerging from gene-manipulated animals (Review) Okabe M, Cummins JM Cell. Mol. Life Sci., 64, 1945-1958 (2007) Sperm-egg interaction and gene manipulated animals (Review) Inoue N, Yamaguchi R, Ikawa M, Okabe M Soc. Reprod. Fertil. Suppl., 65, 363-371 (2007) X-linked GFPマウスを用いた雌雄分別と生殖細胞の動態 (Review) 磯谷綾子, 岡部勝

蛋白質 核酸 酵素, 52, 2060-2066 (2007) 雌雄胚盤胞の遺伝子発現比較により新たにみつけたX染色体上のインプリント遺伝子

Rhox5/Pem (Review) 小林慎, 磯谷綾子, 藤原祥高, 岡部勝

生物の科学 遺伝 別冊, 21, 64-69 (2007) 医薬基盤科学（Biomedical Innovation）

Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production Koizumi N, Yamaguchi T, Kawabata K, Sakurai F, Sasaki T, Watanabe Y, Hayakawa T, Mizuguchi H J. Immunol., 178, 1767-1773 (2007) Rapid construction of small interfering RNA-expressing adenoviral vectors on the basis of direct cloning of short hairpin RNA-coding DNAs Mizuguchi H, Funakoshi N, Hosono T, Sakurai F, Kawabata K, Yamaguchi T, Hayakawa T Hum. Gene Ther., 18, 74-80 (2007) Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors Yamaguchi T, Kawabata K, Koizumi N, Sakurai F, Nakashima K, Sakurai H, Sasaki T, Okada N, Yamanishi K, Mizuguchi H Hum. Gene Ther., 18, 753-762 (2007) Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon Kurachi S, Koizumi N, Sakurai F, Kawabata K, Sakurai H, Nakagawa S, Hayakawa T, Mizuguchi H Gene Ther., 14, 266-274 (2007)

29

Downregulation of human CD46 by adenovirus serotype 35 vectors Sakurai F, Akitomo K, Kawabata K, Hayakawa T, Mizuguchi H Gene Ther., 14, 912-919 (2007) Fiber-modified adenovirus vectors containing the TAT peptide derived from HIV-1 in the fiber knob have efficient gene transfer activity Kurachi S, Tashiro K, Sakurai F, Sakurai H, Kawabata K, Yayama K, Okamoto H, Nakagawa S, Mizuguchi H Gene Ther., 14, 1160-1165 (2007) Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP Kawabata K, Tashiro K, Sakurai F, Osada N, Kusuda J, Hayakawa T, Yamanishi K, Mizuguchi H Gene Ther., 14, 1199-1207 (2007) Interaction of penton base Arg-Gly-Asp motifs with integrins is crucial for adenovirus serotype 35 vector transduction in human hematopoietic cells Murakami S, Sakurai F, Kawabata K, Okada N, Fujita T, Yamamoto A, Hayakawa T, Mizuguchi H Gene Ther., 14, 1525-1533 (2007) Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells Yamashita M, Ino A, Kawabata K, Sakurai F, Mizuguchi H Int. J. Cancer, 121, 1690-1696 (2007) Comparison of gene expression efficiency and innate immune response induced by Ad vector and lipoplex Sakurai H, Sakurai F, Kawabata K, Sasaki T, Koizumi N, Huang H, Tashiro K, Kurachi S, Nakagawa S, Mizuguchi H J. Control. Release, 117, 430-437 (2007) Efficient gene transfer into murine pancreatic islets using adenovirus vectors Mukai E, Fujimoto S, Sakurai F, Kawabata K, Yamashita M, Inagaki N, Mizuguchi H J. Control. Release, 119, 136-141 (2007) Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin Harada M, Kondoh M, Ebihara C, Takahashi A, Komiya E, Fujii M, Mizuguchi H, Tsunoda S, Horiguchi Y, Yagi K, Watanabe Y Biochem. Pharmacol., 73, 206-214 (2007) Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction

