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Soo Yeon, Chung [email protected] 비타민 (VITAMINS) 2012. 11. 5 20122학기

(GAN-Lit) Stability of Vitamins

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  • Soo Yeon, Chung

    [email protected]

    (VITAMINS)

    2012. 11. 5

    2012 2

  • 1.

    1)

    2)

    (, )

    3) ,

    4) 30

    5) (A, D, E, K) (B , C)

    6) vita () + amine (thiamine ) = vitamine vitamin

  • 2.

    1) (provitamins)

    -

    - carotene: A

    - ergosterol 7-dehydrocholesterol: ergocalciferol (D2)

    cholecalciferol (D3)

    2) (antivitamin)

    - ( avidin )

    -

  • - , -

    - -

    -, - ()

    -

    - ()

    - , - - ,

    - - - -

    - -

    A, D, E, K B , C

  • 1. - (retinol), (retinyl esters), (carotenoids) - -ionone isoprene chain , - : carotenoids (, , carotene, -cryptoxanthin) 2. - - (retinol retinal retinoic acid) - - (50-80%), (10%), (25%) - : , , , 3. - A: , , , , , - carotene: (, , , , , , , )

    A

  • 1.

    - sterols

    - (calciferol) D1, D2, D3, D4, D5

    - D2: ergosterol ergocalciferol

    - D3: 7-dehydrocholesterol cholecalciferol

    2.

    - , , ,

    -

    - D A

    - (Ca3(PO4)2) () 3.

    - (, ) , , ,

    D

  • 1.

    -

    - tocol , , , tocopherol 4 () : (100%) > (50%) > (26%) > (10%) - , ( 200oC) ,

    ,

    - E 2.

    - E

    1 (I.U.) = E tocopherol 1 mg - : (, ), ,

    - : (, , , )

    E

  • 1. - : - - : phylloquinone (K1, ), menaquinones (K2, ) - , , , (K3~K5 ): K3 (menadione) - , , 3 - : 2. - : , (, , ), - (K2, menaquinone) - : , , , ,

    K

  • 1. - pyrimidine thiazole - , (aneurin) - thiol B1 + allicine ( ) = allithiamine ( B1) 2. - - ; , (pH 3.5 ), 100oC 10-20% - 20-30%, ( 6) 33% - 10%, 50% , 70-80% - (vitamin B2, lumiflavin, lumichrome, eosine ) - 2-12 ( )

    3. : , , , , ,

    B1 (thiamine)

  • B2 (riboflavin)

    1. - isoalloxazine ribitol - - , , 2 50% 2. - - , B2 ( B2 ) - , - , ; , C - - : , , , , 3. : ,

  • (Vitamin B3)

    1.

    - B2

    - (nicotinic acid)

    2.

    -

    - (, , , , )

    50% - (anti-pellagra), (anti-blacktongue)

    3. : (, , , , , )

    60 mg 1 mg

  • 1.

    - -

    2.

    - , , ,

    - A (coenzyme A, CoA) ,

    3. :

    : 5-10 mg

    - (Vitamin B5)

  • 1.

    - (adermin) pyridoxine (pyridine )

    - pyridoxine, pyridoxal, pyridoxamine

    : pyridoxal-5-phosphate (PLP) - , ,

    - : , ,

    2.

    - ( , )

    B6 (pyridoxine)

  • (biotin) 1. - - purine , , pancreatic amylase 2. , , 3. ( H biotin) 4. avidin () 5. ,

    (folic acid) 1. - pteroyl glutamate (pteridine + p-aminobenzoic acid + glutamic acid) 2. , , 3. B12 4. : , , , 5. : (, , ), , ,

    &

  • 1.

    - porpyrin 1 Co cobalamine

    - (anti-pernicious anemia factor, APAF),

    (animal protein factor, APF), (LLD)

    2.

    -

    -

    3.

    - ,

    - , , , ,

    - B12

  • 1. - hexose , - (L-ascorbic acid, ASA) (dehydroascorbic acid, AA) 1/2 - , A , 2. - (antiscorbutic) - : , , , , , - , , , Fe, Cu - , furfural () - 50% 3. - : , , , , , , , , ,

    - C (ascorbic acid)

  • Soo Yeon, Chung

    [email protected]

    (ENZYMES)

    2012. 11. 5

    2012 2

  • :

    1.

    2.

    1) (, apoenzyme) ( )

    2) (holoenzyme) = apoenzyme + (, )

    3) apoenzyme,

    E

    S

    ES -

    EP -

    E

    P

    + +

  • 1.

    1) :

    2)

    2.

    - ( ) 3.

    (international system of unit, S.I.)

    1 (U) = 1 1 mole

  • 1. : 1) : 30~40

    2) :

    -amylase: 60~70, -amylase: 60 2. pH: pH (pepsin(1.5), trypsin(7.7), arginase(9.7)),

    3. : 1) :

    2) :

    4.

    1) ():

    2) ( ):

    5. (activator):

    6. (inhibitor):

  • I ,

    , , ,

    II

    III

    , , ,

  • IV

    , ,

    ,

    , , ,

    V ,

    , -

    VI ATP

  • 1. Lipoxygenase

    - A

    - ,

    2. Proteases

    - -chymotrypsin: tyrosine, phenylalanine, tryptophan

    - trypsin: arginine, lysine

    - pepsin & carboxypeptidase: phenylalanine

    3. Esterases:

    lipase, phospholipase

  • 4. Amylases: -amylase, -amylase, glucoamylase,

    -galactosidase (lactase: lactose -galactoside )

    5. : - ,

    - 6. Invertase:

    7. Naringinase: naringin

    8. Myrosinase: , sinigrin

    9. Ascorbinase: C

  • , , ,

    , ,

    (, pH )

    (vitamins) 4 5 D E K B1 (thiamine) B2 (riboflavin) (Vitamin B3) - (Vitamin B5) B6 (pyridoxine) & - B12 - C (ascorbic acid) (enzymes) 18 19 20 21 22 23 24 25