Institut für Parasitologie - paras.uzh.chffffffff-ff54-16dd-ffff-ffffaca66384/JB_Buch_2010... · namhafte Drittmittel in einem EU- und in einem KTI-Projekt ein. Für klinische Für

Institut für Parasitologie Vetsuisse-Fakultät und Medizinische Fakultät

Zweijahresbericht 2010/2011 Biannual Report

Zweijahresbericht 2010/2011 Biannual Report Institut für Parasitologie* Vetsuisse-Fakultät und Medizinische Fakultät Universität Zürich Winterthurerstrasse 266a 8057 Zürich * Abkürzung: IPZ Tel.: +41 (0)44/635 85 01 Fax: +41 (0)44/635 89 07 E-mail: [email protected] URL: http://www.paras.uzh.ch Titelbild: Erstlarvalstadium des Herz- und Lungenwurms Angiostrongylus vasorum.

Inhaltsverzeichnis

Einleitung .................................................................................................... 1

Research/Forschung .................................................................................. 3

Scientific Reports ....................................................................................... 3

List of externally funded research grants/projects ............................... 28

Diagnostische Dienstleistungen ............................................................. 37

Publications 2010 and 2011 ..................................................................... 40

Original publications and reviews in peer-reviewed journals ................. 40

Original publications and reviews in non-reviewed journals .................. 46

Doctoral and master theses ................................................................... 47

European College Diploma .................................................................... 48

Books and book contributions ................................................................ 48

Scientific lecture in front of external audience and posters ................ 49

Guest lectures .......................................................................................... 60

Public work: Contributions/interviews ................................................... 62

Parasitologische Fortbildungsseminare des IPZ .................................. 65

Nachwuchsförderung .............................................................................. 68

Forschungsaufenthalte von Angehörigen anderer Institute ................ 72

Aussenbeziehungen ................................................................................ 74

Funktionen von Institutsangehörigen an Universität und Fakultät ..... 75

Bauliches, EDV und Ausstattung ........................................................... 76

Bibliothek, Sammlungen und Unterrichtsmittel .................................... 76

Preise ......................................................................................................... 76

Personal .................................................................................................... 77

Organigramm ............................................................................................ 80

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Einleitung

Das IPZ ist die einzige Institution im Grossraum Zürich, die das Fach Parasitologie in Forschung und Lehre vertritt. Das breite Lehrangebot für die Vetsuisse-, Medizinische und Mathematisch-Naturwissenschaftliche Fakultät der Universität Zürich setzt eine breit gefächerte Kompetenz im Fachbereich voraus. Das etablierte „OneHealth“-Konzept und die Bearbeitung von Projekten sowohl aus der grundlagen- als auch der problemorientierten Forschung haben sich bewährt. Die durchgeführten Strukturanpassungen der letzten Jahre, welche von der Fakultätsleitung effizient unterstützt wurden und welche vor allem dank dem überdurchschnittlichen Einsatz der motivierten Mitarbeitenden möglich waren, stärkten besonders die Forschung. Drei dynamische Forschungsbereiche (Medizinische und Veterinärmedizinische Parasitologie, Leitung Prof. P. Deplazes; Molekulare Parasitologie, Leitung Prof. A. Hehl; Vektor-Entomologie, Leitung Prof. A. Mathis) wurden etabliert, was die Evaluationsstelle UZH in ihrem Evaluationsbericht 2011 denn auch als „klare Vorstellung über die Forschungsstrategien“ des Institutes gewürdigt hat. Alle drei Bereiche werden von habilitierten Forschern geleitet, die eng zusammenarbeiten und in den letzten Jahren beträchtliche Drittmittel einwerben konnten. Die Etablierung der Einheit „Vektor-Entomologie“ hat die Kompetenz des Instituts in diesem wichtigen Gebiet, welches für die „(Veterinary) Public Health“ von zunehmender Bedeutung ist, nachhaltig gestärkt. Die Einheit konnte in den 5 Jahren ihres Bestehens die Infrastruktur für experimentelle Laborforschung wie auch für ökologische Feldforschung aufbauen und Ergebnisse zu Vorkommen, der Biologie, der molekularen Identifizierung und der Vektorkompetenz der in der Schweiz wichtigen Insekten-Vektoren publizieren. Die Einheit ist federführend in einem nationalen Projekt (Spatio-temporal diversity of mosquito fauna in Switzerland) und sie konnte ihre internationale Vernetzung durch Teilnahme an einem EU-Projekt (EDENext) weiter stärken. Damit nimmt die Einheit die führende Position im Gebiet in der Schweiz ein. Die Forschungsleistung des Institutes zeichnet sich durch 56 Publikationen in rezensierten Zeitschriften sowie durch die Präsenz von Forscherinnen und Forschern als eingeladene Vortragende an internationalen Kongressen aus. Am Institut bestehen ausgezeichnete Voraussetzungen für eine weitere Steigerung der Produktivität und Effizienz der Forschungstätigkeiten und für die Ausbildung von Nachwuchsforschenden. Erfreulicherweise haben 2 Veterinärmediziner mit dem MD-PhD-Programm begonnen. Mit Dr. Cornelia Spycher (‚AMBIZIONE‘ Programm des Schweizerischen Nationalfonds) und Dr. Manuela Schnyder (abgeschlossenes European Veterinary Parasitology College EVPC; sie ist in der Endphase ihres Habilitationsprojektes) haben wir eine verstärkte Frauenpräsenz in der Forschung. Auf dem Forschungsplatz Zürich wurde im Berichtsjahr eine engere wissenschaftliche Zusammenarbeit mit dem

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Virologischen Institut unserer Fakultät sowie mit dem Institut für Mikrobiologie der ETH Zürich etabliert, womit wir unsere Kompetenzen im biotechnologischen Bereich bündeln konnten. Mit diesen beiden Partnern warben wir gemeinsam namhafte Drittmittel in einem EU- und in einem KTI-Projekt ein. Für klinische Forschungsprojekte besteht eine intensive Zusammenarbeit mit allen Kliniken. So wurden im Berichtsjahr 16 Publikationen in Zusammenarbeit mit Klinikerinnen und Klinikern publiziert. Im „Joint Appointment“ mit der Grosstierklinik wurden eine Dissertation sowie kleinere Projekte von Residences durchgeführt. Bedingt durch eine Stellenmutation im Sekretariat unseres Institutes war es möglich, die Sekretariate des Virologischen Institutes und des IPZ unter Leitung von Frau Karin Dietze zusammenzulegen, auch unter Anpassung der räumlichen Struktur. Diese Lösung erhöhte die Effizienz und hat sich in innerhalb weniger Monate sehr bewährt. Infolge der Zunahme der Drittmittelbeschaffung in den letzten Jahren und bedingt durch die zahlreicheren Masterstudierenden sind die Platzverhältnisse am Institut äusserst eng. Der Umbau der Institutsbibliothek zu einem Grossraumbüro für Doktorierende und Postdocs wurde sehr positiv aufgenommen, doch leider ist die Kapazität dieses Raumes bereits vollumfänglich ausgelastet. Die Finanzierung des Institutes ist breit abgestützt: Auch im 2011 konnten die Drittmitteleinnahmen auf sehr hohem Niveau gehalten werden. Das Diagnostikzentrum erzielte wiederum einen Rekordertrag mit 761‘633.00 Fr. Im Rahmen der kompetitiven Drittmittel, (NF-Projekte, Ambizione, Forschungskredit der Universität Zürich, und EU – Projekte wurden 476‘530.44 Fr. ausgegeben. Im Bereich der nichtkompetitiven Mittel (BVET-Projekte, KTI-Projekte und Industrie) 720‘171.53 Fr.

Zürich, im Mai 2012 Prof. Dr. P. Deplazes

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Research/Forschung

In view of their great medical importance but also from a variety of other perspectives, including epidemiological, immunological, biochemical and genetic aspects, studies on zoonotic parasites and zoonoses are major research activities at the IPZ. The basic information about the various research projects is summarized below and is also available on the research homepage of the University of Zurich:

http://www.research-projects.unizh.ch/u60.htm

Scientific report on main research projects 2010/11

Molecular basis for protein secretion in the basal parasite Giardia lamblia

http://www.research-projects.uzh.ch/p12268.htm The protozoan parasite Giardia lamblia is a major agent of non-viral diarrhea causing significant morbidity in several hundred million humans each year. In addition, it is a biological model organism of particular interest because of its exceptionally simple cellular organization. Minimization is exemplified by the vesicular transport system for proteins which lacks a Golgi apparatus as a central hub but still supports complex secretory pathways. Interestingly, it could be shown that trophozoites generate cellular compartments during stage-differentiation to infectious cysts which are very similar in function to Golgi cisternae but contain only presorted material to build the protective cyst wall. This is a highly simplified and pulsed version of the classical stacked Golgi apparatus and allows investigation of dynamic transport processes which are not tractable in the complex systems of higher eukaryotes. It is also important to note that data from comparative genomics strongly suggest that the complexity of the giardial trafficking system on the genetic and morphological level is considerably lower that of a putative last common eukaryotic ancestor. Thus Giardia is a unique model system to find out to what extent a transport system can be reduced and still deliver quality controlled proteins to the correct destination at the right time. On the one hand we investigate regulated export of cyst wall components to determine the mechanisms for sorting and concerted secretion. We use a combination of bioinformatics, molecular genetics and imaging of dynamic processes to study how these proteins use their biophysical properties to interact with the minimized export machinery.

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0.2 µm

Another focus of the project is the quality control system in secretory transport. Our genomic survey indicates that large parts of this has been lost in Giardia during evolution, still it is essential for the production of protective surface molecules at all life-cycle stages. To identify the remaining core components we make use of the possibility to selectively boost the expression of the genes coding for these components by subjecting the cells to stress. The interesting part is that although the induction of this stress response is conserved from yeast to man, the components which act as sensors and transduce the stress signal are missing in Giardia. A primary goal therefore is to find this core function in Giardia and determine its evolutionary origin.

Confocal fluorescence microscopy: Detection

of emerging ESV organelles carrying cyst wall

proteins (red) adjacent to ER exit site

structures (green). These ER subdomains

organize export of newly synthesized proteins

and are able to direct secreted proteins to the

appropriate pathway. Nuclear DNA (blue);

inset (overview image)

Giardia lamblia presents a number of distinctive aspects that make it a biological model with broad significance. The simple organization of giardial systems allows an unobstructed view on basic processes and their genetic and molecular underpinnings which are difficult to extract from the highly complex organization of machineries in other organisms.

Institute members: A.B. Hehl (project leader).

Funding: Swiss National Science Foundation.

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Institutional partnership to support a laboratory for the diagnosis of parasitic diseases in Kosovo

http://www.research-projects.uzh.ch/p16369.htm

Accurate epidemiological data concerning the occurrence and distribution of zoonotic parasitic diseases in Kosovo is lacking. According to recent information from the National Institute of Public Health in Kosovo, the number of people infected by zoonotic parasitic diseases is considerable. It is evident that hundreds of people suffering from cystic echinococcosis were operated in different hospitals in Kosovo. Less is known on the actual importance of other parasitic zoonoses, e.g. bovine cysticercosis, leishmaniosis, toxoplasmosis, cutaneous and visceral larva migrans, trichinellosis, cryptosporidiosis, giardiosis and several more.

A major reason for this lack of information on zoonotic parasitic diseases is the fact that actually there are no appropriate laboratories for the investigation of parasitic diseases established in Kosovo. Furthermore, from the epidemiological point of view, carriers of zoonotic parasites, especially carnivores, are abundant in Kosovo, and, in the case of stray animal populations, difficult to control.

This project focuses on building up and strengthening a diagnostic laboratory capable of performing diagnostic investigations on the most important parasitic zoonoses. To reach this goal, the necessary equipment has to be established and techniques have to be transferred to the Department of Veterinary Medicine at the Faculty of Agriculture and Veterinary Medicine of the University of Prishtina. The collaboration with the Institute of Parasitology, University of Zurich (IPZ) will ensure this technological transfer by training staff from Kosovo in modern, accredited diagnostic laboratories in Zurich. Furthermore, three planned studies focussing on the occurrence of parasitic diseases in Kosovo will be supervised by experts of the IPZ. This program will support education of a future ambitious generation of veterinary parasitologists in Kosovo by Swiss experts. In conclusion, the build-up of this laboratory will contribute to expand the veterinary public health activities in the State of Kosovo and thus improve the well-being of humans and animals alike.

Institute members: P. Deplazes, F. Grimm.

External collaborators: Dr. K. Sherifi (Department of Veterinary Medicine, Faculty of Agriculture and Veterinary, University of Prishtina).

Funding: Swiss National Scienes Foundation (SCOPES).

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Epidemiology of echinococcosis and other zoonoses in central Asia


Human cystic echinococcosis caused by the larval stage of the dog tapeworm E. granulosus is a zoonosis of significant public health importance in much of Central Asia. There has been a substantial increase in the transmission of the disease since the start of economic, social and agricultural reforms after the end of the Soviet administration in 1991. For example, the annual human surgical incidence is now 10-20 cases per 100,000 in Kyrgyzstan which is a four to five times higher than in the period before independence from the Soviet Union. In order to design effective and cost-efficient intervention strategies, the dynamics of parasite transmission need to be thoroughly investigated. These data can then be exploited to simulate control strategies, to analyse the economic effects of the disease and to determine the cost for its control. E. multilocularis has recently also been detected with high prevalences in the rural domestic dog population, and studies are ongoing to define the importance of this in the epidemiology of human alveolar echinococcosis.

Diagnosis of these zoonoses can be a challenge, and improved diagnostic tools are being developed. Further, investment has been made in two new zoonoses laboratories in Kyrgyzstan to improve parasitological diagnostics in the medical and veterinary field. This has allowed the investigation of the epidemiology of other important zoonoses in the region including toxoplasmosis and toxocarosis (Torgerson et al., 2009). A training program for young Kyrgyz scientists has also been initiated which will ensure the long term sustainability of the project.

Institute members: P. Deplazes (project leader), A. Schweiger, F. Grimm, I. Ziadinov.

External collaborators: Prof. Kusembekov (Laboratory of Parasitology, Institute of Veterinary Sciences and Pastures, Bishkek, Kyrgyzstan), Prof. Kuttybaev (Bishkek Medical Academy, Kyrgyzstan), Prof. P. Torgerson (Section of epidemiology, Vetsuisse-Faculty, University of Zurich).

Funding: SNF (Personen- und Projektförderung), others, INTAS (up to 2008), SCOPES.

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Surveillance of alveolar echinococcosis and control of Echinococcus multilocularis in Switzerland


Fox population densities drastically increased in Switzerland in the 1990ies, possibly due to the successful rabies vaccination campaigns which eliminated a main cause of mortality of foxes, and foxes started to colonize urban habitats. The IPZ is involved in parasitological and epidemiological investigations of this phenomenon in the framework of an interdisciplinary project (Integrated Fox Project IFP). It was shown that E. multilocularis is present in urban habitats, and especially in urban peripheries an extraordinarily high environmental contamination with parasite eggs was recorded (Stieger et al. 2002, Fischer et al. 2005, Reperant et al. 2007). In these areas, high urban fox densities overlap with the habitat of the most susceptible intermediate hosts Arvicola terrestris and Microtus arvalis that live on meadows and pastures (Deplazes et al. 2004, Hegglin et al. 2007). It could be demonstrated that E. multilocularis profits from high fox densities sustained in urban settings by a high supply of anthropogenic food (Contesse et al. 2004) and that in the transition zone from urban to rural habitats extraordinary high prevalences can be detected in both the fox populations (Hegglin et al. 2007) and the intermediate hosts (Stieger et al. 2002, Burlet et al. 2011).

E. multilocularis is a widespread and common parasite in red fox populations north of the Alps and the adjacent lowlands. South of the Alps, the parasite has been recorded only occasionally. Climatic conditions that adversely affect the survival of E. multilocularis eggs and the lack of suitable intermediate hosts are thought to be the primary causes limiting the parasite distribution. In the Canton Grisons, we investigated the local prevalences of E. multilocularis in a sample of 543 foxes originating from northern and southern parts of the Swiss Alps. The local prevalences varied significantly between 0 and 40%. A prevalence of 14.3% in foxes from the southern Valley “Val Müstair” demonstrated that the southern border of the parasites distribution area cannot simply be explained by a geographic barrier. Apparently, the distribution of E. multilocularis in foxes appears to reflect the availability of local intermediate host populations and the predation rate on these species. Our results suggest that the life cycle of E. multilocularis in the Alps is confined to mainly small scale hot spots which may persist for decades. This could explain why some human cases of alveolar echinococcosis were recorded in endemic areas whereas no such cases were registered in areas free of E. multilocularis (Tanner et al., 2006).

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Distribution of alveolar echinococcosis patients with known place of residence (N=329, diagnosed between 1967 and 2010)

The actual epidemiological situation gave reason for a retrospective study on the incidence of human alveolar echinococcosis (AE) in Switzerland. As hypothesised, the incidence has increased and was 2.6 times higher between 2001 and 2005 than in the 1990ies. This increase correlates with the general increase and the urbanisation of the Swiss fox populations (Schweiger et al., 2007). On the other hand, survival analysis revealed a strongly improved prognosis for AE patients over the last 30 years. Mean life expectancy of patients was reduced by 18.2 and 21.3 years for men and women, respectively, in 1970ies whereas these values were 3.5 and 2.6 years in 2005 (Torgerson et al., 2008). The better survival and the higher incidence caused a steady increase of the prevalence. The actual annual burden of disease in Switzerland is approximately 77.6 DALYs and yearly costs amount to approximately €108,762 per patient or a total of € 2.0 million (Torgerson et al., 2008).

In an experimental field study, the feasibility of E. multilocularis control was tested in urban peripheries. The monthly delivery of Praziquantel-containing baits in six areas of 1 km2 and one 2 km2 area for two years successfully reduced the contamination of defined small urban patches with a high E. multilocularis egg contamination to a very low level (Hegglin et al. 2003). A follow-up study revealed also a significant effect when anthelmintic baits were delivered in 3-months intervals only. However, the effect was much less pronounced. Furthermore it was demonstrated that 2 years after finishing a baiting campaign, the infection pressure had returned to the same level as before baiting started. Remarkably, egg contamination was still very low 3 years after all bait delivery was ended in an area that was baited monthly during a 3.5-year period indicating that a long-lasting control effect could be achieved by local removal of the parasite by monthly anthelmintic bait delivery over several years (Hegglin et and Deplazes, 2008).