30

Ebihara C, Kondoh M, Harada M, Fujii M, Mizuguchi H, Tsunoda S, Horiguchi Y, Yagi K, Watanabe Y Biochem. Pharmacol., 73, 824-830 (2007) Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex Hama S, Akita H, Iida S, Mizuguchi H, Harashima H Nuc. Acids Res., 35, 1533-1543 (2007) Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-γ activation Moriuchi A, Yamasaki H, Shimamura M, Kita A, Kuwahara H, Fujishima K, Satoh T, Fukushima K, Fukushima T, Hayakawa T, Mizuguchi H, Nagayama Y, Abiru N, Kawasaki E, Eguchi K Biochem. Biophys. Res. Commun., 356, 1024-1030 (2007) Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV Xin KQ, Sekimoto Y, Takahashi T, Mizuguchi H, Ichino M, Yoshida A, Okuda K Vaccine, 25, 3809-3815 (2007) Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer Gao JQ, Kanagawa N, Motomura Y, Yanagawa T, Sugita T, Hatanaka Y, Tani Y, Mizuguchi H, Tsutsumi Y, Mayumi T, Okada N, Nakagawa S Gene Ther., 14, 491-502 (2007) Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells Xin H, Kanehira M, Mizuguchi H, Hayakawa T, Kikuchi T, Nukiwa T, Saijo Y Stem Cells, 25, 1618-1626 (2007) Chimeric adenovirus type 5/35 vector encoding SIV gag and HIV env genes affords protective immunity against the simian/human immunodeficiency virus in monkeys Someya K, Xin KQ, Ami Y, Izumi Y, Mizuguchi H, Ohta S, Yamamoto N, Honda M, Okuda K Virology, 367, 390-397 (2007) Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration Gao JQ, Eto Y, Yoshioka Y, Sekiguchi F, Kurachi S, Morishige T, Yao X, Watanabe H, Asavatanabodee R, Sakurai F, Mizuguchi H, Okada Y, Mukai Y, Tsutsumi Y, Mayumi T, Okada N, Nakagawa S J. Control. Release, 122, 102-110 (2007) TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection

31

Yao X, Yoshioka Y, Eto Y, Morishige T, Okada Y, Mizuguchi H, Mukai Y, Okada N, Nakagawa S Biochem. Biophys. Res. Commun., 362, 419-424 (2007) Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells Kanehira M, Xin H, Hoshino K, Maemondo M, Mizuguchi H, Hayakawa T, Matsumoto K, Nakamura T, Nukiwa T, Saijo Y Cancer Gene Ther., 14, 894-903 (2007) Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from Tat transduction domain Kamada H, Okamoto T, Kawamura M, Shibata H, Abe Y, Ohkawa A, Nomura T, Sato M, Mukai Y, Sugita T, Imai S, Nagano K, Tsutsumi Y, Nakagawa S, Mayumi T, Tsunoda S Biol. Pharm. Bull., 30, 218-223 (2007)

A strategy for efficient cross-presentation of CTL-epitope peptides leading to enhanced induction of in vivo tumor immunity Hayashi A, Wakita H, Yoshikawa T, Nakanishi T, Tsutsumi Y, Mayumi T, Mukai Y, Yoshioka Y, Okada N, Nakagawa S J. Control. Release, 117, 11-19 (2007)

The combination of IFN-α2 and IFN-α8 exhibits synergistic antiproliferative activity on renal cell carcinoma (RCC) cell lines through increased binding affinity for IFNAR-2 Tanimoto T, Yamamoto S, Taniai M, Taniguchi M, Ariyasu H, Ushio C, Aga M, Mukai Y, Tsutsumi Y, Ariyasu T, Ohta T, Fukuda S J. Interferon Cytokine Res., 27, 517-523 (2007) Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants Shibata H, Kamada H, Kobayashi-Nishibata K, Yoshioka Y, Nishibata T, Abe Y, Nomura T, Nabeshi H, Minowa K, Mukai Y, Nakagawa S, Mayumi T, Tsunoda S, Tsutsumi Y BBA - Proteins and Proteomics, 1774, 1029-1035 (2007) Creation of a novel cell penetrating peptide, using a random 18mer peptides library Nomura T, Kawamura M, Shibata H, Abe Y, Ohkawa A, Mukai Y, Sugita T, Imai S, Nagano K, Okamoto T, Tsutsumi Y, Kamada H, Nakagawa S, Tsunoda S Pharmazie, 62, 569-573 (2007) Improved cytosolic translocation and tumor-killing activity of Tat-shepherdin conjugates mediated by co-treatment with Tat-fused endosome-disruptive HA2 peptide Sugita T, Yoshikawa T, Mukai Y, Yamanada N, Imai S, Nagano K, Yoshida Y, Shibata H, Yoshioka Y, Nakagawa S, Kamada H, Tsunoda S, Tsutsumi Y

