使用於繁殖方面的 使用於繁殖方面的 hormonehormone

(1) 刺激腦下垂體前葉的分泌 (2) 取代前葉 gonadotrophins 的作用 (3)estrogens

(4)progesterones

(5)prostaglandin

(6)melatonin 。

GnRHGnRH

隱睪 ?

GnRHGnRH

GnRHGnRH

LH sends the same message and rLH sends the same message and results in increased testosterone presults in increased testosterone production by the testis due to LH eoduction by the testis due to LH effect on the Leydig cells of the testffect on the Leydig cells of the testis. is.

LH and FSH are released into the LH and FSH are released into the systemic circulation, traveling to systemic circulation, traveling to the target reproductive organs the target reproductive organs (testes and ovary) where sex (testes and ovary) where sex steroid hormones are controlled. steroid hormones are controlled.

FSH/PMSGFSH/PMSG

隱睪 ?

FSH/PMSGFSH/PMSG

LH/hCGLH/hCG

LH/hCGLH/hCG

ProgesteroneProgesterone

ProgesteroneProgesterone

CIDRCIDR

melengesterol acetate (MGA)

ProgesteroneProgesterone

ProgesteroneProgesterone

PGFPGF22

vascular uteroovarian pathways forvascular uteroovarian pathways for PGFPGF22αα

• Local uteroovarian ：如牛羊，其路徑經子宮肌肉到子宮靜脈、靜脈叢，再滲透進入卵巢動脈。

• System uteroovarian ：如馬兔，其路徑經子宮肌肉到子宮靜脈、體循環達肺臟，再經體循環進入卵巢動脈。

• Combined system and local uteroovarian ：如豬、天竺鼠、蒼鼠及大白屬，若切除一邊子宮角，則黃體仍可停留一段時間，但不超過一個週期以上。

vascular uteroovarian pathways forvascular uteroovarian pathways for PGFPGF22αα

Systemic uteroovarian pathway: Local uteroovarian pathway: Combined systemic and local uteroovarian pathway:horse, rabbit sheep, cattle, swine, guinea pig, swine hamsters, rats

各種家畜對各種家畜對 PGF2PGF2的反應的反應

牛隻使用牛隻使用 PGF2PGF2作發情同期化之策略作發情同期化之策略

Clinical use of PGFClinical use of PGF22

PGFPGF22 及及 GnRHGnRH 的應用的應用

Reproductive meassure in dairy cows inseminated at various times Reproductive meassure in dairy cows inseminated at various times in relation to ovulation synchronized with an injection of GnRHin relation to ovulation synchronized with an injection of GnRH

Hours from 2nd GnRH to timed AI

Item 0 8 16 24 32 total

n 149 148 149 143 143 732

Conception rate(%) 37 41 45 41 32** 39

Pregnancy loss(%) 9** 21 21 21 32 22

Calving rate(%) 31 31 33 29 20* 29

Differs within a row (P< 0.05)

Differs within a row (P< 0.01)

Clinical use of PGFClinical use of PGF22

Clinical use of PGFClinical use of PGF22

Clinical use of PGFClinical use of PGF22

Clinical use of PGFClinical use of PGF22

Clinical use of PGFClinical use of PGF22

Clinical use of Clinical use of PGFPGF22

misalliance

induction of abortioninduction of abortionendometritis/pyometraendometritis/pyometra

only in the case of open pyometra!!only in the case of open pyometra!!

oxytocinoxytocin

oxytocinoxytocin