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For the planning of locally adapted information campaigns, a survey of public knowledge about the risk and the prevention of alveolar echinococcosis was carried out in the Czech Republic, France, Germany and Switzerland (Hegglin et al. 2008). Fewer people had heard of E. multilocularis in the Czech Republic (14%) and France (18%) compared to Germany (63%) and Switzerland (70%). In France, only 17% of the interviewees who knew the parasite felt reasonably informed in contrast to other countries where the corresponding percentages ranged from 54 to 60%. E. multilocularis was perceived as a high risk from 12% (Switzerland) to 43% (France). Promising measures such as deworming dogs as performed in the Czech Republic and Switzerland were not recognized as prevention options. These results and the actual epidemiological circumstances of AE call for proactive information programs.

In the project «Control of Echinococcus multilocularis», we develop a cost-efficient strategy for deworming urban foxes by a) modelling and testing optimised baiting strategies in space and time, b) enhancing bait uptake rate and species-specificity of bait uptake and c) developing a practice-orientated method for bait delivery in the field. In the framework of these investigations, which are part of the interdisciplinary project «Control of Alveolar Echinococcosis & Management of Foxes in Urbanized Areas», it has been shown that intermediate hosts get more frequently infected during winter season. It therefore can be assumed that reducing the infection pressure on intermediate host by the delivery of anthelmintic baits for foxes is more effective during this season than during the rest of the year (Burlet et al. 2011).

Current investigations focus on the transmission potential of common European rodents. In the framework of an European Research program, we will investigate the occurrence, frequency and development stages of E. multilocularis in natural occurring rodent populations of different regions and elucidate the ecological and behavioural mechanisms affecting the transmission dynamic of E. multilocularis (e.g. predation and egg distribution of foxes in relation to intermediate host populations).

Institute members: P. Deplazes (project leader), D. Hegglin, M.T. Armua, D. Ribeiro Almeida Guerra.

Funding: Federal Veterinary Office, Grün Stadt Zürich, Stiftung Echinococcose, EU-Project EMIDA (Emerging and Major Infectious Diseases of Livestock).

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Bluetongue disease vectors (Culicoides spp.): Defining parameters which determine ‘vector free periods/areas’ in Switzerland


Light-traps are operated all year round on suitable farms of 12 locations representing the climate regions of Switzerland. Identification of the very small insects is achieved by microscopy and by multiplex PCRs which will be developed to simultaneously identify and quantify in single runs putative vector species of the bluetongue virus. Additional traps will be used for indoor trapping to assess overwintering strategies and for catching Culicoides spp. in environments with different prevailing hosts (wildlife, domestic animals) to investigate host specificities/preferences among the indigenous midges. Further, their breeding habitats will be identified by incubation putative substrates from the field and identifying eclosing midges. Statistical analyses will allow to determine the importance of different parameters on the abundance and diversity of these insects and to draw vector suitability maps on a national scale. (Wenk et al., 2012; Kaufmann et al., 2012).

Institute members: A. Mathis (project leader), F. Schaffner.

External collaborators: Dr. H.P. Schwermer (BVET).

Funding: Federal Veterinary Office (BVET).

Blood-fed Culicoides biting midge from the Pulicaris group

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Identification of insect vectors using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS)


Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) has emerged as an alternative technique for species identification. This proteomic approach has come of age for the high throughput, accurate and reproducible identification of clinically relevant microorganisms (bacteria, yeasts, filamentous fungi) at low costs and minimal preparation time. This technique has been described for the

Identification of meta- zoans, namely fish species plants (lentil varieties) and insects (Drosophila fruit flies, aphid species). In our project, we aim at investigating the suitability of MALDI-TOF MS analyses to reproducibly identify biomarker masses from insect vectors (focusing on Ceratopogonidae, Culicidae), both from the blood-sucking adult stages as well as from the soil- or water-dwelling juvenile stages.

Institute members: A. Mathis (project leader), F. Schaffner, C. Kaufmann.

External collaborators: Dr. Valentin Pflüger (MABRITEC, Riehen), Dr. Jean-Claude Delécolle (Université de Strasbourg).

Funding: Other Public Sources (e.g. Federal or Cantonal Agencies), Private Sector (e.g. Industry).

Dendrogram of MALDI-TOF mass spectra of adult mosquitoes

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Spatio-temporal diversity of mosquito fauna in Switzerland


Mosquitoes are the most important insect vectors worldwide, and the epidemiology of many of the infectious agents they transmit is changing, mainly due to environmental changes as well as increase of trade and tourism. Also in Switzerland, mosquitoes may be or become sources of hazards for human health, animal health as well as for biodiversity.

A recent pilot study aimed to investigate the Swiss mosquito fauna at selected places along transects in order to gain an overview on the mosquito fauna present and to validate the approach and the trapping methods. Literature analysis revealed the report of 41 mosquito species in Switzerland, two of them being recent invaders (Aedes albopictus, Ae. japonicus). However, 5 species might be considered as doubtful records since only single observations have been reported. Thus, the consolidated list of Swiss mosquitoes currently comprises 36 species. Based on the transect study, the highest diversity of the mosquito fauna was observed in the nature zones where all 13 species identified in this field study were present. In contrast, only 3-4 species were occurring in the urban zones. Finally, the hazards of the Swiss mosquito species in regards to potential threat to human and animal health, as well as to biodiversity were assessed based on literature data, revealing that several of the identified species are putative hazards, including putative vectors for a number of pathogens (arboviruses and malaria of medical importance; arboviruses, protozoa and nematodes of veterinary importance).

Localisation of the 8 transsects in which the mosquito fauna is investigated

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In this project, we propose to expand the investigations reported in the pilot study, focusing on the spatio-temporal diversity of the Swiss mosquito fauna at 8 locations distributed throughout the country. As a result we will gain an overview on the Swiss mosquito fauna at country scale, which might serve as a baseline for the assessment of risk hazards (for human, animal and biodiversity) posed by mosquito species.

The study is done in a collaboration with three other Swiss research groups: the Swiss Tropical and Public Health Institute, Basel; the Cantonal Museum of Zoology, Lausanne; and the Cantonal Institute of Microbiology, Bellinzona. For the field work, two locations are attributed to each partner, and trainings and quality check of identification results are performed.

Institute members: F. Schaffner (project leader).

External collaborators: Olivier Glaizot (Cantonal Museum of Zoology, Lausanne), Orlando Petrini (Cantonal Institute of Microbiology, Bellinzona), Christian Lengeler (Swiss Tropical and Public Health Institute, Basel).

Funding: Federal Office for the Environment (BAFU).

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Mosquitoes of Switzerland and related hazards


The picture of vector-borne diseases (VBD) is changing mainly due to environmental changes as well as increase of trade and tourism. Therefore, further knowledge on the risk of the introduction and spread of VBD in Europe has become a critical issue. Mosquitoes are the major insect vectors worldwide and they are sources of hazards for human/animal health and for biodiversity. Nowadays, several regions of Switzerland are subjected to severe nuisance problems due to the proliferation of human-biting mosquitoes (e.g. Aedes vexans), even to the point that control campaigns are implemented (Ticino, Valais, Gruyère). Further, in the last years, invasive pest and potential vector species have colonized Swiss regions (i.e. Ae. albopictus in Ticino, Ae. japonicus in northern Switzerland ). The local mosquito biodiversity could be endangered when invasive species colonize specific environments (as i.e. shown for Ae. japonicus in USA). In parallel, exotic pathogens have emerged in Europe (e.g. Chikungunya in northern Italy), and some old world pathogens seem to circulate more frequently and were identified in new areas (West Nile, Sindbis, Usutu viruses).

The Swiss mosquito fauna has occasionally and focally been studied in the past but there exists no overview, and related risk assessments are completely missing. Around 35 species are known to occur throughout the country but several other species may be found when investigating specific environments (e.g. reed beds for Culex modestus). The known mosquito fauna of Switzerland includes malaria vectors, malaria having been endemic in Switzerland until the early last century, vectors of arboviruses and filariosis.

In this project, the Swiss mosquito fauna is being investigated at selected places along transects in order to gain an overview on the species present and to validate the approach and the trapping methods. Based on literature data, the mosquito species which pose a hazard (for human or animal health, for biodiversity) will be identified for a specific surveillance in a further long-term study.

Institute members: A. Mathis (project leader), F. Schaffner.

Funding: Federal Office for the Environment (BAFU).

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Silent goodbyes - the role of cell death in giardiosis


We are using two complementary experimental approaches to test the hypothesis that mitochondrial remnant organelles (mitosomes) play a key role in a basic form of programmed cell death (PCD) in the protozoan parasite Giardia lamblia. Even severe Giardiasis of humans and animals elicits surprisingly little inflammation in the gut, suggesting active population control coupled with PCD to eliminate dying parasites and avoid immune stimulation. Since Giardia is exquisitely sensitive to interference with mitosome function we postulate that these minimized organelles play a key role in sensing cell health and in coordinating a basic form of PCD. We plan to combine recently developed novel technologies with large-scale approaches to provide a catalog of quantifiable changes that accompany cell death in these parasites and to define the functional range of mitosomes and their role in coordinating cell death pathways.

Fluorescence microscopy: Detection of mitosome organelles in a transgenic Giardia trophozoite using an epitope-tagged giardial TOM40 homolog (green). TOM 40 is an integral protein of the outer mitochondrial membrane and functions as part of the TOM-TIM complexes for translocation of imported proteins across mitochondrial membranes. Nuclear DNA (blue); inset (bright field image).

Institute members: A.B. Hehl (project leader).

External collaborators: COST BM 0802.

Funding: EU, Other Public Sources (e.g. Federal or Cantonal Agencies).

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Energy metabolism in the reproductive biology of Culicoides spp., the potential vectors of the bluetongue disease virus


Bluetongue disease unexpectedly appeared in 2006 in the Benelux countries and rapidly spread in Central Europe, including Switzerland, in the following years. The only known biological vectors of the bluetongue disease viruses are members of the insect genus Culicoides (Diptera: Ceratopogonidae). Commonly referred to as biting midges, these flies are well known to cause allergic reactions particularly in equines, described as summer eczema, but they also transmit other important veterinary related pathogens, like the African horse sickness viruses. The tiny midges are considered to be the least studied insect vectors in the world, and improving of the knowledge of their biology, especially their physiology, is urgently needed. The central aims of this project focus on the biting midges’ regime of nutritional reserves and their reproductive energetics. Laboratory-reared Culicoides nubeculosus, an indigenous biting midge, will be analysed for energy and flight metabolism of starved, sugar- and blood-fed midges by determining carbohydrate, lipid and protein reserves using biochemical methods. Also, the influence of different feeding conditions on fecundity and the option of multiple blood meals during one gonotrophic cycle will be assessed. Comparative studies on these aspects with field-caught C. nubeculosus will reveal whether laboratory conditions reflect the situation in nature and will contribute to device optimal settings for rearing, also for other indigenous species. These data will also offer valuable clues about the traits of the host seeking behaviour in dependency of the feeding condition. In addition, the question whether different species of biting midges show host preferences will be addressed by analysing blood-fed Culicoides spp. caught in the field with MALDI-TOF. These results will contribute to improve models on the distribution of midges and pathogen transmission by providing more precise estimates of crucial parameters, as well as to establish reliable and realistic systems for vector competence studies in these important insects.

Institute members: C. Kaufmann (project leader), A. Mathis.

Funding: University of Zurich.

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Gene expression of enteroepithelial stages of Toxoplasma gondii in the domestic cat


Felids play a critical role in the transmission of T. gondii. Cats are the only known definitive hosts for this parasite, in which it undergoes sexual development in epithelial cells of the small intestine. This results in the excretion of infectious oocysts with the feces, which constitutes a major route for transmission to humans and animals. Following a primary infection and a period of oocyst shedding, most cats do not shed detectable levels of oocysts when re-exposed to tissue cysts from intermediate hosts. The occurrence of the enteroepithelial cycle appears to be essential for the establishment of this intestinal immunity. Parenteral vaccination of cats with any developmental stage does not prevent oocyst shedding after challenge with orally administered infectious stages. It is assumed that some antigens expressed during the intestinal cycle by the enteroepithelial stages are essential for the immune mechanisms that prevent or impair a new oocyst shedding in previously infected cats. The identification and characterization of these antigens is of great importance, as this will be the first step in the elaboration of vaccines.

The aims of this project are to optimize an isolation and concentration method for enteroepithelial stages of T. gondii harvested from cat intestine and to generate gene expression by RNA deep-sequencing. This data will allow us to identify genes and pathways in Toxoplasma gondii that are essential for the parasite to complete its life cycle in the cat intestine. With this information we will be able to begin designing strategies for a vaccine that will be used to immunise cats in an attempt to block formation and excretion of oocysts of, ultimately preventing infection of people and other animals. This project is conducted in collaboration with the Functional Genomics Centre Zurich.

Institute members: W. Basso (project leader), C. Lippuner (project leader), P. Deplazes (senior), A.B. Hehl (senior), S. Glor.

External collaborators: Dr. Michael Grigg (Molecular Parasitology Unit, Laboratory of Parasitic Diseases, National Institutes of Health, NIAID, Bethesda, USA), Prof. Nick Smith (Queensland Tropical Health Alliance, Faculty of Medicine, Health and Molecular Sciences, James Cook University, Cairns).

Funding: Forschungskredit University of Zurich.

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Applying combinatorial technology in search for vaccine and drug targets in Fasciola hepatica


F. hepatica is a globally distributed helminth parasite of humans and animals. The parasite presents a huge economic burden in animal husbandry causing losses of high magnitude worldwide (US$ 2 billion, Switzerland alone approximately €52 million/year). Vaccine development efforts to date identified a few potential candidate targets, but highly effective vaccine is not yet commercially available. For the last few decades, chemotherapy was focused on the use of Triclabendazole, resulting in development of resistance to this drug as suggested by an increasing number of reports.

To facilitate the identification of novel drug and vaccine targets for control of fasciolosis we take advantage of the two powerful combinatorial technologies, camelid single-domain heavy chain antibody (VHH, nanobody) and peptide phage display libraries. These two technologies provide us with possibility to investigate large number of parasite targets irrespectively of the host immune response. The ligands (peptides and nanobodies) originating from phage libraries are selected against the total repertoire of the parasite targets (structural targets, antigens, receptors) for their binding properties. Using this approach we seek to identify target molecules which are not exposed to, or recognized by, the host immune system during the course of natural infection. Selected high-affinity ligands are subsequently assayed in vitro for their inhibitory potential and later on in vivo using suitable animal models for their protective potential. The acquired knowledge is enabling us to rationally design further vaccine development strategies and alternative systems for delivery of therapeutic biomolecules. Besides this, the identified ligands are valuable molecular tools for investigation of F. hepatica biology.

Institute members: S. Stefanic (project leader), P. Deplazes.

Funding: Forschungskredit University of Zurich.

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Canine angiostrongylosis: clinical and epidemiological investigations


Canine pulmonary angiostrongylosis caused by the nematode species Angiostrongylus vasorum is an emerging snail-borne disease in Europe and has recently emerged in Switzerland (Staebler et al., 2005). Adult parasites reside in the right side of the heart and the pulmonary arteries. Infections are usually characterized by a gradual onset of progressively worsening respiratory distress, due to lung verminous parenchymal inflammations, haemorrhage and arterial thrombosis. However, acute onset of illness followed by sudden death can occur. In an interdisciplinary approach, clinical and laboratory findings as well as imaging methods, i.e. radiology, echocardiography and computed tomography, are employed before and after therapy in controlled experimental infections. Larvicide and adulticide treatments are applied and tested for efficacy under different regimens. A particular prominent attention is given to diagnostic approaches comparing established methods, such as faecal examinations, with recently developed tools for specific antibody (Schucan et al., 2012) or antigen (Schnyder et al., 2011) detection as well as identification of circulating DNA in blood samples.

Transverse computed tomo-gramphic images of the lungs from a dog heavily infected with Angiostrongylus vasorum before (left image) and 9 weeks (right image) after anthelmintic treatment (M. Dennler et al., 2011).

These methods represent key techniques for monitoring the success of anthelmintic treatments and for mass-screening of dog populations in Europe, intended for a better understanding of epidemiological aspects of this emerging canine disease. Seroepidemiological surveys have been initiated in Germany, the United Kingdom, Italy, Poland, Belgium, Denmark, France, and in Switzerland. Furthermore, foxes representing the most prominent wild reservoir of A. vasorum, are currently under investigation applying new ecological standardized approaches. These epidemiological data can provide an important information for the development of risk maps for canine angiostrongylosis in Europe.

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Institute members: M. Schnyder (project leader), P. Deplazes (senior), D. Hegglin, B. Grieder.

External collaborators: Dr. T. Glaus (Clinic for Small Animals, Vetsuisse-Faculty, University of Zurich), Dr. D. Barutzki (Tierärztliches Labor Freiburg, Freiburg i.Br., Germany), Prof. Dr. S.M. Thamsborg (Danish Centre for Experimental Parasitology, Dept. for Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Dankmark), Prof. R. Gasser (The University of Melbourne, Veterinary Science, Associate Dean, Australia), Prof. Dr. E. Morgan (School of Clinical Veterinary Science, University of Bristol), Prof. M. Magi and Lisa Guardone ( Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, Università di Pisa, Italy).

Funding: University of Zurich, Bayer.

Fungal lectins as leads for the vaccination of sheep against Haemonchus contortus


Glycoproteins, naturally occurring in plants and molluscs share epitopes with intestinal cells of blood-feeding nematodes. Certain fungal lectins exhibit a specific binding capacity against these epitopes. This process can be mimicked by specific antibodies, binding to the surface epitopes in the parasites intestine. Following the hypothesis that vaccination of sheep with glycoproteins similar to those in the blood-feeding parasite Haemonchus contortus will induce protective antibodies against this pathogen, lambs were subjected to different immunization protocols. Parasite egg counts and more important worm burdens of lambs, determined after slaughter were significantly lower compared with unvaccinated control lambs. Antigen-specific serum antibodies increased rapidly within 14 days post-vaccination and persisted on a high level for several months. Further studies will have to localize the specific antibody reaction within the broad spectrum of responses against the chosen glycoproteins. As one of the next milestones, glycoproteins, inducing specific humoral responses in vaccinated sheep against the worm intestinal target epitopes will be developed within this collaboration and tested under various infection regimes.

Institute members: P. Deplazes (project leader), H. Hertzberg, K. Stebler.

External collaborators: ETH Zurich, Institute for Microbiology (Prof. M. Aebi, PD Markus Künzler, Dr. Karin Ilg), MALCISBO AG (Dr. Lino Camponovo).

Funding: Kommission für Technologie und Innovation KTI.

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Animal models for intestinal Echinococcus infections and for Alveolar Echinococcosis (AE) in aberrant hosts


It was concluded that foxes are good hosts of E. multilocularis with subtle differences in the biotic potential and egg excretion during the patent period. In contrast, few worms established in cats, and the few eggs that were excreted had a low infectivity (Kapel et al., 2006; Thompson et al., 2006; Al-Sabi et al., 2007). This strongly indicates that cats play an insignificant role in parasite transmission (Deplazes et al., 2011).