32

Biochem. Biophys. Res. Commun., 363, 1027-1032 (2007) Reactivation of latent human immunodeficiency virus 1 by human herpesvirus 6 infection Isegawa Y, Katahira J, Yamanishi K, Sugimoto N Acta. Virol., 51, 13-20 (2007) Real-time PCR determination of human herpesvirus 6 antiviral drug susceptibility Isegawa Y, Takemoto M, Yamanishi K, Ohshima A, Sugimoto N J. Virol. Methods, 140, 25-31 (2007) Influenza hemagglutinin vaccine with poly(γ-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity Okamoto S, Yoshii H, Akagi T, Akashi M, Ishikawa T, Okuno Y, Takahashi M, Yamanishi K, Mori Y Vaccine, 25, 8270-8278 (2007) Deletion in open reading frame 49 of varicella-zoster virus reduces virus growth in human malignant melanoma cells but not in human embryonic fibroblasts Sadaoka T, Yoshii H, Imazawa T, Yamanishi K, Mori Y J. Virol., 81, 12654-12665 (2007) Generation of a recombinant Oka varicella vaccine expressing mumps virus hemagglutinin-neuraminidase protein as a polyvalent live vaccine Somboonthum P, Yoshii H, Okamoto S, Koike M, Gomi Y, Uchiyama Y, Takahashi M, Yamanishi K, Mori Y Vaccine, 25, 8741-8755 (2007) Reciprocal roles of cellular chemokine receptors and human herpesvirus 7-encoded chemokine receptors, U12 and U51 Tadagaki K, Yamanishi K, Mori Y J. Gen. Virol., 88, 1423-1428 (2007) Human herpesvirus 7 infection increases the expression levels of CD46 and CD59 in target cells Takemoto M, Yamanishi K, Mori Y J. Gen. Virol., 88, 1415-1422 (2007) Cloning of full length genome of varicella-zoster virus vaccine strain into a bacterial artificial chromosome and reconstitution of infectious virus Yoshii H, Somboonthum P, Takahashi M, Yamanishi K, Mori Y Vaccine, 25, 5006-5012 (2007) 細胞内薬物導入キャリアとしての細胞内移行ペプチドの応用技術

向洋平, 堤康央, 中川晋作

33

遺伝子医学 MOOK 別冊「絵で見てわかるナノ DDS」, 184-190, (2007) Adenovirus vectors composed of subgroup B adenoviruses (Review) Sakurai F, Kawabata K, Mizuguchi H Curr. Gene Ther., 7, 229-238 (2007) Development of new anti-TNF therapy (Review) Kamada H, Shibata H, Tsutsumi Y Inflammation and Regeneration, 27, 512-515 (2007) アデノウイルスベクター開発の最前線 (Review) 水口裕之

バイオテクノロジージャーナル, 7, 168-173 (2007)

改良型アデノウイルスベクターを用いた各種幹細胞への遺伝子デリバリー (Review) 川端健二, 櫻井文教, 水口裕之

Drug Delivery System, 22, 148-154 (2007)

アデノウイルスベクター (Review) 水口裕之, 早川堯夫

バイオ医薬品の開発と品質・安全性確保 (エル・アイ・シー), 563-577 (2007)

遺伝子治療用医薬品の品質,安全性等の確保 (Review) 早川堯夫, 前田大輔, 水口裕之

バイオ医薬品の開発と品質・安全性確保 (エル・アイ・シー), 551-562 (2007)

