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Infeksi Jamur pada Paru

COCCIDIOIDOMYCOSIS

COCCIDIOIDOMYCOSIS

It may occur as either an acute, benign, self-limited disease or a chronic, malignant disseminated disease involving the cutaneous, subcutaneous, visceral or osseous tissue.

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Coccidioidomycosis: Valley Fever

• Coccidioides immitis - causes coccidioidomycosis

• Distinctive morphology – blocklike arthroconidia in the free-living stage and spherules containing endospores in the lungs

• Lives in alkaline soils in semiarid, hot climates and is endemic to southwestern U.S.

• Arthrospores inhaled from dust, creates spherules and nodules in the lungs

• Amphotericin B treatment

PORTAL OF ENTRY

INHALATION

INOCULATION

(Rare)

Pulmonary Symptoms

• Anorexia

• Shortness of breath

• Weight loss

• Productive cough

• Night sweats

• Arthralgia

• Erythema multiforme

ECOLOGICAL ASSOCIATION

• Desert soil

Archeological middens

Pottery

Rodent burrows

Cotton

Construction sites

SPHERULE

ENDOSPORES

ARTHROCONIDIA

SOIL

ANIMALHUMAN

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CLINICAL SPECIMENS

Sputum

Pus

Gastric washings

CSF

Bronchial washings

Biopsy material

SEROLOGICAL TESTS

• Complement fixation

• Immunodiffusion

• Slide agglutination

• EIA

DRUGS OF CHOICE

• Fluconazole

(mild infection)

• Itraconazole(mild infection)

• Amphotericin B

(severe infections)