In 2011 a new EU-Project "Paravac" was initiated aiming to investigate intestinal protective immunological mechanismus against Echinococcus granulosus.

Extended studies in murine models for metacestode infections have provided important information on immunological mechanisms. However, due to the rapid parasite development in these hosts compared to human patients, they might not be the most appropriate model for the study of clinical and immunological aspects of human alveolar echinococcosis (AE). Therefore, there is a need for alternative models, and other models are being investigated.

Highly progressive and lethal metacestode infections have been recorded in dogs and several monkey species. Therefore, clinical and serological studies of 25 dogs with naturally acquired hepatic AE were initiated (Staebler et al., 2007; Scharf et al., 2004).

Recently, a new project is investigating a rat model for the establishment of E. multilocularis infections and AE in an animal host with low susceptibility.

Institute members: P. Deplazes (project leader), M.T. Armua

External collaborators: Prof. C. Kapel (Department of Ecology, Faculty of Life Sciences, University of Copenhagen), Prof. A. Thompson (School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia), Dr. Catherine Eichwald / Prof. M. Ackermann (Institute of Virology, Vetsuisse Faculty, University of Zurich).

Funding: Other Public Sources (e.g. Federal or Cantonal Agencies), Foundation, Private Sector (e.g. Industry), Danish Veterinary and Agricultural Research Council, Danish National Research Foundation; EU-Project Paravac.

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Bionomics, vector capacity and control of the invasive Asian bush mosquito Aedes japonicus


The Asian bush mosquito Aedes japonicus was first recognized in Switzerland in 2007, and it is the first invasive mosquito species that proliferates and spreads in Central Europe. In the framework of the EU-funded large scale integrating project ‘Biology and control of vector-borne infections in Europe (acronym EDENext), aspects of bionomics, vector capacity and control of this mosquito are investigated, analogous to corresponding investigations of colleagues with the Asian tiger mosquito Aedes albopictus which has invaded large parts of Southern Europe. Hence, the influence of the temperature on the development rate, productivity of breeding sites, survival and diapause of this species is determined in order to assess its putative future expansion in Europe. The vector capacity for West Nile virus is determined under realistic conditions (i.e. fluctuating rather than constant temperatures), and the age of mosquitos which is important for assessing the vector potential, is determined by a rapid test based on cuticular hydrocarbons. As the control of the mosquito by reducing larval habitats might not be feasible as they use of a wide variety of breeding sites, a new concept will be evaluated: the exploitation of the “skip oviposition” behaviour of females to transfer a potent juvenile hormone analogue to the breeding sites, thereby disrupting the development of the larvae.

Institute members: F. Schaffner (project leader), A. Mathis, C. Kaufmann.

External collaborators: 45 groups from all over Europe.

Funding: EU-Project EDENext.

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Epidemiology and pathogenesis of cryptosporidiosis in calves


Diarrhoea, caused by the zoonotic species Cryptosporidium parvum, is a major problem in calves younger than 4 weeks of age. To date, only a few compounds have been approved for prophylactic but none for therapeutic use. Clinically, there is only a limited association between severity of parasite (oocysts) shedding and morbidity or mortality.

The first goal of the present study is to investigate factors which prevent cryptosporidiosis in calves. Our working hypothesis is that pathogenesis of C. parvum in young calves is influenced by (passive) immunity. Immunological factors (antibodies, immune-cells and e.g. cytokines or lipids) can be transferred from the adult animal to the newborn by colostrum.

The calf-model will be used to elucidate potential modulators of the immune system. These factors will be analysed in an epidemiological study to identify further parameters that influence the pathogenesis in calves.

The second goal of the project is to explore the intracellular life of C. parvum. So far, it is not well known which metabolic pathways are active in the intracellular stages and which mRNA's / proteins are expressed during intracellular development. Therefore, calves were experimentally infected with C. parvum oocysts. Intracellular parasites were enriched directly ex vivo. mRNA was isolated and used for deep RNA sequencing (SOLiD method, in close interaction with the Functional Genomics Centre Zürich). The results facilitate to characterise the intracellular developmental stages and their corresponding potential antigenic repertoire. These results will be compared with sporozoites in vitro material.

These results will contribute to expand the knowledge on parasite biology and will lay the base to develop future preventive and treatment options for cryptosporidiosis. The data will later be released in EuPathDB.

Institute members: C. Lippuner (project leader), P. Deplazes, M. Hässig, A.B. Hehl.

External collaborators: FunctionalGenomics Center Zurich.

Funding: Joint Appointment, University of Zurich, Forschungskredit University of Zurich.

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Epidemiology and control of cystic and alveolar echinococcosis in Lithuania


Cystic echinococcosis (CE) is a major public health problem in Lithuania. During 1995–2006, CE was confirmed in 36% of 251 suspected human cases. In small farms from the south–western part of Lithuania, 14.2% of dogs were excreting taeniid eggs. Further investigations by PCR demonstrated a prevalence of Echinococcus granulosus of 3.8% (i.e. approximately one quarter of dogs positive for taeniid eggs). Investigations also demonstrated that 3.2% of the pigs were infected with CE. The G6/7 strain was identified in samples from pig, cattle, human and dogs. A questionnaire revealed a poor knowledge about this zoonosis amongst this rural population (Bružinskaitė et al., 2009). A pilot control program has been initiated by regularly treating dogs in villages with high prevalences of E. granulosus in dogs and pigs.

Alveolar echinococcosis (AE), a serious zoonosis caused by the larval stage of E. multilocularis, has only recently been documented in the Baltic region. During 1997–2006, 80 patients with AE have been diagnosed at two hospitals of Vilnius University (Bružinskaitė et al., 2007). Necropsy studies of final hosts demonstrated that 59% of red foxes and 8% of raccoon dogs were infected with E. multilocularis. Infected animals were found throughout Lithuania and, hence, the whole country should be considered as an endemic area (Bružinskaitė-Schmidhalter et al., 2012).

In a new project the E. multilocularis transmission in Lithuania will be investigated in an European comparative study.

Institute members: P. Deplazes (project leader).

External collaborators: Prof. M. Sarkunas (Department of Infectious Diseases, Lithuanian Veterinary Academy), Dr. A. Marcinkute (Vilnius University, Clinics of Infectious Diseases), Prof. Paul R. Torgerson (Section of epidemiology, Vetsuisse-Faculty, University of Zürich).

Funding: EU-Project EMIDA (Emerging and Major Infectious Diseases of Livestock), Food and Agriculture Organization (FAO, project TCP/LIT/3001 (T)), SwissBalticNet (supporter: Gebert Rüf Stiftung), Bayer.

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Epidemiology of bovine cysticercosis

http://www.research-projects.uzh.ch/p12962.htm Bovine cysticercosis caused by Taenia saginata represents an unsolved zoonotic problem. Cysts in meat cause financial losses due to reduction in meat value and pose a steady source for human tapeworm infections. Aims of the studies are: identification of risk factors for transmission of bovine cysticercosis on farm level in Switzerland, estimation of costs, critical analysis of diagnostic strategies on abattoir and laboratory level, critical evaluation of existing control strategies. In a study in three EU-approved abattoirs, twenty cysticercosis cases were detected among 1088 animals investigated (1.8%), by the routine legal procedure, but there were 29 further cases (2.7%) identified by extended cuts in the heart muscle only. Hence, the prevalence of bovine cysticercosis is heavily underestimated and the actual control strategy is inefficient (Eichenberger et al., 2011). For an enduring control of the epidemiological situation, improved routine diagnostic procedures at slaughterhouses but also a new control strategy including a reporting system involving a quarantine of the affected farms as well as an analysis of the source of infection are required. Further research should concentrate on improving diagnostic methods, treatment of infected animals on farm level and vaccination of herds under high infection risk.

Therefore, in absence of sufficiently validated serological tests for the epidemiological situation in central Europe, we evaluated already published and new established immunodiagnostic tests with blood samples from selected and well-defined naturally infected animals.

Institute members: P. Deplazes (project leader), R. Eichenberger.

External collaborators: Prof. R. Stephan (Institute for Food Safety and Hygiene, Vetsuisse-Faculty, University of Zurich); Prof. Dr. Paul Torgerson (Section of epidemiology, Vetsuisse-Faculty, University of Zürich).


Taenia saginata metacestode (Cysticercus bovis). Viable cyst in heart muscle of a cattle condemned at slaughter (Size approx. 9 x 5 mm).

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The invasive mosquito Aedes japonicus in Central Europe


Complaints about a biting pest led to the recognition of the invasive mosquito Aedes (Finlaya) japonicus japonicus (Theobald) (Diptera: Culicidae) in Central Europe. Larval collections from cemetery vases revealed a colonized area in 2009 of approximately 1,400 km2 in northern Switzerland spreading into bordering Germany, suggesting that the mosquito has been established in this region for several years. Within this range, larvae of Ae. japonicus were recovered from more containers than the most common resident culicid species Culex pipiens. Possible introduction sites (used tyre storage, international airport) revealed few or no larvae, and the mode of introduction remains unclear. Ongoing investigations reveal that the species continous to spread. Given the vector potential of this species for arboviruses, implementation of surveillance and control measures should be considered. (Werner et al., 2012).

Institute members: F. Schaffner (project leader), A. Mathis.


Spread of the eyeworm Thelazia callipaeda northwards? Investigation on the suspected vectors Phortica spp. in Switzerland (Ticino)


The eye worm Thelazia callipaeda (Nematoda, Spirurida, Thelaziidae) is present in Europe since the 1990’s (mainly in Italy), infecting dogs, cats and foxes. Rarely, it can also cause human thelaziosis. The fruit fly Phortica variegata (Diptera, Drosophilidae) which also feeds on lachrymal secretions of mammals is a confirmed vector in southern Italy. The increasing number of reports of dogs infected with these eye worms in Southern Switzerland (canton Ticino) during 2004 triggered an initial study (2005-2006) which revealed overall prevalences of the nematode in dogs of 5.3% (n=529) and in foxes of 5.6% (n=126). Infections were recorded in both host species from southern and central Ticino but not from the northern part. Simultaneously, the presence of P. variegata in the study area was confirmed. In order to investigate a potential spread of the parasite northwards, we investigated the presence of the putative insect vector and its infectious status regarding the eyeworm at four field sites in Ticino and one north of the Alps (Zürich). First, an efficient method for trapping these insects under natural condition had to be developed and compared to the usual but laborious netting around the eyes of dogs and humans. A simple fruit-bated trap made with

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PET bottles revealed to be suitable to catch both females and males of Phortica spp. (up to 68 per week). Whereas insect catches during summer (July-September) ranged from 15 to 117 per month at the sites of southern and central Ticino, a single individuum only was caught in northern Ticino and none at a higher altitude place (1100 meters above sea level) in central Ticino.

Females were all in all predominant in the traps, although males became dominant late in the season. In contrast, 80% of Phortica flies collected around the eyes of dog and human baits by netting were males. PCR for T. callipaeda was negative with all Phortica flies. Morphological examination of the 523 male flies based on features of the eye margin and the number of particular genital sensilla identified 89.1% P. semivirgo, 5.7% P. variegata but also 5.2% intermediate forms. Genetic analyses of partial mitochondrial cox1 and rDNA internal transcribed spacer 1 sequences revealed that these three morphotypes were genetically not distinguishable. The study provided evidence of the presence of Phortica spp. north of the Alps and therefore the risk of T. callipaeda transmission there. The description of a first autochthonous case of T. callipaeda infection in a dog from southern Germany confirmed these results.

The increasing report of cats infected with T. callipaeda incentivized a study about prevalences in cats. Adulticide treatments are applied and tested for efficacy in a field trial with dogs and cats.

Institute members: M. Schnyder (project leader), B. Motta, A. Mathis, P. Deplazes.

External collaborators: Prof. D. Otranto (Department of Veterinary Public Health,University of Bari, Italy), Dr. J. Magnis (Kleintierklinik Dr. S. Wisniewski, Iffezheim), Prof. T. J. Naucke (Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn).

Funding: Novartis.

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List of externally funded research grants/projects in 2010/2011 (project leaders at the institute; for external collaborators see scientific report): Swiss National Science Foundation (SNF)

1) “Molecular basis for protein secretion in the basal parasite Giardia

lamblia”. Project No. 31003A-125389/1 (45080504) Project leader: A.B. Hehl Project period: 1.5.09 – 31.5.12 Project budget: CHF 477’472.-

2) “Kiss and Flush – a minimized endocytic system in the protozoan Giardia lamblia”. Project No. PZ00P3_132120/1 (45080506) Project leader: C. Spycher Project period: 1.2.11 – 31.1.14 Project budget: CHF 438‘118.-

3) “Institutional partnership to support a laboratory for the diagnosis of parasitic diseases in Kosovo”. Project No. IZ74Z0_137399/1 (45080507) Project leaders: P. Deplazes Project period: 1.10.11 – 30.9.14 Project budget: CHF 135’000.-

4) “Epidemiology of echinococcosis and other zoonoses in central Asia”. Project No. IZ32Z0_133959/1 (45080505) Project leaders: P. Deplazes, A. Schweiger, F. Grimm, I. Ziadinov Project period: 1.11.10 – 31.12.10 Project budget: CHF 8’000.-

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Bundesamt für Veterinärwesen 1) “Surveillance of alveolar echinococcosis and control of Echinococcus

multilocularis in Switzerland”, (Bekämpfung der Alveolären Echinoccose & Management von Füchsen im Siedlungsraum). Project No. 1.07.04 (35080504) Project leader: P. Deplazes Project period: 1.2.07 – 31.12.11 Project budget: CHF 341’981.- + CHF 76’050.-

2) „Etablierung einer PCR-Methode zum Nachweis von Culicoides spp.; und Bericht zur Veterinärmedizinischen Arachno-Entomologie in der Schweiz“. Project No. MON-012 (35080020) Project leader: A. Mathis Project period: 1.6.05 – 31.12.10 Project budget: CHF 25’000.-

3) „Blauzungenkrankheit Vektoren (Culicoides spp.): Definition von Parametern, welche Vektor-freie Perioden und Gebiete in der Schweiz bestimmen”. Project No. 1.08.10 (35080510) Project leader: A. Mathis Project period: 1.1.08 – 31.12.11 Project budget: CHF 458’034.-

4) “Identification of insect vectors using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS)“. Project No. MON-082, MON-097 Project leaders: A. Mathis Project period: 1.1.10 – 31.12.11 Project budget: CHF 57’700.- / CHF 65’500.-

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Bundesamt für Umwelt 1) „Mosquitoes of Switzerland and related hazards”.

Project No. 10.0002.PJ / J282-0082 (35080516) Project leader: A. Mathis Project period: 1.7.10 – 31.12.11 Project budget: CHF 25’000.00

2) “Spatio-temporal diversity of mosquito fauna in Switzerland”. Project No. 10.0002.PJ / K222-2990 (35080522)

Project leader: F. Schaffner Project period: 1.6.11 – 30.11.12 Project budget: CHF 70’000.-

Staatssekretariat für Bildung und Forschung SBF 1) “Silent goodbyes - the role of cell death in giardiasis”

Project No. C10.0094 (35080520) Project leader: A.B. Hehl Project period: 1.4.11 – 30.9.12 Project budget: CHF 162‘549.-

2) “Vaccination of goats against haemonchosis”

Project No. C10.0084 (35080521) Project leader: H. Hertzberg Project period: 1.7.11 – 31.12.12 Project budget: CHF 128‘270.-

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Grün Stadt Zürich, Kanton Zürich 1) Zusatzkredit für das BVET Projekt “Surveillance of alveolar

echinococcosis and control of Echinococcus multilocularis in Switzerland”, (Bekämpfung der Alveolären Echinoccose & Management von Füchsen im Siedlungsraum). Project No. 1.07.04 (35080505) Project leader: D. Hegglin Project period: 1.7.07 – 31.12.11 Project budget: CHF 58’000.-

Forschungskredit der Universität Zürich 1) “Energy Metabolism in the Reproductive Biology of Culicoides spp.,the

Potential Vectors of the Bluetongue Disease”. Project No. 55080502 Project leader: C. Kaufmann Project period: 1.11.09 – 30.9.11 Project budget: CHF 104’191.-

2) “Gene expression of enteroepithelial stages of Toxoplasma gondii in the domestic cat”. Project No. 55080503 Project leader: W. Basso, C. Lippuner Project period: 1.1.11 – 31.12.12 Project budget: CHF 95’910.-

3) “Applying combinatorial technology in search for vaccine and drug targets in Fasciola hepatica”. Project No. 55080505 Project leader: S. Stefanic Project period: 1.7.11 – 30.6.12 Project budget: CHF 104’504.-

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4) “Lost in evolution – a stage-regulated Golgi remnant in the protozoan parasite Giardia lamblia”. Project No. 55080504 Project leader: P. Wampfler Project period: 1.7.11 – 30.6.12 Project budget: CHF 53’820.-

Stiftungen 1) “Cysts get naked: understanding regulated secretion in the primitive

eukaryote Giardia lamblia”. Roche Research Foundation Project leaders: A.B. Hehl, C. Spycher Project period: 1.1.08 – 30.6.10 Project budget: CHF 52’500.-

2) “Cysts get naked: understanding regulated secretion in the primitive eukaryote Giardia lamblia”. Novartis Stiftung für medizinisch-biologische Forschung Project leaders: A.B. Hehl, C. Spycher Project period: 1.1.08 – 30.6.10 Project budget: CHF 56’032.-

3) “Cyst formation in Giardia lamblia: transcriptional profiling of stage conversion”. Stiftung für wissenschaftliche Forschung der Universität Zürich Project leader: A.B. Hehl Project period: 15.4.08 – 14.4.11 Project budget: CHF 17’000.-

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4) “Going, Going – Gone? Functional Characterization of a Vanishing Mitochondrion in Giardia lamblia”. Stiftung für wissenschaftliche Forschung der Universität Zürich Project No. 35080515 Project leader: A.B. Hehl Project period: 1.4.10 – 30.4.13 Project budget: CHF 20’000.-

5) “Echinococcose bei Primaten”.