遺伝子導入技術開発とその応用 (Review) 水口裕之

大阪医薬品協会会報, 699, 21-45 (2007)

カプシドタンパク質改変アデノウイルスベクター (Review) 水口裕之, 櫻井文教, 川端健二

遺伝子医学 MOOK 別冊「絵で見てわかるナノ DDS」, 235-242 (2007)

機能性人工タンパク質

堤康央, 石井明子, 早川堯夫

バイオ医薬品の開発と品質・安全性確保 (エル・アイ・シー), 369-378 (2007)

遺伝情報解析学 (Environmental Science and Microbiology) High-frequency phage-mediated gene transfer among Escherichia coli cells, determined at the

34

single-cell level Kenzaka T, Tani K, Sakotani A, Yamaguchi N, Nasu M Appl. Environ. Microbiol., 73, 3291-3299 (2007) Rapid monitoring of bacteria in dialysis fluids by fluorescent vital staining and microcolony methods Yamaguchi N, Baba T, Nakagawa S, Saito A, Nasu M Nephrol. Dial. Transplant., 22, 612-616 (2007)

Rapid quantification of bacterial cells in potable water using a simplified microfluidic device Sakamoto C, Yamaguchi N, Yamada M, Nagase H, Seki M, Nasu M J. Microbiol. Methods, 68, 643-647 (2007) Rapid and automated enumeration of viable bacteria in compost using a micro-colony auto counting system Wang X, Yamaguchi N, Someya T, Nasu M J. Microbiol. Methods, 71, 1-6 (2007) Stimulatory effect of glutamine and pyruvate on plasmid transfer between Pseudomonas strains Jorquera M, Yamaguchi N, Tani K, Nasu M Microb. Environ., 22, 320-326 (2007) Distribution and diversity of Shiga toxin 2 gene in urban rivers Tani K, Kaneshige M, Nasu M J. Health Sci., 53, 486-490 (2007) マイクロコロニー自動計数システムによる水環境中の生菌数の迅速計測

馬場貴志, 山口進康, 青木一洋, 那須正夫 防菌防黴, 35, 719-724 (2007) 透析液製造ラインにおける細菌の動態

馬場貴志, 山口進康, 那須正夫 腎と透析別冊「HDF 療法 2007」, 186-188 (2007) マイクロチップデバイスによる水環境中の細菌群集プロファイリング

山口進康, 新留洋子, 那須正夫 2007 生態工学会年次大会発表論文集, 155-158 (2007) 電子顕微鏡 - in situ ハイブリダイゼーション法を用いた水処理システムの細菌の可視化

馬場貴志, 稗田はつき, 見坂武彦, 山口進康, 那須正夫 2007 生態工学会年次大会発表論文集, 159-162 (2007)

35

宇宙居住環境中の微生物 (Review) 一條知昭, 那須正夫 Eco-Engineering, 19, 185-189 (2007)

蛋白情報解析学 (Protein Molecular Engineering) A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC Circulation Research, 100, 1712-1722 (2007) Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells Tachibana K, Katayama T, Ueda C, Sumitomo M, Tagami M, Ishimoto K, Yamasaki D, Tanaka T, Hamakubo T, Sakai J, Kodama T, Obika S, Imanishi T, Doi T Nucleic Acids Sym. Ser., 51, 441-442 (2007) 金磁性ナノ粒子が遺伝子解析を変える?! ―ポストゲノム研究に貢献する新しい磁気ビーズ

の開発 (Review) 清野智史, 山本孝夫, 中川晋作, 土井健史 化学, 62(6), 24-28 (2007) ペルオキシゾーム増殖剤応答性受容体 (PPAR) の発現量が調節可能なヒト肝癌由来細胞株の

樹立とその応用 (Review) 橘敬祐 薬学雑誌, 127, 1223-1229 (2007)

