Febrele hemoragice

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Febrele hemoragice

Text of Febrele hemoragice

  • Febrele hemoragice

  • Clasificarea febrelor hemoragiceTransmise de cpueFH Crimea-CongoFH de OmscFH de Kiasanur

    Transmise de nariFebra galbenFebra DengheFebra CicunguniaFebra vii Rift

    De contactFH cu sindrom renalFebra LassaFebra MarburgFebra EbolaFebra de ArgentinaFebra de BoliviaFebra de BraziliaFebra de Venesuela

  • Four distinct viral families:

    Filoviridae Ebola MarburgArenaviridae Lassa fever New world hemorrhagic fever Bolivian hemorrhagic fever (Machupo) Argentine hemorrhagic fever (Junin virus) Venezuelan hemorrhagic fever (Guanarito virus) Brazilian hemorrhagic fever (Sabia virus)Bunyaviridae Crimean-Congo hemorrhagic fever Rift Valley fever HantavirusFlaviviridae Dengue Yellow fever Omsk hemorrhagic fever Kyasanur Forest disease

  • Cpuele vectori de transmitere a febrelor hemoragice

  • Animals:Numerous wild and domestic animals, such as cattle, goats, sheep, and hares, serve as amplifying hostsFiloviridae: Same clinical course as that of humansHigh primate mortality rate: ~ 82%Bunyaviridae: CCHF- unapparent infection in livestockRVF- 100% abortion rate and mortality rate of > 90% in young animals and 5-60% in older animalsHantavirus unapparent infection in rodentsFlaviviridae: Non-human primates varying clinical signs (Yellow fever); no clinical signs (Dengue)Livestock no symptoms (Kyasanur Forest Disease)Rodents no symptoms

  • Humans:Clinical signs and symptoms vary by the type of VHFPatients usually present with the following clinical signs and symptoms: Fever 38.3C of < 3 week durationFatigueDizzinessMuscle achesLoss of strengthExhaustionAt least two of the following: Hemorrhagic or purple rashEpistaxisHemoptysisBlood in stoolsPetechiae in nondependent areasNo predisposing factors for hemorrhage and no established alternative diagnosis

  • Filoviridae:

    Most severe hemorrhagic fevers with abrupt onset and death around day 7 to 11; painful recoveryIncubation: 4 to 10 daysCase fatality: 23-33% (Marburg) and 53-88% (Ebola)

    Arenaviridae: Incubation: 10 to 14 daysCase fatality: 5-35%Bunyaviridae:

    Incubation: 3 to 7 days (CCHF); 2 to 5 days (RVF); 7 to 21 days (Hantavirus)Case fatality: 30% (CCHF); 1% (RVF); 1-50% (Hantavirus)

    Flaviviridae Incubation: 2 to 6 daysCase fatality: 1-10% (Dengue); 3-5% (Kyasanur Forest virus); 0.5-3% (Omsk hemorrhagic fever); varies (Yellow fever)

  • Febra hemoragic Crimea-Congo

  • Febra hemoragic Crimea-Congo

  • Febra hemoragic cu sindrom renal

  • Virusul Ebola Virusul MarburgFamilia Filivirusuri

  • Febra hemoragic Ebola i Marburg

  • Manifestri clinice n FH Ebola i Marburg

  • Febra de Argentina i de BoliviaMassive cutaneous ecchymosis

  • Febra LassaDebut bruscSindrom de intoxicaie exprimatSindrom dispeptic cu grea, vom, diareeLimfadenopatie cervicalSindrom hemoragic exprimatFocare de necroz n orofaringeUlceraii cu depuneri fibrinoaseoc toxico-infeciosInsuficien pulmonarInsuficien renalSfrit letal la 15-20%

  • Hantavirus sindrom febril

  • Diagnosticul de laborator

  • Msurile antiepidemice n focare