Zoologischer Garten Basel AG (Zoo Basel) Project No. 35080523 Project leader: P. Deplazes Project period: 1.11.11 – 31.12.13 Project budget: CHF 23’600.-

Industrie und andere Drittmittel 1) “Chemoprophylaxis of Angiostrongylus vasorum in experimentally

infected dogs”. Bayer Animal Health GmbH Project No. 35080509 Project leaders: P. Deplazes, M. Schnyder Project period: 1.4.08 – 30.9.11 Project budget: CHF 318’003.-

2) “Bestätigung der Wirksamkeit von Advocate Spot on gegen eine experimentelle Infektion mit dem Lungenwurm Aelurostrongylus abstrusus (A. abstrusus) bei der Katze”. Bayer Animal Health GmbH Project No. 35080509 Project leaders: P. Deplazes, M. Schnyder Project period: 1.10.11 – 31.12.12 Project budget: CHF 164’408.-

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3) “Thelaziosis, dirofilariosis, angiostrongylosis in dogs and cats in Ticino”. Novartis Animal Health Inc. Project No. 35080512 Project leader: M. Schnyder Project period: 1.7.09 – 31.3.12 Project budget: CHF 32’760.-

4) Project 1: “Diagnosis of Angiostrongylus vasorum”. Project 2: “Canine angiostrongylosis: clinical, diagnostic and epidemiological investigations”. IDEXX Laboratories, Inc. und Bayer Animal Health GmbH Project No. 35080514 Project leader: M. Schnyder / P. Deplazes Project period: 1.3.10 – 31.12.11 Project budget: CHF 71’337.-

5) „A single site, randomized, blinded, and placebo controlled laboratory efficacy study of Milbemax chewable tablets for dogs for the prevention of disease caused by Angiostrongylus vasorum in Beagle dogs “. Novartis Animal Health Inc. Project Nr. SUI-10-001 (35080518) Project leader: M. Schnyder Project period: 1.12.10 – 31.12.13 Project budget: CHF 268’983.-

6) “Dokumentation der Wirksamkeit von Cydectin 10% LA bei Jungrindern und Cydectin 2% LA bei Schafen gegen Magen-Darmwurm- und Lungenwurm-Befall”. Pfizer AG Project No. 35080517 Project leader: H. Hertzberg Project period: 1.11.10 – 30.9.12 Project budget: CHF 84’000.-

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7) “Study to confirm the effectiveness of the combination of ML-3, 141, 301 to repel and kill Culex pipiens mosquitoes on dogs after a single administration”. MERIAL SAS Project No. 35080524 Project leader: A. Mathis Project period: 1.8.11 – 31.12.12 Project budget: CHF 142’290.-

Kommission für Technologie und Innovation KTI 1) „Fungal lectins as leads for the vaccination of sheep against

Haemonchus contortus “. Project Nr. 12392.1 PFLS-LS (35080519) Project leader: P. Deplazes / H. Hertzberg Project period: 1.3.11 – 28.2.13 Project budget KTI: CHF 340’757.- Project budget Wirtschaft: CHF 430’082.-

EU-Projects 1) „Vaccines against helminth parasites of livestock of economic and/or

public health significance “. (Collaboration with Institute of Virology) Project No. KBBE-2010-4-265862 (PARAVAC, 75080502) Project leader: P. Deplazes Project period: 1.4.11 – 31.3.15 Project budget: EUR 624’750.-

2) “Bionomics, vector capacity and control of the invasive Asian bush mosquito Aedes japonicus”. Project No. 261504 (EDENext, 75080501) Project leader: F. Schaffner Project period: 1.1.11 – 31.12.14 Project budget: EUR 48’960.-

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Joint Appointment mit Nutztierklinik, VSF-Fakultät 1) „Epidemiology and pathogenesis of cryptosporidiosis in calves “.

Geldgeber: Bayer Animal Health GmbH Project leader: C. Lippuner / P. Deplazes Project period: 1.1.09 – 31.12.12 Project budget: CHF 7’000.-

Internationale und nationale Programme 1) „Epidemiology and control of cystic and alveolar echinococcosis in

Lithuania “. Food and Agriculture Organization of the United Nations (FAO) Project Nr. UZ-06/488 (35080018) Project leader: P. Deplazes

Project period: 1.1.05 – 31.12.12 Project budget: USD 25’000.-

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Diagnostische Dienstleistungen

Das Diagnostikzentrum Parasitologie (DZP) führt im Auftrag der Vetsuisse-Fakultät und der Medizinischen Fakultät der Universität Zürich diagnostische Dienstleistungen durch. Das DZP wurde im Jahr 2000 als Abteilung am IPZ gegründet und ist seit dem 17.6.2002 als Labor für parasitologische Diagnostik in den Bereichen Veterinär- und Humanmedizin nach der Norm ISO/IEC 17025 (Akkreditierungsnummer: STS 346) akkreditiert.

Die untersuchten Proben stammen von Heim-, Zoo- und Nutztieren, sowie von Menschen. Neben den Kliniken und Instituten der Vetsuisse-Fakultät und dem Universitätsspital Zürich gehören Labors, Tierärzte und Ärzte hauptsächlich aus der Zentral- und Ostschweiz zu den Auftraggebern. Das DZP führt ausserdem Untersuchungen im Auftrag von Forschungsprojekten des IPZ durch. Untersucht werden mehrheitlich Stuhl- und Kotproben mit verschiedenen mikroskopischen Methoden auf Parasiten bzw. Parasitenstadien, Serumproben mit immundiagnostischen Techniken auf spezifische Antikörper und verschiedenste Probenmaterialien mit molekulardiagnostischen Tests auf Parasiten-DNA.

In den Jahren 2010 und 2011 wurden am DZP insgesamt 29'127 bzw. 27'568 Einzeluntersuchungen durchgeführt. 64.4% dieser Untersuchungen erfolgten für die Humanmedizin und 35.6% für die Veterinärmedizin. Die Durchführung von Untersuchungen aus beiden Fachbereichen schafft Synergien und stellt eine unerlässliche Erfahrungsquelle für Lehre und Forschung des IPZ dar.

Das DZP beteiligt sich in den Bereichen der Human- und der Veterinärparasitologie regelmässig an verschiedenen externen Qualitätskontroll-programmen. Die Qualitätsanforderungen wurden in allen Bereichen voll erfüllt.

Zunehmend Probleme bereitet dem DZP die fast zwanzigjährige Laborsoftware. Eine moderne elektronische Resultatübermittlung, die Vernetzung mit Systemen des Tierspitals, des Universitätsspitals und der Verwaltung sind mit der veralteten Software nicht realisierbar. In der Berichtsperiode wurden mögliche Alternativen geprüft und die Ablösung der Software für die nächste Zukunft geplant.

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Mitarbeiterinnen und Mitarbeiter (Stand: Dezember 2011)

Abteilungsleiter: Grimm Felix

Laborantinnen: Bodmer Susy Boller Bettina Ebeid Susanne Kaspar-Witt Vera Lauffer Judith Suter Waltraud Von Niederhäusern Karin Wolfensberger Elisabeth

Untersuchungen

Die in den Jahren 2009, 2010 und 2011 am DZP durchgeführten Untersuchungen und die Einnahmen aus diesen Analysen sind in den folgenden Tabellen zusammengefasst (Zahlen ohne Untersuchungen im Rahmen von Forschungsprojekten).

Humanmedizinische Parasitologie 2009 2010 2011

Parasitologische/Mikroskopische Untersuchungen

8‘436 8‘029 7‘569

Immunologische Untersuchungen 8‘782 10‘741 9‘153

Molekularbiologische Untersuchungen 466 483 572

Total 1 17‘684 19’253 17’294 Veterinärmedizinische Parasitologie

2009 2010 2011

Parasitologische/Mikroskopische Untersuchungen

8‘020 8‘173 8‘402

Immunologische Untersuchungen 1‘615 1‘520 1‘652

Molekularbiologische Untersuchungen

98 181 220

Total 2 9‘733 9‘874 10‘274

Human- und Veterinärmedizinische Parasitologie

2009 2010 2011

(Total 1 + Total 2) 27‘417 29’127 27’568

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Einnahmen1 2009 2010 2011

Humanmedizinische Parasitologie

559'9811 633'0821

587‘4162

Veterinärmedizinische Parasitologie

158'6151 164'5841

174‘2172

Total 718'5961 797'6661 761'6332

¹ Nicht verrechnete Untersuchungen für Kliniken/Institute und Analysen im Rahmen epidemiologischer Projekte nicht

berücksichtigt; Zahlen vom Laborsystem übernommen (ohne Berücksichtigung MwSt-Abzug) 2 Zahlen vom SAP (ohne Berücksichtigung MwSt-Abzug)

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Publications 2010 and 2011 (members of IPZ in bold)

Original publications and reviews in peer-reviewed journals

2010

Al-Sabi, M.N.S., Deplazes, P., Webster, P., Willesen, J.L., Davidson, R.K., Kapel, C.M.O. (2010): PCR detection of Angiostrongylus vasorum in faecal samples of dogs and foxes. Parasitology Research 107 (1), 135-140.

Basso, W., Schares, S., Minke, L., Bärwald, A., Maksimov, A., Peters, M., Schulze, C., Müller, M., Conraths, F.J., Schares, G. (2010): Microsatellite typing and avidity analysis suggest a common source of infection in herds with epidemic Neospora caninum-associated bovine abortion. Veterinary Parasitology 173(1-2), 24-31.

Bottova, I., Sauder, U., Olivieri, V., Hehl, A.B., Sonda, S. (2010): The P-glycoprotein inhibitor GF120918 modulates Ca2+-dependent processes and lipid metabolism in Toxoplasma gondii. PLoS ONE 5 (4), e10062.

Burlet, P., Hegglin, D., Deplazes, P. (2010): Efficient age determination: how freezing affects eye lens weight of the small rodent species Arvicola terrestris. European Journal of Wildlife Research 56(4), 685-688.

Glaus, T.M., Schnyder, M., Dennler, M., Tschuor, F., Wenger, M., Sieber-Ruckstuhl, N.S. (2010): Natürliche Angiostrongylus vasorum Infektion: Charakterisierung des Krankheitsbildes bei drei Hunden mit pulmonärer Hypertonie. Schweizer Archiv für Tierheilkunde 152(7), 331-338.

Hülsmeier, A.J., Deplazes, P., Naem, S., Nonaka, N., Hennet, T., *Köhler, P. (2010): An Echinococcus multilocularis coproantigen is a surface glycoprotein with unique O-gycosylation. Glycobiology 20(1), 127-135. Knubben-Schweizer, G., Deplazes, P., Torgerson, P.R., Rapsch, C., Meli, M.L., Braun, U. (2010): Bovine Fasciolose in der Schweiz: Bedeutung und Bekämpfung. Schweizer Archiv für Tierheilkunde 152(5), 223-229. Knubben-Schweizer, G., Rüegg, S., Torgerson, P.R., Rapsch, C., Grimm, F., Hässig, M., Deplazes, P., Braun, U. (2010): Control of bovine fasciolosis in dairy cattle in Switzerland with emphasis on pasture management. Veterinary Journal 186(2), 188-191.

Konrad, C., Spycher, C., Hehl, A.B. (2010): Selective condensation drives partitioning and sequential secretion of cyst wall proteins in differentiating Giardia lamblia. PLoS Pathogens 6(4), e1000835.

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Kovari, H., Ebnöther, C., Schweiger, A., Berther, N., Kuster, H., Günthard, H.F. (2010): Pulmonary toxoplasmosis, a rare but severe manifestation of a common opportunistic infection in late HIV presenters: report of two cases. Infection 38(2), 141-144. Kranjc, A., Schnyder, M., Dennler, M., Fahrion, A., Makara, M., Ossent, P., Morgan, J., Deplazes, P., Glaus, T.M. (2010): Pulmonary artery thrombosis in experimental Angiostrongylus vasorum infection does not result in pulmonary hypertension and echocardiographic right ventricular changes. Journal of Veterinary Internal Medicine 24(4), 855-862. Labes, E., Hegglin, D., Grimm, F., Nurcahyo, W., Harrison, M.E., Bastian, M.L., Deplazes, P. (2010): Intestinal parasites of endangered orangutans (Pongo pygmaeus) in Central and East Kalimantan, Borneo, Indonesia. Parasitology 137(1), 123-135. Lalle, M., Rosati, M.A., Bien, J., Hehl, A.B., Pozio, E., Tosini, F. (2010): Expression of Cryptosporidium parvum Cpa135/CpCCP1 chimeras in Giardia duodenalis: Organization of the protein domains affects the protein secretion pathway. Experimental Parasitology, Epub. Magnis, J., Naucke, T.J., Mathis, A., Deplazes, P., Schnyder, M. (2010): Local transmission of the eye worm Thelazia callipaeda in southern Germany. Parasitology Research 106(3), 715-717. Morf, L., Spycher, C., Rehrauer, H., Fournier, C.A., Morrison, H.G., Hehl, A.B. (2010): The transcriptional response to encystation stimuli in Giardia lamblia is restricted to a small set of genes. Eukaryotic Cell 9(10), 1566-1576. Nemetschke, L., Eberhardt, A., Hertzberg, H., Streit, A. (2010): Genetics, chromatin diminution, and sex chromosome evolution in the parasitic nematode genus strongyloides. Current Biology 20(19), 1687-1696. Raoul, F., Deplazes, P., Rieffel, D., Lambert, J-C., Giraudoux, P. (2010): Predator dietary response to prey density variation and consequences for cestode transmission. Oecologia 164(1), 129-139.

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Roggero, C., Schaffner, F., Bächli, G., Mathis, A., Schnyder, M. (2010): Survey of Phortica drosophilid flies within and outside of a recently identified transmission area of the eye worm Thelazia callipaeda in Switzerland. Veterinary Parasitology 171(1-2), 58-67. Schnyder, M., Fahrion, A., Riond, B., Ossent, P., Webster, P., Kranjc, A., Glaus, T., Deplazes, P. (2010): Clinical, laboratory and pathological findings in dogs experimentally infected with Angiostrongylus vasorum. Parasitology Research 107(6), 1471-1480. Secka, A., Grimm, F., Victor, B., Marcotty, T., De Deken, R., Nyan, O., Herera, O., Van Marck, E., Geerts, S. (2010): Epilepsy is not caused by cysticercosis in The Gambia. Tropical Medicine & International Health 15(4), 476-479. Sonda, S., Morf, L., Bottova, I., Baetschmann, H., Rehrauer, H., Caflisch, A., Hakimi, M-A., Hehl, A.B. (2010): Epigenetic mechanisms regulate stage differentiation in the minimized protozoan Giardia lamblia. Molecular Microbiology 76(1), 48-67. Stefanic, S., Spycher, C., Morf, L., Fabriàs, G., Casas, J., Schraner, E., Wild, P., Hehl, A.B., Sonda, S. (2010): Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia. Journal of Lipid Research 51(9), 2527-2545. Ziadinov, I., Deplazes, P., Mathis, A., Mutunova, B., Abdykerimov, K., Nurgaziev, R., Torgerson, P.R. (2010): Frequency distribution of Echinococcus multilocularis and other helminths of foxes in Kyrgyzstan. Veterinary Parasitology 171(3-4), 286-292.

2011

Armua-Fernandez, M.T., Nonaka, N., Sakurai, T., Nakamura, S., Gottstein, B., Deplazes, P., Phiri, I.G.K., Katakura, K., Oku, Y. (2011): Development of PCR/dot blot assay for specific detection and differentiation of taeniid cestode eggs in canids. Parasitology International 60(1), 84-89. Basso, W., Schares, G., Gollnick, N.S., Rütten, M., Deplazes, P. (2011): Exploring the life cycle of Besnoitia besnoiti--Experimental infection of putative definitive and intermediate host species. Veterinary Parasitology 178(3-4), 223-234.

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Bruzinskaité-Schmidhalter, R., Sarkunas, M., Malakauskas, A., Mathis, A., Torgerson, P.R., Deplazes, P. (2011): Helminths of red foxes (Vulpes vulpes) and raccoon dogs (Nyctereutes procyonoides) in Lithuania. Parasitology, 1-8. Burlet, P., Deplazes, P., Hegglin, D. (2011): Age, season and spatio-temporal factors affecting the prevalence of Echinococcus multilocularis and Taenia taeniaeformis in Arvicola terrestris. Parasites & Vectors 4, 6. Capelli, G., Drago, A., Martini, S., Montarsi, F., Soppelsa, M., Delai, N., Ravagnan, S., Mazzon, L., Schaffner, F., Mathis, A., Di Luca, M., Romi, R., Russo, F. (2011): First report in Italy of the exotic mosquito species Aedes (Finlaya) koreicus, a potential vector of arboviruses and filariae. Parasites & Vectors 4, 188. Caspari, K., Grimm, F., Kühn, N., Caspari, N.C., Basso, W. (2011): First report of naturally acquired clinical sarcocystosis in a pig breeding stock. Veterinary Parasitology 177 (1-2), 175-178. Conger, R., Chen, Y., Fornaciari, S., Faso, C., Held, M.A., Renna, L., Brandizzi, F. (2011): Evidence for the involvement of the Arabidopsis SEC24A in male transmission. Journal of Experimental Botany 62(14), 4927-4936. Dekoninck, W., Hendrickx, F., Van Bortel, W., Versteirt, V., Coosemans, M., Damiens, D., Hance, T., De Clercq, E.M., Hendrickx, G., Schaffner, F., Grootaert, P. (2011): Human-induced expanded distribution of Anopheles plumbeus, experimental vector of West Nile Virus and a potential vector of Human Malaria in Belgium. Journal of Medical Entomology 48(4), 924-928. Dennler, M., Makara, M., Kranjc, A., Schnyder, M., Ossent, P., Deplazes, P., Ohlerth, S., Glaus, T.M. (2011): Thoracic computed tomography findings in dogs experimentally infected with Angiostrongylus vasorum. Veterinary Radiology and Ultrasound 52(3), 289-294. Deplazes, P., van Knapen, F; Schweiger, A., Overgaauw, P.A.M. (2011): Role of pet dogs and cats in the transmission of helminthic zoonoses in Europe, with a focus on echinococcosis and toxocarosis. Veterinary Parasitology 182(1), 41-53. Eichenberger, R.M., Stephan, R., Deplazes, P. (2011): Increased sensitivity for the diagnosis of Taenia saginata cysticercus infection by additional heart examination compared to the EU-approved routine meat inspection. Food Control 22(6), 989-992.