微生物動態学（Environmental Pharmacometrics） 整形外科領域における大量癌化学療法に対する 5-HT3 受容体拮抗剤の効果比較

竹中美樹, 岡本禎晃, 池田賢二, 橋本陵, 上田孝文, 黒川信夫, 高木達也, 上島悦子 癌と化学療法, 34, 403-407 (2007) 講座「ケモメトリックス入門」第 2回：多重比較法入門

高木達也 生物工学会誌, 85, 227-232 (2007) 講座「ケモメトリックス入門」第 5回：ノンパラメトリック検定とリサンプリング法

岡本晃典 生物工学会誌, 85, 370–375 (2007)

36

講座「ケモメトリックス入門」第 6回：平滑化とノンパラメトリック回帰

高木達也 生物工学会誌, 85, 409-412 (2007) 環境病因病態学 (Clinical and Experimental Pathophysiology) Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene Goto HG, Nishizawa Y, Katayama H, Murashima T, Yamasaki M, Tanigaki Y, Kimura S, Fushiki S, Nishizawa Y Oncol. Rep., 17, 225-232 (2007) Nuclear expression of STAT5 in intraductal papillary mucinous neoplasms of the pancreas Kataoka TR, Ioka T, Tsukamoto Y, Matsumura M, Ishiguro S, Nishizawa Y Int. J. Surg. Pathol., 15, 277-281 (2007) Establishment of a progesterone-sensitive cell line from human lung cancer Nishizawa Y, Yamasaki M, Katayama H, Amakata Y, Fushiki S, Nishizawa Y Oncol. Rep., 18, 685-690 (2007) Loss of smooth muscle calponin results in impaired blood vessel maturation in the tumor-host microenvironment Yamamura H, Hirano N, Koyama H, Nishizawa Y, Takahashi K Cancer Sci., 98, 757-763 (2007) 過活動性膀胱の健康関連生活の質改善に対する牛車腎気丸と propiverine hydrochloride の前

向き無作為比較試験

西澤芳男, 西澤恭子, 吉岡二三, 天方義邦, 野坂修一, 伏木信次 漢方と最新治療, 16, 131-142 (2007) 食道-胃接合部癌の粘液形質：背景胃病変、Helicobacter pylori 感染との関連性 (Review) 石黒信吾, 辻直子, 塚本吉胤, 片岡竜貴, 松村真生子, 西澤恭子 Helicobacter Research, 11, 35-41 (2007) 変形性膝関節症に対する防已黄耆湯加修治附子末の治療効果 (Review) 西澤芳男, 西澤恭子, 吉岡二三, 村嶋照子, 谷垣由美子, 雨森保憲, 野坂修一, 永野富美代, 川田陽子, 平田・大山弥生, 安田理絵, 渋谷令子, 山田まゆみ, 天方義邦, 多田正志, 伏木信次 Pharma Medica, 25, 15-21 (2007) 病原微生物学 (Bacterial Infections)

37

Tetrameric structure of thermostable direct hemolysin from Vibrio parahaemolyticus revealed by ultracentrifugation, small-angle X-ray scattering and electron microscopy Hamada D, Higurashi T, Mayanagi K, Miyata T, Fukui T, Iida T, Honda T, Yanagihara I J. Mol. Biol., 365, 187-195(2007) Polyclonality of Staphylococcus epidermidis residing on the healthy ocular surface Ueta M, Iida T, Sakamoto M, Sotozono C, Takahashi J, Kojima K, Okada K, Chen X, Kinoshita S, Honda T J. Med. Microbiol., 56, 77-82(2007) Lateral transfer of the lux gene cluster Kasai S, Okada K, Hoshino A, Iida T, Honda T J. Biochem., 141, 231-237(2007) Demonstration and characterization of manganese superoxide dismutase of Providencia alcalifaciens Chen X, Kodama T, Iida T, Honda T Microbiol. Immunol., 51, 951-961(2007) Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP Cantarelli VV, Kodama T, Nijstad N, Abolghait SK, Nada S, Okada M, Iida T, Honda T Cellular Microbiology, 9, 1782-1795(2007) A targeting approach for delivery of polymer microparticle-antibody conjugate against Vibrio parahaemolyticus-induced cytotoxicity to human intestinal epithelial cells Gao F, Kodama T, Chen X, Okada K, Honda T J. Drug Targeting, 15, 428-436(2007) 三類感染症 腸管出血性大腸菌感染症

