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Apoptosis ATF6 (p50) ATF6 (p90) PERK IRE1 IRE1 XBP1 mRNA splicing ATF6 (p50) Mitochondria Endoplasmic reticulum Golgi apparatus Cytochrome C UPR genes (GRP78, PDI, GRP94, etc) Secretion ROS Proteasomal degradation ERSEs Unfolded protein Nucleus ATF6 (p90) Pro-caspase-12 Caspase12 Caspase 3 Bcl-2 JNK ATF4 PP1 GADD34 XBP1s EDEM Derlin elF-2α CHOP ATF4 XBP1s ASK1 P P P P P Kinase Phosphatase Transcription factor Ligand Kinase Key Translation ER stress pathway To ﬁnd out more, please visit www.abcam.com Copyright © 2018 Abcam. All rights reserved

ER Stress Pathway · 2018-11-12 · Apoptosis ATF6 (p50) ATF6 (p90) IRE1 PERK IRE1 XBP1 mRNA splicing ATF6 (p50) Mitochondria Endoplasmic reticulum Golgi apparatus Cytochrome C. Title:

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Page 1: ER Stress Pathway · 2018-11-12 · Apoptosis ATF6 (p50) ATF6 (p90) IRE1 PERK IRE1 XBP1 mRNA splicing ATF6 (p50) Mitochondria Endoplasmic reticulum Golgi apparatus Cytochrome C. Title:

Apoptosis

ATF6(p50)

ATF6(p90)

PERKIRE1 IRE1

XBP1 mRNA splicing

ATF6(p50)

Mitochondria

Endoplasmicreticulum

Golgi apparatus

Cytochrome C

UPR genes (GRP78, PDI, GRP94, etc)

Secretion

ROSProteasomal degradation

ERSEs

Unfolded protein

Nucleus

ATF6 (p90)

Pro-caspase-12

Caspase12Caspase 3

Bcl-2 JNK

ATF4

PP1

GADD34XBP1s

EDEMDerlin

elF-2α

CHOP

ATF4 XBP1s

ASK1

PPP P P

Kinase

Phosphatase

Transcriptionfactor

Ligand

Kinase

Key

Translation

ER stress pathway

To find out more, please visit www.abcam.comCopyright © 2018 Abcam. All rights reserved

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