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Fahrion, A.S., Schnyder, M., Wichert, B., Deplazes, P. (2011): Toxocara eggs shed by dogs and cats and their molecular and morphometric species-specific identification: Is the finding of T. cati eggs shed by dogs of epidemiological relevance? Veterinary Parasitology 177 (1-2), 186-189. Faso, C., Hehl, A.B. (2011): Membrane trafficking and organelle biogenesis in Giardia lamblia: Use it or lose it. International Journal for Parasitology 41(5), 471-480. Fiechter, R.M.E., Grimm, F., Müller, G., Schnyder, M. (2011): Häufung von Ornithonyssus bacoti (Tropische Rattenmilbe) Infestationen bei Heimnagern und ihren Besitzern in den Kantonen Zürich und Graubünden. Schweizer Archiv für Tierheilkunde 153(2), 79-85. Harandi, M.F., Moazezi, S.S., Saba, M., Grimm, F., Kamyabi, H., Sheikhzadeh, F., Sharifi, I., Deplazes, P. (2011): Sonographical and Serological Survey of Human Cystic Echinococcosis and Analysis of Risk Factors Associated with Seroconversion in Rural Communities of Kerman, Iran. Zoonoses and Public Health 58(8), 582-588. Kaufmann, C., Ziegler, D., Schaffner, F., Carpenter, S., Pflüger, V., Mathis, A. (2011): Evaluation of matrix-assisted laser desorption/ionization time of flight mass spectrometry for characterization of Culicoides nubeculosus biting midges. Medical and Veterinary Entomology (25)1, 32-38. Labes, E.M., Nurcahyo, W., Deplazes, P., Mathis, A. (2011): Genetic characterization of Strongyloides spp. from captive, semi-captive and wild Bornean orangutans (Pongo pygmaeus) in Central and East Kalimantan, Borneo, Indonesia. Parasitology 138, 1417-1422. Lalle, M., Rosati, M.A., Bien, J., Hehl, A.B., Pozio, E., Tosini, F. (2011): Expression of Cryptosporidium parvum Cpa135/CpCCP1 chimeras in Giardia duodenalis: Organization of the protein domains affects the protein secretion pathway. Experimental Parasitology 127(3), 680-686. Nageshan, R.K., Roy, N., Hehl, A.B., Tatu, U. (2011): Post-transcriptional repair of a split heat shock protein 90 gene by mRNA trans-splicing. Journal of Biological Chemistry 286(9), 7116-7122. Nagy, A., Ziadinov, I., Schweiger, A., Schnyder, M., Deplazes, P. (2011): Fellkontamination mit Eiern von zoonotischen Helminthen bei Hof- und Haushunden sowie bei Füchsen. Berliner und Münchener Tierärztliche Wochenschrift, 503-511.

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Nonaka, N., Nakamura, S., Inoue, T., Oku, Y., Katakura, K., Matsumoto, J., Mathis, A., Chembesofu, M., Phiri, I.G.K. (2011): Coprological survey of alimentary tract parasites in dogs from Zambia and evaluation of a coproantigen assay for canine echinococcosis. Annals of Tropical Medicine & Parasitology 105(7), 521-530. Planzer, J., Kaufmann, C., Worwa, G., Gavier-Widén, D., Hofmann, M A., Chaignat, V., Thür, B. (2011): In vivo and in vitro propagation and transmission of Toggenburg orbivirus. Research in Veterinary Science 91(3), e163-e168. Porretta, D., Canestrelli, D., Urbanelli, S., Bellini, R., Schaffner, F., Petric, D., Nascetti, G. (2011): Southern crossroads of the Western Palaearctic during the Late Pleistocene and their imprints on current patterns of genetic diversity: insights from the mosquito Aedes caspius. Journal of Biogeography 38(1), 20-30. Schares, G., Maksimov, A., Basso, W., Moré, G., Dubey, J.P., Rosenthal, B., Majzoub, M., Rostaher, A., Selmair, J., Langenmayer, M.C., Scharr, J.C., Conraths, F.J., Gollnick, N.S. (2011): Quantitative real time polymerase chain reaction assays for the sensitive detection of Besnoitia besnoiti infection in cattle. Veterinary Parasitology 178(3-4), 208-216. Schnyder, M., Maurelli, M.P., Morgoglione, M.E., Kohler, L., Deplazes, P., Torgerson, P.R., Cringoli, G., Rinaldi, L. (2011): Comparison of faecal techniques including FLOTAC for copromicroscopic detection of first stage larvae of Angiostrongylus vasorum. Parasitology Research 109(1), 63-69. Schnyder, M., Tanner, I., Webster, P., Barutzki, D., Deplazes, P. (2011): An ELISA for sensitive and specific detection of circulating antigen of Angiostrongylus vasorum in serum samples of naturally and experimentally infected dogs. Veterinary Parasitology 179(1-3), 152-158. Secka, A., Grimm, F., Marcotty, T., Geysen, D., Niang, A.N., Ngale, V., Boutche, L., Van Marck, E., Geerts, S. (2011): Old focus of cysticercosis in a senegalese village revisited after half a century. Acta Tropica 119(2-3), 199-202. Sherifi, K., Rexhepi, A., Hamidi, A., Behluli, B., Zessin, K.H., Mathis, A., Deplazes, P. (2011): Detection of patent infections of Echinococcus granulosus ("sheep-strain", G1) in naturally infected dogs in Kosovo. Berliner und Münchener Tierärztliche Wochenschrift 11/12, 518-521.

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Sikó, S.B., Deplazes, P., Ceica, C., Tivadar, C.S., Bogolin, I., Popescu, S., Cozma, V. (2011): Echinococcus multilocularis in south-eastern Europe (Romania). Parasitology Research 108(5), 1093-1097. * Professor emeritus for parasitology of the University of Zurich and former director of the IPZ.

Original publications and reviews in non-reviewed journals and abstracts

2010

Gatt, P., Schaffner, F., Cassar, L.F. (2010): Aedes (Stegomyia) albopictus(Skuse) (Diptera: Culicidae) in Malta - the first winter. European Mosquito Bulletin 28(10), 225-229.

Gollnick, N.S., Klee, W., Scharr, J.C., Langenmayer, M.C., Majzoub, M.,Rostaher, A., Basso, W., Conraths, F.J., Schares, G. (2010): Besnoitia besnoiti auf der Spur. Deutsches Tierärzteblatt 58(4), 482-490.

Gollnick, N.S., Rostaher, A., Gentile, A., Scharr, J.C., Langenmayer, M.C.,Majzoub, M., Basso, W., Conraths, F.J., Schares, G. (2010): Bovine besnoitiosis - an emerging disease. Cattle Practice 18(3), 151-152.

Schaffner, F., Gatt, P., Mall, S., Maroli, M., Spiteri, G., Melillo, T., Zeller, H. (2010): Mosquitoes in Malta: Preliminary entomological investigation and risk assessment for vector-borne diseases (Diptera: Culicidae). Bulletin of the Entomological Society of Malta 3, 41-54.

Schnyder, M. (2010): Lungenwürmer - Relevanz und Maßnahmen in der Kleintierpraxis. Kleintier konkret 13(4), 8-12.

Scholte, E.J., Braks, M., Schaffner, F. (2010): Aircraft-mediated transport of Culex quinquefasciatus. A case report. European Mosquito Bulletin 28, 208-212.

Scholte, E.J., Den Hartog, W., Dik, M., Schoelitsz, B., Brooks, M., Schaffner, F.,Foussadier, R., Braks, M., Beeuwkes, J. (2010): Introduction and control of three invasive mosquito species in the Netherlands, July-October 2010. Eurosurveillance 15(45), 19710.

2011

Eichenberger, R.M., Deplazes, P. (2011): Bandwurmfinnen beim Rind. UFA Revue 5, 43-46.

Gollnick, N.S., Rostaher, A., Scharr, J.C., Langenmayer, M.C., Majzoub, M.,Bauer, B., Basso, W., Conraths, F.J., Schares, G. (2011): Bovine Besnoitiose breitet sich in Europa aus-was tun im Verdachtsfall? Klauentierpraxis 19, 8-12.

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Heinzmann, D., Barbour, A.D., Torgerson, P.R. (2011): A mechanistic individual-based two-host interaction model for the transmission of a parasitic disease. International Journal of Biomathematics 4(4), 443-460.

Michel, A., Mathis, A., Hoby, S., Ryser, M.P. (2011): La babésiose du chamois: une nouvelle maladie? Chasse et Nature 2011, 30-33.

Naucke, T.J., Magnis, J., Auer, H., Schnyder, M. (2011): Zoonotische Nematoden-Infektionen des Hundes - Ausbreitung von Thelaziose und kutaner Dirofilariose. Kleintier konkret 14(4), 3-8.

Schaffner, F., Vazeille, M., Kaufmann, C., Failloux, A-B., Mathis, A. (2011): Vector competence of Aedes japonicus for chikungunya and dengue viruses.European Mosquito Bulletin 29, 141-142.

Doctoral and master theses

Bottova, I. (2010): The role of P-glycoprotein in host-pathogen interactions. Dissertation (Dr. sc. nat.), Mathematisch-naturwissenfschaftliche Fakultät, Universität Zürich, 1.1.07-31.12.09.

Morf, L. (2010): Machineries for Change: Differentiation in the minimized Eukaryote Giardia lamblia. Dissertation (Dr. sc. nat.), Mathematisch-naturwissenfschaftliche Fakultät, Universität Zürich, 1.9.06-31.3.10.

Burlet, P.E. (2011): Age, season and spatio-temporal factors affecting the prevalence of Echinococcus multilocularis and Taenia taeniaeformis in Arvicola terrestris. Dissertation (Dr. med. vet.), Vetsuisse-Fakultät, Universität Zürich, 1.2.07-30.6.09.

Eichenberger, R.M. (2011): New insights into the diagnosis of cysticercoses in cattle and sheep at population and herd level. Dissertation (Dr. med. vet.), Vetsuisse-Fakultät, Universität Zürich, 15.4.08-31.12.11.

Nagy, A.F. (2011): Fellkontamination mit Eiern von zoonotischen Helminthen bei Hof- und Haushunden sowie bei Füchsen. Dissertation (Dr. med. vet.), Vetsuisse-Fakultät, Universität Zürich, 1.11.10-30.4.11.

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European College Diploma European Veterinary Parasitology College: Dr. med. vet. Manuela Schnyder (Residentin und Oberassistentin am IPZ, alternatives Residencyprogramm am IPZ). Bestätigung am 06.12.2011 erhalten. Dr. med. vet. Caroline Frey (externe Residentin des Institutes für Parasitologie, Vetsuisse Fakultät der Universität Bern). Bestätigung am 06.12.2011 erhalten. Books

Kayser, F.H., Böttger, E.C., Zinkernagel, R.M., Haller, O., *Eckert, J.,Deplazes, P. (2010): Medizinische Mikrobiologie: Taschenlehrbuch, Stuttgart, Thieme (774 pages).

* Professor emeritus for parasitology of the University of Zurich and former director of the IPZ.

Book contributions

Deplazes, P. (2010): Small Animal Neurology. Chapter: Parasitic neurological diseases of the dog and cat (10 pages). In: Jaggy, A. (ed.). Schlütersche Verlagsgesellschaft mbH & Co. KG, Hannover.

Torgerson, P.R. (2010): Handbook of Disease Burdens and Quality of Life Measures. Chapter: Financial burdens and disability-adjusted life years (DALYs) in Echinococcosis (17 pages). In: Preedy, V.R., Watson, R.R. (eds.): Volume 1, Springer US.

Heinzmann, D. (2010): Workshop on Branching Processes and Their Applications. Chapter: Time to extinction in a two-host interaction model for the macroparasite Echinococcus granulosus (9 pages). In: González Velasco, M; Puerto, I M; Molina, M; Mota, M; Ramos, A. (eds.): 1st Edition. Springer Berlin Heidelberg.

*Eckert, J. (2011): Progress in Parasitology. Chapter: 50 Years German Society of Parasitology (DGP) (1961 - 2010) (21 pages). In: Mehlhorn, H. (author), Düsseldorf University Press.

*Eckert, J., Deplazes, P., Kern, P. (2011): Oxford Textbook of Zoonoses Biology, Clinical Practice, and Public Health Control. Chapter: Alveolar echinococcosis (Echinococcus multilocularis) and neotropical forms of echinococcosis (Echinococcus vogeli and Echinococcus oligarthrus). In: Palmer , S R; Soulsby, L; Torgerson , P R; Brown , D W G. (authors.): 2. Auflage, pp. 669-699, Oxford University Press.

Hehl, A. B. (2011): Giardia - A model Organism. Chapter: Intracellular protein trafficking (10 pages). In: Lujan, H D; Svärd, S. (eds.): 1st Edition. Springer-Verlag/Wien. * Professor emeritus for parasitology of the University of Zurich and former director of the IPZ.

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Scientific lecture in front of external audience and posters

Basso, W.: Bovine Besnoitiose: Aktuelles über Biologie, Klinik und Diagnostik. Frühjahrestagung der SVVLD, Zürich, 22.04.10.

Basso, W.: Poster: Isolation and molecular characterization of Toxoplasma gondii strains in slaughtered pigs from Argentina. 23rd International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), Buenos Aires, Argentinien, 21.08. - 25.08.11.

Basso, W.: Toxoplasmosis in pigs. Annual Congress of the Swiss Society of Veterinaries, Davos, Switzerland, 15.09. - 16.09.11.

Basso, W.: Poster: Studies on potential intermediate and definitive host species of Besnoitia besnoiti. 23rd International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), Buenos Aires, Argentinien, 21.08. - 25.08.11.

Deplazes, P.: Presentation on Echinococcose. European Food Safety Authority Zoonoses Unit, Visit of Switzerland, BVET, Bern, 06.07.10.

Deplazes, P.: Epidemiology and diagnosis of bovine cysticercosis. 5th Workshop of National Reference Laboratories for Parasites, Istituto Superiore di Sanità, Rome, Italy, 30.06.10.

Deplazes, P., Schweiger, A.: "Toxocara Infektion". Kolloquium für Tropen- und Reisemedizin, Universitätsspital Zürich, 06.09.10.

Deplazes, P.: "Fuchsbandwurm - Erkenntnisse aus schweizweiten Studien". Kantonsspital Münsterlingen, 15.09.10.

Deplazes, P.: Control of vector borne diseases in pets in Switzerland: an ESCCAP action. Annual Meeting of the Swiss Society of Tropical Medicine and Parasitology (SSTMP) Spiez, 28.10.-29.10.10.

Deplazes, P.: Echinococcosis control in Switzerland. Annual Scientific Conference and Annual General Meeting, European College of Veterinary Public Health (ECVPH), Nottwil, 08.10.10.

Deplazes, P.: Persisting helminthic zoonoses in Central Europe. 2011 Australian Society for Parasitology Inc., Annual Conference, Cairns, Australia, 10.07. - 13.07.11.

50

Deplazes, P.: Pet-associated helminthic zoonoses. 23rd International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), Buenos Aires, Argentinien, 21.08. - 25.08.11. Deplazes, P.: Parasiten Magen-Darm-Trakt. 32. Internationaler Fortbildungskurs "Kleintierkrankheiten", Gastroenterologie, Flims, Schweiz, 01.03.11. Deplazes, P.: Alveolar Echinococcosis in humans, diagnosis, treatment, prognosis. Meeting on Echinococcus multilocularis, National Veterinary Institute, Uppsala, Sweden, 02.04.11. Deplazes, P.: Parasitic zoonoses in Europe. Meeting: Wormwise, Albany, Australia, 17.08.11. Deplazes, P.: Epidemiology and Control of Echinococcosis in Europe. Second International Conference of Southeastern and Eastern European Parasitological Society, Zagreb, Croatia, 14.06. - 18.06.11. Deplazes, P.: Alveolar Echinococcosis: Human Costs and Costs for Prevention. Second International Conference of Southeastern and Eastern European Parasitological Society, Zagreb, Croatia, 14.06. - 18.06.11. Deplazes, P.: Epidemiologie in der Schweiz: Ist der Fuchs an allem schuld? Symposium zum 85. Geburtstag von Professor Rudolf W. Ammann, Universitätsspital Zürich, Schweiz, 30.06.11. Eichenberger, R.: Bovine Cysticercose - Evaluation von klassischen und alternativen diagnostischen Verfahren. DVG-Jahrestagung der Fachgruppe "Parasitologie und parasitäre Krankheiten", Munich, 07.07. - 09.07.10. Eichenberger, R.: Ausbruch von Taenia ovis-Cysticercose in einer Schafpopulation in Südwest-England: ein Fallbericht. DVG-Jahrestagung der Fachgruppe ”Parasitologie und parasitäre Krankheiten”, Berlin, Deutschland, 04.07. - 06.07.11. Eichenberger, R.: Immunology and Immunopathology of canine Babesiosis. MD-PhD/-MSc Retreat 2011, Propstei Wislikofen, Schweiz, 23.10. - 25.10.11. Eichenberger, R.: Combating Babesia in dogs; hoist with its own pathogenic petard. SSTMP student meeting 2011, Basel, Schweiz, 15.11.-16.11.11.

51

Eichenberger, R.: Bovine Cysticercose: Aktuelle Bekämpfungsstrategie ineffektiv? Aspekte einer individuellen Fallbearbeitung. Symposium “Wichtige Parasitosen in der Rindermedizin” (GST, SVW, RGD), Lenzburg, Schweiz, 05.04.11. Faso, C.: Poster: Investigating the anterograde and retrieval pathways from the ER to Golgi-like encystation-specific vesicles in the highly reduced protozoan Giardia lamblia. First EMBO ER conference, Girona, Spain, 03.10. - 07.10.10. Faso, C.: Stripping down the secretory pathway in Giardia lamblia: ER exit site presence and function without a Golgi. Annual meeting of the Swiss Society for Tropical Medicine and Parasitology, Basel, Switzerland, 17.11.11. Faso, C.: Towards a basic model for the synthesis of protective biopolymers in protozoa: Implementing high-throughput strategies in Giardia lamblia. Indo-Swiss Symposium on parasitic and infectious diseases, New Delhi, India, November 2011. Faso, C.: Investigating the early secretory pathway in the highly reduced eukaryote Giardia lamblia. Forschungsbesprechung, Institut für Parasitologie, Universität Zürich, 01.03.11. Faso, C.: Encystation in Giardia lamblia: a role for ER exit sites in parasite differentiation. Max F. Perutz Laboratories, Vienna, Austria, March 2011. Faso, C.: Giardia lamblia: eccentric cell biology in a deceivingly simple protozoan. Seminar given at the introductory course for graduate students of the microbiology and immunology graduate programme. Institue of Plant Biology, University of Zurich, 09.06.10. Grimm, F.: Caviar in the skin (a case of a subcutaneous Taenia crassiceps infection in a HIV-positive female Swiss patient). Annual Meeting of the Swiss Society of Tropical Medicine and Parasitology (SSTMP) Spiez, 28.-29.10.10. Grimm, F.: Parasitologische Diagnostik: Von Galilei bis Mullis. Kolloquium Infektiologie und Mikrobiologie, Universitätsspital Zürich, 15.04.10. Grimm, F.: Präanalytik in der Parasitologie. Weiterbildung FAMH, Zürich, 15.01.10. Grimm, F.: Toxoplasma gondii – Biologie. Weiterbildung SGM, Basel, 14.10.10.