谷口暢, 本田武司 日本臨床, 65(増刊号 3), 91-97 (2007） 細菌性腸管感染症研究の現状

本田武司 学術月報, 60, 210-216 (2007） 免疫不全宿主と腸管感染症 3.腸管感染と免疫 明田幸宏, 本田武司 化学療法の領域, 23 (S-1 増刊号), 170-176 (2007)

歩み出した日本・タイ新興再興感染症共同研究センター －ボツリヌス中毒の集団発生を経

38

験して－

谷口暢, 岡田和久, 本田武司 検査と技術, 35, 662 (2007） 残暑厳しい折 O(オー)157 に要注意

本田武司 日刊スポーツ, 13 版(8 月 19 日) (2007) 腸管出血性大腸菌感染症の現況 変貌する細菌感染症

本田武司 医学のあゆみ, 223, 615-618 (2007) 薬用資源学１ (Medicinal Resources) Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in 1α,25 dihydroxyvitamin D3 treated Caco-2 cells Hou XL, Takahashi K, Kinoshita N, Qiu F, Tanaka K, Komatsu K, Takahashi K, Azuma J Int. J. Pharm., 337, 169-177 (2007) New sesquiterpenes and calebin derivatives from Curcuma longa Zeng YC, Qiu F, Takahashi K, Liang JM, Qu GX, Yao XS Chem. Pharm. Bull., 55, 940-943 (2007) Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes Ito T, Fujio Y, Takahashi K, Azuma J J. Biol. Chem., 282, 1152-1160 (2007) Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress Yamane M, Matsuda T, Ito T, Fujio Y, Takahasi K, Azuma J Biochem. Biophys. Res. Commun., 353, 1023-1027 (2007) 薬物相互作用と副作用 (Review) 高橋京子, 東純一

高脂血症診療エキスパートへの手引き (臨床医薬研究協会), 117-129 (2007) 病院薬学教育研究部 (Hospital Pharmacy Education) A retrospective chart review of the antiemetic effectiveness of risperidone in refractory opioid-induced nausea and vomiting in advanced cancer patients

39

Okamoto Y, Tsuneto S, Matsuda Y, Inoue T, Tanimukai H, Tazumi K, Ono Y, Kurokawa N, Uejima E Journal of Pain and Symptom Management, 34, 217-222 (2007) 整形外科領域における大量癌化学療法に対する 5-HT3 受容体拮抗剤の効果比較

竹中美樹, 岡本禎晃, 池田賢二, 橋本陵, 上田孝文, 黒川信夫, 高木達也, 上島悦子

癌と化学療法, 34, 403-407 (2007)

癌疼痛治療 -経口モルヒネ徐放錠(1 回/1 日)の臨床-

岡本禎晃, 野田恵美, 黒川信夫, 上島悦子

Pharma Medica, 25, 152-154 (2007)

化学療法剤および抗生物質に関する文献紹介(22) (Review) 上島悦子

化学療法の領域, 23, 1956-1957 (2007)

化学療法剤および抗生物質に関する文献紹介(20) (Review) 上島悦子

化学療法の領域, 23, 1648-1650 (2007)

化学療法剤および抗生物質に関する文献紹介(18) (Review) 上島悦子

化学療法の領域, 23, 1348-1350 (2007)

化学療法剤および抗生物質に関する文献紹介(16) (Review) 上島悦子

化学療法の領域, 23, 1017-1020 (2007)

化学療法剤および抗生物質に関する文献紹介(14) (Review) 上島悦子

化学療法の領域, 23, 640-643 (2007)

化学療法剤および抗生物質に関する文献紹介(12) (Review) 上島悦子

化学療法の領域, 23, 322-326 (2007)

サテライトファーマシーと医薬品の一元管理 (Review) 上島悦子, 黒川信夫

医薬ジャーナル, 43, 2749-2753 (2007)

