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Featured Article :. Genetic Risk Score Constructed Using 14 Susceptibility Alleles for Type 2 Diabetes Is Associated With the Early Onset of Diabetes and May Predict the Future Requirement of Insulin Injections Among Japanese Individuals. - PowerPoint PPT Presentation
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Genetic Risk Score Constructed Using 14 Susceptibility Alleles for Type 2 Diabetes Is Associated With the Early Onset of Diabetes and May Predict the Future Requirement of
Insulin Injections Among Japanese Individuals
Featured Article:
Minoru Iwata, M.D., Ph.D., Shiro Maeda, M.D., Ph.D., Yutaka Kamura, M.D., Atsuko Takano, M.D., Ph.D., Hiromi Kato, M.D., Ph.D., Shihou Murakami, M.D., Ph.D., Kiyohiro Higuchi, M.D., Ph.D., Atsushi Takahashi, Ph.D.,Hayato Fujita, M.D., Kazuo Hara, M.D., Ph.D., Takashi Kadowaki, M.D., Ph.D., Kazuyuki Tobe, M.D., Ph.D.
Diabetes Care Volume 35: 1763-1770
August, 2012
Study Objective
• To evaluate the clinical usefulness of a genetic risk score (GRS) based on 14 well-established variants for type 2 diabetes
Iwata M et al. Diabetes Care 2012;35:1763-1770
Study Design
• Analyzed 14 SNPs in 1487 Japanese individuals (724 with type 2 diabetes and 763 controls):
• HHEX, CDKAL1, CDKN2B, SLC30A8, KCNJ11, IGF2BP2, PPARG, TCF7L2, FTO, KCNQ1, IRS-1, GCKR, UBE2E2, C2CD4A/B
• GRS calculated according to the number of risk alleles by counting:
• All 14 SNPs (T-GRS)• 11 SNPs related to b-cell function (β-GRS) • Assessed association between each GRS and clinical
features
Iwata M et al. Diabetes Care 2012;35:1763-1770
Results
• 4 SNPs significantly associated with type 2 diabetes in the sample (P = 0.0036)
• T-GRS significantly associated with type 2 diabetes (P = 5.9 x 10-21)
• Among subjects with type 2 diabetes, β-GRS associated with:
• Receiving insulin therapy (β = 0.0131, SE = 0.006, P = 0.0431)
• Age at diagnosis (β = 20.608, SE = 0.204, P = 0.0029)
• Fasting serum C-peptide level (β = 20.032, SE = 0.0140, P = 0.022)
• C-peptide index (β = 20.031, SE = 0.012, P = 0.0125).
Iwata M et al. Diabetes Care 2012;35:1763-1770
Iwata M et al. Diabetes Care 2012;35:1763-1770
Iwata M et al. Diabetes Care 2012;35:1763-1770
Iwata M et al. Diabetes Care 2012;35:1763-1770
Iwata M et al. Diabetes Care 2012;35:1763-1770
Conclusions
• β-GRS is associated with reduced β-cell function and may be useful for selecting patients who should receive more aggressive β-cell–preserving therapy
Iwata M et al. Diabetes Care 2012;35:1763-1770