52

Grimm, F., Lengeler, D. (SwissTPH): Malaria - Endlich Fortschritte in der Bekämpfung. Wissen schafft Wissen. Zürcher Zentrums für Integrative Humanphysiologie (ZIHP), Zürich, 31.05.10. Grimm, F.: Dirofilarien - Biologie und Diagnostik. Kolloquium für Tropen- und Reisemedizin. UniveristätsSpital Zürich, Schweiz, 07.02.11. Hegglin, D.: Control of Echinococcus multilocularis: Epidemiological and strategic considerations. Epidemiology Of Alveolar Echinococcosis in Europe, Technopôle Agro-Véterinaire - Domaine de Pixérécourt, Nancy, 08.12. - 09.12.10. Hegglin, D.: Practical experience of baiting, could eradication by baiting be done in Sweden? Meeting on Echinococcus multilocularis, National Veterinary Institute, Uppsala, 02.04.11. Hegglin, D.: Echinococcus multilocularis: Ecology based control strategies in urban settings. XXIV World Congress of Hydatidology, Urumqi, China, 14.09. - 18.09.11. Hehl, A.B.: „Giardia Zellbiologie“. Institut für Zellbiologie, Universität Bern, 26.03.10. Hehl, A.B.: "Infectious Agents: From molecular biology to disease". Titel: Giardia Zellbiologie (Lehrauftrag), ETH Zürich, 16.04.10. Hehl, A.B.: Giardia stage-differentiation. Department of Microbiology, University of Uppsala, 07.06.10. Hehl, A.B.: “Giardia und Giardiose”. Institut für Veterinär-Pathologie, Universität Zürich, 16.12.10. Hertzberg, H.: Computer-gestütztes Lernprogramm für die koproskopische Diagnostik in der Veterinärparasitologie. DVG-Jahrestagung der Fachgruppe "Parasitologie und parasitäre Krankheiten", München, 07.07. -09.07.10. Hertzberg, H.: A computer-based teaching program for the coproscopical identification of parasite stages in domestic animals. 23rd International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), Buenos Aires, Argentinien, 21.08. - 25.08.11. Hertzberg, H.: Neue Strategie zur Endoparasitenbekämpfung - Wieso wir umdenken müssen. Berner Fortbildungsabend für Tierärzte, Bern, Schweiz, 01.12.11.

53

Hertzberg, H.: Neue Strategie zur Endoparasitenbekämpfung - Umsetzung in der Praxis. Berner Fortbildungsabend für Tierärzte, Bern, Schweiz, 01.12.11. Hertzberg, H.: Parasitenmanagement beim Pferd: Notwendigkeit einer Neuorientierung. Fortbildung für Tierärzte, Bern, Schweiz, 21.09.11. Hertzberg, H.: Selective anthelminthic treatment in horses – the swiss experience. International Workshop, München, Deutschland, 19.01.11. Hertzberg, H.: Selektive anthelminthische Behandlungen beim Pferd: Erfahrungen aus der Schweiz. Jahrestagung der Fachgruppe Parasitologie der Deutschen Veterinärmedizinischen Gesellschaft, Berlin, Deutschland, 05.07.11. Hertzberg, H.: A CD-ROM- and web-based teaching program for the coproscopical identification of parasite stages in domestic animals. Jahrestagung des European College of Veterinary Parasitology, Zagreb, Kroatien, 17.06.11. Hertzberg, H.: Selective Anthelmintic Treatments in Horses. Scientific Workshop at the 23rd. International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), Buenos Aires, Argentinien, 21.08. - 25.08.11. Hertzberg, H.: E-Learning in Education of Parasitology. Second International Conference of Southeastern and Eastern European Parasitological Society, Zagreb, Croatia, 14.06. - 18.06.11. Hertzberg, H.: Parasitenmanagement beim Pferd: Notwendigkeit einer Neuorientierung. Tagung der Gesellschaft Schweizerischer Tierärzte, Davos, Schweiz, 16.09.11. Hertzberg, H.: Neue Strategien zur Parasitenkontrolle beim Pferd. Fortbildungsseminar, Institut für Parasitologie, Universität Zürich, 28.11.11. Hertzberg, H.: Dictyocaulose. Fortbildungstag des Rindergesundheitsdienstes, Lenzburg, Schweiz, 05.04.11. Kaufmann, C.: MALDI-TOF MS for characterization of Culicoides biting midges (Diptera: Ceratopogonidae). Annual Meeting of the Swiss Society of Tropical Medicine and Parasitology (SSTMP) Spiez, 28.10. - 29.10.10. Kaufmann, C.: Sugar-feeding behaviour and its effect on the fecundity of Culicoides biting midges (Diptera: Ceratopogonidae). European Society of Vector Ecology, Wroclaw, Poland, 13.09. - 17.09.10.

54

Kaufmann, C.: Invasion von Aedes japonicus in Zentral Europa. Schweizerische Gesellschaft für Entomologie, Neuchâtel, Switzerland, 06.03.10. Kaufmann, C.: MALDI-TOF-MS for characterization of Culicoides biting midges. Swiss Society of Tropical Medicine and Parasitology, Spiez, Switzerland, 28.10. - 29.10.10. Kaufmann, C.: MALDI-TOF-MS for characterization of Culicoides biting midges (Diptera: Ceratopogonidae). Swiss Systematic Society, Lugano, Switzerland, 26.11.10. Kaufmann, C.: MALDI-TOF-MS for characterization of Culicoides biting midges. Swiss Vector Entomology Group, Bern, Switzerland, 11.11.10. Kaufmann, C.: Biting midges: What do we know and what do we need to know? Colloquium, Pathology, Vetsuisse, University of Zurich, Switzerland, 22.09.11. Kaufmann, C.: From midges to mosquitoes. Fortbildungsseminar, Institut für Parasitologie, Universität Zürich, 27.09.11. Kaufmann, C.: Zuckerfütterungsverhalten und dessen Einfluss auf Reproduktion und Lebensspanne von Culicoides spp. (Diptera: Ceratopogonidae). Schweizerische Gesellschaft für Entomologie, Zürich, Schweiz, 11.03. - 12.03.11. Kaufmann, C.: Bestimmung der einheimischen Gnitzen mittels MALDI-TOF-MS. Diptera Arbeitsgruppe (Schweizerische Gesellschaft für Entomologie), Zürich, Schweiz, 05.02.11. Kaufmann, C.: Poster: Sommerekzem beim Pferd: Vergleich der Immunantwort gegen laborgezüchtete C. nubeculosus Gnitzen und in der Schweiz gefangene Culicoides-Arten. Netzwerktagung Pferdeforschung Avenches, Schweiz, 15.04.11. Lippuner, C.: Poster: The transcriptome of intestinal Cryptosporidium parvum stages. Molecular Parasitology Meeting, Marine Biological Laboratories, Woods Hole, USA, 11.11. - 15.11.11. Lippuner, C.: Omics-Technologien in der Parasitenforschung: Cryptosporidien und andere Parasiten. Seminar, Rinderklinik, Ludwigs-Maximilian Universität München, Deutschland, 16.12.11.

55

Lippuner, C.: Klinik, Immunologie und Therapie. Vetsuisse Nutztierabend 2010/2011, Zürich, Schweiz, 10.05.11. Mathis, A.: Durch Arthropoden übertragene Pathogene in der Schweiz: neue Arthropoden, neue Pathogene, neue Liaisons (aber immer noch dasselbe alte Land) (invited keynote lecture). Jahrestagung der Deutschen Gesellschaft für Medizinische Entomologie und Acarologie, Zürich, 07.10. -09.10.10. Mathis, A.: MALDI-TOF MS for characterization of Culicoides biting midges. 17th European Society for Vector Ecology Conference, Wroclaw, Poland, 13.09. - 17.09.10. Mathis, A.: Evaluation of MALDI-TOF MS for characterization of Culicoides nubeculosus biting midges. DVG Fachgruppentagung Parasitologie, München, 07.07. - 09.07.10. Mathis, A.: MALDI-TOF MS for characterization of Culicoides biting midges. Jahrestagung der Deutschen Gesellschaft für Medizinische Entomologie und Acarologie, Zürich, 07.10. - 09.10.10. Mathis, A.: Ektoparasiten – Neues von den Hauptakteuren. Kolloquium Infektiologie und Mikrobiologie, Universitätsspital Zürich, Schweiz, 01.12. 11. Mathis, A.: Vector Entomology in Switzerland. Meeting EMIDA ERA NET project consortium, London, England, 26.07.11. Mathis, A.: Asiatische Buschmücke. Runder Tisch AWEL/Neobiota, Zürich, Schweiz, 01.09.11. Rout, S.: Investigating the role of Clathrin recruitment using Arfs and Arls as tools during later stages of encystation in Giardia lamblia. Microbiology and Immunology (MIM) Introductory Week 2010, Botanic Garden, University of Zurich, 09.06.10. Rout, S.: Investigating the role of ARF and ARL GTPases during encystation in Giardia lamblia. SSTMP student meeting 2010, Spiez Laboratory, Spiez, 27.10.10. Schaffner, F.: Vector-borne diseases in Europe: a changing picture. B-Fachberaterweiterbildung Amt für Abfall, Wasser, Energie und Luft, Kanton Zürich, Zürich, 19.01.10.

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Schaffner, F. : Entomologie médicale et vétérinaire : enjeux et perspectives. Assemblée générale de la Société entomologique de Mullhouse, 14.03.10. Schaffner, F.: Moustiques vecteurs de maladies: une réalité en évolution. Mücken als Krankheitsüberträger – gestern, heute, morgen, Assemblée annuelle Fédération Suisse des Désinfestateurs / Verband Schweizerischer Schädlingbekämpfer, Bern, 25.03.10. Schaffner, F.: Actualités 2009 sur la présence du moustique Aedes albopictus en France métropolitaine. Place d'un entomologiste médical dans un Centre Hospitalier. Congrès SFMM-SFP-SMV (Société française de mycologie médicale, Société française de parasitologie, Société de médecine des voyages), Angers, France, 19.05. - 21.05.10. Schaffner, F.: Identification of West Nile virus vectors in France. Emerging Diseases in a Changing European Environment (EDEN) annual meeting, Montpellier, France, 10.05. - 12.05.10. Schaffner, F.: The spatial modelling of biodiversity hotspots for endemic mosquito species in temperate Europe, implications for field sample design and spatial MBD risk analysis. A case study in the Benelux. Emerging Diseases in a Changing European Environment (EDEN) annual meeting, Montpellier, France, 10.05. - 12.05.10. Schaffner, F.: Aedes japonicus in Switzerland. Groupe de travail inter-offices 'Vecteurs', Berne, 18.06.10. Schaffner, F.: Mosquitoes and mosquito-borne disease in Europe: a changing picture? Scientific spring meeting of the Dutch Society of Medical Microbiology (NVMM) and the Dutch Society of Microbiology (NVvM), Arnhem, Netherlands, 20.04. - 21.04.10. Schaffner, F.: European Network for Arthropod Vector Surveillance for Human Public Health. WP3 – Invasive Mosquitoes in Europe. VBORNET Annual General Meeting, Antwerp, Belgium, 01.06. - 03.06.10. Schaffner, F.: Mosquitoes of Switzerland. 2nd conference Swiss Vector Entomology Group, Bern, 11.11.10. Schaffner, F.: Controlling invasive mosquitoes and vector borne diseases: a new major stake for Europe. ‘EUROPEST’ CEPA meeting, ‘The role of the Pest Management industry in protecting human health in Europe against invasive species‘, Cracow, Poland, 19.05. - 20.05.11.

57

Schaffner, F.: Poster: Ae. koreicus, a new mosquito imported in Italy. 6th workshop European Mosquito Control Association, Budapest, Hungary, 12.09. - 15.09.11. Schaffner, F.: Asiatische Buschmücke Aedes japonicus. AWEL/Neobiota, Zurich, Switzerland, 08.09.11. Schaffner, F.: Poster: Presence and spread of the invasive mosquito Aedes japonicus in Switzerland. EDENext (Biology and control of vector-borne infections in Europe) annual meeting, Budapest, Hungary, 29.03. - 31.03.2011. Schaffner, F.: Poster: Distribution and abundance of biting midges, the potential vectors of bluetongue disease, in Switzerland. EDENext (Biology and control of vector-borne infections in Europe) annual meeting, Budapest, Hungary, 29.03. - 31.03.11. Schaffner, F.: Poster: Flight performance of the Asian tiger mosquito Aedes albopictus. EDENext (Biology and control of vector-borne infections in Europe) annual meeting, Budapest, Hungary, 29.03. - 31.03.11. Schaffner, F.: Mosquitoes in Europe: Assessing nuisance and vector risks. Entomologentagung DGaaE, Berlin, Deutschland, 21.03.-24.03.11. Schaffner, F., Mathis, A.: Asiatische Buschmücke (Aedes japonicus), Runder Tisch at AWEL, Baudirektion Kanton Zürich, Schweiz, 01.04.11.

Schaffner, F., Mathis, A.: Research project: Aedes japonicus in the canton of Zurich. AWEL/Neobiota, Zurich, Switzerland, 26.04.11.

Schaffner, F.: Guidelines for the surveillance of invasive mosquitoes. ECDC reviewing Meeting, Stockholm, Sweden, 08.12. - 09.12.11.

Schaffner, F.: Mosquitoes as vectors in Switzerland. Fachtagung Biotechnologie (FOEN), Solothurn, Schweiz, 03.11.11. Schaffner, F.: Introduction and establishment of new invasive mosquito species in Europe: just the beginning? Meeting 'Emerging vector borne diseases: the role of Aedes mosquitoes, Cervia, Italy, 09.05. - 11.05.11. Schaffner, F.: Poster: Presence and spread of the invasive mosquito Aedes japonicus in Switzerland. Meeting 'Emerging vector borne diseases: the role of Aedes mosquitoes, Cervia, Italy, 09.05. - 11.05.11.

58

Schaffner, F.: The dynamic of the spread of invasive mosquitoes as vectors of infectious diseases on the European continent. WHO/EMCA meeting on vector-related risk of introduction of Chikungunya and Dengue fever and spread of Ae. albopictus and Ae. japonicus within Europe, Speyer, Germany, 30.05. - 31.05.11. Schaffner, F.: Disease vector mapping and surveillance. 3rd meeting of the Swiss Vector Entomology Group, Neuchâtel, Switzerland, 05.02.11. Schaffner, F.: The CEPIA Platform, an efficient partner for assessing the competence of European Anopheles mosquitoes for Plasmodium falciparum. 6th workshop European Mosquito Control Association, Budapest, Hungary, 12.09. - 15.09.11. Schaffner, F.: Implementing surveillance and monitoring programmes of mosquitoes: key issues and harmonization within Europe. 6th workshop European Mosquito Control Association, Budapest, Hungary, 12.09. - 15.09.11. Schaffner, F.: Research activities on exotic mosquitoes. EDENext, Mosquito-borne diseases Group workshop, Rome, Italy, 31.01. - 02.02.11. Schaffner, F.: Vector competence of Swiss mosquitoes: from extrapolation to experimentation. SSTMP annual meeting, Basel, Switzerland, 17.11.11. Schnyder, M.: Neues zur serologischen Diagnostik der caninen Angiostrongylose. DVG-Jahrestagung der Fachgruppe "Parasitologie und parasitäre Krankheiten", Munich, 07.07. - 09.07.10. Schnyder, M.: Diagnostik der Angiostrongylose: Neue Methoden. Frühjahrestagung der SVVLD , Zürich, 22.04.10. Schnyder, M.: Zur Therapie und Diagnostik von Infektionen mit caninen Lungenwürmern. Parasitologisches Symposium organisiert von BayerHealth Care Tiergesundheit, Berlin, 30.04.-01.05.10. Schnyder, M.: Angiostrongylus vasorum (French Heartworm) infection in a dog. Joint Tropical Veterinary Parasitology and EVPC Annual Congress 2010, Munich, 29.04. - 30.04.10. Schnyder, M.: "Diagnostik der Angiostrongylose" und "Ausbreitung des Augenwurms Thelazia callipaeda in Europa". 5. Parasitologisches Round Table Gespräch organisiert von BayerHealth Care Tiergesundheit, Salzburg, 24.09. - 26.09.10.

59

Schnyder, M.: Poster: Seroepidemiological survey for canine angiostrongylosis in dogs from Germany and the United Kingdom. 23rd International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), Buenos Aires, Argentinien, 21.08. - 25.08.11. Schnyder, M.: New insights into the epidemiology and diagnosis of canine and feline lung nematodes. 23rd International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), Buenos Aires, Argentinien, 21.08. - 25.08.11. Schnyder, M.: Seroepidemiologische Untersuchungen zur caninen Angiostrongylose in Deutschland und Grossbritannien. DVG-Jahrestagung der Fachgruppe “Parasitologie und parasitäre Krankheiten”, Berlin, Deutschland, 04.07. - 06.07.11. Schnyder, M.: Wie sauber sind unsere Hunde? Untersuchungen zur Fellkontamination mit zoonotischen Helminthen. DVG-Jahrestagung der Fachgruppe “Parasitologie und parasitäre Krankheiten”, Berlin, Deutschland, 04.07. - 06.07.11. Schnyder, M.: Poster: Control of Giardia duodenalis in a dog kennel. 23rd International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), Buenos Aires, Argentinien, 21.08. - 25.08.11 Schweiger, A.: Alveolar echinococcosis. 12th International Symposium, Current Topics in Infectious Diseases, Grindelwald, 24.01. - 29.01.10. Schweiger, A., Grimm, F.: Parasitologische Diagnostik: Von Galilei bis Mullis. Kolloquium Infektiologie und Mikrobiologie, Universitätsspital Zürich, 15.04.10. Schweiger, A.: Alveolar Echinococcosis in Switzerland- Current epidemiological situation. Alveolar Echinococcosis in Poland, Lithuania and Switzerland, Institut für Parasitologie, Universität Zürich, 17.11. - 19.11.10. Schweiger, A.: Human alveolar echinococcosis in Switzerland 1956 - 2008. Epidemiology Of Alveolar Echinococcosis in Europe, Technopôle Agro-Véterinaire - Domaine de Pixérécourt, Nancy, 08.12. - 09.12.10. Stefanic, S.: The silence of the flukes: RNAi in Schistosoma mansoni and Fasciola hepatica. Fortbildungsseminar, Institut für Parasitologie, Universität Zürich, 12.04.11.

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Wampfler, P.: Encystation specific vesicles in Giardia lamblia. Microbiology and Immunology (MIM) Introductory Week 2010, Botanischer Garten, Universität Zürich, 09.06.10. Wampfler, P.: Lost in evolution – a stage-regulated Golgi-remnant in the protozoan parasite Giardia lamblia. 1st Microbiology and Immunology (MIM) Thesis Committee Meeting, Institut für Parasitologie, Universität Zürich, 23.09.10. Wampfler, P.: Lost in evolution – a stage-regulated Golgi-remnant in the protozoan parasite Giardia lamblia. SSTMP student meeting 2010, Labor Spiez, Spiez, 21.10.10. Wampfler, P.: Proteomics of secretory organelles in Giardia lamblia. 2nd Microbiology and Immunology (MIM) Thesis Committee Meeting, Institut für Parasitologie, Universität Zürich, 06.12.11. Wampfler, P.: Proteomics of secretory organelles in Giardia lamblia. Forschungsbesprechung, Institut für Parasitologie, Universität Zürich, 06.12.11.