薬品管理室の業務の実際 (Review) 澤田昌良, 黒川信夫, 上島悦子,

医薬ジャーナル, 43, 2305-2312 (2007)

40

病棟定数配置薬の管理の実際 (Review) 上田幹子, 黒川信夫, 上島悦子

医薬ジャーナル, 43, 1876-1881 (2007)

重点管理薬品（麻薬・向精神薬・毒薬・劇薬など）(Review) 田烏とも子, 黒川信夫, 上島悦子

医薬ジャーナル, 43, 1433-1439 (2007)

手術部サテライトファーマシーにおける薬品管理の実際 (Review) 岡本禎晃, 木村彩子, 黒川信夫, 上島悦子

医薬ジャーナル, 43, 974-981 (2007) 手術部サテライトファーマシーの歴史とその役割 (Review) 上島悦子, 黒川信夫

医薬ジャーナル, 43, 161-165 (2007)

がん化学療法と薬学的安全管理 2：プロトコール管理と安全対策 (Review) 上島悦子

医薬ジャーナル, 43, 883-889 (2007)

応用環境生物学 (Applied Environmental Biology) Removal of phenolic endocrine disruptors by Portulaca oleracea Imai S, Shiraishi A, Gamo K, Watanabe I, Okuhata H, Miyasaka H, Ikeda K, Bamba T, Hirata K J. Biosci. Bioeng., 103, 420-426 (2007) A novel gene with antisalt and anticadmium stress activities from a halotolerant marine green alga Chlamydomonas sp.W80 Tanaka S, Suda Y, Ikeda K, Ono M, Miyasaka H, Watanabe M, Sasaki K, Hirata K FEMS Microbiol. Lett., 271, 48-52 (2007) A novel method using cyanobacteria for ecotoxicity test of veterinary antimicrobial agents Ando T, Nagase H, Eguchi K, Hirooka T, Nakamura T, Miyamoto K, Hirata K Environ. Toxicol. Chem., 26, 601–606 (2007) Periploca sepium Bunge as a model plant for rubber biosynthesis study Bamba T, Sando T, Miyabashira A, Gyokusen K, Nakazawa Y, Su Y, Fukusaki E, Kobayashi A Z. Naturforsch., 62c, 579-582 (2007) Functional analysis of very long-chain fatty acid elongase gene, HpELO2, in the methylotrophic yeast Hansenula polymorpha

41

Prasitchoke P, Kaneko Y, Sugiyama M, Bamba T, Fukusaki E, Kobayashi A, Harashima S Appl. Microbiol. Biotechnol., 76, 417-427 (2007) Identification and characterization of a very long-chain fatty acid elongase gene in the methylotrophic yeast, Hansenula polymorpha Prasitchoke P, Kaneko Y, Bamba T, Fukusaki E, Kobayashi A, Harashima S Gene, 391, 16–25 (2007) 微生物共生系による余剰バイオマスを原料とする水素生産 (Review) 平田收正, 宮本和久 生物工学, 85, 212-214 (2007) 超臨界流体クロマトグラフィーを用いた疎水性代謝物の分離分析 (Review) 馬場健史, 福崎英一郎 質量分析, 55, 193-199 (2007) メタボロミクス（代謝物総体解析）の原理と食品工学への応用 (Review) 福崎英一郎, 馬場健史 FFI ジャーナル, 212, 380-388 (2007) 融合研究部３ (Environmental Bioengineering) A novel method using cyanobacteria for ecotoxicity test of veterinary antimicrobial agents Ando T, Nagase H, Eguchi K, Hirooka T, Nakamura T, Miyamoto K, Hirata K Environ. Toxic. Chem., 26, 601-606 (2007) Rapid quantification of bacterial cells in potable water using a simplified microfluidic device Sakamoto C, Yamaguchi N, Yamada M, Nagase H, Seki M, Nasu M J. Microbiol. Methods, 68, 643-647 (2007) 紫外線照射による排水からの環境ホルモンの分解・回収技術 (Review) 永瀬裕康, 齊藤博

排水・汚水処理技術集成 (エヌ・ティー・エス), 647-654 (2007)