Guest lectures

Basso, W.: Parasitic diseases of domestic animals in Argentina, challenges for the veterinarian, talk at the Veterinary Faculty, Veterinary and Pharmacy University, Brno, Czech Republic, 16.05.11.

Basso, W.: Bovine besnoitiosis, Department of Parasitology, talk at the Faculty of Science, Charles University, Prague, Czech Republic, 16.05.11.

Deplazes, P.: 1½ day practicals and lectures on Cestode Biology at the course Basic Parasitology, MSc education in Parasitology, Faculty of Life Sciences, University of Copenhagen, 30.09.10.

Deplazes, P., Hehl, A.B.: Zecken unterm Mikroskop. Labor-Kurs der Kinder-Universität Zürich, 5. und 6. Primarklasse, 06.11.10.

Deplazes, P., Schweiger, A.: Informal International Exploratory Workshop “Alveolar Echinococcosis in Poland, Lithuania and Switzerland”, Institut für Parasitologie, Universität Zürich, 19.11.10.

Deplazes, P.: Vortrag für das Graduiertenkolleg " Epidemiology of Alveolar Echinococcosis in Europe: A changing picture?", Humboldt-Universität zu Berlin, Deutschland.

61

Deplazes, P.: Introduction to Cestodes / Tapeworms (D.latum-Taenia-Echinococcus), Lecture in Basic Parasitology (Blok 1 - modul A+B), University of Copenhagen, Denmark, 07.10. 11.

Deplazes, P., Kaufmann, C.: Zecken unterm Mikroskop, Labor-Kurs der Kinder-Universität Zürich, 29.10.11.

Deplazes, P.: Parasitic Zoonoses in Central Europe, Übersichtsvorlesung 4 Stunden, University of Prishtina, Faculty of Agriculture and Veterinary, 10.11. - 11.11.11.

Deplazes, P.: Vorlesung Studium Pharmakologie ETH Zürich: Forschung in der Parasitologie, eine Übersicht (2h), ETH Hönggerberg, 20.12.11.

Faso, C.: Giardia lamblia: eccentric cell biology in a deceivingly simple protozoan. Introductory Course at the Graduate School in Microbiology and Immunology, University of Zurich and ETH-Zurich, Switzerland, June 2011.

Hegglin, D.: "Discussion of preventive measures". Informal International Exploratory Workshop “Alveolar Echinococcosis in Poland, Lithuania and Switzerland”, Institute of Parasitology, University of Zurich, 19.11.10.

Hegglin, D., Deplazes, P.: Practical experience of baiting - could eradication by baiting be done in Sweden? Meeting on Echinococcus multilocularis with special reference to the present Swedish situation, National Veterinary Institute, Uppsala, Sweden, 01.04.11.

Hegglin, D.: Füchse im Siedlungsraum: Konflikte und Management, Kurs CAS Säugetiere / Carnivora: Artenkenntnis, Biologie und Ökologie, Zürcher Hochschule für Angewandte Wissenschaften ZHAW, Institut Umwelt und Natürliche Ressourcen, IUNR, Wädenswil, 30.04.11.

Hehl, A.B.: Vorlesung Zellbiologisches Institut, Universität Bern, 25.3.11.

Mathis, A., Kaufmann, C.: Stechende Mücken - hautnah. Labor-Kurs der Kinder-Universität Zürich, 4. und 5. Primarklasse, 20.11.10.

Schaffner, F.: Biology and identification of mosquitoes, as part of the training course ‘Arthropod vectors and human health’, Institut Pasteur, Paris, France, 23.05. - 25.05.11.

Schaffner, F.: Invasive Mosquitoes in Europe: Surveillance and Risk Assessment. Centre for Vector Biology, Rutgers University, New Brunswick (New Jersey), USA, 27.10.11.

62

Schaffner, F.: Training course on identification of mosquitoes, Attendees: Centre for Monitoring of Vectors, Wageningen, The Netherlands Friedrich-Loeffler-Institut, Greifswald, Germany, at the Royal Belgian Institute of Natural Sciences, Brussels, Belgium, 23.11. - 25.11.11.

Schaffner, F., Kaufmann, C.: Training course on identification of mosquitoes and quality check of sample identifications, BAFU-funded project “Spatio-temporal diversity of mosquito fauna in Switzerland’, 2011-2012, Institut für Parasitologie, Universität Zürich, 16.12.11.

Schweiger, A.: "Alveolar echinococcosis in Switzerland - Current epidemiological situation". Informal International Exploratory Workshop “Alveolar Echinococcosis in Poland, Lithuania and Switzerland”, Institute of Parasitology, University of Zurich, 19.11.10.

Schweiger, A.: "Diagnostic tools for Cystic and Alveolar Echinococcosis in humans". Informal International Exploratory Workshop “Alveolar Echinococcosis in Poland, Lithuania and Switzerland”, Institute of Parasitology, University of Zurich, 19.11.10.

Spycher, C.: Vorlesung im Rahmen der Vorlesungsreihe “Host Parasite interaction“ am Swiss Tropical and Public Health Institute, Basel. "Secretion and endocytosis in Giardia lamblia: how they do it in the absence of a classical Golgi apparatus", 13.04.10.

Public work: Contributions/interviews for newspapers, radio and TV

Faso, C.: Interviewed von Sascha Renner für das Uni Journal im Abschnitt “Who is Who”, Nr. 3, Mai 2011.

Deplazes, P.: Beitrag in der Sendung "tierisch" von TeleM1 über Füchse und Fuchsbandwurm, 03.06.10.

Deplazes, P.: Beitrag und Interview über Fuchskrankheiten, Schweizer Familie Nr. 34, S. 32-38

Deplazes, P.: Stadtfuchs und Fuchsbandwurm. Bildungsevent: Vortrag für 4. und 5. Primarklassen, Schulhaus Kappeli Zürich, 05.10.10.

Grimm, F.: "Malaria - Endlich Fortschritte in der Bekämpfung". Öffentliche Veranstaltung des ZIHP der Universität Zürich, 31.05.10.

63

Hegglin, D.: "Stadtluft macht auch Füchse frei". Beitrag Zürichsee Zeitung, 19.04.11.

Hegglin, D.: "Der Fuchs mitten unter uns". Schweizer Radio DRS, Sendung Treffpunkt.

Hegglin, D.: "Füchse im Siedlungsraum: Freud und Leid mit einem Nachbar".Vortrag in der Vortragsreihe der Greifensee-Stiftung, Greifensse, 13.05. 11.

Hehl, A.B.: Interview zum Artikel „Der Feind im Kopf“, DAS MAGAZIN, 23.07.11.

Hertzberg, H.: Parasitenprophylaxe beim Pferd: Wo stehen wir heute? Fortbildungskurs Pferdehaltung, Egolzwil (LU), 27.04.10.

Hertzberg, H.: Anforderungen an eine zeitgemässe Parasitenkontrolle beim Pferd, Vortrag an der BEA Bern, 03.05.10.

Herztberg, H.: Parasitenproblematik in der ökologischen Rinderhaltung. Fortbildungstagung für landwirtschaftliche Berater, Würzburg, 27.10.10.

Kaufmann, C.: "Stechen Stechmücken manche Menschen tatsächlich häufiger?". Radio-Beitrag, Radio 1, Rubrik Alleswisser, 18.05.10.

Kaufmann, C.: : Grün Stadt Zürich und Migros Kulturprozent: NahReisen 11 – Im Reich der Sinne. Exkursion über die Asiatische Buschmücken, Aedes japonicus. 30.06.11 und 12.07.11.

Kaufmann, C.: TeleTop. Rubrik Top News: «Asiatische Buschmücke» bedroht TOP-Land. 09.07.11.

Kaufmann, C.: Bayrisches Fernsehen. Faszination Wissen: Kleine Biester, grosse Plage – Tropenkrankheiten auf dem Vormarsch. 10.07.11.

Kaufmann, C.: Radio 1. Rubrik Alleswisser: Sind Stechmücken nützlich? 21.07.11.

Mathis, A.: "Tierisch" (Wissenschaftsendung von diversen Privaten Fernseh-stationen): Interview über Zecken. Ausstrahlung im Mai 2010.

Mathis, A.: TV-Interview über Asiatische Buschmücke (Tele Top), 21.04.11.

Mathis, A.: TV-Interview über Zecken (Keystone, für Internet-Medien), 21.04.11.

Mathis, A.: Telephon-Interview über Asiatische Buschmücke (20 Minuten), 08.06.11.

Mathis, A.: Telephon-Interview DRS2 Wissenschaftsmagazin (Wolbachien/ Mücken), 24.08.11.

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Mathis, A.: Zeitungsartikel 20 min, Aedes japonicus, 30.08.11.

Mathis, A.: Studiointerview DRS1, 02.09.11.

Mathis, A.: Zeitungsartikel St. Galler Tagblatt (invasive Mücken), 02.09.11.

Mathis, A.: Telephon-Interview über Asiatische Buschmücke (Belgisches Radio), 25.10.11.

Schaffner, F.: Interview by Herbert Hackl, Wissenschafts-Journalist, im Auftrag von ARD/BR/3sat/Arte, 16.05.11.

Schaffner, F.: Interview Bayrisches Fernsehen, ‘Invasives species’, 15.06.2011 (diffusion 10.07.11).

Schaffner, F.: Interview scientific journalist ‘Science et Vie’ on ‘Invasive species’, 21.06.11 (publication August 2011).

Schaffner, F.: Interview Radio Suisse Romande (Silvio Dolzan) on ‘VECMAP project’, 30.06.2011 (diffusion 24.08.11).

Schaffner, F.: Interview by Joachim Budde for the radio Deutschlandfunk (at EMCA meeting), 15.09.11.

Schaffner, F.: Interview by Isabelle Cornaz for the Radio Française de Londres, on ‘Malaria’, 29.11.11 (diffusion 03.12.11).

Schnyder, M.: Beitrag Zeitung "20Minuten": "Ekliger Parasit: Augenwurm bald in der Deutschschweiz". 04.05.10.

65

Parasitologische Fortbildungsseminare des IPZ

Die Fortbildungsseminare am IPZ dienen vor allem der Weiterbildung akademischer Mitarbeiter/-innen und Doktoranden/-innen des Institutes sowie dem Informationsaustausch zwischen Fachinstituten im In- und Ausland und dem IPZ. Die Veranstaltungen wurden hauptsächlich von Gastreferenten/-innen aus der Schweiz und dem Ausland bestritten und behandelten folgende Themen: 23.02.2010 David Smith (Moredun Research Institute, Edinburgh,

Scotland): “Vaccination against haemonchosis” 02.03.2010 Jürg Utzinger (Schweizerisches Tropen- und Public Health-

Institut, Basel): "Integration of neglected tropical disease control programmes: why and how"

09.03.2010 Christian Kaufmann (Institut für Parasitologie, Universität

Zürich): „Biology of invasive insect vectors“ 10.05.2010 Simone Caccio (Istituto Superiore di Sanità, Roma): "Molecular epidemiology of cryptosporidiosis and giardiasis: facts and open issues" 25.05.2010 Gioia Capelli (Istituto Zooprofilattico Sperimentale delle

Venezie, Legnaro Italy): „Emerging vector-borne diseases in Northern Italy“

19.10.2010 Prof. Břetislav Koudela (Department of Parasitology, Univer-

sity of Veterinary and Pharmaceutical Science Brno, Czech Republic): “Toxoplasma research in the Czech Republic”

26.10.2010 Prof. Christina Strube (Institut für Parasitologie, TiHo

Hannover): "Transkriptomanalyse beim bovinen Lungenwurm Dictyocaulus viviparus"

02.11.2010 Dr. Giulio Grandi (Dipartimento di Salute Animale, Facoltà di

Medicina Veterinaria, Universita' degli Studi di Parma): "Dirofilaria, endosymbiosis and therapeutic strategies"

66

16.11.2010 Dr. Markus Künzler (Institute of Microbiology/Institut für Mikrobiologie, ETH Zürich): “Molecular characterization of alectin-mediated defense of fungi against predators and its exploitation for the development of a vaccine against parasitic nematodes”

23.11.2010 Dr. Elisabeth A. Innes (Moredun Research Institute, Edin-

burgh, UK): “Protozoal diseases of importance in farm live-stock”

30.11.2010 Dr. Alessandro Broglia (European Food Safety Authority –

EFSA, Parma, Italy): "Fish transmitted zoonoses” 22.02.2011 Luis Madeira de Carvalho (Faculty of Veterinary Medicine,

Technical University of Lisbon, Portugal): “Deworm or not deworm a horse – here is the question”

08.03.2011 Conrad von Schubert (Biozentrum, University of Basel):

"Theileria schizonts: hitching a ride to division." 22.03.2011 Thomas Barth (Institute of Pathology, University of Ulm,

Germany): "Histologie und Immunhistologie in der Diagnostik der Echinococcosen"

12.04.2011 Sasa Stefanic (Institute of Parasitology, University of Zürich):

“The silence of the flukes: RNAi in Schistosoma mansoni and Fasciola hepatica”

17.05.2011 Eva Veronesi (Institute for Animal Health, Pirbright, UK):

“Bluetongue virus and its emergence across Europe. Can we control vector-borne diseases?”

31.05.2011 Toni Aebischer (Robert Koch Institut, Berlin, Germany):

“Adaptations of Leishmania to its intracellular habitat: Interpreting and exploiting proteomic datasets for drug discovery and vaccine design”

27.09.2011 Christian Kaufmann (Institute of Parasitology, University of Zürich): “From Midges to Mosquitoes”

04.10.2011 Masterstudierende stellen ihre Arbeiten vor 11.10.2011 Christoph Lippuner (Institute of Parasitology, University of

Zürich): “Transcriptomics of intestinal stages of Cryptosporidium”

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18.10.2011 Stefanie Wagner (Institute of Parasitology, University of Zürich): “Mosquitoes in Central Europe: ecological and physiological investigations”

25.10.2011 Michael Grigg (Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda): “Biology of Toxoplasma Pathogenesis: Strain Type and Polyparasitism as Predictors of Disease”

08.11.2011 Dr. Catherine Eichwald (Institute of Virology, University of

Zürich): “Bacillus subtilis spores, a safe alternative for enteric antigen delivery”

15.11.2011 Dr. sc. Relja Beck (DVM Head of Laboratory for Parasitology,

Department for Bacteriology and Parasitology, Croatian Veterinary Institute): “Vector borne diseases in Croatia”

29.11.2011 Prof. Nick Smith (Queensland Tropical Health Alliance,

James Cook University, Cairns Australia): “The Molecular Biology of Oocyst Wall Formation in Coccidian Parasites”

20.12.2011 Dr. Gabriella Worwa (Center for Vectorborne Diseases, School of Veterinary Medicine, University of California, Davis, USA): “Potential mechanisms of West Nile virus persistence in California”

68

Nachwuchsförderung

Durch Drittmittel geförderte Nachwuchskräfte am Institut

Name Vorname Funktion Projekt Drittmittelgeber Datum von Datum bis

Eichenberger Ramon Doktorand Diagnose der Cysticercose beim Rind. BVET,

Industrie 15.04.08 31.12.11

Faso Carmen Postdoktorandin Molecular basis for protein secretion in the

basal parasite Giardia lamblia. NF 01.02.10 31.07.11

Hegglin Daniel Postdoktorand ⁄

Wissenschaftl. Mitarbeiter

Bekämpfung der Alveolären Echinococcose

und Management von Füchsen im

Siedlungsraum.

BVET 01.02.07 31.12.11

Kaufmann Christian Urs Postdoktorand

Bluetongue disease vectors (Culicoides

spp.): Defining parameters which determine

vector free periods⁄ areas in Switzerland.

BVET 17.03.08 28.02.11

Morf Laura Ursina PhD-Doktorandin

The function of Rab GTPases in development

of infective stages of the protozoan parasite

Giardia lamblia.

SBF, NF 01.09.06 31.03.10

Motta Bruna Doktorandin

Investigation on the prevalence of Thelazia

callipaeda and Dirofilariasis in cats and of

Angiostrongylus vasorum in dogs in Southern

Ticino and evaluation of therapeutic

measures against Thelazia callipaeda in dogs

and cats.

Industrie 01.09.09 28.07.11

69

Rout Samuel PhD-Doktorandin Molecular basis for protein secretion in the


Schucan Angela Doktorandin Serologische Diagnose der Angiostrongylose. Industrie 15.04.08 30.06.10

Spycher Cornelia Postdoktorandin Stress and quality control mechanisms during

protein export in Giardia lamblia.

SBF, Industrie,

NF 15.01.07 30.11.10

Steinmann Irene Doktorandin

Biologie von Gnitzen (Culicoides spp.):

Vorkommen, Brutplätze, Wirtspräferenzen,

Überwintertungsstrategien.

BVET 15.10.09 15.03.11

Wampfler Petra PhD-Doktorandin Molecular basis for protein secretion in the


Wenk Claudia Doktorandin

Etablieren von Real-Time Multiplex PCRs zur

Identifizierung von Gnitzen-Arten (Culicoides

spp.).

BVET 18.02.08 31.03.10

Ziadinov Iskenderali Postdoktorand Echinococcosis in Kyrgyzstan. NIH, Industrie 01.07.08 31.12.10

Armua-Fernandez Maria Teresa Postdoktorandin Biology and Immunology of Echinococcus on

its definitive hosts PARAVAC 01.10.11 30.09.12

Balmer Nicole Doktorandin

Dokumentation der Wirksamkeit von Cydectin

10 Prozent LA bei Jungrindern und Cydectin

2 Prozent LA bei Schafen gegen Magen-

Darm- und Lungenwurm-Befall

Pfizer AG 14.03.11 31.05.12

Eichenberger Ramon PhD-Doktorand Immunology and immunopathology of canine

babesiosis BVET 15.04.08 31.03.12

70

Faso Carmen Postdoktorandin Molecular basis for protein secretion in the

basal parasite Giardia lamblia. COST 01.02.10 30.04.12

Grieder Barbara Doktorandin Verteilung von Angiostrongylus vasorum in

der Schweiz Bayer 15.07.10 30.06.12

Hegglin Daniel Postdoktorand ⁄

Wissenschaftl. Mitarbeiter

Bekämpfung der Alveolären Echinococcose

& Management von Füchsen im

Siedlungsraum

Novartis 01.01.12 31.12.12

Kaufmann Christian Urs Postdoktorand

Bluetongue disease vectors (Culicoides

spp.): Defining parameters which determine

vector free periods⁄ areas in Switzerland.

BVET 01.11.09 31.12.11

Lippuner Christoph Postdoktorand Epidemiologie und Pathogenese der Kälber-

Cryptosporidiose

Joint

Appointment

mit

Nutztierklinik

01.03.09 31.12.12

Meier Lorena Doktorandin Vakzinierung von Ziegen gegen Haemonchus

contortus auf der Basis nativer Glycoproteine COST 01.11.11 31.10.12

Motta Bruna Doktorandin

Investigation on the prevalence of Thelazia

callipaeda and Dirofilariasis in cats and of

Angiostrongylus vasorum in dogs in Southern

Ticino and evaluation of therapeutic

measures against Thelazia callipaeda in dogs

and cats.

Novartis 01.01.09 31.03.12

71

Rout Samuel PhD-Doktorand Exploring reductive evolution of essential

organelles in Giardia lamblia SNF 15.02.10 31.12.13

Spycher Cornelia Postdoktorandin "Kiss and Flush" - a minimized endocytic

system in the protozoan Giardia lamblia

SNF

AMBIZIONE 01.02.11 30.09.13

Zumthor Jon Paulin PhD-Doktorand Endocytosis in Giardia lamblia: a promising

port of entry for drug delivery SNF 01.02.11 31.12.12

Durch Forschungskredit der Universität Zürich geförderte Nachwuchskräfte

Name Vorname Funktion Projekt Datum von

Datum bis

Kaufmann Christian Urs

Postdoktorand Energy metabolism in the reproductive biology of Culicoides spp., the potential vectors of the bluetongue disease.

01.11.09 30.09.11

Glor Sabine Doktorandin Toxoplasma gondii infection in domestic animals: humoral immune response against different parasite stages and antigens

15.01.11 31.12.12

Lippuner Christoph Postdoktorand Transcriptome of enteroepithelial stages of Cryptosporidium parvum 01.01.11 30.09.12

Stefanic Sasa Postdoktorand Applying combinatorial technology in search for vaccine and drug targets in Fasciola hepatica

01.07.11 30.06.12

Wampfler Petra PhD-Doktorandin

Molecular basis for protein secretion in the basal parasite Giardia lamblia. 15.11.09 30.06.12

Durch Drittmittel geförderte Nachwuchskräfte im Ausland Radziulis Kestutis Doktorand Lithuanian Veterinary Academy, Kaunas, Litauen. 01.01.10 31.12.11

72

Forschungsaufenthalte von Angehörigen anderer Forschungsinstitute am Institut

Name Aufenthaltszweck Datum

Adam Michel (cand. vet.med.)

Forschungsprojekt Babesiose Wildwiederkäuer

01.03. – 30.09.10

Bergmann Daniela Bachelorarbeit (Studentin) 01.03. – 30.06.10 Christiansen Lise-Lotte (Technician)

Forschungszusammenarbeit 06.10. – 07.10.10

Danielli Sara Research (Studentin) 31.05. - 04.06.10 Francione Enrico (Dr. med. vet.)

Methoden lernen, E. multilocularis

22.11. – 26.11.10

Jaya Ricko Laino (Dr. med. vet.)

Weiterbildung 22.11. – 23.11.10

Jurankova Jana (Dr.) Collaboration for T. gondii experiment

06.12. – 10.12.10

Lalkovsky Nikolay (Dr.) Ausbildung in Methoden 02.11. – 05.11.10 Mauti Stephanie (med. vet.) Dissertation (Swiss TPH) 13.12. – 17.12.10 Manzanell Ralph (Dr.) Sabbatical 03.05. – 31.05.10 Neumayerova Helena (Mgr.) Cooperation on Toxoplasma gondii

experiment 06.12. – 10.12.10

Pirro Franz Diskussion Cryptosporiden-Forschung am IPZ

03.08. – 04.08.10

Rahmi Erdiansyah (Dr. med. vet.)


Smith David (med. vet.) Projektkooperation 23.02. – 24.02.10 Sperlich Christine Praktikum (Studentin) 22.11. - 05.12.10 Suter Denise (Dr. med. vet.)

Schulung 22.06.2010

Thompson Andrew C. (Prof.)

Forschungszusammenarbeit 25.04. – 28.04.10

Wahyudi Rachmad (Dr. med. vet.)


Azuhriwi Blasius Post Mortem Analysen Schafe 23.03. – 01.04.11 Bee Anja (Dr. med. vet.) FVH-Weiterbildung 01.02. – 28.02.11 Beiromvand Molouk (PhD Studentin)

Akademischer Gast 02.10.11 28.02.12

Blaser Alexandra (Studentin)

Masterarbeit 01.03.11 – 31.07.12

Boubaker Ghalia (PhD Student)

Research 20.06. – 24.06.11

73

Crisi Paolo Emidio (Student)

Project Aelurostongylus abstrusus 10.10. – 12.10.11

da Conceicao dos Reis Paomole Antonia (PhD Studentin)

Research 20.06. – 24.06.11

Danielli Sara (Dr.) Scholarship to deepen the argument of the thesis

02.11. – 16.12.11

Derdix Raissa Praktikum (Austauschstudentin) 04.07. - 29.08.11 Dersch Alexander (Bachelor of Medicine)

Untersuchung ⁄ Ausbildung 04.01.2011

Di Cesare Angela (Dr.) wissenschaftliche Zusammenarbeit mit Dr. M. Schnyder

06.06. – 10.06.11

Di Cesare Angela (Dr.) Project Aelurostongylus abstrusus 10.10. – 12.10.11 Dvorak Jan (Dr.) wissenschaftliche Zusammenarbeit

mit Dr. S. Stefanic 14.03. – 16.03.11

Ebneter Jacqueline (Studentin)

Semesterarbeit 01.09. – 31.12.11

Frei Damaris Vorbereitung für LAP 20.04.2011 Grigg Michael E. (PhD) NIH-Projekt 21.10. – 28.10.11 Guardone Lisa (PhD) Externe PhD Studentin 04.04. - 31.07.11 Hauser Magdalena (Studentin)

Masterarbeit 11.03.11 – 31.08.12

Kadohira Mutsuyo Discussion Zoonosen – Wildtier 23.03.2011 Kinnunen Katri Praktikum 28.03. – 31.03.11 Klotz Christian Laborarbeit 07.03. – 08.03.11 Lurati Laura (Studentin) Masterarbeit 01.03.11 – 31.07.12 Lustenberger Marion (Studentin)

Masterarbeit 04.04.11 – 31.05.12

Mantey Sabrina (Studentin) Masterarbeit 01.09.11 – 31.08.12 Müller Stefan Praktikum 18.08. – 31.12.11 Niebel Nadine (Studentin) Masterarbeit 04.04.11 – 31.08.12 Ribeiro Almeida Guerra Diogo

Erasmus Student 03.10.11 – 31.01.12

Schmid Vincent (Dr.) Novartis Studie 16.03.2011 Smith Nick (Prof.) NIH-Projekt 21.10. – 28.10.11 Tranchard Elodie Novartis-Project 14.01. – 18.01.11 Völlger Melanie (Studentin) Erlernung Serologischer Methoden,

Kultivierung 04.04. – 08.04.11

Wagner Stefanie (Studentin) Masterarbeit 01.08.10 – 31.07.11 Yoshikawa Yasuhiro Discussion Zoonosen – Wildtier 23.03.2011

74

Aussenbeziehungen

Tätigkeit in Institutionen der Forschungsförderung und Behörden

Prof. P. Deplazes: Ist Vorstandsmitglied des Stiftungsrates der Karl-Enigk-Stiftung und des Stiftungsrates der Echinococcose-Stiftung. Er ist Gründungsmitglied des EVPC (European Veterinary Parasitology College) und des ESCCAP (European Scientific Counsel Companion Animal Parasites). Er bekleidet das Amt eines "Visiting Professor" am Danish Centre for Experimental Parasitology, Kopenhagen und ist Mitglied des Editorial Board von "Infection" und des Advisory Board von „Veterinary Parasitology“ und fungierte in der Be-richtsperiode als Gutachter verschiedener Fachzeitschriften und internationaler und nationaler Forschungsfonds. Dr. F. Grimm: Ist Mitglied der Diagnostik-Kommission der Schweizerischen Gesellschaft für Tropenmedizin und Parasitologie. Prof. A.B. Hehl: Fungierte in der Berichtsperiode als Gutachter für verschiedene Fachzeitschriften sowie für den Schweizerischen Nationalfonds, die Wellcome Foundation, den NIH, die Österreichische Akademie der Wissenschaften und den Romanian National Council for Scientific Research. Er ist Mitglied der scientific advisory boards von EuPathDB und GiardiaDB. Er ist Kuratoriumsmitglied der Stiftung für wissenschaftliche Forschung an der Universität Zürich sowie Stiftungsrat und wissenschaftlicher Berater von Lepra.ch. PD Dr. H. Hertzberg: Ist Mitglied des EVPC (European Veterinary Parasitology College) und fungierte in der Berichtsperiode als Gutachter verschiedener Fachzeitschriften. Prof. A. Mathis: War in der Berichtsperiode Gutachter für deutsche und französische Forschungsfonds und verschiedener Fachzeitschriften. Er ist Vorsitzender der ‚Swiss Vector Entomology Group‘. Dr. M. Schnyder: Ist Mitglied des Vorstandes der Schweizerischen Gesellschaft für Tropenmedizin und Parasitologie (SGTP) und von ESCCAP (European Scientific Counsel Companion Animal Parasites) Schweiz. Ist Mitglied der Gesellschaft Schweizer Tierärzte (GST), der Schweizerischen Vereinigung für Kleintiermedizin (SVK) und der Schweizerischen Vereinigung der Veterinär-Labordiagnostiker (SVVLD). Ist ausserdem Mitglied des EVPC (European Veterinary Parasitology College). Sie fungiert als Gutachterin in verschiedenen Fachzeitschriften.

75

Dr. R.M. Eichenberger: Ist Mitglied der Gesellschaft Schweizer Tierärzte (GST) und der Schweizierischen Gesellschaft für Tropenmedizin und Parasitologie (SGTP).

Funktionen von Institutsangehörigen an der Univer-sität und Fakultät

Prof. P. Deplazes ist Mitglied der Prüfungskommission für die eidgenössischen Medizinalprüfungen und war Vertreter der Vetsuisse-Fakultät in der Nachwuchsförderungskommission der Universität Zürich. Er war Mitglied der Stipendienkammer der Forschungskommission des NF und in der Nachwuchsförderungskommission der Stiefel-Zangger-Stiftung sowie verschiedener fakultärer Kommissionen. Er ist Mitglied des Microbiology and Immunology (MIM) PhD Programs der Life Sciences Graduate School Zürich. Prof. A.B. Hehl ist Mitglied der Vetsuisse-Forschungskommission und der Kommission für Arbeitssicherheit und Gesundheitsschutz der Universität Zürich. Er ist Mitglied der Microbiology and Immunology (MIM) und der Ecology PhD Programme der Life Sciences Graduate School Zürich. Er hat Promotionsrecht an der Mathematisch-Naturwissenschaftlichen Fakultät (MNF) der Universität Zürich.

Prof. A. Mathis ist Vorstandsmitglied der PD-Vereinigung UZH, Standesvertreter PD/TP in Senat UZH, Vetsuisse-Kommission Berufungs- und Beförderungsgeschäfte, Vetsuisse-Fakultätsversammlung.

Dr. M. Schnyder ist Vertretung der Assistierenden in der ständigen Vetsuisse-Kommission für Berufungen und Beförderungen. Dr. R.M. Eichenberger ist im Organisationskomitee des MD-PhD Retreats 2012 des MD-PhD Programms der Universität Zürich. Er war 2010/2011 in der Berufungskommission Nachfolge Lehrstuhl Tierernährung Vetsuisse-Zürich.

76

Bauliches, EDV und Ausstattung

Ende 2011 waren insgesamt 22 PCs und 18 Notebooks am Instituts im Einsatz. Weitere 8 PCs werden zur Steuerung von Geräten oder für andere Zwecke eingesetzt. Grössere Probleme wurden weder beim Server noch bei PCs oder Notebooks registriert. Die tägliche Datensicherung hat sich wiederum sehr bewährt. Es konnten mehrmals 'verlorene' oder irrtümlich gelöschte Daten restauriert werden. Das IPZ lizenziert seit mehreren Jahren seine Standardsoftware unter dem Microsoft Campus Agreement. Dies ermöglicht es, auf allen Geräten jederzeit die aktuellsten Versionen zu installieren und trägt damit zu einem möglichst reibungslosen Betrieb bei. Die +4 Grad Kühlzelle wurde im Jahr 2010 totalsaniert. Im Investitionskredit 2011 wurde dem IPZ und dem Virologischen Institut eine gemeinsame -20 Grad Kühlzelle zugesprochen, welche die vielen alten, zum Teil nicht mehr erlaubten Kühlgeräte aus den 70er und den 80er Jahren ersetzt.

Bibliothek, Sammlungen und Unterrichtsmittel

Für die Betreuung der Bibliothek ist weiterhin Prof. A. Mathis verantwortlich. Die Bibliothek wurde 2010 umgebaut, um Büroarbeitsplätze zu schaffen; dazu wurde ein Grossteil der Bücher ausgelagert (Lagerraum der Fakultätsbibliothek). Ende 2011 verzeichnete die Bibliothek des IPZ folgende Bestände (in Klammern Änderungen im Vergleich zu 2009): Abonnierte Zeitschriften 16 (unverändert); Bücher 1237 (+13) (z.T. mehrteilige Bände und Neuauflagen); Dissertationen 555 (+5). Für Unterrichtsmittel sowie Unterrichtsvorbereitungen ist Frau L.Kohler und Herr S. Müller verantwortlich. Unterrichtsmittel (Präparate usw.) werden zum Teil auch an andere Ausbildungsstätten oder an Einzelpersonen ausgeliehen.

Preise

Preise im Jahre 2011: Prize for best Oral Presentation in the Control Session: Hegglin, Daniel, Dr. & Deplazes, Peter, Prof.

Echinococcus multilocularis: Ecology based control strategies in urban settings. XXIV World Congress of Hydatidology, 14th-18th September 2011, Urumqi, China

77

Personal

Organisation und Mitarbeiterstab (Stand: Dezember 2011)

Leitung

Deplazes Peter Prof. Dr. med. vet. FVH, EVPC, Direktor

Lehre / Infrastruktur

Kohler Lucia Diplomierte Biomedizinische Analytikerin HF, Cheflaborantin

Müller Hanspeter Tierpfleger

Sekretariat

Dietze Karin Verwaltungsassistentin (Anstellung Virologie) Andersen Stefania Verwaltungssekretärin (Anstellung Virologie) Racca Valentina Verwaltungssekretärin Züst Esther Verwaltungssekretärin

Forschung / Research

Vektor Entomologie

Mathis Alexander Prof. Dr. sc. nat. ETH, Wissenschaftlicher Abteilungsleiter

Hauri Jeannine Diplomierte Biomedizinische Analytikerin HF Kaufmann Christian PhD Dr. phil. nat., Postdoktorand Schaffner Francis PhD Biosystématique, Wissenschaftl. Mitarb.

Molekulare Parasitologie

Hehl Adrian B. Prof. Dr. phil. nat., Wissenschaftlicher Abteilungsleiter

Faso Carmen PhD Dr., Postdoktorandin Huggel Katharina Diplomierte Biomedizinische Analytikerin HF Michel Therese Laborantin Rout Samuel MSc KIIT University, PhD-Doktorand Spycher Cornelia PhD Dr. phil. nat., Postdoktorandin Wampfler Petra MSc ETH, PhD-Doktorandin Zumthor Jon Paulin Dr. med. vet., PhD-Doktorand

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Med. und vet. Parasitologie

Deplazes Peter Prof. Dr. med. Vet. FVH, EVPC Armua Maria Teresa Dr. med. vet., Postdoktorandin Balmer Nicole Med. vet., Doktorandin Basso Walter Dr. med. vet., Assistent Eichenberger Ramon PhD Dr. med. vet., Postdoktorand Fiechter Ruth Dr. med. vet., Assistentin Glor Sabine Med. vet., Doktorandin Grieder Barbara Med. vet., Doktorandin Hegglin Daniel Dr. sc. nat., Postdoktorand Hertzberg Hubertus PD Dr. med. vet., EVPC, Wissenschaftl. Mitarb. Huggel Katharina Diplomierte Biomedizinische Analytikerin HF Kohler Lucia Diplomierte Biomedizinische Analytikerin HF,

Cheflaborantin Meier Lorena Med. vet., Doktorandin Motta Bruna Med. vet., Doktorandin Schnyder Manuela Dr. med. vet., Oberassistentin, EVPC Stebler Kathrina Diplomierte Biomedizinische Analytikerin HF Stefanic Sasa Dr. med. vet., Assistent Ziadinov Iskenderali Dr. med. vet., Postdoktorand

Diagnostikzentrum Parasitologie (DZP)

Grimm Felix Dr. phil. II, Wissenschaftl. Abteilungsleiter Bodmer Susy Diplomierte Biomedizinische Analytikerin HF Boller Bettina Diplomierte Biomedizinische Analytikerin HF Ebeid Susanne Laborantin Kaspar-Witt Vera Diplomierte Biomedizinische Analytikerin HF Lauffer Judith Diplomierte Biomedizinische Analytikerin HF Salathé Bogdana Laborhilfe Suter Waltraud Laborantin Von Niederhäusern Karin Laborantin mbA Wolfensberger Elisabeth Laborantin

Joint Appointment mit Fakultät

Schnyder Manuela Dr. med. vet., Oberassistentin Merz Esther Tierpflegerin Rüdemann Armin Tierpfleger

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Joint Appointment mit Nutztierklinik

Deplazes Peter Prof. Dr. med. vet. FVH, EVPC Lippuner Christoph Dr. rer. nat., Postdoktorand

Erasmus Guerra Diogo

Gast Beiromvand Molouk

Stellenmutationen 2010 und 2011

Eintritte:

Faso Carmen, Rout Samuel, von Niederhäusern Karin, Hammes Karen, Grieder Barbara, Hälg Claudia, Stefanic, Sasa, Racca Valentina, Nagy Anina, Glor Sabine, Spycher Cornelia, Zumthor Jon Paulin, Balmer Nicole, Stebler Kathrina, Huggel Katharina, Armua Fernandez Maria Teresa, Züst Esther, Meier Lorena.

Austritte:

de Vries Viviane, Morf Laura, Wenk Claudia, Nagy Anina, Schucan Angela, Molleyres Eva, Tamburini Katja, Steinmann Irene, Tanner Isabelle, Schlumpf Priska, Schweiger Alexander.

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Organigramm IPZ

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Documents

Institut für Parasitologie - paras.uzh.chffffffff-ff54-16dd-ffff-ffffaca66384/JB_Buch_2010... · namhafte Drittmittel in einem EU- und in einem KTI-Projekt ein. Für klinische Für